DK3643795T3 - Fremganffremgangsmåde til bestemmelse af celle- eller vævsdød ved analyse af dna-methylering - Google Patents

Fremganffremgangsmåde til bestemmelse af celle- eller vævsdød ved analyse af dna-methylering Download PDF

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Publication number
DK3643795T3
DK3643795T3 DK19209237.7T DK19209237T DK3643795T3 DK 3643795 T3 DK3643795 T3 DK 3643795T3 DK 19209237 T DK19209237 T DK 19209237T DK 3643795 T3 DK3643795 T3 DK 3643795T3
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Prior art keywords
analysis
dna methylation
determining cell
tissue death
death
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DK19209237.7T
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English (en)
Inventor
Yuval Dor
Ruth Shemer
Benjamin Glaser
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Yissum Research And Development Company Of The Hebrew Univ Of Jerusalem Ltd
Hadasit Med Res Service
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6881—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for tissue or cell typing, e.g. human leukocyte antigen [HLA] probes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/154—Methylation markers

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)
  • Cell Biology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
DK19209237.7T 2014-04-14 2015-04-14 Fremganffremgangsmåde til bestemmelse af celle- eller vævsdød ved analyse af dna-methylering DK3643795T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201461979233P 2014-04-14 2014-04-14
EP15720481.9A EP3132055A2 (en) 2014-04-14 2015-04-14 A method and kit for determining the tissue or cell origin of dna

Publications (1)

Publication Number Publication Date
DK3643795T3 true DK3643795T3 (da) 2022-05-09

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Family Applications (2)

Application Number Title Priority Date Filing Date
DK19209237.7T DK3643795T3 (da) 2014-04-14 2015-04-14 Fremganffremgangsmåde til bestemmelse af celle- eller vævsdød ved analyse af dna-methylering
DK22158931.0T DK4026917T5 (da) 2014-04-14 2015-04-14 Fremgangsmåde og kit til bestemmelse af cellers eller vævs død eller dna's vævs- eller celleoprindelse ved dna-methyleringsanalyse

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DK22158931.0T DK4026917T5 (da) 2014-04-14 2015-04-14 Fremgangsmåde og kit til bestemmelse af cellers eller vævs død eller dna's vævs- eller celleoprindelse ved dna-methyleringsanalyse

Country Status (14)

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US (3) US11203784B2 (da)
EP (4) EP3132055A2 (da)
JP (1) JP6750879B2 (da)
CN (1) CN106574296B (da)
DK (2) DK3643795T3 (da)
ES (1) ES2974838T3 (da)
FI (1) FI4026917T3 (da)
HR (1) HRP20240189T1 (da)
IL (1) IL248299B (da)
LT (1) LT4026917T (da)
PL (1) PL4026917T3 (da)
PT (1) PT4026917T (da)
SI (1) SI4026917T1 (da)
WO (2) WO2015159293A2 (da)

Families Citing this family (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11913065B2 (en) 2012-09-04 2024-02-27 Guardent Health, Inc. Systems and methods to detect rare mutations and copy number variation
US10876152B2 (en) 2012-09-04 2020-12-29 Guardant Health, Inc. Systems and methods to detect rare mutations and copy number variation
EP2893040B1 (en) 2012-09-04 2019-01-02 Guardant Health, Inc. Methods to detect rare mutations and copy number variation
US20160040229A1 (en) 2013-08-16 2016-02-11 Guardant Health, Inc. Systems and methods to detect rare mutations and copy number variation
JP6571665B2 (ja) 2013-12-28 2019-09-04 ガーダント ヘルス， インコーポレイテッド 遺伝的バリアントを検出するための方法およびシステム
CN106574296B (zh) 2014-04-14 2021-03-02 耶路撒冷希伯来大学伊森姆研究发展公司 用于测定dna的组织或细胞来源的方法和试剂盒
TW202409295A (zh) 2014-07-18 2024-03-01 香港中文大學 Dna混合物中之組織甲基化模式分析
HUE059407T2 (hu) 2015-07-20 2022-11-28 Univ Hong Kong Chinese Szövetekben lévõ haplotípusok metilációs mintázatelemzése DNS-keverékekben
WO2017106768A1 (en) 2015-12-17 2017-06-22 Guardant Health, Inc. Methods to determine tumor gene copy number by analysis of cell-free dna
WO2017181146A1 (en) 2016-04-14 2017-10-19 Guardant Health, Inc. Methods for early detection of cancer
US11384382B2 (en) 2016-04-14 2022-07-12 Guardant Health, Inc. Methods of attaching adapters to sample nucleic acids
WO2017201606A1 (en) * 2016-05-04 2017-11-30 Queen's University At Kingston Cell-free detection of methylated tumour dna
CN109196120B (zh) 2016-05-30 2022-08-02 香港中文大学 使用血液中的无细胞dna检测血液病症
US11499196B2 (en) 2016-06-07 2022-11-15 The Regents Of The University Of California Cell-free DNA methylation patterns for disease and condition analysis
WO2018035340A1 (en) 2016-08-17 2018-02-22 The Regents Of The University Of California A novel immunoprobe-based method to assess organ injury status through a biofluid-based cell-free dna (cfdna) assay
US11959125B2 (en) * 2016-09-15 2024-04-16 Sun Genomics, Inc. Universal method for extracting nucleic acid molecules from a diverse population of one or more types of microbes in a sample
AU2017347790B2 (en) 2016-10-24 2024-06-13 Grail, Inc. Methods and systems for tumor detection
KR20230062684A (ko) 2016-11-30 2023-05-09 더 차이니즈 유니버시티 오브 홍콩 소변 및 기타 샘플에서의 무세포 dna의 분석
MX2019007444A (es) 2016-12-22 2019-08-16 Guardant Health Inc Metodos y sistemas para analisis de moleculas de acido nucleico.
CA3051509A1 (en) 2017-01-25 2018-08-02 The Chinese University Of Hong Kong Diagnostic applications using nucleic acid fragments
US11781188B2 (en) 2017-04-06 2023-10-10 Cornell University Methods of detecting cell-free DNA in biological samples
CN111032868A (zh) * 2017-06-30 2020-04-17 加利福尼亚大学董事会 用于评估无细胞dna中的dna甲基化的方法和系统
EP3652343A1 (en) 2017-07-13 2020-05-20 Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. Dual-probe digital droplet pcr strategy for specific detection of tissue-specific circulating dna molecules
EP3652344A1 (en) 2017-07-13 2020-05-20 Yissum Research and Development Company of the Hebrew University of Jerusalem Ltd. Dna targets as tissue-specific methylation markers
EP3652342A1 (en) * 2017-07-13 2020-05-20 Yissum Research and Development Company of the Hebrew University of Jerusalem Ltd. Detecting tissue-specific dna
DE102017126248B4 (de) * 2017-11-09 2019-10-17 Epiontis Gmbh ERGIC1 als epigenetischer Marker zur Identifizierung von Immunzellen, insbesonderemonozytischem myeloid-abgeleiteten Suppressor-Zellen (mMDSCs)
US20210087630A1 (en) * 2018-02-18 2021-03-25 Yissum Research Development Company Of The Hebrew University Of Jerusalmem Ltd. Cell free dna deconvolusion and use thereof
AU2019234843A1 (en) 2018-03-13 2020-09-24 Grail, Llc Anomalous fragment detection and classification
US11884966B2 (en) * 2018-03-15 2024-01-30 Grail, Llc Tissue-specific methylation marker
AU2019249422A1 (en) 2018-04-02 2020-10-15 Grail, Llc Methylation markers and targeted methylation probe panels
WO2019209884A1 (en) 2018-04-23 2019-10-31 Grail, Inc. Methods and systems for screening for conditions
JP2021112127A (ja) * 2018-04-26 2021-08-05 暁生 黒田 膵β細胞の傷害検査方法
EP3801623A4 (en) 2018-06-01 2022-03-23 Grail, LLC NEURAL CONVOLUTIONAL NETWORK SYSTEMS AND DATA CLASSIFICATION METHODS
CA3111887A1 (en) 2018-09-27 2020-04-02 Grail, Inc. Methylation markers and targeted methylation probe panel
AU2019384154A1 (en) 2018-11-21 2021-06-10 Agilent Technologies, Inc. Methods for targeted nucleic acid library formation
US11581062B2 (en) 2018-12-10 2023-02-14 Grail, Llc Systems and methods for classifying patients with respect to multiple cancer classes
CN113661542A (zh) * 2018-12-18 2021-11-16 格里尔公司 使用甲基化信息估计细胞来源部分的系统和方法
WO2020155149A1 (en) * 2019-02-02 2020-08-06 Lenovo (Beijing) Limited Enhanced scheduling of time sensitive networking
IL265451B (en) 2019-03-18 2020-01-30 Frumkin Dan Methods and systems for the detection of methylation changes in DNA samples
WO2020202162A1 (en) * 2019-04-03 2020-10-08 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Primers for multiplex pcr
US11773450B2 (en) 2019-04-03 2023-10-03 Grail, Llc Methylation-based false positive duplicate marking reduction
US11396679B2 (en) 2019-05-31 2022-07-26 Universal Diagnostics, S.L. Detection of colorectal cancer
US11001898B2 (en) 2019-05-31 2021-05-11 Universal Diagnostics, S.L. Detection of colorectal cancer
CA3151538A1 (en) 2019-09-30 2021-04-08 Stefanie Ann Ward Mortimer Compositions and methods for analyzing cell-free dna in methylation partitioning assays
US11898199B2 (en) 2019-11-11 2024-02-13 Universal Diagnostics, S.A. Detection of colorectal cancer and/or advanced adenomas
JP2023513470A (ja) 2020-01-30 2023-03-31 プログノミック インコーポレイテッド 肺バイオマーカーおよびそれらの使用方法
CN115997035A (zh) 2020-06-30 2023-04-21 通用诊断股份公司 用于检测多种癌症类型的系统和方法
CA3231038A1 (en) 2021-09-13 2023-03-16 Bruce Wilcox Enhanced detection and quantitation of biomolecules
US20230212674A1 (en) * 2021-12-30 2023-07-06 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Compositions and methods for identifying cell types
WO2023178109A2 (en) * 2022-03-15 2023-09-21 Resonant Llc Neuronal methylation signatures from cell free dna as a pre-symptomatic neurodegenerative condition surveillance diagnostic
WO2024038457A1 (en) 2022-08-18 2024-02-22 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. A method for determining the tissue or cell of origin of dna

Family Cites Families (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL154600B (nl) 1971-02-10 1977-09-15 Organon Nv Werkwijze voor het aantonen en bepalen van specifiek bindende eiwitten en hun corresponderende bindbare stoffen.
NL154598B (nl) 1970-11-10 1977-09-15 Organon Nv Werkwijze voor het aantonen en bepalen van laagmoleculire verbindingen en van eiwitten die deze verbindingen specifiek kunnen binden, alsmede testverpakking.
NL154599B (nl) 1970-12-28 1977-09-15 Organon Nv Werkwijze voor het aantonen en bepalen van specifiek bindende eiwitten en hun corresponderende bindbare stoffen, alsmede testverpakking.
US3901654A (en) 1971-06-21 1975-08-26 Biological Developments Receptor assays of biologically active compounds employing biologically specific receptors
US3853987A (en) 1971-09-01 1974-12-10 W Dreyer Immunological reagent and radioimmuno assay
US3867517A (en) 1971-12-21 1975-02-18 Abbott Lab Direct radioimmunoassay for antigens and their antibodies
NL171930C (nl) 1972-05-11 1983-06-01 Akzo Nv Werkwijze voor het aantonen en bepalen van haptenen, alsmede testverpakkingen.
US3850578A (en) 1973-03-12 1974-11-26 H Mcconnell Process for assaying for biologically active molecules
US3935074A (en) 1973-12-17 1976-01-27 Syva Company Antibody steric hindrance immunoassay with two antibodies
US3996345A (en) 1974-08-12 1976-12-07 Syva Company Fluorescence quenching with immunological pairs in immunoassays
US4034074A (en) 1974-09-19 1977-07-05 The Board Of Trustees Of Leland Stanford Junior University Universal reagent 2-site immunoradiometric assay using labelled anti (IgG)
US3984533A (en) 1975-11-13 1976-10-05 General Electric Company Electrophoretic method of detecting antigen-antibody reaction
US4098876A (en) 1976-10-26 1978-07-04 Corning Glass Works Reverse sandwich immunoassay
US4458066A (en) 1980-02-29 1984-07-03 University Patents, Inc. Process for preparing polynucleotides
US4879219A (en) 1980-09-19 1989-11-07 General Hospital Corporation Immunoassay utilizing monoclonal high affinity IgM antibodies
US5011771A (en) 1984-04-12 1991-04-30 The General Hospital Corporation Multiepitopic immunometric assay
US4666828A (en) 1984-08-15 1987-05-19 The General Hospital Corporation Test for Huntington's disease
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US4801531A (en) 1985-04-17 1989-01-31 Biotechnology Research Partners, Ltd. Apo AI/CIII genomic polymorphisms predictive of atherosclerosis
US4800159A (en) 1986-02-07 1989-01-24 Cetus Corporation Process for amplifying, detecting, and/or cloning nucleic acid sequences
US5322770A (en) 1989-12-22 1994-06-21 Hoffman-Laroche Inc. Reverse transcription with thermostable DNA polymerases - high temperature reverse transcription
US5272057A (en) 1988-10-14 1993-12-21 Georgetown University Method of detecting a predisposition to cancer by the use of restriction fragment length polymorphism of the gene for human poly (ADP-ribose) polymerase
US5192659A (en) 1989-08-25 1993-03-09 Genetype Ag Intron sequence analysis method for detection of adjacent and remote locus alleles as haplotypes
KR100236506B1 (ko) 1990-11-29 2000-01-15 퍼킨-엘머시터스인스트루먼츠 폴리머라제 연쇄 반응 수행 장치
CA2218875C (en) 1991-07-23 2000-11-07 The Research Foundation Of State University Of New York Improvements in the in situ pcr
US5281521A (en) 1992-07-20 1994-01-25 The Trustees Of The University Of Pennsylvania Modified avidin-biotin technique
US5612473A (en) 1996-01-16 1997-03-18 Gull Laboratories Methods, kits and solutions for preparing sample material for nucleic acid amplification
GB9620209D0 (en) 1996-09-27 1996-11-13 Cemu Bioteknik Ab Method of sequencing DNA
GB9626815D0 (en) 1996-12-23 1997-02-12 Cemu Bioteknik Ab Method of sequencing DNA
JP2001519525A (ja) * 1997-10-07 2001-10-23 メルク エンド カムパニー インコーポレーテッド Ｆｒｅｔを用いる核内受容体リガンドに関するアッセイ
US6274320B1 (en) 1999-09-16 2001-08-14 Curagen Corporation Method of sequencing a nucleic acid
AU2002352143A1 (en) * 2001-11-23 2003-06-10 Epigenomics Ag Method and nucleic acids for the analysis of a lymphoid cell proliferative disorder
DK1342794T3 (da) * 2002-03-05 2006-04-24 Epigenomics Ag Fremgangsmåde og anordning til at bestemme vævsspecificitet af fritflydende DNA i legemsvæsker
US7709194B2 (en) * 2004-06-04 2010-05-04 The Chinese University Of Hong Kong Marker for prenatal diagnosis and monitoring
DK3101141T3 (da) 2007-06-08 2020-02-03 Epigenomics Ag Fremgangsmåde til methyleringsanalyse
JP5502864B2 (ja) 2009-07-01 2014-05-28 シャープ株式会社 アクティブマトリクス基板及び有機ｅｌ表示装置
WO2011101728A2 (en) 2010-02-19 2011-08-25 Nucleix Identification of source of dna samples
US9366632B2 (en) 2010-02-12 2016-06-14 Raindance Technologies, Inc. Digital analyte analysis
JP2013524805A (ja) 2010-04-20 2013-06-20 ニュークレイックス Ｄｎａ試料のメチル化プロファイリング
US20140112895A1 (en) 2010-10-08 2014-04-24 Universiti Putra Malaysia Glp-1 promoter mediated insulin expression for the treatment of diabetes
EP2723901B1 (en) * 2011-06-22 2018-08-08 Yale University Compositions and methods of diagnosing diseases and disorders associated with cell death
EP2820157B1 (en) 2012-03-02 2019-05-01 Winthrop-University Hospital Method for using probe based pcr detection to measure the levels of circulating demethylated beta cell derived dna as a measure of beta cell loss in diabetes
WO2014013813A1 (ja) 2012-07-20 2014-01-23 株式会社村田製作所 生体センサ
WO2014138133A1 (en) 2013-03-04 2014-09-12 Islet Sciences, Inc. Compositions and methods for detecting hypo-methylated dna in body fluids
WO2014149356A1 (en) 2013-03-15 2014-09-25 Abbott Molecular Inc. Detection of bisulfite converted nucleotide sequences
CN106574296B (zh) 2014-04-14 2021-03-02 耶路撒冷希伯来大学伊森姆研究发展公司 用于测定dna的组织或细胞来源的方法和试剂盒
MA39951A (fr) 2014-05-09 2017-03-15 Lifecodexx Ag Détection de l'adn provenant d'un type spécifique de cellule et méthodes associées
WO2017011390A1 (en) 2015-07-10 2017-01-19 Winthrop-University Hospital System, method and kit for analysis of circulating differentially methylated dna as a biomarker of b-cell loss
EP3652343A1 (en) 2017-07-13 2020-05-20 Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. Dual-probe digital droplet pcr strategy for specific detection of tissue-specific circulating dna molecules
EP3652342A1 (en) 2017-07-13 2020-05-20 Yissum Research and Development Company of the Hebrew University of Jerusalem Ltd. Detecting tissue-specific dna
EP3652344A1 (en) 2017-07-13 2020-05-20 Yissum Research and Development Company of the Hebrew University of Jerusalem Ltd. Dna targets as tissue-specific methylation markers

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Publication number Publication date
IL248299B (en) 2021-04-29
LT4026917T (lt) 2024-03-12
CN106574296A (zh) 2017-04-19
PT4026917T (pt) 2024-02-12
JP6750879B2 (ja) 2020-09-02
FI4026917T3 (fi) 2024-02-14
JP2017511142A (ja) 2017-04-20
PL4026917T3 (pl) 2024-04-08
IL248299A0 (en) 2016-11-30
EP4306659A3 (en) 2024-03-27
US20170121767A1 (en) 2017-05-04
EP3132055A2 (en) 2017-02-22
EP3643795A1 (en) 2020-04-29
DK4026917T3 (da) 2024-02-12
SI4026917T1 (sl) 2024-05-31
WO2015159293A2 (en) 2015-10-22
US11203784B2 (en) 2021-12-21
EP4026917B1 (en) 2023-11-15
CN106574296B (zh) 2021-03-02
HRP20240189T1 (hr) 2024-04-26
DK4026917T5 (da) 2024-07-15
EP3643795B1 (en) 2022-03-30
EP4306659A2 (en) 2024-01-17
WO2015159292A3 (en) 2015-12-10
ES2974838T3 (es) 2024-07-01
US20220064730A1 (en) 2022-03-03
WO2015159293A3 (en) 2015-12-10
EP4026917A1 (en) 2022-07-13
US20230242985A1 (en) 2023-08-03
WO2015159292A2 (en) 2015-10-22

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