OA12339A - Use of cox-2 inhibitors for preventing immunodeficiency. - Google Patents
Use of cox-2 inhibitors for preventing immunodeficiency. Download PDFInfo
- Publication number
- OA12339A OA12339A OA1200300011A OA1200300011A OA12339A OA 12339 A OA12339 A OA 12339A OA 1200300011 A OA1200300011 A OA 1200300011A OA 1200300011 A OA1200300011 A OA 1200300011A OA 12339 A OA12339 A OA 12339A
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- OA
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- Prior art keywords
- cox
- cells
- daims
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Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2003530437A (ja) * | 2000-04-13 | 2003-10-14 | マヨ ファウンデーション フォー メディカル エデュケーション アンド リサーチ | Ａβ４２低下物質 |
| EP1303265B1 (en) | 2000-07-20 | 2007-07-11 | Lauras AS | Use of cox-2 inhibitors as immunostimulants in the treatment of hiv or aids |
| GB0221443D0 (en) | 2002-09-16 | 2002-10-23 | Glaxo Group Ltd | Pyridine derivates |
| WO2004071431A2 (en) * | 2003-02-05 | 2004-08-26 | Myriad Genetics, Inc. | Method and composition for treating neurodegenerative disorders |
| KR20060040676A (ko) * | 2003-07-11 | 2006-05-10 | 미리어드 제네틱스, 인크. | 알츠하이머병을 치료하기 위한 약제학적 방법, 투약 방법및 제형 |
| WO2005013902A2 (en) * | 2003-08-04 | 2005-02-17 | Mayo Foundation For Medical Education And Research | Methods and compositions for inhibiting the proliferation of prostate cancer cells |
| WO2006001877A2 (en) * | 2004-04-13 | 2006-01-05 | Myriad Genetics, Inc. | Combination treatment for neurodegenerative disorders comprising r-flurbiprofen |
| AU2005241023A1 (en) * | 2004-04-29 | 2005-11-17 | Keystone Retaining Wall Systems, Inc. | Veneers for walls, retaining walls and the like |
| WO2006020850A2 (en) * | 2004-08-11 | 2006-02-23 | Myriad Genetics, Inc. | Pharmaceutical composition and method for treating neurodegenerative disorders |
| WO2006020852A2 (en) * | 2004-08-11 | 2006-02-23 | Myriad Genetics, Inc. | Pharmaceutical composition and method for treating neurodegenerative disorders |
| BRPI0514303A (pt) * | 2004-08-11 | 2008-06-10 | Myriad Genetics Inc | composição farmacêutica e método para tratar distúrbios neurodegenerativos |
| CA2615063A1 (en) * | 2005-07-22 | 2007-02-01 | Myriad Genetics, Inc. | High drug load formulations and dosage forms |
| WO2007013997A2 (en) * | 2005-07-22 | 2007-02-01 | H. Lee Moffitt Cancer Center And Research Institute | Inhibition of the raf/mek/p-erk pathway for treating cancer |
| US20070281927A1 (en) * | 2006-06-06 | 2007-12-06 | Shanthakumar Tyavanagimatt | Anti-inflammatory and analgesic compositions and related methods |
| WO2008006099A2 (en) * | 2006-07-07 | 2008-01-10 | Myriad Genetics, Inc. | Treatment of psychiatric disorders |
| JP5200223B2 (ja) | 2006-12-15 | 2013-06-05 | ベーリンガー インゲルハイム フェトメディカ インコーポレイテッド | Ｐｃｖ２抗原によるブタの処置 |
| EP1941903A1 (en) | 2007-01-03 | 2008-07-09 | Boehringer Ingelheim Vetmedica Gmbh | Prophylaxis and treatment of PRDC |
| EP1958644A1 (en) | 2007-02-13 | 2008-08-20 | Boehringer Ingelheim Vetmedica Gmbh | Prevention and treatment of sub-clinical pcvd |
| IN2014CH00396A (https=) | 2013-02-05 | 2015-04-03 | Nitto Denko Corp | |
| CN108849912B (zh) * | 2018-07-26 | 2020-06-30 | 河南省农业科学院植物保护研究所 | 1,5-二芳基-3-三氟甲基吡唑类化合物在防治农业真菌病害中的应用 |
Family Cites Families (144)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US1325832A (en) * | 1919-12-23 | Beak-axle mounting eor tractors | ||
| US2011239A (en) * | 1933-07-31 | 1935-08-13 | Packard Motor Car Co | Motor vehicle |
| US2163981A (en) * | 1938-12-06 | 1939-06-27 | Norman E Lawrence | Rear wheel suspension for motor vehicles |
| US2606036A (en) * | 1945-11-01 | 1952-08-05 | Six Wheels Inc | Mounting for wheel brake operating mechanism |
| US2635896A (en) * | 1949-07-26 | 1953-04-21 | Brown Trailers Inc | Vehicle wheel suspension |
| US2877010A (en) * | 1956-10-16 | 1959-03-10 | Gouirand Rene | Pneumatic suspension for motor vehicles |
| US2913252A (en) * | 1957-08-02 | 1959-11-17 | Pacific Car & Foundry Co | Vehicle suspension using air spring |
| NL232523A (https=) * | 1957-11-27 | |||
| NL302468A (https=) * | 1961-05-11 | |||
| US3434707A (en) * | 1966-06-02 | 1969-03-25 | John E Raidel | Suspensions |
| FR1573973A (https=) * | 1968-03-28 | 1969-07-11 | ||
| US3547215A (en) * | 1968-06-07 | 1970-12-15 | Neway Equipment Co | Automotive vehicle suspension structure |
| US3630541A (en) * | 1970-06-11 | 1971-12-28 | Int Harvester Co | Vehicle axle suspension |
| US3707298A (en) * | 1970-10-06 | 1972-12-26 | Lear Siegler Inc | Suspension structure for land vehicles |
| US3785673A (en) * | 1971-09-20 | 1974-01-15 | Western Unit Corp | Preloaded spring beam and method employed alone or in combination with air bellows spring |
| US3771812A (en) * | 1972-04-25 | 1973-11-13 | Lear Siegler Inc | Air suspension with improved axle lifting structure |
| US3961826A (en) * | 1975-03-06 | 1976-06-08 | American Carrier Equipment, Inc. | Suspension unit |
| DE2523121C2 (de) * | 1975-05-24 | 1984-06-20 | Volkswagenwerk Ag, 3180 Wolfsburg | Hinterachsaufhängung für Kraftfahrzeuge |
| US4027898A (en) * | 1976-04-07 | 1977-06-07 | Southwest Wheel And Manufacturing Company | Level load leaf spring drop axle |
| US4065153A (en) * | 1976-08-19 | 1977-12-27 | United States Steel Corporation | Vehicle wheel suspension assembly |
| US4174855A (en) * | 1977-01-13 | 1979-11-20 | Turner Quick-Lift Corporation | Wheeled vehicle axle suspension system |
| US4352509A (en) * | 1978-01-18 | 1982-10-05 | H. Neil Paton | Damped rubber tired vehicle suspension |
| US4293145A (en) * | 1978-02-28 | 1981-10-06 | Taylor Glenn E | Auxiliary lift axle wheel assembly |
| US4166640B1 (en) * | 1978-04-14 | 1994-03-22 | Boler Company Inc | Axle suspension for wheeled vehicles |
| US4371190A (en) * | 1980-01-28 | 1983-02-01 | Turner Quick-Lift Corporation | Axle suspension system |
| US4310171A (en) * | 1980-06-11 | 1982-01-12 | General Motors Corporation | Vehicle axle attachment |
| US4415179A (en) * | 1981-04-15 | 1983-11-15 | Marinelli Joseph A | Axle and air bag suspension |
| US4529224A (en) * | 1981-05-21 | 1985-07-16 | Raidel John E | Wide base air spring suspension assembly |
| US4537420A (en) * | 1981-07-28 | 1985-08-27 | Nissan Motor Company, Limited | Swing-arm-type suspension with a lateral rod for an automotive vehicle |
| US4427213A (en) * | 1982-01-21 | 1984-01-24 | Raidel Jr John E | Vehicle suspension with rigid torque beam |
| US4494771A (en) * | 1982-01-21 | 1985-01-22 | Raidel John E | Suspension system with U-joint mounted load carrying torque arm |
| US4504080A (en) * | 1983-05-16 | 1985-03-12 | Turner Quick-Lift Corporation | Leaf spring lift axle suspension system |
| US4541643A (en) * | 1983-06-27 | 1985-09-17 | Ivan Pavincic | Two wheel skating device |
| US4566719A (en) * | 1984-02-17 | 1986-01-28 | Turner Quick Lift Corporation | Spaced axle-to-beam connection for suspension of the rigid beam type |
| US4693486A (en) * | 1986-04-09 | 1987-09-15 | Lear Siegler, Inc. | Trailing arm suspension with wrapper compression axle mounting |
| US4691937A (en) * | 1986-05-19 | 1987-09-08 | Raidel John E | Vehicle suspension assembly |
| US4902035A (en) * | 1987-02-04 | 1990-02-20 | Raidel John E | Suspension system with axle seat removable from universal torque beam |
| US5002305A (en) * | 1987-02-04 | 1991-03-26 | Raidel John E | Vehicle suspension system with standardized torque beam and special monopivot bushing assembly |
| US4763923A (en) * | 1987-03-02 | 1988-08-16 | Raidel John E | Suspension assembly with air spring and self contained air lift spring |
| US4878691A (en) * | 1988-03-23 | 1989-11-07 | Dbx Corporation | Trailer suspension apparatus |
| GB8814057D0 (en) * | 1988-06-14 | 1988-07-20 | Lundbeck & Co As H | New enantiomers & their isolation |
| US4943081A (en) * | 1989-02-10 | 1990-07-24 | Rancho Industries, Inc. | Vehicle suspension assembly |
| DE3913697A1 (de) * | 1989-04-26 | 1990-10-31 | Bergische Achsen Kotz Soehne | Achsaggregat |
| US4991868A (en) * | 1989-12-19 | 1991-02-12 | The Boler Company | Vehicle suspension beam pivot connection |
| US5504108A (en) | 1990-01-12 | 1996-04-02 | The Ohio State University Research Foundation | Optically pure 4-aryl-2-hydroxytetronic acids |
| US5058916A (en) * | 1990-06-18 | 1991-10-22 | Lear Siegler Truck Products Corp. | Apparatus for providing additional lift in a retractable suspension |
| US5037126A (en) * | 1990-09-07 | 1991-08-06 | The Boler Company | Lightweight beam suspension system |
| AU9137591A (en) | 1990-12-13 | 1992-07-08 | Smithkline Beecham Corporation | Novel csaids |
| US5112078A (en) * | 1990-12-21 | 1992-05-12 | Neway Corp. | Axle mounting assembly |
| US5127668A (en) * | 1991-01-24 | 1992-07-07 | Raidel John E | Torque beam with clamped mono-pivot bushing and flexible axle seat |
| US5203585A (en) * | 1991-07-12 | 1993-04-20 | Neway Corp. | Split-beam suspension system |
| US5171036A (en) * | 1991-08-27 | 1992-12-15 | The Boler Company | Rebound strap |
| US5240929A (en) | 1992-08-03 | 1993-08-31 | Warner-Lambert Company | 2-heterocyclic-5-hydroxy-1,3-pyrimidines useful as antiinflammatory agents |
| AU666572B2 (en) * | 1992-10-19 | 1996-02-15 | Hendrickson International Corporation | Axle suspension systems |
| EP0595546B1 (en) | 1992-10-28 | 1996-03-20 | Shionogi & Co., Ltd. | Benzylidene derivatives |
| JP3465277B2 (ja) * | 1992-11-26 | 2003-11-10 | トヨタ自動車株式会社 | アンダボデー構造 |
| US5604260A (en) | 1992-12-11 | 1997-02-18 | Merck Frosst Canada Inc. | 5-methanesulfonamido-1-indanones as an inhibitor of cyclooxygenase-2 |
| US5543297A (en) * | 1992-12-22 | 1996-08-06 | Merck Frosst Canada, Inc. | Human cyclooxygenase-2 cDNA and assays for evaluating cyclooxygenase-2 activity |
| EP0679157B1 (en) | 1993-01-15 | 1997-11-19 | G.D. Searle & Co. | Novel 3,4-diaryl thiophenes and analogs thereof having use as antiinflammatory agents |
| US5409944A (en) | 1993-03-12 | 1995-04-25 | Merck Frosst Canada, Inc. | Alkanesulfonamido-1-indanone derivatives as inhibitors of cyclooxygenase |
| WO1994026781A1 (en) | 1993-05-18 | 1994-11-24 | Korea Institute Of Science And Technology | Thermoresistant alpha-1-antitrypsin mutein |
| US5380738A (en) | 1993-05-21 | 1995-01-10 | Monsanto Company | 2-substituted oxazoles further substituted by 4-fluorophenyl and 4-methylsulfonylphenyl as antiinflammatory agents |
| JPH10507997A (ja) * | 1993-06-11 | 1998-08-04 | クールター コーポレイション | Ｔ細胞の活性化および増殖を誘導するための抗ｃｄ３抗体−アミノデキストラン結合体 |
| US5474995A (en) | 1993-06-24 | 1995-12-12 | Merck Frosst Canada, Inc. | Phenyl heterocycles as cox-2 inhibitors |
| US5375871A (en) * | 1993-07-02 | 1994-12-27 | Ridewell Corporation | Vehicle suspension system comprising a wide base beam and axle shell |
| US5593992A (en) | 1993-07-16 | 1997-01-14 | Smithkline Beecham Corporation | Compounds |
| US5344991A (en) * | 1993-10-29 | 1994-09-06 | G.D. Searle & Co. | 1,2 diarylcyclopentenyl compounds for the treatment of inflammation |
| DE69422306T4 (de) | 1993-11-30 | 2000-09-07 | G.D. Searle & Co., Chicago | Substituierte pyrazolyl-benzolsulfonamide zur behandlung von entzündungen |
| US5434178A (en) * | 1993-11-30 | 1995-07-18 | G.D. Searle & Co. | 1,3,5 trisubstituted pyrazole compounds for treatment of inflammation |
| US5475018A (en) * | 1993-11-30 | 1995-12-12 | G. D. Searle & Co. | 1,5-diphenyl pyrazole compounds for treatment of inflammation |
| US5403031A (en) * | 1993-12-08 | 1995-04-04 | The Boler Company | Parallelogram lift axle suspension system with a control for axle caster adjustment |
| DK0743938T3 (da) | 1994-02-10 | 1999-10-25 | Searle & Co | Substituerede spiroforbindelser til behandling af inflammation |
| US5393790A (en) * | 1994-02-10 | 1995-02-28 | G.D. Searle & Co. | Substituted spiro compounds for the treatment of inflammation |
| US5639110A (en) * | 1994-04-14 | 1997-06-17 | Nai Neway, Inc. | Trailing arm suspension |
| US5643960A (en) * | 1994-04-15 | 1997-07-01 | Duke University | Method of delaying onset of alzheimer's disease symptoms |
| US5486534A (en) | 1994-07-21 | 1996-01-23 | G. D. Searle & Co. | 3,4-substituted pyrazoles for the treatment of inflammation |
| AU3201095A (en) | 1994-07-27 | 1996-02-22 | G.D. Searle & Co. | Substituted thiazoles for the treatment of inflammation |
| US5616601A (en) | 1994-07-28 | 1997-04-01 | Gd Searle & Co | 1,2-aryl and heteroaryl substituted imidazolyl compounds for the treatment of inflammation |
| US5620999A (en) | 1994-07-28 | 1997-04-15 | Weier; Richard M. | Benzenesulfonamide subtituted imidazolyl compounds for the treatment of inflammation |
| GB9415529D0 (en) * | 1994-08-01 | 1994-09-21 | Wellcome Found | Phenyl xanthine derivatives |
| US5464245A (en) * | 1994-08-08 | 1995-11-07 | The Boler Company | Suspension for light duty trucks |
| GB9417249D0 (en) * | 1994-08-26 | 1994-10-19 | Wellcome Found | A novel salt |
| US5521213A (en) | 1994-08-29 | 1996-05-28 | Merck Frosst Canada, Inc. | Diaryl bicyclic heterocycles as inhibitors of cyclooxygenase-2 |
| US5837735A (en) * | 1994-10-05 | 1998-11-17 | Helsinn Healthcare S.A. | Antiinflammatory agent for external use |
| US5739166A (en) | 1994-11-29 | 1998-04-14 | G.D. Searle & Co. | Substituted terphenyl compounds for the treatment of inflammation |
| DE4442560A1 (de) | 1994-11-30 | 1996-06-05 | Basf Ag | Iminooxybenzylcrotonsäureester, Verfahren zu ihrer Herstellung und ihre Verwendung |
| US5603724A (en) | 1995-02-13 | 1997-02-18 | Tnco, Inc. | Suction punch |
| BR9607035A (pt) | 1995-02-13 | 1997-11-04 | Searle & Co | Isoxazois substituidos para o tratamento de inflamação |
| CN1186492A (zh) | 1995-04-04 | 1998-07-01 | 葛兰素集团有限公司 | 咪唑并[1,2－α]吡啶衍生物 |
| US5720489A (en) * | 1995-05-17 | 1998-02-24 | The Boler Company | Movable subframe for tractor-trailers |
| US5510368A (en) * | 1995-05-22 | 1996-04-23 | Merck Frosst Canada, Inc. | N-benzyl-3-indoleacetic acids as antiinflammatory drugs |
| GB9514518D0 (en) | 1995-07-15 | 1995-09-13 | Sod Conseils Rech Applic | Guanidine salt inhibitors of NO synthase and cyclooxygenase |
| US5785345A (en) * | 1995-10-16 | 1998-07-28 | The Boler Company | Means for and method of controlling frame rise in vehicle suspensions |
| SE9600070D0 (sv) * | 1996-01-08 | 1996-01-08 | Astra Ab | New oral pharmaceutical dosage forms |
| ZA97175B (en) * | 1996-01-11 | 1997-11-04 | Smithkline Beecham Corp | Novel substituted imidazole compounds. |
| DK0880363T3 (da) | 1996-02-13 | 2003-01-20 | Searle & Co | Kombinationer der omfatter en cyclooxygenase-2 hæmmer samt en leukotrien A4 hydrolasehæmmer, som har immunsuppressive virkninger |
| ATE233743T1 (de) | 1996-04-12 | 2003-03-15 | Searle & Co | N-((4-(5-methyl-3-phenylisoxazol-4- yl)phenyl)sulphonylpropylamid und sein natriumsalz als pro-pharmakon von cox-2 inhibitoren |
| US5690353A (en) * | 1996-05-09 | 1997-11-25 | Suspensions Incorporated | Suspension system with improved beam |
| US5950971A (en) * | 1996-06-28 | 1999-09-14 | The Boler Company | Assembly for and method of mounting a suspension member to an axle housing |
| WO1998001443A1 (en) | 1996-07-09 | 1998-01-15 | Smithkline Beecham S.P.A. | Indole derivatives for the treatment of osteoporosis |
| JP2001506230A (ja) | 1996-08-09 | 2001-05-15 | スミスクライン・ビーチャム・コーポレイション | 新規ピペラジン含有化合物 |
| US6005000A (en) | 1996-08-22 | 1999-12-21 | Oxis International, Inc. | 5,5-Disubstituted-3, 4-dihydroxy-2(5H)-furanones and methods of use therefor |
| US5996981A (en) * | 1996-08-28 | 1999-12-07 | The Boler Company | Reduced size bushing for beam-type axle suspension system |
| DE29616257U1 (de) * | 1996-09-19 | 1996-11-07 | Otto Sauer Achsenfabrik Keilberg, 63856 Bessenbach | Aufhängung für luftgefederte Fahrzeugradachse |
| ITMI962356A1 (it) | 1996-11-13 | 1998-05-13 | Uni Degli Studi Di Brescia D I | Uso di composti derivati da molecole ad attivita' antinfiammatoria di tipo non steroideo per la prevenzione e il trattamento di |
| US5921570A (en) * | 1996-11-21 | 1999-07-13 | The Boler Company | Weld-on axle bracket with U-bolt connection |
| JP4167733B2 (ja) | 1996-12-16 | 2008-10-22 | 花王株式会社 | ＮＦ−κＢ活性化抑制剤 |
| US5810377A (en) * | 1997-01-21 | 1998-09-22 | The Boler Company | Fabricated steer axle |
| DE69816047T2 (de) | 1997-03-14 | 2004-04-22 | Merck Frosst Canada & Co, Kirkland | (methylsulfonyl)phenyl-2-(5h)-furanone mit sauerstoff-bindung als cox-2-hemmer |
| EP0975604B1 (en) | 1997-03-14 | 2004-07-21 | Merck Frosst Canada & Co. | Pyridazinones as inhibitors of cyclooxygenase-2 |
| WO1998043966A1 (en) | 1997-04-02 | 1998-10-08 | Merck Frosst Canada & Co. | Alpha-methylene gamma lactones as selective cyclooxygenase-2 inhibitors |
| SE9701304D0 (sv) | 1997-04-09 | 1997-04-09 | Astra Pharma Prod | Compounds |
| TW492959B (en) | 1997-04-18 | 2002-07-01 | Merck & Co Inc | Process for making 2-aryl-3-aryl-5-halo pyridines useful as cox-2 inhibitors |
| US5944339A (en) * | 1997-05-06 | 1999-08-31 | Meritor Heavy Vehicle Systems, Llc | Integrated axle suspension anti-roll arrangement for push-pull suspension |
| US6073946A (en) * | 1997-07-16 | 2000-06-13 | Neway Anchorlok International, Inc. | Trailing arm suspension |
| US5887881A (en) * | 1997-08-11 | 1999-03-30 | The Boler Company. | Leaf spring attachment member |
| US5988672A (en) * | 1997-08-11 | 1999-11-23 | Meritor Heavy Vehicle Suspension Systems, Inc. | Suspension system with integral box beam |
| DK1032575T3 (da) | 1997-09-05 | 2003-10-20 | Glaxo Group Ltd | 2,3-diaryl-pyrazol(1,5-b)pyridazinderivater, deres fremstilling og anvendelse som cyclooxygenase 2 (COX-2) inhibitor |
| CA2301742C (en) | 1997-09-12 | 2004-05-18 | Richard Friesen | 2,3,5-trisubstituted pyridines as inhibitors of cyclooxygenase-2 |
| EP1015431B1 (en) | 1997-09-12 | 2005-04-20 | Merck Frosst Canada & Co. | 2-aminopyridines as inhibitors of cyclooxygenase-2 |
| US6039336A (en) * | 1997-09-19 | 2000-03-21 | Otto Sauer Achsenfabrik Keilberg | Vehicle axle suspension assembly |
| CN1271352A (zh) | 1997-09-24 | 2000-10-25 | 麦克公司 | 用作环氧合酶－2抑制剂的3－芳氧基,4－芳基呋喃－2－酮的制备方法 |
| AR015938A1 (es) | 1997-09-25 | 2001-05-30 | Merck Sharp & Dohme | Procedimiento para preparar diaril piridinas utiles como inhibidores cox-2 y compuesto intermediario |
| CA2306646A1 (en) | 1997-10-22 | 1999-04-29 | Merck & Co., Inc. | Combination therapy for reducing the risks associated with cardio- and cerebrovascular disease |
| EP1028951A1 (en) | 1997-10-30 | 2000-08-23 | Merck Frosst Canada Inc. | Diaryl-5-alkyl-5-methyl-2(5h)-furanones as selective cyclooxygenase-2 inhibitors |
| US6025353A (en) * | 1997-11-19 | 2000-02-15 | G.D. Searle & Co. | Method of using cyclooxygenase-2 inhibitors as anti-angiogenic agents |
| US5938221A (en) * | 1997-12-08 | 1999-08-17 | The Boler Company | Tapered convolute leaf spring for truck suspensions |
| JP2002515891A (ja) | 1997-12-19 | 2002-05-28 | スミスクライン・ビーチャム・コーポレイション | 新規なピペリジン含有化合物 |
| EP1082966A4 (en) * | 1998-05-15 | 2004-07-21 | Wakamoto Pharma Co Ltd | ANTI-INFLAMMATORY EYE DROPS |
| SK20012000A3 (sk) * | 1998-06-29 | 2001-08-06 | Pharmaceuticals Applications Asociates, Llc | Transdermálny prostriedok na zmiernenie bolesti |
| MXPA00012632A (es) * | 1998-07-02 | 2002-07-02 | Boler Co | Sistema de eje/suspension de brazo de remolque. |
| US6420403B1 (en) * | 1998-10-29 | 2002-07-16 | Edwin J. Iwanowicz | Inhibitors of IMPDH enzyme |
| US6209895B1 (en) * | 1998-12-03 | 2001-04-03 | Reyco Industries, Inc. | Axle suspension system for a wheeled vehicle |
| WO2000040243A1 (en) * | 1999-01-08 | 2000-07-13 | Smithkline Beecham Corporation | Novel compounds |
| US6123349A (en) * | 1999-04-09 | 2000-09-26 | Standen's Limited | Vehicle air suspension system |
| MXPA01011606A (es) * | 1999-05-14 | 2003-09-10 | Univ California | Terapia anti-inflamatoria para infeccion mediada por inflamacion. |
| US20030138399A1 (en) * | 1999-05-14 | 2003-07-24 | Anton Peter A. | Anti-inflammatory therapy for inflammatory mediated infection |
| ES2236011T3 (es) * | 1999-12-08 | 2005-07-16 | Pharmacia Corporation | Formas cristalinas polimorficas de celecoxib. |
| US6264231B1 (en) * | 2000-03-20 | 2001-07-24 | The Boler Company | Axle suspension connection |
| ES2249426T3 (es) * | 2000-03-22 | 2006-04-01 | Hendrickson International Corporation | Dispositivo de suspension de chasis en aluminio para sistemas de eje/sispension. |
| US6306842B1 (en) * | 2000-06-02 | 2001-10-23 | Medinox, Inc. | Protected forms of a combination of pharmacologically active agents and uses therefor |
| EP1303265B1 (en) | 2000-07-20 | 2007-07-11 | Lauras AS | Use of cox-2 inhibitors as immunostimulants in the treatment of hiv or aids |
| GB0021716D0 (en) * | 2000-09-05 | 2000-10-18 | Meritor Heavy Vehicle Sys Ltd | Vehicle suspension axle wrap |
| US7007960B2 (en) * | 2002-02-01 | 2006-03-07 | Watson & Chalin Manufacturing, Inc. | Suspension system having reduced stress axle connection |
-
2001
- 2001-07-20 EP EP01949787A patent/EP1303265B1/en not_active Expired - Lifetime
- 2001-07-20 HU HU0302068A patent/HUP0302068A3/hu unknown
- 2001-07-20 OA OA1200300011A patent/OA12339A/en unknown
- 2001-07-20 RU RU2003104981/15A patent/RU2303452C2/ru not_active IP Right Cessation
- 2001-07-20 NZ NZ524252A patent/NZ524252A/en unknown
- 2001-07-20 AT AT01949787T patent/ATE366569T1/de not_active IP Right Cessation
- 2001-07-20 JP JP2002513457A patent/JP2004510705A/ja active Pending
- 2001-07-20 US US10/333,657 patent/US7790738B2/en not_active Expired - Fee Related
- 2001-07-20 PT PT01949787T patent/PT1303265E/pt unknown
- 2001-07-20 PL PL01359556A patent/PL359556A1/xx not_active Application Discontinuation
- 2001-07-20 DE DE60129330T patent/DE60129330T2/de not_active Expired - Lifetime
- 2001-07-20 AP APAP/P/2003/002719A patent/AP1780A/en active
- 2001-07-20 ES ES01949787T patent/ES2290157T3/es not_active Expired - Lifetime
- 2001-07-20 CZ CZ20030177A patent/CZ302448B6/cs not_active IP Right Cessation
- 2001-07-20 CN CNB018143199A patent/CN100488500C/zh not_active Expired - Fee Related
- 2001-07-20 CA CA2415577A patent/CA2415577C/en not_active Expired - Fee Related
- 2001-07-20 AU AU7090201A patent/AU7090201A/xx not_active Withdrawn
- 2001-07-20 WO PCT/GB2001/003284 patent/WO2002007721A2/en not_active Ceased
- 2001-07-20 DK DK01949787T patent/DK1303265T3/da active
-
2003
- 2003-01-20 NO NO20030276A patent/NO330509B1/no not_active IP Right Cessation
-
2007
- 2007-10-08 CY CY20071101278T patent/CY1107069T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PT1303265E (pt) | 2007-10-09 |
| WO2002007721A3 (en) | 2002-04-18 |
| PL359556A1 (en) | 2004-08-23 |
| HUP0302068A2 (hu) | 2003-11-28 |
| CA2415577A1 (en) | 2002-01-31 |
| CA2415577C (en) | 2010-10-19 |
| NO20030276L (no) | 2003-03-18 |
| ES2290157T3 (es) | 2008-02-16 |
| DE60129330T2 (de) | 2008-04-10 |
| CN1561204A (zh) | 2005-01-05 |
| EP1303265A2 (en) | 2003-04-23 |
| JP2004510705A (ja) | 2004-04-08 |
| US7790738B2 (en) | 2010-09-07 |
| AP2003002719A0 (en) | 2003-06-30 |
| AU7090201A (en) | 2002-02-05 |
| ATE366569T1 (de) | 2007-08-15 |
| US20040082640A1 (en) | 2004-04-29 |
| HUP0302068A3 (en) | 2005-05-30 |
| DK1303265T3 (da) | 2007-11-12 |
| CZ302448B6 (cs) | 2011-05-25 |
| NO330509B1 (no) | 2011-05-09 |
| HK1055087A1 (en) | 2003-12-24 |
| NO20030276D0 (no) | 2003-01-20 |
| EP1303265B1 (en) | 2007-07-11 |
| CN100488500C (zh) | 2009-05-20 |
| WO2002007721A2 (en) | 2002-01-31 |
| CY1107069T1 (el) | 2012-10-24 |
| AP1780A (en) | 2007-09-26 |
| RU2303452C2 (ru) | 2007-07-27 |
| DE60129330D1 (de) | 2007-08-23 |
| NZ524252A (en) | 2004-03-26 |
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