OA11047A - Compositions pharmaceutiques stabilisées à base dequinupristine et de dalfopristine et leur prépara tion - Google Patents
Compositions pharmaceutiques stabilisées à base dequinupristine et de dalfopristine et leur prépara tion Download PDFInfo
- Publication number
- OA11047A OA11047A OA9900100A OA9900100A OA11047A OA 11047 A OA11047 A OA 11047A OA 9900100 A OA9900100 A OA 9900100A OA 9900100 A OA9900100 A OA 9900100A OA 11047 A OA11047 A OA 11047A
- Authority
- OA
- OAPI
- Prior art keywords
- pharmaceutical composition
- solution
- dalfopristine
- quinupristine
- composition according
- Prior art date
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- 239000008194 pharmaceutical composition Substances 0.000 title claims abstract description 28
- 238000002360 preparation method Methods 0.000 title claims description 12
- PPKJUHVNTMYXOD-CEHYXHNTSA-N quinupristin-dalfopristin Chemical group O=C([C@@H]1N(C2=O)CC[C@H]1S(=O)(=O)CCN(CC)CC)O[C@H](C(C)C)[C@H](C)\C=C/C(=O)NC\C=C/C(/C)=C\[C@@H](O)CC(=O)CC1=NC2=CO1.N([C@@H]1C(=O)N[C@@H](C(N2CCC[C@H]2C(=O)N(C)[C@@H](CC=2C=CC(=CC=2)N(C)C)C(=O)N2C[C@@H](CS[C@H]3C4CCN(CC4)C3)C(=O)CC2C(=O)N[C@H](C(=O)O[C@@H]1C)C=1C=CC=CC=1)=O)CC)C(=O)C1=NC=CC=C1O PPKJUHVNTMYXOD-CEHYXHNTSA-N 0.000 title description 2
- AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 claims abstract description 52
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims abstract description 38
- SUYRLXYYZQTJHF-VMBLUXKRSA-N dalfopristin Chemical compound O=C([C@@H]1N(C2=O)CC[C@H]1S(=O)(=O)CCN(CC)CC)O[C@H](C(C)C)[C@H](C)\C=C\C(=O)NC\C=C\C(\C)=C\[C@@H](O)CC(=O)CC1=NC2=CO1 SUYRLXYYZQTJHF-VMBLUXKRSA-N 0.000 claims abstract description 38
- WTHRRGMBUAHGNI-LCYNINFDSA-N quinupristin Chemical compound N([C@@H]1C(=O)N[C@@H](C(N2CCC[C@H]2C(=O)N(C)[C@@H](CC=2C=CC(=CC=2)N(C)C)C(=O)N2C[C@@H](CS[C@H]3C4CCN(CC4)C3)C(=O)C[C@H]2C(=O)N[C@H](C(=O)O[C@@H]1C)C=1C=CC=CC=1)=O)CC)C(=O)C1=NC=CC=C1O WTHRRGMBUAHGNI-LCYNINFDSA-N 0.000 claims description 40
- 229940098779 methanesulfonic acid Drugs 0.000 claims description 22
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 22
- 238000000034 method Methods 0.000 claims description 10
- 239000003795 chemical substances by application Substances 0.000 claims description 9
- 239000004480 active ingredient Substances 0.000 claims description 7
- 239000002671 adjuvant Substances 0.000 claims description 5
- 239000007788 liquid Substances 0.000 claims description 2
- 230000006641 stabilisation Effects 0.000 claims 1
- 238000011105 stabilization Methods 0.000 claims 1
- 239000000243 solution Substances 0.000 description 79
- 239000012535 impurity Substances 0.000 description 26
- 229960002615 dalfopristin Drugs 0.000 description 13
- 108700028430 dalfopristin Proteins 0.000 description 13
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- 238000006731 degradation reaction Methods 0.000 description 10
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- PPKJUHVNTMYXOD-PZGPJMECSA-N c49ws9n75l Chemical compound O=C([C@@H]1N(C2=O)CC[C@H]1S(=O)(=O)CCN(CC)CC)O[C@H](C(C)C)[C@H](C)\C=C\C(=O)NC\C=C\C(\C)=C\[C@@H](O)CC(=O)CC1=NC2=CO1.N([C@@H]1C(=O)N[C@@H](C(N2CCC[C@H]2C(=O)N(C)[C@@H](CC=2C=CC(=CC=2)N(C)C)C(=O)N2C[C@@H](CS[C@H]3C4CCN(CC4)C3)C(=O)C[C@H]2C(=O)N[C@H](C(=O)O[C@@H]1C)C=1C=CC=CC=1)=O)CC)C(=O)C1=NC=CC=C1O PPKJUHVNTMYXOD-PZGPJMECSA-N 0.000 description 9
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Classifications
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
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- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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- A61K31/445—Non condensed piperidines, e.g. piperocaine
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- A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Inorganic Chemistry (AREA)
- Organic Chemistry (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Dermatology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Virology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9614062A FR2755857B1 (fr) | 1996-11-19 | 1996-11-19 | Compositions pharmaceutiques stabilisees, a base de quinupristine et de dalfopristine et leur preparation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| OA11047A true OA11047A (fr) | 2003-03-07 |
Family
ID=9497744
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| OA9900100A OA11047A (fr) | 1996-11-19 | 1999-05-19 | Compositions pharmaceutiques stabilisées à base dequinupristine et de dalfopristine et leur prépara tion |
Country Status (44)
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2772272B1 (fr) * | 1997-12-16 | 2000-01-14 | Rhone Poulenc Rorer Sa | Compositions pharmaceutiques a base de dalfopristine et de quinupristine et leur preparation |
| DK1115417T3 (da) | 1998-09-25 | 2006-07-31 | Cubist Pharm Inc | Anvendelse af daptomycin |
| EP1582204B1 (en) * | 1999-03-03 | 2013-09-25 | Eli Lilly & Company | Echinocandin pharmaceutical formulations containing micelle-forming surfactants |
| TWI233805B (en) * | 1999-07-01 | 2005-06-11 | Fujisawa Pharmaceutical Co | Stabilized pharmaceutical composition in lyophilized form as antifungal agent |
| US6119269A (en) * | 1999-09-23 | 2000-09-19 | Imler; Jack | Fishing vest with removable storage container system |
| US6696412B1 (en) | 2000-01-20 | 2004-02-24 | Cubist Pharmaceuticals, Inc. | High purity lipopeptides, Lipopeptide micelles and processes for preparing same |
| FR2812549B1 (fr) * | 2000-08-03 | 2003-03-21 | Aventis Pharma Sa | Associations dalfopristine/quinupristine avec le cefpirome |
| US20060014674A1 (en) | 2000-12-18 | 2006-01-19 | Dennis Keith | Methods for preparing purified lipopeptides |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2549065B1 (fr) * | 1983-07-13 | 1985-10-25 | Rhone Poulenc Sante | Nouveaux derives de synergistines, leur preparation et les compositions pharmaceutiques qui les contiennent |
| FR2576022B1 (fr) * | 1985-01-11 | 1987-09-11 | Rhone Poulenc Sante | Nouveaux derives de la pristinamycine ii b, leur preparation et les compositions pharmaceutiques qui les contiennent |
| FR2599036B1 (fr) * | 1986-05-22 | 1988-09-09 | Rhone Poulenc Sante | Nouveaux derives de synergistines, leur preparation et les compositions pharmaceutiques qui les contiennent |
-
1996
- 1996-11-19 FR FR9614062A patent/FR2755857B1/fr not_active Expired - Fee Related
-
1997
- 1997-11-13 PE PE1997001017A patent/PE13999A1/es not_active Application Discontinuation
- 1997-11-13 IN IN3274DE1997 patent/IN187038B/en unknown
- 1997-11-14 UA UA99052713A patent/UA59376C2/uk unknown
- 1997-11-14 SK SK660-99A patent/SK284311B6/sk not_active IP Right Cessation
- 1997-11-14 BR BR9713087-7A patent/BR9713087A/pt not_active Application Discontinuation
- 1997-11-14 JP JP52326598A patent/JP4278115B2/ja not_active Expired - Lifetime
- 1997-11-14 UY UY24780A patent/UY24780A1/es not_active IP Right Cessation
- 1997-11-14 PL PL97333850A patent/PL190164B1/pl not_active IP Right Cessation
- 1997-11-14 EE EEP199900127A patent/EE03668B1/xx not_active IP Right Cessation
- 1997-11-14 CZ CZ0174899A patent/CZ299913B6/cs not_active IP Right Cessation
- 1997-11-14 EP EP97945926A patent/EP0949923B1/fr not_active Expired - Lifetime
- 1997-11-14 AP APAP/P/1999/001530A patent/AP998A/en active
- 1997-11-14 AU AU51256/98A patent/AU740291B2/en not_active Ceased
- 1997-11-14 EA EA199900479A patent/EA002025B1/ru unknown
- 1997-11-14 DK DK97945926T patent/DK0949923T3/da active
- 1997-11-14 AT AT97945926T patent/ATE223217T1/de not_active IP Right Cessation
- 1997-11-14 KR KR10-1999-7004364A patent/KR100530836B1/ko not_active Expired - Fee Related
- 1997-11-14 NZ NZ334949A patent/NZ334949A/xx unknown
- 1997-11-14 CN CNB97198901XA patent/CN1146417C/zh not_active Expired - Fee Related
- 1997-11-14 PT PT97945926T patent/PT949923E/pt unknown
- 1997-11-14 RS YUP-224/99A patent/RS49608B/sr unknown
- 1997-11-14 MY MYPI97005468A patent/MY123805A/en unknown
- 1997-11-14 HU HU9904327A patent/HUP9904327A3/hu unknown
- 1997-11-14 TR TR1999/01096T patent/TR199901096T2/xx unknown
- 1997-11-14 ES ES97945926T patent/ES2179375T3/es not_active Expired - Lifetime
- 1997-11-14 CA CA002271095A patent/CA2271095C/fr not_active Expired - Fee Related
- 1997-11-14 MA MA24866A patent/MA26448A1/fr unknown
- 1997-11-14 IL IL12960797A patent/IL129607A0/xx not_active IP Right Cessation
- 1997-11-14 DE DE69715247T patent/DE69715247T2/de not_active Expired - Lifetime
- 1997-11-14 WO PCT/FR1997/002047 patent/WO1998022107A1/fr not_active Ceased
- 1997-11-15 JO JO19971992A patent/JO1992B1/en active
- 1997-11-17 HR HR970615A patent/HRP970615B1/xx not_active IP Right Cessation
- 1997-11-18 DZ DZ970199A patent/DZ2349A1/xx active
- 1997-11-18 TN TNTNSN97184A patent/TNSN97184A1/fr unknown
- 1997-11-19 ZA ZA9710435A patent/ZA9710435B/xx unknown
- 1997-11-19 TW TW086117271A patent/TW474816B/zh not_active IP Right Cessation
- 1997-11-19 CO CO97067661A patent/CO4910113A1/es unknown
- 1997-11-19 AR ARP970105410A patent/AR008695A1/es unknown
- 1997-11-26 SA SA97180645A patent/SA97180645B1/ar unknown
-
1999
- 1999-04-26 IL IL129607A patent/IL129607A/en unknown
- 1999-05-19 OA OA9900100A patent/OA11047A/fr unknown
- 1999-05-19 NO NO992399A patent/NO992399D0/no not_active Application Discontinuation
- 1999-05-19 US US09/314,070 patent/US5994338A/en not_active Expired - Lifetime
- 1999-05-19 BG BG103412A patent/BG63621B1/bg unknown
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