HK1232256A1 - 混合物中的組織甲基化模式分析 - Google Patents

混合物中的組織甲基化模式分析

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Publication number
HK1232256A1
HK1232256A1 HK17105776.0A HK17105776A HK1232256A1 HK 1232256 A1 HK1232256 A1 HK 1232256A1 HK 17105776 A HK17105776 A HK 17105776A HK 1232256 A1 HK1232256 A1 HK 1232256A1
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HK
Hong Kong
Prior art keywords
dna
tissues
pattern analysis
methylation pattern
mixture
Prior art date
Application number
HK17105776.0A
Other languages
English (en)
Inventor
Rossa Wai Kwun Chiu
Kwan Chee Chan
Yuk Ming Dennis Lo
Peiyong Jiang
Kun Sun
Original Assignee
Univ Hong Kong Chinese
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Filing date
Publication date
Application filed by Univ Hong Kong Chinese filed Critical Univ Hong Kong Chinese
Publication of HK1232256A1 publication Critical patent/HK1232256A1/zh

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    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6809—Methods for determination or identification of nucleic acids involving differential detection
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6888—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
    • C12Q1/689—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • G16B20/20—Allele or variant detection, e.g. single nucleotide polymorphism [SNP] detection
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids
    • G16B30/10—Sequence alignment; Homology search
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/112—Disease subtyping, staging or classification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/154—Methylation markers
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • G16B20/10—Ploidy or copy number detection
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Analytical Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Theoretical Computer Science (AREA)
  • Medical Informatics (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Evolutionary Biology (AREA)
  • Immunology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Algebra (AREA)
  • General Physics & Mathematics (AREA)
  • Mathematical Analysis (AREA)
  • Mathematical Optimization (AREA)
  • Mathematical Physics (AREA)
  • Pure & Applied Mathematics (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
HK17105776.0A 2014-07-18 2017-06-12 混合物中的組織甲基化模式分析 HK1232256A1 (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201462026330P 2014-07-18 2014-07-18
US201562158466P 2015-05-07 2015-05-07
US201562183669P 2015-06-23 2015-06-23
PCT/CN2015/084442 WO2016008451A1 (en) 2014-07-18 2015-07-20 Methylation pattern analysis of tissues in dna mixture

Publications (1)

Publication Number Publication Date
HK1232256A1 true HK1232256A1 (zh) 2018-01-05

Family

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HK17105776.0A HK1232256A1 (zh) 2014-07-18 2017-06-12 混合物中的組織甲基化模式分析

Country Status (10)

Country Link
US (2) US11062789B2 (zh)
EP (3) EP3543356B1 (zh)
CN (1) CN106795562B (zh)
DK (1) DK3543356T3 (zh)
ES (2) ES2741400T3 (zh)
HK (1) HK1232256A1 (zh)
HU (1) HUE056267T2 (zh)
PT (1) PT3543356T (zh)
TW (4) TWI813141B (zh)
WO (1) WO2016008451A1 (zh)

Families Citing this family (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101153336B (zh) 2006-09-27 2011-09-07 香港中文大学 检测dna甲基化程度的方法和试剂盒
US9892230B2 (en) 2012-03-08 2018-02-13 The Chinese University Of Hong Kong Size-based analysis of fetal or tumor DNA fraction in plasma
US9128861B2 (en) 2013-01-17 2015-09-08 Personalis, Inc. Methods and systems for genetic analysis
TWI813141B (zh) 2014-07-18 2023-08-21 香港中文大學 Ｄｎａ混合物中之組織甲基化模式分析
CN117402950A (zh) 2014-07-25 2024-01-16 华盛顿大学 确定导致无细胞dna的产生的组织和/或细胞类型的方法以及使用其鉴定疾病或紊乱的方法
EP3212808B1 (en) 2014-10-30 2022-03-02 Personalis, Inc. Methods for using mosaicism in nucleic acids sampled distal to their origin
US10364467B2 (en) 2015-01-13 2019-07-30 The Chinese University Of Hong Kong Using size and number aberrations in plasma DNA for detecting cancer
WO2017012544A1 (en) 2015-07-20 2017-01-26 The Chinese University Of Hong Kong Methylation pattern analysis of haplotypes in tissues in dna mixture
TW202332776A (zh) 2015-07-23 2023-08-16 香港中文大學 游離dna(cell-free dna)之片段化模式分析
WO2017181146A1 (en) 2016-04-14 2017-10-19 Guardant Health, Inc. Methods for early detection of cancer
US11299783B2 (en) 2016-05-27 2022-04-12 Personalis, Inc. Methods and systems for genetic analysis
CA3025708A1 (en) * 2016-05-30 2017-12-07 The Chinese University Of Hong Kong Detecting hematological disorders using cell-free dna in blood
JP2019521673A (ja) 2016-06-07 2019-08-08 ザ リージェンツ オブ ザ ユニヴァーシティー オブ カリフォルニア 疾患および状態の分析のためのセルフリーｄｎａメチル化パターン
WO2018027176A1 (en) * 2016-08-05 2018-02-08 The Broad Institute, Inc. Methods for genome characterization
CN109804086B (zh) 2016-08-10 2023-06-13 格里尔公司 制备双标签dna库用于亚硫酸盐转化定序的方法
AU2017347790A1 (en) 2016-10-24 2019-05-23 Grail, Inc. Methods and systems for tumor detection
CA3039685A1 (en) * 2016-11-30 2018-06-07 The Chinese University Of Hong Kong Analysis of cell-free dna in urine and other samples
CN110168108A (zh) * 2016-12-21 2019-08-23 加利福尼亚大学董事会 血浆中稀少dna的去卷积和检测
SG11201906397UA (en) 2017-01-25 2019-08-27 Univ Hong Kong Chinese Diagnostic applications using nucleic acid fragments
EP3366780B1 (en) * 2017-02-23 2020-05-06 Siemens Healthcare GmbH Single-molecule sequence and high sensitivity methylation analysis for tissue-specific analysis
US20210115506A1 (en) * 2017-04-04 2021-04-22 The Board Of Trustees Of The Leland Stanford Junior University Quantification of transplant-derived circulating cell-free DNA in the absence of a donor genotype
WO2018209704A1 (zh) * 2017-05-19 2018-11-22 深圳华大基因研究院 基于dna测序数据的样本来源检测方法、装置和存储介质
CN111094590A (zh) * 2017-07-12 2020-05-01 大学健康网络 使用甲基化组分析进行癌症检测和分类
EP3658684B1 (en) * 2017-07-26 2023-08-30 The Chinese University Of Hong Kong Enhancement of cancer screening using cell-free viral nucleic acids
TWI650664B (zh) * 2017-08-21 2019-02-11 遺傳軌跡股份有限公司 建立蛋白質功能缺失評估模型的方法以及利用上述模型的風險評估方法與系統
WO2019055819A1 (en) 2017-09-14 2019-03-21 Grail, Inc. METHODS FOR PREPARING A SEQUENCING LIBRARY FROM SINGLE STRANDED DNA
EP4026915B1 (en) 2017-09-28 2023-10-25 Grail, LLC Enrichment of short nucleic acid fragments in sequencing library preparation
US11168356B2 (en) * 2017-11-02 2021-11-09 The Chinese University Of Hong Kong Using nucleic acid size range for noninvasive cancer detection
WO2019084659A1 (en) * 2017-11-03 2019-05-09 University Health Network Cancer detection, classification, prognostication, therapy prediction and therapy monitoring using methylome analysis
WO2019165375A1 (en) * 2018-02-26 2019-08-29 Dana-Farber Cancer Institute, Inc. Compositions and methods for identification, assessment and treatment of cancer using dna methylation fingerprints
EP3766076A4 (en) * 2018-03-15 2021-12-29 Grail, Inc. Tissue-specific methylation marker
AU2019249422A1 (en) * 2018-04-02 2020-10-15 Grail, Llc Methylation markers and targeted methylation probe panels
CN112204666A (zh) * 2018-04-13 2021-01-08 格里尔公司 用于癌症侦测的多重化验预测模型
US11814750B2 (en) 2018-05-31 2023-11-14 Personalis, Inc. Compositions, methods and systems for processing or analyzing multi-species nucleic acid samples
US10801064B2 (en) 2018-05-31 2020-10-13 Personalis, Inc. Compositions, methods and systems for processing or analyzing multi-species nucleic acid samples
CA3098321A1 (en) 2018-06-01 2019-12-05 Grail, Inc. Convolutional neural network systems and methods for data classification
JP2021527436A (ja) * 2018-06-22 2021-10-14 ブルースター ジェノミクス， インコーポレイテッド 起源組織を割り当てるための無細胞核酸サンプルのヒドロキシメチル化分析および関連する使用方法
AU2019351130A1 (en) 2018-09-27 2021-04-08 Grail, Llc Methylation markers and targeted methylation probe panel
CA3121926A1 (en) * 2018-12-18 2020-06-25 Grail, Inc. Systems and methods for estimating cell source fractions using methylation information
ES2968457T3 (es) * 2018-12-19 2024-05-09 Univ Hong Kong Chinese Características de los extremos del ADN extracelular circulante
WO2020132572A1 (en) * 2018-12-21 2020-06-25 Grail, Inc. Source of origin deconvolution based on methylation fragments in cell-free-dna samples
WO2020194057A1 (en) * 2019-03-22 2020-10-01 Cambridge Epigenetix Limited Biomarkers for disease detection
WO2020192680A1 (en) 2019-03-25 2020-10-01 The Chinese University Of Hong Kong Determining linear and circular forms of circulating nucleic acids
US11773450B2 (en) 2019-04-03 2023-10-03 Grail, Llc Methylation-based false positive duplicate marking reduction
IL294153B2 (en) * 2019-08-16 2023-09-01 Univ Hong Kong Chinese Determination of base changes of nucleic acids
US11427874B1 (en) 2019-08-26 2022-08-30 Epi One Inc. Methods and systems for detection of prostate cancer by DNA methylation analysis
EP4078594A1 (en) * 2019-12-18 2022-10-26 Grail, LLC Systems and methods for estimating cell source fractions using methylation information
MX2022009582A (es) * 2020-02-05 2022-08-25 Univ Hong Kong Chinese Analisis moleculares usando fragmentos largos extracelulares circulantes en el embarazo.
US11475981B2 (en) 2020-02-18 2022-10-18 Tempus Labs, Inc. Methods and systems for dynamic variant thresholding in a liquid biopsy assay
US11211144B2 (en) 2020-02-18 2021-12-28 Tempus Labs, Inc. Methods and systems for refining copy number variation in a liquid biopsy assay
US11211147B2 (en) 2020-02-18 2021-12-28 Tempus Labs, Inc. Estimation of circulating tumor fraction using off-target reads of targeted-panel sequencing
CN112397151B (zh) * 2021-01-21 2021-04-20 臻和(北京)生物科技有限公司 基于靶向捕获测序的甲基化标志物筛选与评价方法及装置
WO2023225659A2 (en) * 2022-05-19 2023-11-23 Personalis, Inc. Methods and system for using methylation data for disease detection and quantification
WO2024015138A1 (en) * 2022-07-15 2024-01-18 Massachusetts Institute Of Technology Mixture deconvolution method for identifying dna profiles

Family Cites Families (104)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2422890C (en) 2000-09-29 2013-04-23 The Johns Hopkins University School Of Medicine Method of predicting the clinical response to chemotherapeutic treatment with alkylating agents
ES2253461T3 (es) 2002-03-05 2006-06-01 Epigenomics Ag Procedimiento y dispositivo para la determinacion de la especificidad del tejido y del adn que flota libre en tejidos corporales.
US8150626B2 (en) 2003-05-15 2012-04-03 Illumina, Inc. Methods and compositions for diagnosing lung cancer with specific DNA methylation patterns
US20060183128A1 (en) 2003-08-12 2006-08-17 Epigenomics Ag Methods and compositions for differentiating tissues for cell types using epigenetic markers
WO2005042713A2 (en) 2003-10-28 2005-05-12 The Johns Hopkins University Quantitative multiplex methylation-specific pcr
US7709194B2 (en) 2004-06-04 2010-05-04 The Chinese University Of Hong Kong Marker for prenatal diagnosis and monitoring
ITRM20050068A1 (it) 2005-02-17 2006-08-18 Istituto Naz Per Le Malattie I Metodo per la rivelazione di acidi nucleici di agenti patogeni batterici o di parassiti nelle urine.
US7914982B2 (en) 2005-02-17 2011-03-29 Trovagene, Inc. Methods for detecting pathogen specific nucleic acids in urine
ITRM20050067A1 (it) 2005-02-17 2006-08-18 Istituto Naz Per Le Malattie I Metodo per la rivelazione di acidi nucleici virali o di origine virale nelle urine.
DE602005009324D1 (de) 2005-04-06 2008-10-09 Maurice Stroun Methode zur Krebsdiagnose mittels Nachweis von DNA und RNA im Kreislauf
KR20080011287A (ko) 2005-04-15 2008-02-01 에피제노믹스 아게 세포 증식 질환을 분석하기 위한 방법 및 핵산
JP2008545418A (ja) 2005-05-27 2008-12-18 ジョン ウェイン キャンサー インスティチュート 癌の診断、予後診断、および治療のための遊離循環ｄｎａの使用
US20070141582A1 (en) 2005-12-15 2007-06-21 Weiwei Li Method and kit for detection of early cancer or pre-cancer using blood and body fluids
US9183349B2 (en) 2005-12-16 2015-11-10 Nextbio Sequence-centric scientific information management
US8768629B2 (en) 2009-02-11 2014-07-01 Caris Mpi, Inc. Molecular profiling of tumors
CN101153336B (zh) 2006-09-27 2011-09-07 香港中文大学 检测dna甲基化程度的方法和试剂盒
CA2668818C (en) 2006-10-10 2018-06-26 Xenomics, Inc. Compositions, methods and kits for isolating nucleic acids from body fluids using anion exchange media
US7899626B2 (en) 2007-01-10 2011-03-01 Illumina, Inc. System and method of measuring methylation of nucleic acids
JP5378687B2 (ja) 2007-03-02 2013-12-25 エフ．ホフマン−ラ ロシュ アーゲー Ｂａｓｐ１遺伝子および／またはｓｒｄ５ａ２遺伝子中のメチル化シトシンを利用する、肝臓癌、肝臓癌発症リスク、肝臓癌再発リスク、肝臓癌悪性度および肝臓癌の経時的進展の検出方法
US9290803B2 (en) 2007-04-12 2016-03-22 University Of Southern California DNA methylation analysis by digital bisulfite genomic sequencing and digital methylight
WO2008155549A2 (en) 2007-06-19 2008-12-24 Oncomethylome Sciences Sa Improved urine sample collecting and processing
US20100112590A1 (en) 2007-07-23 2010-05-06 The Chinese University Of Hong Kong Diagnosing Fetal Chromosomal Aneuploidy Using Genomic Sequencing With Enrichment
FI2557517T3 (fi) 2007-07-23 2022-11-30 Nukleiinihapposekvenssiepätasapainon määrittäminen
DK2183379T3 (en) 2007-08-01 2015-07-27 Dana Farber Cancer Inst Inc ENRICHMENT OF A TARGET SEQUENCE
ES2660785T3 (es) 2007-08-22 2018-03-26 Trovagene, Inc. Métodos de uso de ARNmi para la detección de la muerte de células in vivo
JP2010017179A (ja) 2008-06-11 2010-01-28 Sumitomo Chemical Co Ltd Ｄｎａを定量又は検出する方法
EP2358915B1 (en) 2008-10-31 2016-08-10 TrovaGene, Inc. A genetic marker for detection of human papillomavirus
US20110028333A1 (en) 2009-05-01 2011-02-03 Brown University Diagnosing, prognosing, and early detection of cancers by dna methylation profiling
US20120221249A1 (en) 2009-05-15 2012-08-30 The Trustees of The Uniiversity of Pennsylvania Long Hepitype Distribution (LHD)
CN102021233B (zh) * 2009-09-22 2014-06-04 复旦大学附属华山医院 一种定量检测akap12甲基化水平的方法及其应用
WO2011038507A1 (en) 2009-10-02 2011-04-07 Centre For Addiction And Mental Health Method for analysis of dna methylation profiles of cell-free circulating dna in bodily fluids
EP2496713B1 (en) 2009-11-06 2018-07-18 The Chinese University of Hong Kong Size-based genomic analysis
CN102597272A (zh) 2009-11-12 2012-07-18 艾索特里克斯遗传实验室有限责任公司 基因座的拷贝数分析
US9260745B2 (en) 2010-01-19 2016-02-16 Verinata Health, Inc. Detecting and classifying copy number variation
US10388403B2 (en) 2010-01-19 2019-08-20 Verinata Health, Inc. Analyzing copy number variation in the detection of cancer
EP2536854B1 (en) 2010-02-18 2017-07-19 The Johns Hopkins University Personalized tumor biomarkers
ES2703769T3 (es) * 2010-04-16 2019-03-12 Chronix Biomedical Biomarcadores de ácidos nucleicos en circulación asociados al cáncer de mama
KR102037019B1 (ko) 2010-04-29 2019-10-25 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 게놈 모델에 대한 데이터 통합을 이용하는 경로 인지 알고리즘 （ｐａｒａｄｉｇｍ）
EP2576837B1 (en) 2010-06-04 2017-09-06 Chronix Biomedical Prostate cancer associated circulating nucleic acid biomarkers
WO2012012703A2 (en) * 2010-07-23 2012-01-26 Esoterix Genetic Laboratories, Llc Identification of differentially represented fetal or maternal genomic regions and uses thereof
WO2012031329A1 (en) 2010-09-10 2012-03-15 Murdoch Childrens Research Institute Assay for detection and monitoring of cancer
MY169852A (en) 2010-11-30 2019-05-17 Univ Hong Kong Chinese Detection of genetic or molecular aberrations associated with cancer
US20120190020A1 (en) * 2011-01-25 2012-07-26 Aria Diagnostics, Inc. Detection of genetic abnormalities
WO2012149171A1 (en) 2011-04-27 2012-11-01 The Regents Of The University Of California Designing padlock probes for targeted genomic sequencing
US20130059738A1 (en) 2011-04-28 2013-03-07 Life Technologies Corporation Methods and compositions for multiplex pcr
EP2707508A4 (en) 2011-05-10 2015-07-29 Brunangelo Falini BIOMARKERS OF TRICHOLEUCOCYTE LEUKEMIA AND METHODS OF USE THEREOF
US20140178348A1 (en) 2011-05-25 2014-06-26 The Regents Of The University Of California Methods using DNA methylation for identifying a cell or a mixture of cells for prognosis and diagnosis of diseases, and for cell remediation therapies
US10125394B2 (en) 2011-06-22 2018-11-13 Yale University Compositions and methods for diagnosing diseases and disorders associated with β cell death
US8712697B2 (en) 2011-09-07 2014-04-29 Ariosa Diagnostics, Inc. Determination of copy number variations using binomial probability calculations
EP2758538B1 (en) 2011-09-22 2018-10-31 Lineage Biosciences, Inc. Methods for analyzing heterogeneous samples
TR201815382T4 (tr) 2011-09-26 2018-11-21 Qiagen Gmbh Ekstraselüler nükleik asitleri izole etmek için hızlı yöntem.
US9367663B2 (en) 2011-10-06 2016-06-14 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
CA2850785C (en) 2011-10-06 2022-12-13 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
CA2852098C (en) 2011-10-21 2023-05-02 Chronix Biomedical Colorectal cancer associated circulating nucleic acid biomarkers
EP2771483A1 (en) 2011-10-25 2014-09-03 ONCOTYROL - Center for Personalized Cancer Medicine GmbH Method for diagnosing a disease based on plasma-dna distribution
AU2012327251A1 (en) 2011-10-27 2013-05-23 Verinata Health, Inc. Set membership testers for aligning nucleic acid samples
AU2012380717B2 (en) 2012-05-24 2018-08-16 Fundacio Institucio Catalana De Recerca I Estudis Avancats Method for the identification of the origin of a cancer of unknown primary origin by methylation analysis
US11261494B2 (en) 2012-06-21 2022-03-01 The Chinese University Of Hong Kong Method of measuring a fractional concentration of tumor DNA
US20150197785A1 (en) 2012-08-10 2015-07-16 The Broad Institute, Inc. Methods and apparatus for analyzing and quantifying dna alterations in cancer
IL305303A (en) 2012-09-04 2023-10-01 Guardant Health Inc Systems and methods for detecting rare mutations and changes in number of copies
US20140066317A1 (en) 2012-09-04 2014-03-06 Guardant Health, Inc. Systems and methods to detect rare mutations and copy number variation
US20160040229A1 (en) 2013-08-16 2016-02-11 Guardant Health, Inc. Systems and methods to detect rare mutations and copy number variation
EP4335929A3 (en) 2012-09-20 2024-05-29 The Chinese University of Hong Kong Non-invasive determination of methylome of tumor from plasma
US9732390B2 (en) * 2012-09-20 2017-08-15 The Chinese University Of Hong Kong Non-invasive determination of methylome of fetus or tumor from plasma
US20140274767A1 (en) 2013-01-23 2014-09-18 The Johns Hopkins University Dna methylation markers for metastatic prostate cancer
CA3156663A1 (en) 2013-03-15 2014-09-18 Verinata Health, Inc. Generating cell-free dna libraries directly from blood
KR20160004265A (ko) 2013-03-15 2016-01-12 이뮤코 쥐티아이 다이아그노스틱스, 아이엔씨. 무세포 dna를 이용하는 신장 상태의 평가를 위한 방법 및 조성물
EP2997159B1 (en) 2013-05-13 2019-07-24 Rheinisch-Westfälische Technische Hochschule (RWTH) Aachen Method for determining a human individual's predisposition to contract a hematopoietic malignant myeloid disease
CN104250663B (zh) 2013-06-27 2017-09-15 北京大学 甲基化CpG岛的高通量测序检测方法
CN105555965B (zh) 2013-07-30 2020-06-05 深圳华大基因股份有限公司 确定核酸混合物中核酸组成的方法
AU2014308980C1 (en) 2013-08-19 2021-09-30 Invitae Corporation Assays for single molecule detection and use thereof
EP4227947A1 (en) 2013-10-21 2023-08-16 Verinata Health, Inc. Method for improving the sensitivity of detection in determining copy number variations
GB201319779D0 (en) 2013-11-08 2013-12-25 Cartagenia N V Genetic analysis method
US10801070B2 (en) 2013-11-25 2020-10-13 The Broad Institute, Inc. Compositions and methods for diagnosing, evaluating and treating cancer
WO2015095225A1 (en) 2013-12-19 2015-06-25 The Board Of Trustees Of The Leland Stanford Junior University Quantification of mutant alleles and copy number variation using digital pcr with nonspecific dna-binding dyes
WO2015116837A1 (en) 2014-01-30 2015-08-06 The Regents Of The University Of California Methylation haplotyping for non-invasive diagnosis (monod)
GB2524948A (en) 2014-03-07 2015-10-14 Oxford Gene Technology Operations Ltd Detecting Increase or Decrease in the Amount of a Nucleic Acid having a Sequence of Interest
DK3643795T3 (da) 2014-04-14 2022-05-09 Yissum Research And Development Company Of The Hebrew Univ Of Jerusalem Ltd Fremganffremgangsmåde til bestemmelse af celle- eller vævsdød ved analyse af dna-methylering
JP6659575B2 (ja) 2014-04-21 2020-03-04 ナテラ， インコーポレイテッド 変異の検出および染色体分節の倍数性
EP2942400A1 (en) 2014-05-09 2015-11-11 Lifecodexx AG Multiplex detection of DNA that originates from a specific cell-type
EP3140421B8 (en) 2014-05-09 2020-05-06 Eurofins LifeCodexx GmbH Detection of dna that originates from a specific cell-type and related methods
CA2953469A1 (en) 2014-06-26 2015-12-30 10X Genomics, Inc. Analysis of nucleic acid sequences
TWI813141B (zh) 2014-07-18 2023-08-21 香港中文大學 Ｄｎａ混合物中之組織甲基化模式分析
CN117402950A (zh) 2014-07-25 2024-01-16 华盛顿大学 确定导致无细胞dna的产生的组织和/或细胞类型的方法以及使用其鉴定疾病或紊乱的方法
CN107002118B (zh) 2014-08-22 2022-07-08 分析生物科学有限公司 用于无细胞dna的定量遗传分析的方法
CN107077537B (zh) 2014-09-12 2021-06-22 伊鲁米纳剑桥有限公司 用短读测序数据检测重复扩增
EP3018213A1 (en) 2014-11-04 2016-05-11 Genesupport SA Method for determining the presence of a biological condition by determining total and relative amounts of two different nucleic acids
EP3889611A1 (en) 2014-12-12 2021-10-06 Exact Sciences Development Company, LLC Compositions and methods for performing methylation detection assays
WO2016094839A2 (en) 2014-12-12 2016-06-16 Exact Sciences Corporation Compositions and methods for performing methylation detection assays
US11072814B2 (en) 2014-12-12 2021-07-27 Verinata Health, Inc. Using cell-free DNA fragment size to determine copy number variations
US20170342500A1 (en) 2014-12-19 2017-11-30 Danmarks Tekniske Universitet Method for identification of tissue or organ localization of a tumour
US20180143198A1 (en) 2014-12-26 2018-05-24 Peking University Method for detecting differentially methylated cpg islands associated with abnormal state of human body
EP3240911B1 (en) 2014-12-31 2020-08-26 Guardant Health, Inc. Detection and treatment of disease exhibiting disease cell heterogeneity and systems and methods for communicating test results
US10364467B2 (en) 2015-01-13 2019-07-30 The Chinese University Of Hong Kong Using size and number aberrations in plasma DNA for detecting cancer
US9984201B2 (en) 2015-01-18 2018-05-29 Youhealth Biotech, Limited Method and system for determining cancer status
WO2016127944A1 (en) 2015-02-10 2016-08-18 The Chinese University Of Hong Kong Detecting mutations for cancer screening and fetal analysis
US10196395B2 (en) 2015-02-12 2019-02-05 Crystal Pharmatech Co., Ltd Crystalline form alpha of IPI-145 and preparation method thereof
EP3271848A4 (en) 2015-03-16 2018-12-05 Personal Genome Diagnostics Inc. Systems and methods for analyzing nucleic acid
WO2016183106A1 (en) 2015-05-11 2016-11-17 Natera, Inc. Methods and compositions for determining ploidy
WO2016189288A1 (en) 2015-05-22 2016-12-01 Cambridge Epigenetix Ltd Nucleic acid sample enrichment
WO2017012544A1 (en) 2015-07-20 2017-01-26 The Chinese University Of Hong Kong Methylation pattern analysis of haplotypes in tissues in dna mixture
TW202332776A (zh) 2015-07-23 2023-08-16 香港中文大學 游離dna(cell-free dna)之片段化模式分析
CA3025708A1 (en) 2016-05-30 2017-12-07 The Chinese University Of Hong Kong Detecting hematological disorders using cell-free dna in blood
CA3039685A1 (en) 2016-11-30 2018-06-07 The Chinese University Of Hong Kong Analysis of cell-free dna in urine and other samples

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