OA12650A - Crystals including a malic acid salt of N-Ä2-(diethylamino)ethylÜ-5-Ä(5-fluoro-2-oxo-3H-indole-3-ylidene)methylÜ-2,4-dimethyl-1H-pyrrole-3-carboxamide, processes for its preparation and compositions thereof. - Google Patents

Crystals including a malic acid salt of N-Ä2-(diethylamino)ethylÜ-5-Ä(5-fluoro-2-oxo-3H-indole-3-ylidene)methylÜ-2,4-dimethyl-1H-pyrrole-3-carboxamide, processes for its preparation and compositions thereof. Download PDF

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Publication number
OA12650A
OA12650A OA1200400044A OA1200400044A OA12650A OA 12650 A OA12650 A OA 12650A OA 1200400044 A OA1200400044 A OA 1200400044A OA 1200400044 A OA1200400044 A OA 1200400044A OA 12650 A OA12650 A OA 12650A
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OA
OAPI
Prior art keywords
crystal
malic acid
diethylamino
oxo
dimethyl
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OA1200400044A
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English (en)
Inventor
Thomas J Fleck
Michael Hawley
Mark T Maloney
Stephen P Prescott
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Upjohn Co
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Application filed by Upjohn Co filed Critical Upjohn Co
Publication of OA12650A publication Critical patent/OA12650A/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Oncology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrrole Compounds (AREA)
OA1200400044A 2001-08-15 2002-08-13 Crystals including a malic acid salt of N-Ä2-(diethylamino)ethylÜ-5-Ä(5-fluoro-2-oxo-3H-indole-3-ylidene)methylÜ-2,4-dimethyl-1H-pyrrole-3-carboxamide, processes for its preparation and compositions thereof. OA12650A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US31235301P 2001-08-15 2001-08-15

Publications (1)

Publication Number Publication Date
OA12650A true OA12650A (en) 2006-06-19

Family

ID=23211067

Family Applications (1)

Application Number Title Priority Date Filing Date
OA1200400044A OA12650A (en) 2001-08-15 2002-08-13 Crystals including a malic acid salt of N-Ä2-(diethylamino)ethylÜ-5-Ä(5-fluoro-2-oxo-3H-indole-3-ylidene)methylÜ-2,4-dimethyl-1H-pyrrole-3-carboxamide, processes for its preparation and compositions thereof.

Country Status (43)

Country Link
US (2) US20030069298A1 (pt)
EP (3) EP2332934B1 (pt)
JP (1) JP4159988B2 (pt)
KR (1) KR100639281B1 (pt)
CN (2) CN100364991C (pt)
AP (1) AP1660A (pt)
AR (1) AR036261A1 (pt)
AU (1) AU2002324684B2 (pt)
BG (1) BG108553A (pt)
BR (1) BR0211612A (pt)
CA (1) CA2455050C (pt)
CO (1) CO5550431A2 (pt)
CU (1) CU23713B7 (pt)
CY (1) CY1121552T1 (pt)
CZ (1) CZ2004196A3 (pt)
DK (2) DK1419151T3 (pt)
EA (1) EA006445B9 (pt)
EC (1) ECSP044975A (pt)
ES (3) ES2453164T3 (pt)
GE (1) GEP20063777B (pt)
HK (2) HK1066542A1 (pt)
HR (1) HRP20040112B1 (pt)
HU (1) HU229206B1 (pt)
IL (1) IL160097A0 (pt)
IS (1) IS7147A (pt)
MA (1) MA27058A1 (pt)
ME (1) ME00414B (pt)
MX (1) MXPA04001452A (pt)
MY (1) MY139383A (pt)
NO (1) NO326508B1 (pt)
NZ (1) NZ531232A (pt)
OA (1) OA12650A (pt)
PL (1) PL216524B1 (pt)
PT (2) PT1419151E (pt)
RS (1) RS53251B (pt)
SI (2) SI3168218T1 (pt)
SK (1) SK902004A3 (pt)
TN (1) TNSN04028A1 (pt)
TR (1) TR201900509T4 (pt)
TW (1) TWI269796B (pt)
UA (1) UA76483C2 (pt)
WO (1) WO2003016305A1 (pt)
ZA (1) ZA200400706B (pt)

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SI3168218T1 (sl) 2019-05-31
CA2455050C (en) 2007-02-20
AP2004002976A0 (en) 2004-03-31
HK1088008A1 (en) 2006-10-27
NZ531232A (en) 2004-11-26
ZA200400706B (en) 2005-05-25
MXPA04001452A (es) 2004-05-20
ECSP044975A (es) 2004-03-23
AU2002324684B2 (en) 2006-10-05
CU20040029A7 (es) 2008-03-14
BG108553A (bg) 2005-04-30
TWI269796B (en) 2007-01-01
ES2705063T3 (es) 2019-03-21
EP1419151B1 (en) 2014-02-26
CA2455050A1 (en) 2003-02-27
MY139383A (en) 2009-09-30
IL160097A0 (en) 2004-06-20
EP3168218A1 (en) 2017-05-17
CN100439360C (zh) 2008-12-03
CN100364991C (zh) 2008-01-30
ES2453164T3 (es) 2014-04-04
CN1789264A (zh) 2006-06-21
US7435832B2 (en) 2008-10-14
HK1066542A1 (en) 2005-03-24
CY1121552T1 (el) 2020-05-29
RS53251B (sr) 2014-08-29
SI1419151T1 (sl) 2014-04-30
HUP0700036A2 (en) 2008-10-28
HRP20040112B1 (en) 2012-03-31
KR100639281B1 (ko) 2006-10-31
NO326508B1 (no) 2008-12-15
EA006445B9 (ru) 2017-02-28
EA200400183A1 (ru) 2004-08-26
EP1419151A1 (en) 2004-05-19
ME00414B (me) 2011-10-10
DK3168218T3 (en) 2019-01-14
UA76483C2 (en) 2006-08-15
EP3168218B1 (en) 2018-11-14
AP1660A (en) 2006-09-09
BR0211612A (pt) 2004-08-24
AR036261A1 (es) 2004-08-25
ES2623094T3 (es) 2017-07-10
HU229206B1 (en) 2013-09-30
PL368317A1 (en) 2005-03-21
MA27058A1 (fr) 2004-12-20
TR201900509T4 (tr) 2019-02-21
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