MX2022009582A - Analisis moleculares usando fragmentos largos extracelulares circulantes en el embarazo. - Google Patents
Analisis moleculares usando fragmentos largos extracelulares circulantes en el embarazo.Info
- Publication number
- MX2022009582A MX2022009582A MX2022009582A MX2022009582A MX2022009582A MX 2022009582 A MX2022009582 A MX 2022009582A MX 2022009582 A MX2022009582 A MX 2022009582A MX 2022009582 A MX2022009582 A MX 2022009582A MX 2022009582 A MX2022009582 A MX 2022009582A
- Authority
- MX
- Mexico
- Prior art keywords
- dna fragments
- free dna
- cell
- snps
- cpg sites
- Prior art date
Links
- 239000012634 fragment Substances 0.000 title abstract 8
- 238000004458 analytical method Methods 0.000 title abstract 2
- 230000035935 pregnancy Effects 0.000 title 1
- 108020004414 DNA Proteins 0.000 abstract 7
- 108091029430 CpG site Proteins 0.000 abstract 6
- 239000012472 biological sample Substances 0.000 abstract 2
- 210000003754 fetus Anatomy 0.000 abstract 1
- 239000002773 nucleotide Substances 0.000 abstract 1
- 125000003729 nucleotide group Chemical group 0.000 abstract 1
- 102000054765 polymorphisms of proteins Human genes 0.000 abstract 1
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- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
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- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
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- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
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- G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
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- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
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- G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
- G16B20/10—Ploidy or copy number detection
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- G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
- G16B20/30—Detection of binding sites or motifs
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- G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids
- G16B30/10—Sequence alignment; Homology search
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- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
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- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Physics & Mathematics (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Analytical Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
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- Spectroscopy & Molecular Physics (AREA)
- Evolutionary Biology (AREA)
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- General Engineering & Computer Science (AREA)
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- Biochemistry (AREA)
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- Chemical Kinetics & Catalysis (AREA)
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- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
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Abstract
Los métodos y sistemas descritos en la presente implican el uso de fragmentos largos de ADN extracelular circulante para analizar una muestra biológica de una persona gestante. El estado de los sitios de CpG metilados y los polimorfismos de un solo nucleótido (SNP) se usa a menudo para analizar fragmentos de ADN de una muestra biológica. Un sitio CpG y un SNP suelen estar separados del sitio CpG o SNP más cercano por cientos o miles de pares de bases. Es improbable o imposible encontrar dos o más sitios de CpG o SNP consecutivos en la mayoría de los fragmentos de ADN extracelular circulante. Los fragmentos de ADN extracelular circulante de más de 600 pb pueden incluir múltiples sitios de CpG y/o SNP. La presencia de múltiples sitios de CpG y/o SNP en fragmentos largos de ADN extracelular circulante puede permitir un análisis que solo con fragmentos cortos de ADN extracelular circulante. Los fragmentos largos de ADN extra-celular circulante pueden usarse para identificar un tejido de origen y/o proporcionar información sobre un feto en una mujer embarazada.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202062970634P | 2020-02-05 | 2020-02-05 | |
| US202163135486P | 2021-01-08 | 2021-01-08 | |
| PCT/CN2021/075394 WO2021155831A1 (en) | 2020-02-05 | 2021-02-05 | Molecular analyses using long cell-free fragments in pregnancy |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2022009582A true MX2022009582A (es) | 2022-08-25 |
Family
ID=77199166
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2022009582A MX2022009582A (es) | 2020-02-05 | 2021-02-05 | Analisis moleculares usando fragmentos largos extracelulares circulantes en el embarazo. |
| MX2022009820A MX2022009820A (es) | 2020-02-05 | 2022-08-04 | Analisis moleculares usando fragmentos largos extracelulares circulantes en el embarazo. |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2022009820A MX2022009820A (es) | 2020-02-05 | 2022-08-04 | Analisis moleculares usando fragmentos largos extracelulares circulantes en el embarazo. |
Country Status (14)
| Country | Link |
|---|---|
| US (3) | US20210265007A1 (es) |
| EP (1) | EP4069864A4 (es) |
| JP (3) | JP7311934B2 (es) |
| KR (2) | KR20230113840A (es) |
| CN (2) | CN115066504A (es) |
| AU (3) | AU2021216616B2 (es) |
| BR (2) | BR122022015680A2 (es) |
| CA (1) | CA3164433A1 (es) |
| GB (4) | GB2605736B (es) |
| IL (3) | IL303888A (es) |
| MX (2) | MX2022009582A (es) |
| NZ (2) | NZ790326A (es) |
| TW (3) | TWI784407B (es) |
| WO (1) | WO2021155831A1 (es) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2605736B (en) | 2020-02-05 | 2023-05-24 | Univ Hong Kong Chinese | Molecular analyses using long cell-free fragments in pregnancy |
| US20230279498A1 (en) * | 2021-11-24 | 2023-09-07 | Centre For Novostics Limited | Molecular analyses using long cell-free dna molecules for disease classification |
| KR20240144954A (ko) * | 2022-02-07 | 2024-10-04 | 센터 포 노보스틱스 | 메틸화 및 질환을 측정하기 위한 단편화 |
| WO2023217101A1 (en) * | 2022-05-10 | 2023-11-16 | Centre For Novostics | Analysis of nucleic acids associated with extracellular vesicles |
| KR20230172174A (ko) * | 2022-06-15 | 2023-12-22 | 주식회사 지씨지놈 | 무세포 핵산의 단일염기변이를 이용한 암 진단 및 암 종 예측방법 |
| CN114898802B (zh) * | 2022-07-14 | 2022-09-30 | 臻和(北京)生物科技有限公司 | 基于血浆游离dna甲基化测序数据的末端序列频率分布特征确定方法、评价方法及装置 |
| WO2024044749A1 (en) * | 2022-08-26 | 2024-02-29 | Fred Hutchinson Cancer Center | Cell-free dna sequence data analysis techniques for estimating fetal fraction and predicting preeclampsia |
| WO2024049915A1 (en) * | 2022-08-30 | 2024-03-07 | The General Hospital Corporation | High-resolution and non-invasive fetal sequencing |
| WO2024173756A1 (en) * | 2023-02-17 | 2024-08-22 | Illumina, Inc. | Cell-free dna signals as biomarkers of preeclampsia |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20070111233A1 (en) * | 2003-10-30 | 2007-05-17 | Bianchi Diana W | Prenatal diagnosis using cell-free fetal DNA in amniotic fluid |
| WO2007027970A2 (en) * | 2005-09-02 | 2007-03-08 | The New England Medical Center Hospitals | Prenatal diagnosis using cell-free fetal dna in amniotic fluid |
| FI3783110T3 (fi) * | 2009-11-05 | 2023-03-02 | Fetaalisen genomin analyysi maternaalisesta biologisesta näytteestä | |
| JP5770737B2 (ja) * | 2009-11-06 | 2015-08-26 | ザ チャイニーズ ユニバーシティ オブ ホンコン | サイズに基づくゲノム分析 |
| WO2011075774A1 (en) * | 2009-12-23 | 2011-06-30 | Genetic Technologies Limited | Methods of enriching and detecting fetal nucleic acids |
| US9323888B2 (en) * | 2010-01-19 | 2016-04-26 | Verinata Health, Inc. | Detecting and classifying copy number variation |
| AU2015203579B2 (en) * | 2010-01-19 | 2017-12-21 | Verinata Health, Inc. | Sequencing methods and compositions for prenatal diagnoses |
| US9892230B2 (en) * | 2012-03-08 | 2018-02-13 | The Chinese University Of Hong Kong | Size-based analysis of fetal or tumor DNA fraction in plasma |
| DK3543356T3 (da) * | 2014-07-18 | 2021-10-11 | Univ Hong Kong Chinese | Analyse af methyleringsmønster af væv i DNA-blanding |
| WO2016038220A1 (en) * | 2014-09-12 | 2016-03-17 | Illumina Cambridge Limited | Detecting repeat expansions with short read sequencing data |
| WO2016049877A1 (zh) * | 2014-09-30 | 2016-04-07 | 深圳华大基因股份有限公司 | 无创产前亲子鉴定中基于str分型技术的检测方法和系统 |
| CA2965500A1 (en) * | 2014-10-24 | 2016-04-28 | Abbott Molecular Inc. | Enrichment of small nucleic acids |
| US10319463B2 (en) * | 2015-01-23 | 2019-06-11 | The Chinese University Of Hong Kong | Combined size- and count-based analysis of maternal plasma for detection of fetal subchromosomal aberrations |
| US10689706B2 (en) * | 2015-07-20 | 2020-06-23 | The Chinese University Of Hong Kong | Methylation pattern analysis of haplotypes in tissues in a DNA mixture |
| HUE057821T2 (hu) * | 2015-07-23 | 2022-06-28 | Univ Hong Kong Chinese | Sejtmentes DNS fragmentációs mintázatának elemzése |
| US10095831B2 (en) * | 2016-02-03 | 2018-10-09 | Verinata Health, Inc. | Using cell-free DNA fragment size to determine copy number variations |
| CN109890984B (zh) * | 2016-10-19 | 2024-03-29 | 香港中文大学 | 通过母体血浆dna的甲基化和大小谱分析进行胎龄评估 |
| WO2018090991A1 (en) | 2016-11-18 | 2018-05-24 | The Chinese University Of Hong Kong | Universal haplotype-based noninvasive prenatal testing for single gene diseases |
| US10858691B2 (en) * | 2017-04-18 | 2020-12-08 | Covaris, Inc. | Differential shearing of nucleic acids |
| US11168356B2 (en) * | 2017-11-02 | 2021-11-09 | The Chinese University Of Hong Kong | Using nucleic acid size range for noninvasive cancer detection |
| KR20210014111A (ko) * | 2018-05-03 | 2021-02-08 | 더 차이니즈 유니버시티 오브 홍콩 | 세포-무함유 혼합물의 특성을 측정하기 위한 크기-태깅된 바람직한 말단 및 배향-인지 분석 |
| US11926821B2 (en) * | 2018-10-22 | 2024-03-12 | The Chinese University Of Hong Kong | Cell-free DNA quality |
| CN109402247B (zh) * | 2018-11-06 | 2020-04-07 | 苏州首度基因科技有限责任公司 | 一种基于dna变异计数的胎儿染色体检测系统 |
| GB2605736B (en) | 2020-02-05 | 2023-05-24 | Univ Hong Kong Chinese | Molecular analyses using long cell-free fragments in pregnancy |
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