NZ717423A - Non-invasive determination of methylome of fetus or tumor from plasma - Google Patents

Non-invasive determination of methylome of fetus or tumor from plasma

Info

Publication number
NZ717423A
NZ717423A NZ717423A NZ71742313A NZ717423A NZ 717423 A NZ717423 A NZ 717423A NZ 717423 A NZ717423 A NZ 717423A NZ 71742313 A NZ71742313 A NZ 71742313A NZ 717423 A NZ717423 A NZ 717423A
Authority
NZ
New Zealand
Prior art keywords
methylation
fetus
tumor
dna
profile
Prior art date
Application number
NZ717423A
Other languages
English (en)
Inventor
Rossa Wai Kwun Chiu
Kwan Chee Chan
Yuk-Ming Dennis Lo
Miu Fan Lun
Peiyong Jiang
Wai Man Chan
Original Assignee
Univ Hong Kong Chinese
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=50340462&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NZ717423(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US13/842,209 external-priority patent/US9732390B2/en
Application filed by Univ Hong Kong Chinese filed Critical Univ Hong Kong Chinese
Publication of NZ717423A publication Critical patent/NZ717423A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6881—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for tissue or cell typing, e.g. human leukocyte antigen [HLA] probes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2523/00—Reactions characterised by treatment of reaction samples
    • C12Q2523/10—Characterised by chemical treatment
    • C12Q2523/125—Bisulfite(s)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2535/00—Reactions characterised by the assay type for determining the identity of a nucleotide base or a sequence of oligonucleotides
    • C12Q2535/122—Massive parallel sequencing
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/112—Disease subtyping, staging or classification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/154—Methylation markers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
  • Cell Biology (AREA)
  • Theoretical Computer Science (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Medical Informatics (AREA)
  • Evolutionary Biology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
NZ717423A 2012-09-20 2013-09-20 Non-invasive determination of methylome of fetus or tumor from plasma NZ717423A (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201261703512P 2012-09-20 2012-09-20
US13/842,209 US9732390B2 (en) 2012-09-20 2013-03-15 Non-invasive determination of methylome of fetus or tumor from plasma
US201361830571P 2013-06-03 2013-06-03
NZ706269A NZ706269A (en) 2012-09-20 2013-09-20 Non-invasive determination of methylome of fetus or tumor from plasma

Publications (1)

Publication Number Publication Date
NZ717423A true NZ717423A (en) 2017-08-25

Family

ID=50340462

Family Applications (2)

Application Number Title Priority Date Filing Date
NZ717423A NZ717423A (en) 2012-09-20 2013-09-20 Non-invasive determination of methylome of fetus or tumor from plasma
NZ706269A NZ706269A (en) 2012-09-20 2013-09-20 Non-invasive determination of methylome of fetus or tumor from plasma

Family Applications After (1)

Application Number Title Priority Date Filing Date
NZ706269A NZ706269A (en) 2012-09-20 2013-09-20 Non-invasive determination of methylome of fetus or tumor from plasma

Country Status (27)

Country Link
EP (6) EP3839065A1 (hr)
JP (5) JP6317354B2 (hr)
KR (5) KR102307424B1 (hr)
CN (2) CN117757932A (hr)
AU (4) AU2013317708C1 (hr)
BR (3) BR122021021823B1 (hr)
CA (2) CA2884066C (hr)
CY (1) CY1124139T1 (hr)
DK (4) DK3536807T3 (hr)
EA (1) EA201500327A1 (hr)
ES (3) ES2969567T3 (hr)
FI (2) FI4056712T3 (hr)
HK (3) HK1206797A1 (hr)
HR (2) HRP20240210T1 (hr)
HU (2) HUE066054T2 (hr)
IL (4) IL313451A (hr)
LT (2) LT3354747T (hr)
MX (1) MX360034B (hr)
MY (2) MY173356A (hr)
NZ (2) NZ717423A (hr)
PH (1) PH12015500547A1 (hr)
PL (3) PL2898100T5 (hr)
PT (4) PT3354747T (hr)
SG (2) SG10201705198UA (hr)
TW (5) TWI806621B (hr)
WO (1) WO2014043763A1 (hr)
ZA (1) ZA201501772B (hr)

Families Citing this family (82)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI335354B (en) 2006-09-27 2011-01-01 Univ Hong Kong Chinese Methods for the detection of the degree of the methylation of a target dna and kits
US9892230B2 (en) 2012-03-08 2018-02-13 The Chinese University Of Hong Kong Size-based analysis of fetal or tumor DNA fraction in plasma
US9732390B2 (en) 2012-09-20 2017-08-15 The Chinese University Of Hong Kong Non-invasive determination of methylome of fetus or tumor from plasma
LT3354747T (lt) 2012-09-20 2021-04-12 The Chinese University Of Hong Kong Neinvazinis naviko metilomos nustatymas iš plazmos
US10706957B2 (en) 2012-09-20 2020-07-07 The Chinese University Of Hong Kong Non-invasive determination of methylome of tumor from plasma
ES2685893T3 (es) * 2013-07-30 2018-10-15 Bgi Genomics Co., Limited Método para determinar la composición de ácidos nucleicos de una mezcla de ácidos nucleicos
US10174375B2 (en) * 2013-09-20 2019-01-08 The Chinese University Of Hong Kong Sequencing analysis of circulating DNA to detect and monitor autoimmune diseases
US12054771B2 (en) * 2014-02-18 2024-08-06 Bionano Genomics, Inc. Methods of determining nucleic acid structural information
EP2942400A1 (en) 2014-05-09 2015-11-11 Lifecodexx AG Multiplex detection of DNA that originates from a specific cell-type
WO2015169947A1 (en) 2014-05-09 2015-11-12 Lifecodexx Ag Detection of dna that originates from a specific cell-type and related methods
EP3169813B1 (en) * 2014-07-18 2019-06-12 The Chinese University Of Hong Kong Methylation pattern analysis of tissues in dna mixture
WO2016010401A1 (ko) * 2014-07-18 2016-01-21 에스케이텔레콘 주식회사 산모의 혈청 dna를 이용한 태아의 단일유전자 유전변이의 예측방법
US20170211143A1 (en) 2014-07-25 2017-07-27 University Of Washington Methods of determining tissues and/or cell types giving rise to cell-free dna, and methods of identifying a disease or disorder using same
US10364467B2 (en) 2015-01-13 2019-07-30 The Chinese University Of Hong Kong Using size and number aberrations in plasma DNA for detecting cancer
HUE058263T2 (hu) 2015-02-10 2022-07-28 Univ Hong Kong Chinese Mutációk detektálása rákszûrési és magzatelemzési célból
PT3739061T (pt) 2015-07-20 2022-04-05 Univ Hong Kong Chinese Análise do padrão da metilação de haplótipos em tecidos em mistura de adn
EP3967775B1 (en) * 2015-07-23 2023-08-23 The Chinese University Of Hong Kong Analysis of fragmentation patterns of cell-free dna
TWI793586B (zh) 2015-08-12 2023-02-21 香港中文大學 血漿dna之單分子定序
CN115035949A (zh) 2015-09-22 2022-09-09 香港中文大学 通过母亲血浆dna的浅深度测序准确定量胎儿dna分数
US10260088B2 (en) * 2015-10-30 2019-04-16 New England Biolabs, Inc. Compositions and methods for analyzing modified nucleotides
EP4180532A1 (en) * 2015-11-09 2023-05-17 Roche Molecular Systems, Inc. Methods for determining the origin of dna molecules
DK3168309T3 (da) 2015-11-10 2020-06-22 Eurofins Lifecodexx Gmbh Detektion af føtale kromosomale aneuploidier under anvendelse af dna-regioner med forskellig metylering mellem fosteret og det gravide hunkøn
AU2016370835B2 (en) * 2015-12-17 2020-02-13 Illumina, Inc. Distinguishing methylation levels in complex biological samples
CN109072309B (zh) * 2016-02-02 2023-05-16 夸登特健康公司 癌症进化检测和诊断
US11514289B1 (en) 2016-03-09 2022-11-29 Freenome Holdings, Inc. Generating machine learning models using genetic data
KR102522067B1 (ko) 2016-05-03 2023-04-13 유니버시티 헬스 네트워크 무-세포 메틸화된 dna의 포획 방법 및 이의 이용
EP3452620A4 (en) * 2016-05-04 2020-01-01 Queen's University At Kingston CELL-FREE DETECTION OF METHYLATED TUMOR DNA
US10781490B2 (en) 2016-05-30 2020-09-22 The Chinese University Of Hong Kong Detecting hematological disorders using cell-free DNA in blood
US20220076779A1 (en) * 2016-06-16 2022-03-10 The Johns Hopkins University Methods and system for epigenetic analysis
US11999998B2 (en) 2016-08-24 2024-06-04 Center For Excellence In Molecular Cell Science, Chinese Academy Of Sciences Modification of 5-methylcytosine catalyzed by Cmd1 enzyme and application thereof
SG11201903346QA (en) 2016-10-19 2019-05-30 Univ Hong Kong Chinese Gestational age assessment by methylation and size profiling of maternal plasma dna
EP3535415A4 (en) 2016-10-24 2020-07-01 The Chinese University of Hong Kong TUMOR DETECTION METHODS AND SYSTEMS
IL315032A (en) 2016-11-30 2024-10-01 The Chinese Univ Of Hong Kong Analysis of cell-free DNA in urine and other samples
EP4450648A2 (en) * 2016-12-13 2024-10-23 Bellwether Bio, Inc. Determining a physiological condition in an individual by analyzing cell-free dna fragment endpoints in a biological sample
MX2019008320A (es) * 2017-01-11 2019-09-09 Quest Diagnostics Invest Llc Metodo para la deteccion prenatal no invasiva de aneuploidia.
WO2018137496A1 (zh) * 2017-01-24 2018-08-02 深圳华大基因股份有限公司 确定生物样本中预定来源的游离核酸比例的方法及装置
TWI803477B (zh) 2017-01-25 2023-06-01 香港中文大學 使用核酸片段之診斷應用
CN107247873B (zh) * 2017-03-29 2020-04-14 电子科技大学 一种差异甲基化位点识别方法
WO2018209361A2 (en) * 2017-05-12 2018-11-15 President And Fellows Of Harvard College Universal early cancer diagnostics
JP2020537487A (ja) * 2017-07-12 2020-12-24 ユニバーシティー ヘルス ネットワーク メチローム解析を用いる癌の検出及び分類
CN111492433B (zh) * 2017-07-12 2024-07-02 安德股份有限公司 模式识别系统
ES2959360T3 (es) * 2017-07-26 2024-02-23 Univ Hong Kong Chinese Mejora del cribado del cáncer mediante ácidos nucleicos víricos acelulares
US20200263170A1 (en) 2017-09-14 2020-08-20 Grail, Inc. Methods for preparing a sequencing library from single-stranded dna
EP4026915B1 (en) 2017-09-28 2023-10-25 Grail, LLC Enrichment of short nucleic acid fragments in sequencing library preparation
US11168356B2 (en) 2017-11-02 2021-11-09 The Chinese University Of Hong Kong Using nucleic acid size range for noninvasive cancer detection
AU2019234843A1 (en) 2018-03-13 2020-09-24 Grail, Llc Anomalous fragment detection and classification
SG11202008957VA (en) * 2018-03-15 2020-10-29 Grail Inc Tissue-specific methylation marker
WO2019195268A2 (en) 2018-04-02 2019-10-10 Grail, Inc. Methylation markers and targeted methylation probe panels
CN112218957A (zh) * 2018-04-16 2021-01-12 格里尔公司 用于确定在无细胞核酸中的肿瘤分数的系统及方法
WO2019209884A1 (en) 2018-04-23 2019-10-31 Grail, Inc. Methods and systems for screening for conditions
US11932899B2 (en) * 2018-06-07 2024-03-19 10X Genomics, Inc. Methods and systems for characterizing nucleic acid molecules
CN109448789A (zh) * 2018-09-17 2019-03-08 上海派森诺生物科技股份有限公司 一种基于perl语言的种群特异SNP位点的自动化分析方法
WO2020069350A1 (en) 2018-09-27 2020-04-02 Grail, Inc. Methylation markers and targeted methylation probe panel
CN109295230A (zh) * 2018-10-24 2019-02-01 福建翊善生物科技有限公司 一种基于ctDNA的多基因联合突变检测评估肿瘤动态变化的方法
JP2022513124A (ja) 2018-11-21 2022-02-07 アヴィダ バイオメッド， インコーポレイテッド 標的化された核酸ライブラリー形成のための方法
EP4300500A3 (en) * 2018-12-19 2024-03-27 The Chinese University of Hong Kong Cell-free dna end characteristics
EP3899953A1 (en) 2018-12-21 2021-10-27 Grail, Inc. Source of origin deconvolution based on methylation fragments in cell-free-dna samples
WO2020163410A1 (en) 2019-02-05 2020-08-13 Grail, Inc. Detecting cancer, cancer tissue of origin, and/or a cancer cell type
AU2020217719A1 (en) 2019-02-05 2021-08-19 Grail, Llc Detecting cancer, cancer tissue of origin, and/or a cancer cell type
CA3130810A1 (en) 2019-03-25 2020-10-01 The Chinese University Of Hong Kong Determining linear and circular forms of circulating nucleic acids
US11773450B2 (en) 2019-04-03 2023-10-03 Grail, Llc Methylation-based false positive duplicate marking reduction
JP2022530920A (ja) * 2019-05-03 2022-07-04 コーネル ユニバーシティー 核酸配列の変異、発現、スプライスバリアント、転座、コピー数、またはメチル化変化を特定及び定量するためのマーカー
KR102452413B1 (ko) * 2019-08-19 2022-10-11 주식회사 지씨지놈 핵산 단편간 거리 정보를 이용한 염색체 이상 검출 방법
AU2020333348B2 (en) * 2019-08-19 2023-11-23 Green Cross Genome Corporation Method for detecting chromosomal abnormality by using information about distance between nucleic acid fragments
GB201915469D0 (en) 2019-10-24 2019-12-11 Univ London Cancer detection methods
CA3158101A1 (en) * 2019-11-27 2021-06-03 M. Cyrus MAHER Systems and methods for evaluating longitudinal biological feature data
CN115103909A (zh) 2020-01-31 2022-09-23 艾维达生物医学公司 用于靶向核酸捕获的系统和方法
US11211144B2 (en) 2020-02-18 2021-12-28 Tempus Labs, Inc. Methods and systems for refining copy number variation in a liquid biopsy assay
US11211147B2 (en) 2020-02-18 2021-12-28 Tempus Labs, Inc. Estimation of circulating tumor fraction using off-target reads of targeted-panel sequencing
US11475981B2 (en) 2020-02-18 2022-10-18 Tempus Labs, Inc. Methods and systems for dynamic variant thresholding in a liquid biopsy assay
US20210292845A1 (en) * 2020-02-28 2021-09-23 Grail, Inc. Identifying methylation patterns that discriminate or indicate a cancer condition
CN112662764A (zh) * 2020-03-17 2021-04-16 博尔诚（北京）科技有限公司 一种检测11种癌症的探针组合物
RU2738675C1 (ru) * 2020-07-28 2020-12-15 Федеральное государственное автономное образовательное учреждение высшего образования "Белгородский государственный национальный исследовательский университет" (НИУ "БелГУ") Способ прогнозирования риска развития преэклампсии у женщин без отягощенного семейного анамнеза с учетом генетических факторов
CN112813148A (zh) * 2021-02-02 2021-05-18 博淼生物科技（北京）有限公司 飞行时间质谱检测5-羟甲基胞嘧啶的方法
WO2023052917A1 (en) * 2021-09-28 2023-04-06 Act Genomics (ip) Limited Methylation biomarker selection apparatuses and methods
KR20230059423A (ko) 2021-10-26 2023-05-03 주식회사 지씨지놈 메틸화된 무세포 핵산을 이용한 암 진단 및 암 종 예측방법
EP4384633A1 (en) * 2021-11-04 2024-06-19 Universal Diagnostics, S.A. Systems and methods for preparing biological samples for genetic sequencing
CN115064211B (zh) * 2022-08-15 2023-01-24 臻和(北京)生物科技有限公司 一种基于全基因组甲基化测序的ctDNA预测方法及装置
CN115612723B (zh) * 2022-09-26 2023-07-14 广州女娲生命科技有限公司 植入前胚胎的筛选方法
WO2024203348A1 (ja) * 2023-03-31 2024-10-03 ソニーグループ株式会社 腫瘍の解析方法、腫瘍の解析システム、及び腫瘍の解析データ生成方法
CN117025753A (zh) * 2023-08-15 2023-11-10 广州女娲生命科技有限公司 检测染色体变异的方法和装置
CN117079822B (zh) * 2023-10-17 2024-01-02 北京大学第三医院（北京大学第三临床医学院） 一种妊娠早中期四因子预测胎儿脑损伤的系统

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6927028B2 (en) * 2001-08-31 2005-08-09 Chinese University Of Hong Kong Non-invasive methods for detecting non-host DNA in a host using epigenetic differences between the host and non-host DNA
DK1342794T3 (da) † 2002-03-05 2006-04-24 Epigenomics Ag Fremgangsmåde og anordning til at bestemme vævsspecificitet af fritflydende DNA i legemsvæsker
WO2004046332A2 (en) * 2002-11-19 2004-06-03 Amgen Inc. Amplified genes involved in cancer
US20060183128A1 (en) † 2003-08-12 2006-08-17 Epigenomics Ag Methods and compositions for differentiating tissues for cell types using epigenetic markers
DE10348407A1 (de) 2003-10-17 2005-05-19 Widschwendter, Martin, Prof. Prognostische und diagnostische Marker für Zell-proliferative Erkrankungen von Brustgeweben
CA2559209C (en) * 2004-03-08 2016-06-07 Rubicon Genomics, Inc. Methods and compositions for generating and amplifying dna libraries for sensitive detection and analysis of dna methylation
EP1888786A4 (en) 2005-05-27 2009-12-30 Wayne John Cancer Inst USE FREE CIRCULATIVE DNA FOR THE DIAGNOSIS, FORECAST AND TREATMENT OF CANCER
US7901884B2 (en) * 2006-05-03 2011-03-08 The Chinese University Of Hong Kong Markers for prenatal diagnosis and monitoring
US7754428B2 (en) 2006-05-03 2010-07-13 The Chinese University Of Hong Kong Fetal methylation markers
TWI335354B (en) * 2006-09-27 2011-01-01 Univ Hong Kong Chinese Methods for the detection of the degree of the methylation of a target dna and kits
EP2173897A2 (en) 2007-06-19 2010-04-14 Oncomethylome Sciences SA Improved urine sample collecting and processing
EP3770275A1 (en) 2007-07-23 2021-01-27 The Chinese University of Hong Kong Determining a fetal aneuploidy
US20110028333A1 (en) * 2009-05-01 2011-02-03 Brown University Diagnosing, prognosing, and early detection of cancers by dna methylation profiling
US8563242B2 (en) * 2009-08-11 2013-10-22 The Chinese University Of Hong Kong Method for detecting chromosomal aneuploidy
US20120208711A1 (en) 2009-10-02 2012-08-16 Centre For Addiction And Mental Health Method for Analysis of DNA Methylation Profiles of Cell-Free Circulating DNA in Bodily Fluids
HUE061110T2 (hu) * 2009-11-05 2023-05-28 Univ Hong Kong Chinese Magzati genomelemzés anyai biológiai mintából
US8620593B2 (en) 2009-11-06 2013-12-31 The Chinese University Of Hong Kong Size-based genomic analysis
AU2011207544A1 (en) † 2010-01-19 2012-09-06 Verinata Health, Inc. Identification of polymorphic sequences in mixtures of genomic DNA by whole genome sequencing
BR112012018458A2 (pt) * 2010-01-26 2018-07-10 Nipd Genetics Ltd métodos e composições para diagnóstico pré-natal não invasivo de aneuploidias fetais
CA2796272C (en) † 2010-04-29 2019-10-01 The Regents Of The University Of California Pathway recognition algorithm using data integration on genomic models (paradigm)
GB201007944D0 (en) 2010-05-12 2010-06-30 Univ Aberystwyth Methods
EP2576832B1 (en) 2010-05-25 2016-05-04 The Johns Hopkins University Compositions and methods for detecting a neoplasia
EP2596127A2 (en) * 2010-07-23 2013-05-29 Esoterix Genetic Laboratories, LLC Identification of differentially represented fetal or maternal genomic regions and uses thereof
KR20130041961A (ko) * 2010-07-23 2013-04-25 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 체액에서 질환 또는 상태의 특징을 검출하는 방법
WO2012031329A1 (en) 2010-09-10 2012-03-15 Murdoch Childrens Research Institute Assay for detection and monitoring of cancer
MX349568B (es) † 2010-11-30 2017-08-03 Univ Hong Kong Chinese Deteccion de aberraciones geneticas o moleculares asociadas con el cancer.
LT3354747T (lt) 2012-09-20 2021-04-12 The Chinese University Of Hong Kong Neinvazinis naviko metilomos nustatymas iš plazmos

Also Published As

Publication number Publication date
ES2969567T3 (es) 2024-05-21
CN104781422B (zh) 2023-12-26
TW201907013A (zh) 2019-02-16
AU2017251832B2 (en) 2019-10-10
PT3354747T (pt) 2021-05-07
KR20230145530A (ko) 2023-10-17
EP3354747A1 (en) 2018-08-01
HK1257868A1 (zh) 2019-11-01
MX2015003571A (es) 2015-06-22
EP3354747B1 (en) 2021-02-17
EP4056712B1 (en) 2024-07-31
EP4335929A2 (en) 2024-03-13
FI3536807T3 (fi) 2024-02-01
AU2013317708B2 (en) 2017-08-03
PL3536807T3 (pl) 2024-05-06
JP2022031753A (ja) 2022-02-22
FI4056712T3 (fi) 2024-08-29
ES2665273T3 (es) 2018-04-25
KR102148547B1 (ko) 2020-08-26
HRP20240210T1 (hr) 2024-05-10
PH12015500547A1 (en) 2015-05-04
ES2862726T3 (es) 2021-10-07
HK1207124A1 (en) 2016-01-22
BR122021021823B1 (pt) 2023-04-25
EP2898100A1 (en) 2015-07-29
DK3536807T3 (da) 2024-02-05
AU2022201026A1 (en) 2022-03-10
PL2898100T5 (pl) 2023-11-06
MX360034B (es) 2018-10-19
HUE053822T2 (hu) 2021-07-28
DK2898100T3 (en) 2018-02-26
EP2898100B9 (en) 2023-08-02
IL237495A0 (en) 2015-04-30
SG11201501927VA (en) 2015-04-29
KR20150082228A (ko) 2015-07-15
JP6683752B2 (ja) 2020-04-22
AU2013317708A1 (en) 2015-04-09
HK1206797A1 (en) 2016-01-15
KR102390711B1 (ko) 2022-04-26
PT4056712T (pt) 2024-08-08
DK3354747T3 (da) 2021-04-19
DK4056712T3 (da) 2024-08-26
CN104781422A (zh) 2015-07-15
IL299444A (en) 2023-02-01
AU2020200128B2 (en) 2021-11-18
PL3354747T3 (pl) 2021-07-26
BR112015006183A2 (pt) 2017-07-04
EP3536807B1 (en) 2023-11-29
JP6317354B2 (ja) 2018-04-25
BR122021021825B1 (pt) 2022-05-24
TWI640634B (zh) 2018-11-11
MY187444A (en) 2021-09-22
NZ706269A (en) 2016-08-26
IL268512A (en) 2019-09-26
EA201500327A1 (ru) 2015-07-30
ES2665273T5 (es) 2023-10-02
BR112015006183B1 (pt) 2022-04-26
CY1124139T1 (el) 2022-05-27
HUE066054T2 (hu) 2024-07-28
JP2018121644A (ja) 2018-08-09
ZA201501772B (en) 2016-10-26
CN117757932A (zh) 2024-03-26
JP2024009833A (ja) 2024-01-23
KR102307424B1 (ko) 2021-09-29
PT3536807T (pt) 2024-02-01
AU2020200128A1 (en) 2020-01-30
LT4056712T (lt) 2024-09-10
EP4335929A3 (en) 2024-05-29
HRP20210716T1 (hr) 2021-06-11
TW202043483A (zh) 2020-12-01
CA2884066C (en) 2021-08-10
JP2015536639A (ja) 2015-12-24
AU2013317708C1 (en) 2017-11-23
KR102587176B1 (ko) 2023-10-06
EP3536807A1 (en) 2019-09-11
IL299444B1 (en) 2024-07-01
DK2898100T4 (da) 2023-07-24
TW201418474A (zh) 2014-05-16
KR20210120124A (ko) 2021-10-06
TW202334438A (zh) 2023-09-01
TW202305145A (zh) 2023-02-01
SG10201705198UA (en) 2017-07-28
EP2898100B1 (en) 2017-11-22
JP6985753B2 (ja) 2021-12-22
LT3354747T (lt) 2021-04-12
KR20200085928A (ko) 2020-07-15
IL313451A (en) 2024-08-01
IL237495B (en) 2019-09-26
KR20220065034A (ko) 2022-05-19
EP2898100A4 (en) 2016-05-11
TWI806621B (zh) 2023-06-21
CA3122779A1 (en) 2014-03-27
EP2898100B2 (en) 2023-05-10
EP3839065A1 (en) 2021-06-23
MY173356A (en) 2020-01-21
CA2884066A1 (en) 2014-03-27
EP4056712A1 (en) 2022-09-14
TWI707953B (zh) 2020-10-21
JP2020108400A (ja) 2020-07-16
WO2014043763A1 (en) 2014-03-27
PL2898100T3 (pl) 2018-06-29
IL268512B2 (en) 2023-06-01
TWI784258B (zh) 2022-11-21
PT2898100T (pt) 2018-02-26
AU2017251832A1 (en) 2017-11-16

Similar Documents

Publication Publication Date Title
PH12015500547A1 (en) Non-invasive determination of methylome of fetus or tumor from plasma
WO2013132305A8 (en) Size-based analysis of fetal dna fraction in maternal plasma
WO2015048665A3 (en) Method to estimate the age of tissues and cell types based on epigenetic markers
SG11201805531UA (en) Molecular detection/diagnosis reagent for tumor
EP3865135A3 (en) Neuroactive steroids for use in therapy
BR112012018458A2 (pt) métodos e composições para diagnóstico pré-natal não invasivo de aneuploidias fetais
EP4219765A3 (en) Prostate cancer prognosis using biomarkers
PH12013501667A1 (en) Vitrectomy probe with adjustable cutter port size
WO2014201092A8 (en) Non-invasive blood based monitoring of genomic alterations in cancer
NZ627864A (en) Cancer patient selection for administration of wnt signaling inhibitors using rnf43 mutation status
SG10201807047XA (en) Noninvasive prenatal molecular karyotyping from maternal plasma
PH12015500430A1 (en) Method for screening cancer
MX2019012260A (es) Metodos de analisis mutacional y de metilacion del adn para vigilancia del cancer de vejiga.
HK1181086A1 (en) Methods, probe sets, and kits for detection of deletion of tumor suppressor genes by fluorescence in situ hybridization
WO2011087709A3 (en) Eml4-alk translocations in lung cancer
WO2013169771A3 (en) Methods and compositions for the prognosis and treatment of relapsed leukemia
WO2010007083A3 (en) Methods and nucleic acids for analyses of cell proliferative disorders
WO2010099489A3 (en) Ovarian cancer methylome
TW201144809A (en) Marker for gastric cancer and method for detecting gastric cancer
EP4335920A3 (en) Use of rhoa in cancer diagnosis and inhibitor screening
NZ706192A (en) Mir-18b for use as a marker of cancer progression and target for therapies to treat cancer
WO2019103421A3 (ko) 유전자의 cpg 메틸화 변화를 이용한 간암의 예후 또는 위험도를 평가하는 방법
WO2015003150A3 (en) Allele-specific pcr detection and discrimination of cyp2c19*4a, *4b and *17
PLOS ONE Staff Correction: Metabolomics Profiling for Identification of Novel Potential Markers in Early Prediction of Preeclampsia
Clements Selective lymphadenectomy not superior in endometrial cancer

Legal Events

Date Code Title Description
PSEA Patent sealed
RENW Renewal (renewal fees accepted)

Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 20 SEP 2019 BY CPA GLOBAL

Effective date: 20180809

RENW Renewal (renewal fees accepted)

Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 20 SEP 2020 BY CPA GLOBAL

Effective date: 20190808

RENW Renewal (renewal fees accepted)

Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 20 SEP 2021 BY CPA GLOBAL

Effective date: 20200806

RENW Renewal (renewal fees accepted)

Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 20 SEP 2022 BY CPA GLOBAL

Effective date: 20210806

RENW Renewal (renewal fees accepted)

Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 20 SEP 2023 BY CPA GLOBAL

Effective date: 20220804

RENW Renewal (renewal fees accepted)

Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 20 SEP 2024 BY CPA GLOBAL

Effective date: 20230803

RENW Renewal (renewal fees accepted)

Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 20 SEP 2025 BY ABHISHEK KUMAR - CPA-PTO PAYMENTS

Effective date: 20240809