AR045551A1 - Compuestos fenil o piridil amida como prostaglandina e2 antagonistas - Google Patents

Compuestos fenil o piridil amida como prostaglandina e2 antagonistas

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Publication number
AR045551A1
AR045551A1 ARP040103132A ARP040103132A AR045551A1 AR 045551 A1 AR045551 A1 AR 045551A1 AR P040103132 A ARP040103132 A AR P040103132A AR P040103132 A ARP040103132 A AR P040103132A AR 045551 A1 AR045551 A1 AR 045551A1
Authority
AR
Argentina
Prior art keywords
groups
group
atoms
alkyl
substituted
Prior art date
Application number
ARP040103132A
Other languages
English (en)
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of AR045551A1 publication Critical patent/AR045551A1/es

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    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C233/81—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C07C233/82—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/87—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom of a carbon skeleton containing six-membered aromatic rings
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4412—Non condensed pyridines; Hydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring
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Abstract

Compuestos útiles para el tratamiento de patologías mediadas por prostaglandina tales como dolor o similar en mamíferos. Esta proporciona también una co0mposición farmacéutica que comprende el compuesto anterior. Reivindicación 1: Un compuesto de fórmula (1) en la que A representa un grupo fenilo o un grupo piridilo; B representa un grupo arilo o un grupo heteroarilo; E representa un grupo 1,2-fenileno; R1 y R2 representan independientemente un átomo de H, un átomo de halógeno, un grupo alquilo C1-4, un grupo alcoxi C1-4, un grupo haloalquilo C1-4, un grupo haloalcoxi C1-4, un grupo ciano o un grupo aminocarbonilo; R3 y R4 representan independientemente un átomo de H o un grupo alquilo C1-4, o R3 y R4 pueden unirse formando una cadena alquileno C2-6; R5 representa -CO2H, CO2W, o como se muestra en el grupo de fórmulas (2); R6 representa un grupo alquilo C1-6, un grupo cicloalquilo C3-7 átomos de anillo, un grupo arilo o un grupo heteroarilo; X representa un grupo metileno, un átomo de O o un átomo de S; dichos grupos arilo tienen C6-10; dichos grupos heteroarilo son grupos heterocíclicos aromáticos de 5 a 10 miembros que contienen de 1 a 3 heteroátomos seleccionados entre el grupo compuesto por átomos de S, átomos de O y átomos de N; dichos grupos arilo y dichos grupos heteroarilo a los que se hace referencia en las definiciones de B no están sustituidos o están sustituidos con al menos un sustituyente seleccionado entre el grupo compuesto por sustituyentes alfa; dicho grupo 1,4-fenileno al que se hace referencia en la definición de E no está sustituido o está sustituido con al menos un sustituyente seleccionado entre el grupo constituido por sustituyentes beta; dichos grupos arilo y heteroarilo a los que se hace referencia en las definiciones de R6 y alfa no están sustituidos o están sustituidos con al menos un sustituyente seleccionado entre el grupo constituido por sustituyentes beta; dichos sustituyentes alfa se seleccionan entre el grupo compuesto por átomos de halógeno, grupos alquilo C1-4, grupos alcoxi C1-4, grupos haloalquilo C1-4, grupos haloalcoxi C1-4, grupos ciano, grupos alquinilo C2-6, grupos alcanoilo C1-5, grupos cicloalquilo C3-7 átomos de anillo, grupo heteroarilo, grupos arilo, grupos aralcoxi C7-10, grupos arilcarbonilo, dos grupos alfa adyacentes se juntan opcionalmente formando una cadena alquileno o alquenileno C3-4, grupos aminocarbonilo, grupos alquenilo C2-5, grupos alquiltio C1-4, grupos aminosulfinilo, grupos aminosulfonilo, grupos hidroxi, grupos hidroxialquilo C1-4, grupos nitro, grupos amino, grupos carboxi, grupos alcoxicarbonilo C2-5, grupos alcoxialquilo C1-4, grupos alquilsulfonilo C1-4, grupos alcanoilamino C1-4, grupos alcanoil(alquil)amino C1-6, grupos alcanoilaminoalquilo que tiene de 1 a 6 átomos de C en la parte alcanoilo y alquilo, grupos alcanoil(alquil)aminoalquilo que tienen de 1 a 6 átomos de C en la parte alcanoilo y en cada una de las partes alquilo, grupos alquilsulfonilamino C1-4, grupos mono- o di-alquilaminocarbonilo C1-6, grupos mono o di-alquilaminosulfinilo C1-6, grupos mono o dialquilaminosulfonilo C1-6, grupos aminoalquilo C1-4, grupos mono o di-alquilamino C1-6, grupos mono o di- alquilaminoalquilo C1-6 en cada parte alquilo, grupos aralquilo que tienen de 7 a 10 átomos de C, grupos heteroarilalquilo que tienen de 1 a 4 átomos de C en la parte alquilo, grupos heteroarilalcoxi que tienen de 1 a 4 átomos de C en la parte alcoxi y grupos alquilsulfonilamino que tienen de 1 a 4 átomos de C; dichos constituyentes beta se seleccionan entre el grupo compuesto por átomos de halógeno, grupos alquilo C1-4, grupos alcoxi C1-4, grupos haloalquilo C1-4, grupos haloalcoxi C1-4 y grupos ciano; W es un grupo éster profármaco farmacéuticamente aceptable; con la condición de que R1 y R2 no representen un átomo de H simultáneamente; o una sal farmacéuticamente aceptable del mismo.
ARP040103132A 2003-09-03 2004-09-01 Compuestos fenil o piridil amida como prostaglandina e2 antagonistas AR045551A1 (es)

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Families Citing this family (70)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101160290B (zh) 2004-12-02 2011-01-19 第一三共株式会社 7-元环化合物、其制备方法和药物用途
UY30121A1 (es) 2006-02-03 2007-08-31 Glaxo Group Ltd Nuevos compuestos
CA2648729A1 (en) * 2006-04-24 2007-11-01 Merck Frosst Canada Ltd. Indole amide derivatives as ep4 receptor antagonists
WO2007139230A1 (ja) * 2006-05-31 2007-12-06 Asubio Pharma Co., Ltd. ７員環化合物並びにその製造法および医薬用途
CA2654811A1 (en) * 2006-06-12 2007-12-21 Merck Frosst Canada Ltd. Indoline amide derivatives as ep4 receptor ligands
ITMI20061368A1 (it) * 2006-07-14 2008-01-15 Acraf Composto 2-arilindolico sostituito in posizione 5, composizione farmaceutica che lo comprende nonche' composti intermedi e procedimento per prepararlo
CA2660133C (en) * 2006-08-11 2015-10-27 Merck Frosst Canada Ltd. Thiophenecarboxamide derivatives as ep4 receptor ligands
KR20090089868A (ko) 2006-12-15 2009-08-24 글락소 그룹 리미티드 Ｅｐ４ 수용체 작동제로서 벤즈아미드 유도체
US8158671B2 (en) * 2007-02-26 2012-04-17 Merck Canada Inc. Indole and indoline cyclopropyl amide derivatives as EP4 receptor antagonists
EP2460787A1 (en) 2007-07-03 2012-06-06 Astellas Pharma Inc. Amide compounds and their use as PGE2 antagonists.
EP2185534A1 (en) * 2007-08-09 2010-05-19 Merck Sharp & Dohme Corp. Process for making thiophene carboxamide derivative
GB0721611D0 (en) * 2007-11-02 2007-12-12 Glaxo Group Ltd Novel compounds
NZ585085A (en) * 2007-11-16 2012-08-31 Abbott Lab Method of treating arthritis using arylsulfonamide compounds
PT2565191E (pt) * 2008-05-14 2014-12-04 Astellas Pharma Inc Derivados do ácido 4-(indol-7- ilcarbonilaminometil)ciclo-hexanocarboxílico como antagonistas de receptores ep4, úteis no tratamento de insuficiência renal crónica ou de nefropatia diabética
TW200951139A (en) * 2008-05-27 2009-12-16 Astrazeneca Ab Chemical compounds 293
GB0810313D0 (en) * 2008-06-05 2008-07-09 Glaxo Group Ltd Novel compounds
JP5536773B2 (ja) 2008-08-14 2014-07-02 ベータ・ファーマ・カナダ・インコーポレイテッド Ｅｐ４受容体アンタゴニストとしてのヘテロ環式アミド誘導体
ME02642B (me) * 2008-12-05 2017-06-20 Abbvie Inc Sulfonamid derivati i kao BCL- 2 selektivni agensi za induciranje apoptoze namijenjeni liječenju raka i imunih bolesti
WO2010087425A1 (ja) 2009-01-30 2010-08-05 国立大学法人京都大学 前立腺癌の進行抑制剤および進行抑制方法
ES2960438T3 (es) * 2009-04-22 2024-03-04 Askat Inc Sustancia antagonista del receptor EP4 selectivo para el tratamiento del cáncer
CA2789665C (en) * 2010-02-22 2020-06-16 Raqualia Pharma Inc. Use of ep4 receptor antagonists in the treatment of il-23 mediated diseases
BR112013002484B1 (pt) * 2010-09-21 2021-10-13 Eisai R&D Management Co. , Ltd. Composto, composição farmacêutica, e, usos de um composto
US8828987B2 (en) 2010-12-10 2014-09-09 Rottapharm Biotech S.R.L. Pyridine amide derivatives as EP4 receptor antagonists
IN2014CN00719A (es) 2011-07-04 2015-04-03 Rottapharm Spa
KR101412794B1 (ko) 2011-07-27 2014-07-01 보령제약 주식회사 혈관생성억제 작용을 갖는 신규한 화합물, 이의 제조방법 및 이를 포함하는 약학적 조성물
WO2013032971A1 (en) 2011-08-29 2013-03-07 Ticona Llc Melt-extruded substrate for use in thermoformed articles
JP2014525499A (ja) 2011-08-29 2014-09-29 ティコナ・エルエルシー 低い融解温度をもつ耐熱性液晶ポリマー組成物
US9045685B2 (en) 2011-08-29 2015-06-02 Ticona Llc Cast molded parts formed from a liquid crystalline polymer
TW201313884A (zh) 2011-08-29 2013-04-01 Ticona Llc 液晶聚合物之固態聚合
JP2014529627A (ja) 2011-08-29 2014-11-13 ティコナ・エルエルシー 芳香族アミド化合物
CN103764793B (zh) 2011-08-29 2016-09-14 提克纳有限责任公司 高流动液晶聚合物组合物
JP2014525498A (ja) 2011-08-29 2014-09-29 ティコナ・エルエルシー 高流動性液晶ポリマー組成物
WO2013032975A1 (en) 2011-08-29 2013-03-07 Ticona Llc Thermotropic liquid crystalline polymer with improved low shear viscosity
JP2014525500A (ja) 2011-08-29 2014-09-29 ティコナ・エルエルシー 低溶融粘度液晶ポリマーの溶融重合
AR091429A1 (es) 2012-06-29 2015-02-04 Lilly Co Eli Compuestos de fenoxietil piperidina
UA115576C2 (uk) 2012-12-06 2017-11-27 Байєр Фарма Акцієнгезелльшафт Похідні бензимідазолу як антагоністи ер4
PT3239134T (pt) * 2013-01-31 2021-01-28 Vertex Pharma Piridona amidas como moduladores dos canais de sódio
TW201443004A (zh) 2013-02-15 2014-11-16 Lilly Co Eli 苯氧基乙氧基化合物
WO2014130275A2 (en) 2013-02-22 2014-08-28 Ticona Llc High performance polymer composition with improved flow properties
KR102239641B1 (ko) 2013-03-19 2021-04-13 에스크엣 인크. 연골질환 치료에서의 ep4 수용체 길항제의 용도
US10391086B2 (en) 2013-03-19 2019-08-27 Askat Inc. Use of EP4 receptor antagonists in the treatment of cartilage disease
TWI636046B (zh) 2013-05-17 2018-09-21 美國禮來大藥廠 苯氧基乙基二氫－１ｈ－異喹啉化合物
US9206300B2 (en) 2013-06-07 2015-12-08 Ticona Llc High strength thermotropic liquid crystalline polymer
NO3009426T3 (es) 2013-06-12 2018-09-29
CA2916653C (en) 2013-06-27 2017-07-18 Pfizer Inc. Heteroaromatic compounds and their use as dopamine d1 ligands
WO2015048553A1 (en) * 2013-09-27 2015-04-02 Allergan, Inc. Compounds and methods for skin repair
ES2727329T3 (es) * 2013-12-17 2019-10-15 Lilly Co Eli Compuestos de ácido dimetilbenzoico
CA2928593A1 (en) * 2013-12-17 2015-06-25 Eli Lilly And Company Phenoxyethyl cyclic amine derivatives and their activity as ep4 receptor modulators
TW201607943A (zh) 2013-12-19 2016-03-01 拜耳製藥公司 作為ｅｐ４配體之新穎苯并咪唑衍生物
WO2016021742A1 (en) * 2014-08-07 2016-02-11 Takeda Pharmaceutical Company Limited Heterocyclic compounds as ep4 receptor antagonists
WO2016088903A1 (en) * 2014-12-05 2016-06-09 Takeda Pharmaceutical Company Limited Heterocyclic compounds
KR102369674B1 (ko) 2015-02-17 2022-03-04 삼성디스플레이 주식회사 디스플레이 장치, 및 이를 포함하는 전자 기기
CR20180323A (es) 2015-11-20 2018-08-06 Idorsia Pharmaceuticals Ltd Derivados de indol n-sustituídos como moduladores de los receptores de pge2
CN109563053B (zh) * 2016-06-28 2023-02-28 肯塔基大学研究基金会 前列腺素e合成酶抑制剂及使用其的方法
US10342785B2 (en) 2016-11-04 2019-07-09 Askat Inc. Use of EP4 receptor antagonists for the treatment of NASH-associated liver cancer
CA3060394A1 (en) 2017-05-18 2018-11-22 Idorsia Pharmaceuticals Ltd Pyrimidine derivatives as pge2 receptor modulators
EP3625224B1 (en) 2017-05-18 2021-08-04 Idorsia Pharmaceuticals Ltd N-substituted indole derivatives
US11446298B2 (en) 2017-05-18 2022-09-20 Idorsia Pharmaceuticals Ltd Pyrimidine derivatives
WO2018210987A1 (en) 2017-05-18 2018-11-22 Idorsia Pharmaceuticals Ltd Benzofurane and benzothiophene derivatives as pge2 receptor modulators
HUE056080T2 (hu) 2017-05-18 2022-01-28 Idorsia Pharmaceuticals Ltd Fenilszármazékok mint PGE2 receptor modulátorok
WO2019121143A1 (en) 2017-12-20 2019-06-27 Basf Se Substituted cyclopropyl derivatives
WO2019186297A1 (en) * 2018-03-29 2019-10-03 Zietchick Research Institute, Llc Methods for treating high blood glucose
US10973834B2 (en) 2018-04-16 2021-04-13 Arrys Therapeutics, Inc. EP4 inhibitors and use thereof
WO2020014445A1 (en) * 2018-07-11 2020-01-16 Arrys Therapeutics, Inc. Ep4 inhibitors and synthesis thereof
EP3693359A1 (en) * 2019-02-08 2020-08-12 Medibiofarma, S.L. New n-benzyl-2-phenoxybenzamide derivatives as prostaglandin e2 (pge2) receptors modulators
WO2021226162A1 (en) 2020-05-05 2021-11-11 Arrys Therapeutics, Inc. Ep4 antagonists and their use in the treatment of proliferative diseases
GB2594931A (en) * 2020-05-06 2021-11-17 Syngenta Crop Protection Ag Improvements in or relating to organic compounds
JPWO2022102731A1 (es) 2020-11-13 2022-05-19
JPWO2022138792A1 (es) * 2020-12-24 2022-06-30
TW202246217A (zh) * 2021-01-28 2022-12-01 大陸商深圳晶泰科技有限公司 咪唑醯胺衍生物及其製備方法和應用

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2500157C2 (de) 1975-01-03 1983-09-15 Hoechst Ag, 6230 Frankfurt N-Acyl-4-(2-aminoäthyl)-benzoesäuren, deren Salze und Ester, Verfahren zu deren Herstellung und deren Verwendung
DE2706977A1 (de) 1977-02-18 1978-08-24 Hoechst Ag Benzoesaeuren und deren derivate sowie verfahren zu ihrer herstellung
DE19655143A1 (de) * 1996-12-13 2000-06-08 Doht Gmbh Pfeil für eine Armbrust
TW523506B (en) * 1996-12-18 2003-03-11 Ono Pharmaceutical Co Sulfonamide or carbamide derivatives and drugs containing the same as active ingredients
JP2000510481A (ja) * 1997-04-04 2000-08-15 ファイザー・プロダクツ・インク ニコチンアミド誘導体
ES2261202T3 (es) 1999-04-28 2006-11-16 Sanofi-Aventis Deutschland Gmbh Derivados de acido de triarilo como ligandos para el receptor ppar.
KR20020076330A (ko) * 2000-02-22 2002-10-09 오노 야꾸힝 고교 가부시키가이샤 안식향산 유도체, 이들의 제조 방법 및 이들을 유효성분으로서 함유하는 약제
EP1229034B1 (en) * 2001-01-31 2005-04-13 Pfizer Products Inc. Nicotinamide derivatives and their mimetics as inhibitors of PDE4 isozymes
JP4529119B2 (ja) * 2001-08-09 2010-08-25 小野薬品工業株式会社 カルボン酸誘導体化合物およびその化合物を有効成分として含有する薬剤
CA2492019A1 (en) * 2002-08-13 2004-02-19 Warner-Lambert Company Llc Isoquinoline derivatives as matrix metalloproteinase inhibitors

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