OA11513A - Composés morpholiniques antagonistes du récepteur de la NK-1. - Google Patents

Composés morpholiniques antagonistes du récepteur de la NK-1. Download PDF

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Publication number
OA11513A
OA11513A OA1200000324A OA1200000324A OA11513A OA 11513 A OA11513 A OA 11513A OA 1200000324 A OA1200000324 A OA 1200000324A OA 1200000324 A OA1200000324 A OA 1200000324A OA 11513 A OA11513 A OA 11513A
Authority
OA
OAPI
Prior art keywords
compound
formula
receptor
morpholin
acid
Prior art date
Application number
OA1200000324A
Other languages
English (en)
French (fr)
Inventor
Theresa Maria Ballard
Guy Andrew Higgins
Torsten Hoffmann
Sonia Maria Poli
Andrew Sleight
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of OA11513A publication Critical patent/OA11513A/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Pulmonology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Otolaryngology (AREA)
  • Hospice & Palliative Care (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
OA1200000324A 1999-11-29 2000-11-29 Composés morpholiniques antagonistes du récepteur de la NK-1. OA11513A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP99123685 1999-11-29

Publications (1)

Publication Number Publication Date
OA11513A true OA11513A (fr) 2004-02-03

Family

ID=8239481

Family Applications (1)

Application Number Title Priority Date Filing Date
OA1200000324A OA11513A (fr) 1999-11-29 2000-11-29 Composés morpholiniques antagonistes du récepteur de la NK-1.

Country Status (50)

Country Link
EP (1) EP1103545B1 (ko)
JP (1) JP3480835B2 (ko)
KR (1) KR100390117B1 (ko)
CN (1) CN1152016C (ko)
AR (1) AR033659A1 (ko)
AT (1) ATE253561T1 (ko)
AU (1) AU775292B2 (ko)
BG (1) BG64622B1 (ko)
BR (1) BRPI0005616B8 (ko)
CA (1) CA2326529C (ko)
CO (1) CO5251405A1 (ko)
CZ (1) CZ299286B6 (ko)
DE (2) DE60006340T2 (ko)
DK (1) DK1103545T3 (ko)
DO (1) DOP2000000106A (ko)
EA (1) EA004404B1 (ko)
ES (2) ES2208205T3 (ko)
FR (1) FR2801590A1 (ko)
GB (1) GB2356863A (ko)
GC (1) GC0000151A (ko)
GE (1) GEP20022763B (ko)
GT (1) GT200000197A (ko)
HK (1) HK1036759A1 (ko)
HR (1) HRP20000809A2 (ko)
HU (1) HU224703B1 (ko)
ID (1) ID28483A (ko)
IL (1) IL139868A (ko)
IS (1) IS2212B (ko)
IT (1) IT1320120B1 (ko)
JO (1) JO2298B1 (ko)
MA (1) MA26754A1 (ko)
MX (1) MXPA00011672A (ko)
MY (1) MY127426A (ko)
NO (1) NO317264B1 (ko)
NZ (1) NZ508386A (ko)
OA (1) OA11513A (ko)
PA (1) PA8507201A1 (ko)
PE (1) PE20010901A1 (ko)
PL (1) PL195957B1 (ko)
PT (1) PT1103545E (ko)
SG (1) SG97171A1 (ko)
SI (1) SI1103545T1 (ko)
SK (1) SK285373B6 (ko)
SV (1) SV2002000227A (ko)
TN (1) TNSN00226A1 (ko)
TR (1) TR200302077T4 (ko)
UA (1) UA70326C2 (ko)
UY (1) UY26458A1 (ko)
YU (1) YU73400A (ko)
ZA (1) ZA200006964B (ko)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR0008489A (pt) 1999-02-24 2002-02-05 Hoffmann La Roche Derivados de fenil- e piridinila
DK1394150T3 (da) * 1999-02-24 2011-03-21 Hoffmann La Roche 4-phenylpyridinderivater og deres anvendelse som NK-1-receptorantagonister
DK1303490T3 (da) * 2000-07-14 2008-08-25 Hoffmann La Roche N-oxider som NK1-receptorantagoniskprodugs af 4-phenyl-pyridinderivater
TWI287003B (en) * 2000-07-24 2007-09-21 Hoffmann La Roche 4-phenyl-pyridine derivatives
TWI259180B (en) * 2000-08-08 2006-08-01 Hoffmann La Roche 4-Phenyl-pyridine derivatives
US20030083345A1 (en) * 2001-07-10 2003-05-01 Torsten Hoffmann Method of treatment and/or prevention of brain, spinal or nerve injury
CA2473128A1 (en) * 2002-01-31 2003-08-07 F. Hoffmann-La Roche Ag Genetic polymorphisms in the preprotachykinin gene
DK1643998T3 (da) 2003-07-03 2007-12-27 Hoffmann La Roche NK1/NK3-antagonister til behandling af skizofreni
TWI280239B (en) 2003-07-15 2007-05-01 Hoffmann La Roche Process for preparation of pyridine derivatives
MX2007000198A (es) 2004-07-06 2007-03-15 Hoffmann La Roche Proceso para la preparacion de derivados de carboxamida-piridina utilizados como intermediarios en la sintesis de antagonistas del receptor nk-1.
EP2281556A1 (en) 2005-02-25 2011-02-09 F. Hoffmann-La Roche AG Tablets with improved drugs substance dispersibility
DK1863767T3 (da) 2005-03-23 2009-05-04 Hoffmann La Roche Metabolitter til NK-I-antagonister til emesis
DE602006011485D1 (de) 2005-09-23 2010-02-11 Hoffmann La Roche Neue dosierformulierung
BRPI0807972A2 (pt) 2007-01-24 2014-06-10 Glaxo Group Ltd Composições farmacêuticas compreendendo 3,5-diamino-6-(2,3-diclofenil)-l,2,4-triazina ou r(-)-2,4-diamino-5-(2,3-diclorofenil)-6-fluorometilpirim idina e uma nk1
US8426450B1 (en) * 2011-11-29 2013-04-23 Helsinn Healthcare Sa Substituted 4-phenyl pyridines having anti-emetic effect
MX2015011448A (es) 2013-03-15 2016-06-06 Global Blood Therapeutics Inc Compuestos y sus usos para modular la hemoglobina.
WO2015068744A1 (ja) 2013-11-08 2015-05-14 キッセイ薬品工業株式会社 カルボキシメチルピペリジン誘導体
EP3868745A1 (en) 2014-02-07 2021-08-25 Global Blood Therapeutics, Inc. Crystalline polymorphs of the free base of 2-hydroxy-6-((2-(1-isopropyl-1h-pyrazol-5-yl)pyridin-3-yl)methoxy)benzaldehyde
TWI649307B (zh) 2014-05-07 2019-02-01 日商橘生藥品工業股份有限公司 Cyclohexylpyridine derivative
KR101948238B1 (ko) 2016-08-19 2019-02-14 (주)케어젠 미녹시딜과 펩타이드의 결합체

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0916346A3 (en) * 1991-09-20 2000-12-06 Glaxo Group Limited NK-1 receptor antagonists and 5HT3 receptor antagonists for the treatment of emesis
IL106142A (en) * 1992-06-29 1997-03-18 Merck & Co Inc Morpholine and thiomorpholine tachykinin receptor antagonists, their preparation and pharmaceutical compositions containing them
IL111960A (en) * 1993-12-17 1999-12-22 Merck & Co Inc Morpholines and thiomorpholines their preparation and pharmaceutical compositions containing them
ES2164758T3 (es) * 1993-12-29 2002-03-01 Merck Sharp & Dohme Derivados de morfolina sustituidos y su uso como agentes terapeuticos.
TW385308B (en) * 1994-03-04 2000-03-21 Merck & Co Inc Prodrugs of morpholine tachykinin receptor antagonists
TW394773B (en) * 1995-03-24 2000-06-21 Takeda Chemical Industries Ltd Cyclic compounds for antagonizing tachykinin receptor, substance p receptor and neurokinin a receptor, their production and pharmaceutical composition
US5972938A (en) * 1997-12-01 1999-10-26 Merck & Co., Inc. Method for treating or preventing psychoimmunological disorders
DK1394150T3 (da) * 1999-02-24 2011-03-21 Hoffmann La Roche 4-phenylpyridinderivater og deres anvendelse som NK-1-receptorantagonister
US6303790B1 (en) * 1999-11-29 2001-10-16 Hoffman-La Roche Inc. Process for the preparation of pyridine derivatives
DK1303490T3 (da) * 2000-07-14 2008-08-25 Hoffmann La Roche N-oxider som NK1-receptorantagoniskprodugs af 4-phenyl-pyridinderivater
TWI287003B (en) * 2000-07-24 2007-09-21 Hoffmann La Roche 4-phenyl-pyridine derivatives
TWI259180B (en) * 2000-08-08 2006-08-01 Hoffmann La Roche 4-Phenyl-pyridine derivatives

Also Published As

Publication number Publication date
SK285373B6 (sk) 2006-12-07
NZ508386A (en) 2003-02-28
FR2801590A1 (fr) 2001-06-01
ES2208205T3 (es) 2004-06-16
JP2001151754A (ja) 2001-06-05
CA2326529A1 (en) 2001-05-29
EP1103545B1 (en) 2003-11-05
PT1103545E (pt) 2004-03-31
HU0004725D0 (ko) 2001-02-28
PL344147A1 (en) 2001-06-04
IL139868A0 (en) 2002-02-10
DOP2000000106A (es) 2002-07-30
BR0005616A (pt) 2001-07-17
PL195957B1 (pl) 2007-11-30
EP1103545A1 (en) 2001-05-30
BRPI0005616B1 (pt) 2017-12-12
SK17932000A3 (sk) 2001-11-06
JP3480835B2 (ja) 2003-12-22
CA2326529C (en) 2009-12-22
KR100390117B1 (ko) 2003-07-04
PE20010901A1 (es) 2001-09-20
SG97171A1 (en) 2003-07-18
HRP20000809A2 (en) 2001-12-31
IT1320120B1 (it) 2003-11-18
ITMI20002575A1 (it) 2002-05-29
GEP20022763B (en) 2002-08-26
CN1152016C (zh) 2004-06-02
MA26754A1 (fr) 2004-12-20
HU224703B1 (en) 2006-01-30
EA004404B1 (ru) 2004-04-29
BG64622B1 (bg) 2005-09-30
CZ299286B6 (cs) 2008-06-04
AU7178700A (en) 2001-05-31
HUP0004725A2 (hu) 2002-04-29
TR200302077T4 (tr) 2004-01-21
EA200001114A2 (ru) 2001-08-27
MXPA00011672A (es) 2002-08-20
UY26458A1 (es) 2001-05-31
GT200000197A (es) 2002-05-22
BG104992A (en) 2001-11-30
BRPI0005616B8 (pt) 2021-07-06
ZA200006964B (en) 2001-06-05
YU73400A (sh) 2003-02-28
ID28483A (id) 2001-05-31
NO317264B1 (no) 2004-09-27
JO2298B1 (en) 2005-09-12
IL139868A (en) 2009-09-01
GB2356863A (en) 2001-06-06
ES2171134A1 (es) 2002-08-16
GB0028566D0 (en) 2001-01-10
DE60006340D1 (de) 2003-12-11
AU775292B2 (en) 2004-07-29
NO20006012L (no) 2001-05-30
CN1297888A (zh) 2001-06-06
IS2212B (is) 2007-02-15
IS5725A (is) 2001-05-29
PA8507201A1 (es) 2002-02-21
CZ20004399A3 (cs) 2001-07-11
HK1036759A1 (en) 2002-01-18
ATE253561T1 (de) 2003-11-15
SV2002000227A (es) 2002-02-05
DK1103545T3 (da) 2004-03-15
MY127426A (en) 2006-11-30
SI1103545T1 (en) 2004-02-29
AR033659A1 (es) 2004-01-07
UA70326C2 (en) 2004-10-15
CO5251405A1 (es) 2003-02-28
NO20006012D0 (no) 2000-11-28
DE60006340T2 (de) 2004-09-09
GC0000151A (en) 2005-06-29
EA200001114A3 (ru) 2001-12-24
KR20010051983A (ko) 2001-06-25
TNSN00226A1 (fr) 2002-05-30
DE10058310A1 (de) 2001-05-31

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