OA13134A - Broadspectrum 2-amino-benzoxazole sulfamide HIV protease inhibitors. - Google Patents

Broadspectrum 2-amino-benzoxazole sulfamide HIV protease inhibitors. Download PDF

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Publication number
OA13134A
OA13134A OA1200300277A OA1200300277A OA13134A OA 13134 A OA13134 A OA 13134A OA 1200300277 A OA1200300277 A OA 1200300277A OA 1200300277 A OA1200300277 A OA 1200300277A OA 13134 A OA13134 A OA 13134A
Authority
OA
OAPI
Prior art keywords
alkyl
compound
aryl
het1
het2
Prior art date
Application number
OA1200300277A
Other languages
English (en)
Inventor
Dominique Louis Nestor Ghislain Surleraux
Sandrine Marie Helene Vendeville
Wim Gaston Verschueren
Marie-Pierre T M M G De Bethune
Herman Augustinus De Kock
Abdellah Tahri
Original Assignee
Tibotec Pharm Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tibotec Pharm Ltd filed Critical Tibotec Pharm Ltd
Publication of OA13134A publication Critical patent/OA13134A/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
    • C07D263/58—Benzoxazoles; Hydrogenated benzoxazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
OA1200300277A 2001-05-11 2002-05-10 Broadspectrum 2-amino-benzoxazole sulfamide HIV protease inhibitors. OA13134A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP01201732 2001-05-11

Publications (1)

Publication Number Publication Date
OA13134A true OA13134A (en) 2006-12-13

Family

ID=8180286

Family Applications (1)

Application Number Title Priority Date Filing Date
OA1200300277A OA13134A (en) 2001-05-11 2002-05-10 Broadspectrum 2-amino-benzoxazole sulfamide HIV protease inhibitors.

Country Status (32)

Country Link
US (2) US7622490B2 (no)
EP (1) EP1387842B1 (no)
JP (1) JP4467889B2 (no)
KR (1) KR100878853B1 (no)
CN (1) CN100549007C (no)
AP (1) AP1652A (no)
AR (1) AR035970A1 (no)
AT (1) ATE429431T1 (no)
AU (1) AU2002310818B2 (no)
BG (1) BG66350B1 (no)
BR (1) BR0209594A (no)
CA (1) CA2444895C (no)
CY (1) CY1109247T1 (no)
CZ (1) CZ304524B6 (no)
DE (1) DE60232067D1 (no)
DK (1) DK1387842T3 (no)
EA (1) EA009590B1 (no)
EE (1) EE05307B1 (no)
ES (1) ES2325809T3 (no)
HK (1) HK1062912A1 (no)
HR (1) HRP20031026B1 (no)
HU (1) HUP0400438A3 (no)
IL (1) IL158093A0 (no)
MX (1) MXPA03010258A (no)
NO (1) NO326883B1 (no)
NZ (1) NZ529250A (no)
OA (1) OA13134A (no)
PL (1) PL209029B1 (no)
PT (1) PT1387842E (no)
SK (1) SK287952B6 (no)
WO (1) WO2002092595A1 (no)
ZA (1) ZA200307799B (no)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1175205B1 (en) 1999-11-12 2006-06-14 Abbott Laboratories Solid dispersion comprising ritonavir, fenofibrate or griseofulvin
DE10026698A1 (de) 2000-05-30 2001-12-06 Basf Ag Selbstemulgierende Wirkstoffformulierung und Verwendung dieser Formulierung
EP1483254A4 (en) 2002-01-07 2005-06-08 Sequoia Pharmaceuticals INHIBITORS OF ANTI-RESISTANCE RETROVIRAL PROTEASE
US7157489B2 (en) 2002-03-12 2007-01-02 The Board Of Trustees Of The University Of Illinois HIV protease inhibitors
US8025899B2 (en) 2003-08-28 2011-09-27 Abbott Laboratories Solid pharmaceutical dosage form
EA011891B1 (ru) * 2003-09-30 2009-06-30 Тиботек Фармасьютикалз Лтд. Способы получения соединений бензоксазолсульфонамида и их промежуточные соединения
US20050131042A1 (en) * 2003-12-11 2005-06-16 Flentge Charles A. HIV protease inhibiting compounds
US8193227B2 (en) 2003-12-11 2012-06-05 Abbott Laboratories HIV protease inhibiting compounds
JP4818124B2 (ja) 2003-12-23 2011-11-16 テイボテク・フアーマシユーチカルズ・リミテツド （３Ｒ，３ａＳ，６ａＲ）−ヘキサヒドロフロ〔２，３−ｂ〕フラン−３−イル（１Ｓ，１Ｒ）−３−〔〔（４−アミノフェニル）スルホニル〕（イソブチル）アミノ〕−１−ベンジル−２−ヒドロキシプロピルカルバマートの製造方法
EP1725566B1 (en) 2003-12-23 2009-06-17 Tibotec Pharmaceuticals Ltd. Process for the preparation of (3r,3as,6ar)-hexahydrofuro [2,3-b] furan-3-yl (1s,2r)-3-[[(4-aminophenyl) sulfonyl] (isobutyl) amino]-1-benzyl-2-hydroxypropylcarbamate
AU2005244121B2 (en) * 2004-05-07 2012-01-19 Sequoia Pharmaceuticals, Inc. Resistance-repellent retroviral protease inhibitors
KR101333627B1 (ko) 2005-02-25 2013-11-27 얀센 알 앤드 디 아일랜드 프로테아제 저해제 전구체 합성
AR053845A1 (es) 2005-04-15 2007-05-23 Tibotec Pharm Ltd 5-tiazolilmetil[(1s,2r)-3-[[(2-amino-6-benzoxazolil)sulfonil)](2-metilpropil)amino]-2-hidroxi-1-(fenilmetil)propil]carbamato como mejorador de farmacos metabolizados por el citocromo p450
US20120220520A1 (en) * 2006-10-17 2012-08-30 Van T Klooster Gerben Albert Eleutherius Bioavailable combinations for hcv treatment
WO2014194519A1 (en) 2013-06-07 2014-12-11 Merck Sharp & Dohme Corp. Imidazole derivatives and methods of use thereof for improving pharmacokinetics of drug

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SE8204879D0 (sv) 1982-08-26 1982-08-26 Haessle Ab Novel chemical intermediates
ATE141635T1 (de) 1990-03-09 1996-09-15 Milliken Res Corp Organische materialien, die sulfonamidogebundene poly(oxyalkylen)gruppen tragen und ihre herstellung
US5145684A (en) 1991-01-25 1992-09-08 Sterling Drug Inc. Surface modified drug nanoparticles
KR100296461B1 (ko) * 1992-08-25 2001-11-14 죤 에이치. 뷰센 레트로바이러스프로테아제저해제로서유용한n-(알카노일아미노-2-히드록시프로필)-술폰아미드
PH30929A (en) 1992-09-03 1997-12-23 Janssen Pharmaceutica Nv Beads having a core coated with an antifungal and a polymer.
EP0715618B1 (en) 1993-08-24 1998-12-16 G.D. Searle & Co. Hydroxyethylamino sulphonamides useful as retroviral protease inhibitors
DE69429357T2 (de) 1993-10-01 2002-08-14 Astrazeneca Ab, Soedertaelje Verfahren i
CA2210889C (en) 1995-01-20 2007-08-28 G.D. Searle & Co. Bis-sulfonamide hydroxyethylamino retroviral protease inhibitors
US5756533A (en) * 1995-03-10 1998-05-26 G.D. Searle & Co. Amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors
DE69625183T2 (de) 1995-03-10 2003-10-09 G.D. Searle & Co., Chicago Heterocyclocarbonyl-aminosäure-hydroxyethylamino-sulfonamid inhibitoren retroviraler proteasen
US5705500A (en) * 1995-03-10 1998-01-06 G.D. Searle & Co. Sulfonylalkanoylamino hydroxyethylamino sulfonamide retroviral protease inhibitors
US6150556A (en) * 1995-03-10 2000-11-21 G. D. Dearle & Co. Bis-amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors
AU7722296A (en) * 1995-11-15 1997-06-05 G.D. Searle & Co. Substituted sulfonylalkanoylamino hydroxyethylamino sulfonamide retroviral protease inhibitors
HU227745B1 (en) 1996-05-20 2012-02-28 Janssen Pharmaceutica Nv Antifungal compositions containing itraconazole
BR9806174A (pt) 1997-03-26 1999-10-19 Janssen Pharmaceutica Nv Péletes tendo um núcleo revestido com um antifúngico e um polìmero
GB9717849D0 (en) 1997-08-23 1997-10-29 Seal Sands Chemicals Limited Preparation of pyridene derivatives
AU2010299A (en) 1997-12-24 1999-07-19 Vertex Pharmaceuticals Incorporated Prodrugs os aspartyl protease inhibitors
US6436989B1 (en) 1997-12-24 2002-08-20 Vertex Pharmaceuticals, Incorporated Prodrugs of aspartyl protease inhibitors
WO1999033795A1 (en) 1997-12-24 1999-07-08 Vertex Pharmaceuticals Incorporated Prodrugs of aspartyl protease inhibitors
TR200002402T2 (tr) 1997-12-24 2001-01-22 Vertex Pharmaceuticals Incorporated Aspartil proteaz inhibitörü ön-ilaçlar.
AU4828199A (en) * 1998-06-23 2000-01-10 Board Of Trustees Of The University Of Illinois, The Multi-drug resistant retroviral protease inhibitors and associated methods
PT2336134T (pt) 1998-06-23 2016-10-19 The Board Of Trustees Of The Univ Of Illionis Ensaio de aptidão e métodos para reduzir a resistência do hiv à terapia
AR035819A1 (es) * 2001-04-09 2004-07-14 Tibotec Pharm Ltd 2-(amino sustituido)-benzoxazol sulfonamidas, inhibidoras de la proteasa del hiv, composiciones farmaceuticas que comprenden dichos compuestos, metodo in vitro para inhibir la replicacion retroviral y uso de dichos compuestos en la fabricacion de medicamentos

Also Published As

Publication number Publication date
IL158093A0 (en) 2004-03-28
PT1387842E (pt) 2009-07-20
KR100878853B1 (ko) 2009-01-15
AP1652A (en) 2006-08-11
DE60232067D1 (de) 2009-06-04
PL209029B1 (pl) 2011-07-29
CA2444895A1 (en) 2002-11-21
NZ529250A (en) 2005-05-27
NO20034988D0 (no) 2003-11-10
CY1109247T1 (el) 2014-07-02
NO326883B1 (no) 2009-03-09
CZ20033290A3 (cs) 2004-05-12
US7863306B2 (en) 2011-01-04
EE200300547A (et) 2004-02-16
CA2444895C (en) 2011-02-15
ZA200307799B (en) 2005-03-30
ES2325809T3 (es) 2009-09-18
CZ304524B6 (cs) 2014-06-18
PL366780A1 (en) 2005-02-07
CN100549007C (zh) 2009-10-14
JP4467889B2 (ja) 2010-05-26
MXPA03010258A (es) 2005-03-07
EA200301234A1 (ru) 2004-04-29
US20040106661A1 (en) 2004-06-03
US7622490B2 (en) 2009-11-24
BG108309A (bg) 2004-12-30
EA009590B1 (ru) 2008-02-28
EE05307B1 (et) 2010-06-15
SK14902003A3 (sk) 2004-07-07
AR035970A1 (es) 2004-07-28
EP1387842B1 (en) 2009-04-22
JP2004534757A (ja) 2004-11-18
WO2002092595A1 (en) 2002-11-21
HRP20031026B1 (en) 2012-07-31
HK1062912A1 (en) 2004-12-03
DK1387842T3 (da) 2009-08-10
BG66350B1 (bg) 2013-08-30
CN1507446A (zh) 2004-06-23
BR0209594A (pt) 2004-03-30
EP1387842A1 (en) 2004-02-11
HRP20031026A2 (en) 2005-10-31
AU2002310818B2 (en) 2007-12-13
ATE429431T1 (de) 2009-05-15
SK287952B6 (sk) 2012-06-04
US20100029632A1 (en) 2010-02-04
KR20040022417A (ko) 2004-03-12
HUP0400438A3 (en) 2007-08-28
HUP0400438A2 (hu) 2004-08-30
AP2003002904A0 (en) 2003-12-31

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