DK1157019T3 - 4-alkenyl- (og alkynyl-)oxindoler som inhibitorer af cyklinafhængige kinaser, især CDK2 - Google Patents
4-alkenyl- (og alkynyl-)oxindoler som inhibitorer af cyklinafhængige kinaser, især CDK2Info
- Publication number
- DK1157019T3 DK1157019T3 DK99963422T DK99963422T DK1157019T3 DK 1157019 T3 DK1157019 T3 DK 1157019T3 DK 99963422 T DK99963422 T DK 99963422T DK 99963422 T DK99963422 T DK 99963422T DK 1157019 T3 DK1157019 T3 DK 1157019T3
- Authority
- DK
- Denmark
- Prior art keywords
- oxindoles
- cyclin
- alkynyl
- alkenyl
- inhibitors
- Prior art date
Links
- 108091007914 CDKs Proteins 0.000 title 1
- 102000015792 Cyclin-Dependent Kinase 2 Human genes 0.000 title 1
- 108010024986 Cyclin-Dependent Kinase 2 Proteins 0.000 title 1
- 102000003903 Cyclin-dependent kinases Human genes 0.000 title 1
- 108090000266 Cyclin-dependent kinases Proteins 0.000 title 1
- 125000000304 alkynyl group Chemical group 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 150000005623 oxindoles Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11259198P | 1998-12-17 | 1998-12-17 | |
| US14907399P | 1999-08-16 | 1999-08-16 | |
| PCT/EP1999/009624 WO2000035908A1 (en) | 1998-12-17 | 1999-12-08 | 4-alkenyl (and alkynyl) oxindoles as inhibitors of cyclin-dependent kinases, in particular cdk2 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1157019T3 true DK1157019T3 (da) | 2003-07-14 |
Family
ID=26810131
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK99963422T DK1157019T3 (da) | 1998-12-17 | 1999-12-08 | 4-alkenyl- (og alkynyl-)oxindoler som inhibitorer af cyklinafhængige kinaser, især CDK2 |
Country Status (20)
| Country | Link |
|---|---|
| US (3) | US6130239A (da) |
| EP (1) | EP1157019B1 (da) |
| JP (1) | JP2002532492A (da) |
| KR (1) | KR100649925B1 (da) |
| CN (1) | CN1138773C (da) |
| AR (1) | AR024847A1 (da) |
| AT (1) | ATE234830T1 (da) |
| AU (1) | AU770375B2 (da) |
| BR (1) | BR9916327A (da) |
| CA (1) | CA2354873A1 (da) |
| CO (1) | CO5261600A1 (da) |
| DE (1) | DE69906152T2 (da) |
| DK (1) | DK1157019T3 (da) |
| ES (1) | ES2192877T3 (da) |
| PE (1) | PE20001537A1 (da) |
| PT (1) | PT1157019E (da) |
| TR (1) | TR200101860T2 (da) |
| TW (1) | TW550262B (da) |
| UY (1) | UY25857A1 (da) |
| WO (1) | WO2000035908A1 (da) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6569868B2 (en) | 1998-04-16 | 2003-05-27 | Sugen, Inc. | 2-indolinone derivatives as modulators of protein kinase activity |
| DK1157019T3 (da) * | 1998-12-17 | 2003-07-14 | Hoffmann La Roche | 4-alkenyl- (og alkynyl-)oxindoler som inhibitorer af cyklinafhængige kinaser, især CDK2 |
| US6878733B1 (en) | 1999-11-24 | 2005-04-12 | Sugen, Inc. | Formulations for pharmaceutical agents ionizable as free acids or free bases |
| ES2367007T3 (es) * | 1999-11-24 | 2011-10-27 | Sugen, Inc. | Derivados de indolinona ionizables y su uso como ligandos de ptk. |
| US20020010203A1 (en) * | 1999-12-22 | 2002-01-24 | Ken Lipson | Methods of modulating c-kit tyrosine protein kinase function with indolinone compounds |
| RS50444B (sr) * | 2000-02-15 | 2010-03-02 | Sugen Inc. | Inhibitori 2-indolinon protein kinaze supstituisani pirolom |
| EP1272483A2 (en) * | 2000-03-24 | 2003-01-08 | Millenium Pharmaceuticals, Inc. | OXINDOLE INHIBITORS OF FACTOR Xa |
| MY128449A (en) | 2000-05-24 | 2007-02-28 | Sugen Inc | Prodrugs of 3-(pyrrol-2-ylmethylidene)-2-indolinone derivatives |
| CA2410509A1 (en) | 2000-06-02 | 2001-12-13 | Sugen, Inc. | Indolinone derivatives as protein kinase/phosphatase inhibitors |
| WO2002002551A1 (en) | 2000-06-30 | 2002-01-10 | Sugen, Inc. | 4-heteroaryl-3-heteroarylidenyl-2-indolinones and their use as protein kinase inhibitors |
| CA2432114A1 (en) | 2000-12-20 | 2002-07-18 | Sugen, Inc. | 4-(hetero)aryl substituted indolinones |
| US6504034B2 (en) | 2001-01-23 | 2003-01-07 | Hoffmann-La Roche Inc. | Naphthostyrils |
| AR042586A1 (es) | 2001-02-15 | 2005-06-29 | Sugen Inc | 3-(4-amidopirrol-2-ilmetiliden)-2-indolinona como inhibidores de la protein quinasa; sus composiciones farmaceuticas; un metodo para la modulacion de la actividad catalitica de la proteinquinasa; un metodo para tratar o prevenir una afeccion relacionada con la proteinquinasa |
| FR2822155B1 (fr) * | 2001-03-13 | 2003-12-12 | Aventis Pharma Sa | Composes derives des oxindoles et leur application therapeutique en cancerologie |
| IL160097A0 (en) * | 2001-08-15 | 2004-06-20 | Upjohn Co | Crystals including a malic acid salt of n-[2-(diethylamino) ethyl]-5-[(5-fluoro-2-oxo-3h-indole 3-ylidene) methyl]2-(dimethyl-1h-pyrrole-3-carboxamide, processes for its preparation and compositions thereof |
| WO2003031438A1 (en) | 2001-10-10 | 2003-04-17 | Sugen, Inc. | 3-[4-(substituted heterocyclyl)-pyrrol-2-ylmethylidene]-2-indolinone derivatives as kinase inhibitors |
| AU2002360753B2 (en) * | 2001-12-27 | 2008-08-21 | Theravance, Inc. | Indolinone derivatives useful as protein kinase inhibitors |
| TW200526224A (en) * | 2003-12-22 | 2005-08-16 | Alcon Inc | Short form c-Maf transcription factor antagonists for treatment of glaucoma |
| FR2948940B1 (fr) * | 2009-08-04 | 2011-07-22 | Servier Lab | Nouveaux derives dihydroindolones, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| US20140205537A1 (en) * | 2011-06-24 | 2014-07-24 | Zenobia Therapeutics, Inc. | Lrrk2 inhibitors |
| WO2016188421A1 (zh) * | 2015-05-25 | 2016-12-01 | 中国医学科学院药物研究所 | 含丙炔酰胺基的2-苯基咪唑类衍生物及其制法和药物组合物与用途 |
| EP3682881A4 (en) | 2017-09-14 | 2021-08-11 | Daiichi Sankyo Company, Limited | CONNECTION WITH CYCLICAL STRUCTURE |
| AR124154A1 (es) | 2020-11-27 | 2023-02-22 | Rhizen Pharmaceuticals Ag | Inhibidores de cdk |
| WO2022149057A1 (en) | 2021-01-05 | 2022-07-14 | Rhizen Pharmaceuticals Ag | Cdk inhibitors |
| TW202309030A (zh) | 2021-05-07 | 2023-03-01 | 美商凱麥拉醫療公司 | Cdk2降解劑及其用途 |
Family Cites Families (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4556672A (en) * | 1984-03-19 | 1985-12-03 | Pfizer Inc. | 3-Substituted 2-oxindole-1-carboxamides as analgesic and anti-inflammatory agents |
| US5086186A (en) * | 1989-05-25 | 1992-02-04 | Pfizer Inc. | N-trichloroacetyl-2-oxindole-1-carboxamides |
| ES2110965T3 (es) * | 1989-07-25 | 1998-03-01 | Taiho Pharmaceutical Co Ltd | Derivado de oxoindol. |
| WO1991009598A1 (en) * | 1990-01-05 | 1991-07-11 | Pfizer Inc. | Azaoxindole derivatives |
| GB9004483D0 (en) * | 1990-02-28 | 1990-04-25 | Erba Carlo Spa | New aryl-and heteroarylethenylene derivatives and process for their preparation |
| WO1992007830A2 (en) * | 1990-10-29 | 1992-05-14 | Pfizer Inc. | Oxindole peptide antagonists |
| GB9115160D0 (en) * | 1991-07-12 | 1991-08-28 | Erba Carlo Spa | Methylen-oxindole derivatives and process for their preparation |
| US5322950A (en) * | 1991-12-05 | 1994-06-21 | Warner-Lambert Company | Imidazole with angiotensin II antagonist properties |
| FR2694004B1 (fr) * | 1992-07-21 | 1994-08-26 | Adir | Nouvelles 3-(Hydroxybenzylidényl)-indoline-2-ones et 3-(hydroxybenzylidényl)-indoline-2-thiones, leurs procédés de préparation, et les compositions pharmaceutiques qui les contiennent. |
| GB9226855D0 (en) * | 1992-12-23 | 1993-02-17 | Erba Carlo Spa | Vinylene-azaindole derivatives and process for their preparation |
| GB9313638D0 (en) * | 1993-07-01 | 1993-08-18 | Erba Carlo Spa | Arylidene and heteroarylidene oxindole derivatives and process for their preparation |
| GB9326136D0 (en) * | 1993-12-22 | 1994-02-23 | Erba Carlo Spa | Biologically active 3-substituted oxindole derivatives useful as anti-angiogenic agents |
| GB9412719D0 (en) * | 1994-06-24 | 1994-08-17 | Erba Carlo Spa | Substituted azaindolylidene compounds and process for their preparation |
| GB9423997D0 (en) * | 1994-11-28 | 1995-01-11 | Erba Carlo Spa | Substituted 3-arylidene-7-azaoxindole compounds and process for their preparation |
| GB9501567D0 (en) * | 1995-01-26 | 1995-03-15 | Pharmacia Spa | Hydrosoluble 3-arylidene-2-oxindole derivatives as tyrosine kinase inhibitors |
| GB9507298D0 (en) * | 1995-04-07 | 1995-05-31 | Pharmacia Spa | Substituted indolylmethylene-oxindale analogues as tyrosine kinase inhibitors |
| US5880141A (en) * | 1995-06-07 | 1999-03-09 | Sugen, Inc. | Benzylidene-Z-indoline compounds for the treatment of disease |
| CA2231509C (en) * | 1995-09-11 | 2008-07-08 | Osteoarthritis Sciences, Inc. | Protein tyrosine kinase inhibitors for treating osteoarthritis |
| US5733920A (en) * | 1995-10-31 | 1998-03-31 | Mitotix, Inc. | Inhibitors of cyclin dependent kinases |
| GB9610964D0 (en) * | 1996-05-24 | 1996-07-31 | Pharmacia & Upjohn Spa | Substituted tetralylmethylen-oxindole analogues as tyrosine kinase inhibitors |
| GB9611797D0 (en) * | 1996-06-06 | 1996-08-07 | Pharmacia Spa | Substituted quinolylmethylen-oxindole analogues as tyrosine kinase inhibitors |
| JP2001503736A (ja) * | 1996-08-23 | 2001-03-21 | スージェン・インコーポレーテッド | 疾病の治療のためのインドリノンのコンビナトリアルライブラリーおよび関連する生成物および方法 |
| AU7622698A (en) * | 1996-12-05 | 1998-06-29 | Sugen, Inc. | Use of indolinone compounds as modulators of protein kinases |
| WO1998050356A1 (en) * | 1997-05-07 | 1998-11-12 | Sugen, Inc. | 2-indolinone derivatives as modulators of protein kinase activity |
| GB9716557D0 (en) * | 1997-08-06 | 1997-10-08 | Glaxo Group Ltd | Benzylidene-1,3-dihydro-indol-2-one derivatives having anti-cancer activity |
| GB9718913D0 (en) * | 1997-09-05 | 1997-11-12 | Glaxo Group Ltd | Substituted oxindole derivatives |
| WO1999048868A2 (en) * | 1998-03-26 | 1999-09-30 | Sugen, Inc. | Heterocyclic classes of compounds for the modulating tyrosine protein kinase |
| IL139934A (en) * | 1998-05-29 | 2007-10-31 | Sugen Inc | History 2 - Indulinone converted to pyrrole and pharmaceutical preparations containing them |
| JP2002522452A (ja) * | 1998-08-04 | 2002-07-23 | スージェン・インコーポレーテッド | 蛋白質キナーゼの調節剤３−メチリデニル−２−インドリノン |
| EP1117397A1 (en) * | 1998-08-31 | 2001-07-25 | Sugen, Inc. | Geometrically restricted 2-indolinone derivatives as modulators of protein kinase activity |
| DK1157019T3 (da) * | 1998-12-17 | 2003-07-14 | Hoffmann La Roche | 4-alkenyl- (og alkynyl-)oxindoler som inhibitorer af cyklinafhængige kinaser, især CDK2 |
-
1999
- 1999-12-08 DK DK99963422T patent/DK1157019T3/da active
- 1999-12-08 AU AU19727/00A patent/AU770375B2/en not_active Ceased
- 1999-12-08 TR TR2001/01860T patent/TR200101860T2/xx unknown
- 1999-12-08 PT PT99963422T patent/PT1157019E/pt unknown
- 1999-12-08 CA CA002354873A patent/CA2354873A1/en not_active Abandoned
- 1999-12-08 AT AT99963422T patent/ATE234830T1/de not_active IP Right Cessation
- 1999-12-08 BR BR9916327-6A patent/BR9916327A/pt not_active Application Discontinuation
- 1999-12-08 EP EP99963422A patent/EP1157019B1/en not_active Expired - Lifetime
- 1999-12-08 DE DE69906152T patent/DE69906152T2/de not_active Expired - Fee Related
- 1999-12-08 JP JP2000588168A patent/JP2002532492A/ja active Pending
- 1999-12-08 WO PCT/EP1999/009624 patent/WO2000035908A1/en not_active Ceased
- 1999-12-08 KR KR1020017007610A patent/KR100649925B1/ko not_active Expired - Fee Related
- 1999-12-08 ES ES99963422T patent/ES2192877T3/es not_active Expired - Lifetime
- 1999-12-08 CN CNB998145246A patent/CN1138773C/zh not_active Expired - Fee Related
- 1999-12-14 PE PE1999001251A patent/PE20001537A1/es not_active Application Discontinuation
- 1999-12-14 CO CO99078069A patent/CO5261600A1/es not_active Application Discontinuation
- 1999-12-15 AR ARP990106414A patent/AR024847A1/es not_active Application Discontinuation
- 1999-12-15 US US09/464,502 patent/US6130239A/en not_active Expired - Fee Related
- 1999-12-16 UY UY25857A patent/UY25857A1/es not_active Application Discontinuation
- 1999-12-16 TW TW088122068A patent/TW550262B/zh active
-
2000
- 2000-04-14 US US09/549,864 patent/US6252086B1/en not_active Expired - Fee Related
- 2000-05-05 US US09/566,054 patent/US6303793B1/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CN1138773C (zh) | 2004-02-18 |
| UY25857A1 (es) | 2001-07-31 |
| TR200101860T2 (tr) | 2001-12-21 |
| KR20010101274A (ko) | 2001-11-14 |
| DE69906152D1 (de) | 2003-04-24 |
| TW550262B (en) | 2003-09-01 |
| US6130239A (en) | 2000-10-10 |
| DE69906152T2 (de) | 2004-02-12 |
| WO2000035908A1 (en) | 2000-06-22 |
| PT1157019E (pt) | 2003-06-30 |
| KR100649925B1 (ko) | 2007-02-28 |
| AU1972700A (en) | 2000-07-03 |
| AR024847A1 (es) | 2002-10-30 |
| CN1330647A (zh) | 2002-01-09 |
| CO5261600A1 (es) | 2003-03-31 |
| BR9916327A (pt) | 2001-09-18 |
| ES2192877T3 (es) | 2003-10-16 |
| ATE234830T1 (de) | 2003-04-15 |
| CA2354873A1 (en) | 2000-06-22 |
| EP1157019A1 (en) | 2001-11-28 |
| JP2002532492A (ja) | 2002-10-02 |
| EP1157019B1 (en) | 2003-03-19 |
| US6252086B1 (en) | 2001-06-26 |
| US6303793B1 (en) | 2001-10-16 |
| PE20001537A1 (es) | 2001-01-09 |
| AU770375B2 (en) | 2004-02-19 |
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