PT3739061T - Análise do padrão da metilação de haplótipos em tecidos em mistura de adn - Google Patents

Análise do padrão da metilação de haplótipos em tecidos em mistura de adn

Info

Publication number
PT3739061T
PT3739061T PT201839867T PT20183986T PT3739061T PT 3739061 T PT3739061 T PT 3739061T PT 201839867 T PT201839867 T PT 201839867T PT 20183986 T PT20183986 T PT 20183986T PT 3739061 T PT3739061 T PT 3739061T
Authority
PT
Portugal
Prior art keywords
haplotypes
tissues
pattern analysis
dna mixture
methylation pattern
Prior art date
Application number
PT201839867T
Other languages
English (en)
Original Assignee
Univ Hong Kong Chinese
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Hong Kong Chinese filed Critical Univ Hong Kong Chinese
Publication of PT3739061T publication Critical patent/PT3739061T/pt

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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B30/00ICT specially adapted for sequence analysis involving nucleotides or amino acids
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/154Methylation markers
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/156Polymorphic or mutational markers
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/172Haplotypes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Evolutionary Biology (AREA)
  • Medical Informatics (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Theoretical Computer Science (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
PT201839867T 2015-07-20 2016-07-20 Análise do padrão da metilação de haplótipos em tecidos em mistura de adn PT3739061T (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201562194702P 2015-07-20 2015-07-20

Publications (1)

Publication Number Publication Date
PT3739061T true PT3739061T (pt) 2022-04-05

Family

ID=57833669

Family Applications (1)

Application Number Title Priority Date Filing Date
PT201839867T PT3739061T (pt) 2015-07-20 2016-07-20 Análise do padrão da metilação de haplótipos em tecidos em mistura de adn

Country Status (12)

Country Link
US (2) US10689706B2 (pt)
EP (3) EP4063517A1 (pt)
CN (2) CN115287348A (pt)
AU (2) AU2016295712B2 (pt)
CA (1) CA2993588A1 (pt)
DK (1) DK3739061T3 (pt)
ES (1) ES2911613T3 (pt)
HK (2) HK1248283A1 (pt)
HU (1) HUE059407T2 (pt)
PT (1) PT3739061T (pt)
TW (2) TWI732771B (pt)
WO (1) WO2017012544A1 (pt)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI813141B (zh) 2014-07-18 2023-08-21 香港中文大學 Dna混合物中之組織甲基化模式分析
WO2018099418A1 (en) 2016-11-30 2018-06-07 The Chinese University Of Hong Kong Analysis of cell-free dna in urine and other samples
MY197535A (en) 2017-01-25 2023-06-21 Univ Hong Kong Chinese Diagnostic applications using nucleic acid fragments
SG11201911538YA (en) * 2017-06-20 2020-01-30 Illumina Inc Methods and systems for decomposition and quantification of dna mixtures from multiple contributors of known or unknown genotypes
WO2019020057A1 (en) 2017-07-26 2019-01-31 The Chinese University Of Hong Kong ENHANCING CANCER SCREENING WITH ACELLULAR VIRAL NUCLEIC ACIDS
EP3752641A1 (en) * 2018-02-18 2020-12-23 Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. Cell free dna deconvolution and use thereof
WO2019210873A1 (en) 2018-05-03 2019-11-07 The Chinese University Of Hong Kong Size-tagged preferred ends and orientation-aware analysis for measuring properties of cell-free mixtures
BR112020023296A2 (pt) * 2018-05-16 2021-05-04 Twinstrand Biosciences, Inc. métodos e reagentes para resolver misturas de ácido nucleico e populações de células mistas e aplicações associadas
CA3111887A1 (en) 2018-09-27 2020-04-02 Grail, Inc. Methylation markers and targeted methylation probe panel
AU2019401636A1 (en) * 2018-12-18 2021-06-17 Grail, Llc Systems and methods for estimating cell source fractions using methylation information
EP3938534A4 (en) * 2019-03-13 2023-03-29 Grail, LLC SYSTEMS AND METHODS FOR ENRICHMENT OF CANCER DERIVED FRAGMENTS USING FRAGMENT SIZE
KR102658592B1 (ko) * 2019-08-16 2024-04-17 더 차이니즈 유니버시티 오브 홍콩 핵산의 염기 변형의 결정
JP2022552723A (ja) * 2019-10-18 2022-12-19 ワシントン・ユニバーシティ 細胞状態を測定するための方法及びシステム
KR102662186B1 (ko) * 2020-02-05 2024-05-07 더 차이니즈 유니버시티 오브 홍콩 임신 중 긴 세포유리 단편을 사용한 분자 분석

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100112590A1 (en) 2007-07-23 2010-05-06 The Chinese University Of Hong Kong Diagnosing Fetal Chromosomal Aneuploidy Using Genomic Sequencing With Enrichment
CA2694007C (en) 2007-07-23 2019-02-26 The Chinese University Of Hong Kong Determining a nucleic acid sequence imbalance
US8563242B2 (en) * 2009-08-11 2013-10-22 The Chinese University Of Hong Kong Method for detecting chromosomal aneuploidy
HRP20230134T1 (hr) 2009-11-05 2023-03-31 The Chinese University Of Hong Kong Analiza genoma fetusa iz biološkog uzorka majke
MX2012005217A (es) 2009-11-06 2012-07-23 Univ Hong Kong Chinese Analisis genomico a base de tamaño.
AU2011335891B2 (en) 2010-11-30 2015-03-26 The Chinese University Of Hong Kong Detection of genetic or molecular aberrations associated with cancer
JP6105485B2 (ja) * 2011-01-05 2017-04-05 ザ・チャイニーズ・ユニバーシティー・オブ・ホンコンThe Chinese University Of Hong Kong 胎児の性染色体遺伝子型の非侵襲的出生前同定
CA3160848A1 (en) * 2011-02-24 2013-03-28 The Chinese University Of Hong Kong Molecular testing of multiple pregnancies
US11261494B2 (en) 2012-06-21 2022-03-01 The Chinese University Of Hong Kong Method of measuring a fractional concentration of tumor DNA
US9732390B2 (en) * 2012-09-20 2017-08-15 The Chinese University Of Hong Kong Non-invasive determination of methylome of fetus or tumor from plasma
WO2014043763A1 (en) * 2012-09-20 2014-03-27 The Chinese University Of Hong Kong Non-invasive determination of methylome of fetus or tumor from plasma
CN105121660B (zh) 2013-03-15 2018-09-28 香港中文大学 确定多胎妊娠的胎儿基因组
US20150004601A1 (en) 2013-06-28 2015-01-01 Ariosa Diagnostics, Inc. Massively parallel sequencing of random dna fragments for determination of fetal fraction
CN106232833A (zh) 2014-01-30 2016-12-14 加利福尼亚大学董事会 用于非侵入性诊断的甲基化单体型分析(monod)
WO2015159292A2 (en) 2014-04-14 2015-10-22 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. A method and kit for determining the tissue or cell origin of dna
TWI813141B (zh) 2014-07-18 2023-08-21 香港中文大學 Dna混合物中之組織甲基化模式分析

Also Published As

Publication number Publication date
CA2993588A1 (en) 2017-01-26
CN115287348A (zh) 2022-11-04
EP3739061A1 (en) 2020-11-18
AU2016295712A1 (en) 2018-02-08
US10689706B2 (en) 2020-06-23
EP3325663A4 (en) 2018-07-25
EP3325663B1 (en) 2020-08-19
AU2022218555A1 (en) 2022-09-15
ES2911613T3 (es) 2022-05-20
EP4063517A1 (en) 2022-09-28
HK1248283A1 (zh) 2018-10-12
AU2016295712B2 (en) 2022-06-02
EP3739061B1 (en) 2022-03-23
US20170029900A1 (en) 2017-02-02
HUE059407T2 (hu) 2022-11-28
HK1252222A1 (zh) 2019-05-24
US20200270707A1 (en) 2020-08-27
EP3325663A1 (en) 2018-05-30
CN108138233A (zh) 2018-06-08
TW202205300A (zh) 2022-02-01
DK3739061T3 (da) 2022-04-19
TWI798718B (zh) 2023-04-11
WO2017012544A1 (en) 2017-01-26
TW201718871A (zh) 2017-06-01
CN108138233B (zh) 2022-08-26
TWI732771B (zh) 2021-07-11

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