HK1252222A1 - Dna混合物中組織的單倍型的甲基化模式分析 - Google Patents

Dna混合物中組織的單倍型的甲基化模式分析

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Publication number
HK1252222A1
HK1252222A1 HK18111459.1A HK18111459A HK1252222A1 HK 1252222 A1 HK1252222 A1 HK 1252222A1 HK 18111459 A HK18111459 A HK 18111459A HK 1252222 A1 HK1252222 A1 HK 1252222A1
Authority
HK
Hong Kong
Prior art keywords
haplotypes
tissues
pattern analysis
dna mixture
methylation pattern
Prior art date
Application number
HK18111459.1A
Other languages
English (en)
Inventor
盧煜明
陳君賜
趙慧君
江培勇
孫坤
Original Assignee
香港中文大學
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 香港中文大學 filed Critical 香港中文大學
Publication of HK1252222A1 publication Critical patent/HK1252222A1/zh

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/154—Methylation markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/172—Haplotypes
HK18111459.1A 2015-07-20 2018-09-06 Dna混合物中組織的單倍型的甲基化模式分析 HK1252222A1 (zh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201562194702P 2015-07-20 2015-07-20

Publications (1)

Publication Number Publication Date
HK1252222A1 true HK1252222A1 (zh) 2019-05-24

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Family Applications (2)

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HK18107601.6A HK1248283A1 (zh) 2015-07-20 2018-06-12 Dna混合物中組織的單倍型甲基化模式分析
HK18111459.1A HK1252222A1 (zh) 2015-07-20 2018-09-06 Dna混合物中組織的單倍型的甲基化模式分析

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Country Status (12)

Country Link
US (2) US10689706B2 (zh)
EP (3) EP3325663B1 (zh)
CN (2) CN115287348A (zh)
AU (2) AU2016295712B2 (zh)
CA (1) CA2993588A1 (zh)
DK (1) DK3739061T3 (zh)
ES (1) ES2911613T3 (zh)
HK (2) HK1248283A1 (zh)
HU (1) HUE059407T2 (zh)
PT (1) PT3739061T (zh)
TW (2) TWI732771B (zh)
WO (1) WO2017012544A1 (zh)

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TWI727156B (zh) 2014-07-18 2021-05-11 香港中文大學 Ｄｎａ混合物中之組織甲基化模式分析
US11435339B2 (en) 2016-11-30 2022-09-06 The Chinese University Of Hong Kong Analysis of cell-free DNA in urine
CN110291212A (zh) 2017-01-25 2019-09-27 香港中文大学 使用核酸片段的诊断应用
EP3642747A1 (en) * 2017-06-20 2020-04-29 Illumina, Inc. Methods and systems for decomposition and quantification of dna mixtures from multiple contributors of known or unknown genotypes
SG11202000609SA (en) * 2017-07-26 2020-02-27 Univ Hong Kong Chinese Enhancement of cancer screening using cell-free viral nucleic acids
WO2019159184A1 (en) * 2018-02-18 2019-08-22 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Cell free dna deconvolution and use thereof
AU2019263869A1 (en) * 2018-05-03 2020-11-26 Grail, Inc. Size-tagged preferred ends and orientation-aware analysis for measuring properties of cell-free mixtures
EP3794120A4 (en) * 2018-05-16 2022-03-23 Twinstrand Biosciences, Inc. METHODS AND REAGENTS FOR RESOLVING MIXTURES OF NUCLEIC ACIDS AND MIXED CELL POPULATIONS AND RELATED APPLICATIONS
WO2020069350A1 (en) 2018-09-27 2020-04-02 Grail, Inc. Methylation markers and targeted methylation probe panel
CN113661542A (zh) * 2018-12-18 2021-11-16 格里尔公司 使用甲基化信息估计细胞来源部分的系统和方法
EP3938534A4 (en) * 2019-03-13 2023-03-29 Grail, LLC SYSTEMS AND METHODS FOR ENRICHMENT OF CANCER DERIVED FRAGMENTS USING FRAGMENT SIZE
NZ784999A (en) 2019-08-16 2022-08-26 Univ Hong Kong Chinese Determination of base modifications of nucleic acids
JP2022552723A (ja) * 2019-10-18 2022-12-19 ワシントン・ユニバーシティ 細胞状態を測定するための方法及びシステム
CN116004786A (zh) 2020-02-05 2023-04-25 香港中文大学 使用孕妇体内的长游离片段进行的分子分析

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KR101972994B1 (ko) 2007-07-23 2019-04-29 더 차이니즈 유니버시티 오브 홍콩 대규모 병렬 게놈 서열분석을 이용한 태아 염색체 이수성의 진단 방법
US20100112590A1 (en) 2007-07-23 2010-05-06 The Chinese University Of Hong Kong Diagnosing Fetal Chromosomal Aneuploidy Using Genomic Sequencing With Enrichment
US8563242B2 (en) * 2009-08-11 2013-10-22 The Chinese University Of Hong Kong Method for detecting chromosomal aneuploidy
PT3783110T (pt) * 2009-11-05 2023-01-02 Sequenom Inc Análise genómica fetal a partir de uma amostra biológica materna
MX2012005217A (es) 2009-11-06 2012-07-23 Univ Hong Kong Chinese Analisis genomico a base de tamaño.
EA038374B1 (ru) 2010-11-30 2021-08-17 Те Чайниз Юниверсити Ов Гонконг Способ анализа биологического образца организма для выявления хромосомных делеций или амплификаций, ассоциированных с раком
EP3680909B1 (en) * 2011-01-05 2021-06-30 The Chinese University Of Hong Kong Noninvasive prenatal genotyping of fetal sex chromosomes
WO2013041921A1 (en) * 2011-02-24 2013-03-28 The Chinese University Of Hong Kong Molecular testing of multiple pregnancies
US11261494B2 (en) 2012-06-21 2022-03-01 The Chinese University Of Hong Kong Method of measuring a fractional concentration of tumor DNA
US9732390B2 (en) * 2012-09-20 2017-08-15 The Chinese University Of Hong Kong Non-invasive determination of methylome of fetus or tumor from plasma
WO2014043763A1 (en) * 2012-09-20 2014-03-27 The Chinese University Of Hong Kong Non-invasive determination of methylome of fetus or tumor from plasma
CN105121660B (zh) 2013-03-15 2018-09-28 香港中文大学 确定多胎妊娠的胎儿基因组
US20150004601A1 (en) * 2013-06-28 2015-01-01 Ariosa Diagnostics, Inc. Massively parallel sequencing of random dna fragments for determination of fetal fraction
US20160340740A1 (en) 2014-01-30 2016-11-24 The Regents Of The University Of California Methylation haplotyping for non-invasive diagnosis (monod)
PT4026917T (pt) 2014-04-14 2024-02-12 Yissum Research And Development Company Of The Hebrew Univ Of Jerusalem Ltd Método e kit para determinar a morte de células ou de tecido ou a origem de tecidos ou de células de dna por análise de metilação do dna
TWI727156B (zh) 2014-07-18 2021-05-11 香港中文大學 Ｄｎａ混合物中之組織甲基化模式分析

Also Published As

Publication number Publication date
TW202205300A (zh) 2022-02-01
HK1248283A1 (zh) 2018-10-12
AU2022218555A1 (en) 2022-09-15
ES2911613T3 (es) 2022-05-20
HUE059407T2 (hu) 2022-11-28
US20200270707A1 (en) 2020-08-27
CN115287348A (zh) 2022-11-04
US20170029900A1 (en) 2017-02-02
EP3325663B1 (en) 2020-08-19
US10689706B2 (en) 2020-06-23
CA2993588A1 (en) 2017-01-26
TWI732771B (zh) 2021-07-11
CN108138233A (zh) 2018-06-08
EP3739061A1 (en) 2020-11-18
EP3325663A4 (en) 2018-07-25
AU2016295712B2 (en) 2022-06-02
WO2017012544A1 (en) 2017-01-26
TW201718871A (zh) 2017-06-01
CN108138233B (zh) 2022-08-26
AU2016295712A1 (en) 2018-02-08
EP4063517A1 (en) 2022-09-28
EP3325663A1 (en) 2018-05-30
EP3739061B1 (en) 2022-03-23
TWI798718B (zh) 2023-04-11
DK3739061T3 (da) 2022-04-19
PT3739061T (pt) 2022-04-05

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