DE69903319D1 - Fkbp inhibitoren - Google Patents

Fkbp inhibitoren

Info

Publication number
DE69903319D1
DE69903319D1 DE69903319T DE69903319T DE69903319D1 DE 69903319 D1 DE69903319 D1 DE 69903319D1 DE 69903319 T DE69903319 T DE 69903319T DE 69903319 T DE69903319 T DE 69903319T DE 69903319 D1 DE69903319 D1 DE 69903319D1
Authority
DE
Germany
Prior art keywords
fkbp inhibitors
fkbp
inhibitors
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69903319T
Other languages
English (en)
Other versions
DE69903319T2 (de
Inventor
Martin James Wythes
Michael John Palmer
Mark Ian Kemp
Malcolm Christian Mackenny
Robert John Maguire
Blake, Jr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Ltd
Pfizer Inc
Original Assignee
Pfizer Ltd
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Ltd, Pfizer Inc filed Critical Pfizer Ltd
Publication of DE69903319D1 publication Critical patent/DE69903319D1/de
Application granted granted Critical
Publication of DE69903319T2 publication Critical patent/DE69903319T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42Oxazoles
    • A61K31/423Oxazoles condensed with carbocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425Thiazoles
    • A61K31/428Thiazoles condensed with carbocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • A61P21/04Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D211/00Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14Ortho-condensed systems
DE69903319T 1998-07-20 1999-07-01 Fkbp inhibitoren Expired - Fee Related DE69903319T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9815696.1A GB9815696D0 (en) 1998-07-20 1998-07-20 Heterocyclics
PCT/IB1999/001227 WO2000005231A1 (en) 1998-07-20 1999-07-01 Fkbp inhibitors

Publications (2)

Publication Number Publication Date
DE69903319D1 true DE69903319D1 (de) 2002-11-07
DE69903319T2 DE69903319T2 (de) 2003-01-30

Family

ID=10835773

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69903319T Expired - Fee Related DE69903319T2 (de) 1998-07-20 1999-07-01 Fkbp inhibitoren

Country Status (45)

Country Link
US (2) US6166011A (de)
EP (1) EP1098894B1 (de)
JP (1) JP3545341B2 (de)
KR (1) KR20010083130A (de)
CN (1) CN1315951A (de)
AP (1) AP2001002045A0 (de)
AR (1) AR016501A1 (de)
AT (1) ATE225346T1 (de)
AU (1) AU756769B2 (de)
BG (1) BG105249A (de)
BR (1) BR9912307A (de)
CA (1) CA2338276C (de)
CO (1) CO5080761A1 (de)
CZ (1) CZ2001224A3 (de)
DE (1) DE69903319T2 (de)
DK (1) DK1098894T3 (de)
DZ (1) DZ2848A1 (de)
EA (1) EA200100051A1 (de)
EE (1) EE200100043A (de)
ES (1) ES2183567T3 (de)
GB (1) GB9815696D0 (de)
GT (1) GT199900113A (de)
HK (1) HK1040706A1 (de)
HN (1) HN1999000101A (de)
HR (1) HRP20010053A2 (de)
HU (1) HUP0103020A3 (de)
ID (1) ID27022A (de)
IL (1) IL140243A0 (de)
IS (1) IS5799A (de)
MA (1) MA26661A1 (de)
NO (1) NO20010299L (de)
NZ (1) NZ508839A (de)
OA (1) OA11586A (de)
PA (1) PA8477601A1 (de)
PE (1) PE20000867A1 (de)
PL (1) PL345705A1 (de)
PT (1) PT1098894E (de)
SI (1) SI1098894T1 (de)
SK (1) SK702001A3 (de)
TN (1) TNSN99146A1 (de)
TR (1) TR200100133T2 (de)
UA (1) UA60368C2 (de)
WO (1) WO2000005231A1 (de)
YU (1) YU83100A (de)
ZA (1) ZA200100229B (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9815696D0 (en) * 1998-07-20 1998-09-16 Pfizer Ltd Heterocyclics
GB9815880D0 (en) * 1998-07-21 1998-09-16 Pfizer Ltd Heterocycles
GB0008939D0 (en) 2000-04-11 2000-05-31 Glaxo Group Ltd Process for preparing substituted benzimidazole compounds
JP2004526425A (ja) 2000-11-28 2004-09-02 ワイス 前立腺癌の診断および治療に有用なfkbp核酸およびポリペプチドの発現分析
US7186518B2 (en) * 2003-11-21 2007-03-06 Dade Behring Inc. Method and composition useful for determining FK 506
US8354557B2 (en) 2008-06-17 2013-01-15 Concert Pharmaceuticals, Inc. Synthesis of deuterated morpholine derivatives
DE102008060549A1 (de) 2008-12-04 2010-06-10 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Wirkstoff-Peptid-Konstrukt zur extrazellulären Anreicherung
TWI534142B (zh) 2011-03-15 2016-05-21 大正製藥股份有限公司 Azole derivatives
EP2705856A1 (de) 2012-09-07 2014-03-12 Deutsches Zentrum für Neurodegenerative Erkrankungen e.V. Verbindungen zur Behandlung von neurodegenerativen Erkrankungen
CN106138044B (zh) * 2016-07-15 2017-05-03 鲁俊东 一种治疗腰椎间盘突出症的药物

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI91859C (fi) * 1987-06-17 1994-08-25 Eisai Co Ltd Analogiamenetelmä antiallergisena aineena aktiivisen bentsotiatsolijohdannaisen valmistamiseksi
FR2696176B1 (fr) * 1992-09-28 1994-11-10 Synthelabo Dérivés de pipéridine, leur préparation et leur application en thérapeutique.
CO4520280A1 (es) * 1993-10-26 1997-10-15 Boehringer Ingelheim Pharma Derivados de pirrolidina, inhibidores de la bioscientesis de leucotrienos
US5801187A (en) * 1996-09-25 1998-09-01 Gpi-Nil Holdings, Inc. Heterocyclic esters and amides
GB9700597D0 (en) * 1997-01-14 1997-03-05 Sandoz Pharma Uk Organic compounds
US5721256A (en) * 1997-02-12 1998-02-24 Gpi Nil Holdings, Inc. Method of using neurotrophic sulfonamide compounds
GB9815696D0 (en) * 1998-07-20 1998-09-16 Pfizer Ltd Heterocyclics
GB9815880D0 (en) * 1998-07-21 1998-09-16 Pfizer Ltd Heterocycles
US6509464B1 (en) * 1999-07-15 2003-01-21 Pfizer Inc FKBP inhibitors

Also Published As

Publication number Publication date
ATE225346T1 (de) 2002-10-15
JP3545341B2 (ja) 2004-07-21
TR200100133T2 (tr) 2001-06-21
ES2183567T3 (es) 2003-03-16
AP2001002045A0 (en) 2001-03-31
HUP0103020A3 (en) 2002-10-28
IL140243A0 (en) 2002-02-10
NO20010299D0 (no) 2001-01-18
EA200100051A1 (ru) 2001-08-27
CA2338276A1 (en) 2000-02-03
PT1098894E (pt) 2003-02-28
KR20010083130A (ko) 2001-08-31
US6166011A (en) 2000-12-26
PE20000867A1 (es) 2000-08-31
NZ508839A (en) 2003-01-31
AU4385599A (en) 2000-02-14
CN1315951A (zh) 2001-10-03
EP1098894A1 (de) 2001-05-16
HUP0103020A2 (hu) 2002-05-29
IS5799A (is) 2000-12-29
CZ2001224A3 (cs) 2001-08-15
YU83100A (sh) 2003-04-30
DZ2848A1 (fr) 2003-12-01
DK1098894T3 (da) 2002-10-28
UA60368C2 (uk) 2003-10-15
NO20010299L (no) 2001-03-15
PA8477601A1 (es) 2000-09-29
SK702001A3 (en) 2001-12-03
ZA200100229B (en) 2002-04-09
CO5080761A1 (es) 2001-09-25
TNSN99146A1 (fr) 2005-11-10
HN1999000101A (es) 2000-11-11
EP1098894B1 (de) 2002-10-02
HK1040706A1 (zh) 2002-06-21
GT199900113A (es) 2001-01-09
DE69903319T2 (de) 2003-01-30
US20040058905A1 (en) 2004-03-25
AU756769B2 (en) 2003-01-23
PL345705A1 (en) 2002-01-02
BG105249A (en) 2001-11-30
SI1098894T1 (en) 2002-12-31
ID27022A (id) 2001-02-22
GB9815696D0 (en) 1998-09-16
BR9912307A (pt) 2001-05-02
MA26661A1 (fr) 2004-12-20
OA11586A (en) 2004-07-26
AR016501A1 (es) 2001-07-04
CA2338276C (en) 2007-01-09
EE200100043A (et) 2002-06-17
JP2002521381A (ja) 2002-07-16
WO2000005231A1 (en) 2000-02-03
HRP20010053A2 (en) 2001-12-31

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee