MX2022009820A - Analisis moleculares usando fragmentos largos extracelulares circulantes en el embarazo. - Google Patents

Analisis moleculares usando fragmentos largos extracelulares circulantes en el embarazo.

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Publication number
MX2022009820A
MX2022009820A MX2022009820A MX2022009820A MX2022009820A MX 2022009820 A MX2022009820 A MX 2022009820A MX 2022009820 A MX2022009820 A MX 2022009820A MX 2022009820 A MX2022009820 A MX 2022009820A MX 2022009820 A MX2022009820 A MX 2022009820A
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Mexico
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dna fragments
free dna
cell
snps
cpg sites
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MX2022009820A
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English (en)
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Peiyong Jiang
Kwan Chee Chan
Wenlei Peng
Yuk- Ming Dennis Lo
Rossa Wai Kwun Chiu
Suk Hang Cheng
Cheuk Yin Yu
Yee Ting Cheung
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Univ Hong Kong Chinese
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Publication of MX2022009820A publication Critical patent/MX2022009820A/es

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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
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    • G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
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    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
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    • C12Q2600/00—Oligonucleotides characterized by their use
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Abstract

Los métodos y sistemas descritos en la presente implican el uso de fragmentos largos de ADN extracelular circulante para analizar una muestra biológica de una persona gestante. El estado de los sitios de CpG metilados y los polimorfismos de un solo nucleótido (SNP) se usa a menudo para analizar fragmentos de ADN de una muestra biológica. Un sitio CpG y un SNP suelen estar separados del sitio CpG o SNP más cercano por cientos o miles de pares de bases. Es improbable o imposible encontrar dos o más sitios de CpG o SNP consecutivos en la mayoría de los fragmentos de ADN extracelular circulante. Los fragmentos de ADN extracelular circulante de más de 600 pb pueden incluir múltiples sitios de CpG y/o SNP. La presencia de múltiples sitios de CpG y/o SNP en fragmentos largos de ADN extracelular circulante puede permitir un análisis que solo con fragmentos cortos de ADN extracelular circulante. Los fragmentos largos de ADN extracelular circulante pueden usarse para identificar un tejido de origen y/o proporcionar información sobre un feto en una mujer embarazada.
MX2022009820A 2020-02-05 2022-08-04 Analisis moleculares usando fragmentos largos extracelulares circulantes en el embarazo. MX2022009820A (es)

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US202062970634P 2020-02-05 2020-02-05
US202163135486P 2021-01-08 2021-01-08

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US (3) US20210265007A1 (es)
EP (1) EP4069864A4 (es)
JP (3) JP7311934B2 (es)
KR (2) KR102662186B1 (es)
CN (2) CN116004786A (es)
AU (3) AU2021216616B2 (es)
BR (2) BR122022015680A2 (es)
CA (1) CA3164433A1 (es)
GB (3) GB2605736B (es)
IL (3) IL303888A (es)
MX (2) MX2022009582A (es)
NZ (1) NZ790326A (es)
TW (1) TWI784407B (es)
WO (1) WO2021155831A1 (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ790326A (en) 2020-02-05 2023-07-28 Univ Hong Kong Chinese Molecular analyses using long cell-free fragments in pregnancy
US20230279498A1 (en) * 2021-11-24 2023-09-07 Centre For Novostics Limited Molecular analyses using long cell-free dna molecules for disease classification
WO2023147783A1 (en) * 2022-02-07 2023-08-10 Centre For Novostics Limited Fragmentation for measuring methylation and disease
WO2023217101A1 (en) * 2022-05-10 2023-11-16 Centre For Novostics Analysis of nucleic acids associated with extracellular vesicles
KR20230172174A (ko) * 2022-06-15 2023-12-22 주식회사 지씨지놈 무세포 핵산의 단일염기변이를 이용한 암 진단 및 암 종 예측방법
CN114898802B (zh) * 2022-07-14 2022-09-30 臻和(北京)生物科技有限公司 基于血浆游离dna甲基化测序数据的末端序列频率分布特征确定方法、评价方法及装置
WO2024044749A1 (en) * 2022-08-26 2024-02-29 Fred Hutchinson Cancer Center Cell-free dna sequence data analysis techniques for estimating fetal fraction and predicting preeclampsia
WO2024049915A1 (en) * 2022-08-30 2024-03-07 The General Hospital Corporation High-resolution and non-invasive fetal sequencing

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070111233A1 (en) * 2003-10-30 2007-05-17 Bianchi Diana W Prenatal diagnosis using cell-free fetal DNA in amniotic fluid
HUE034854T2 (en) * 2009-11-05 2018-03-28 Univ Hong Kong Chinese Fetal genomic analysis from maternal biological samples
EP3406737B1 (en) * 2009-11-06 2023-05-31 The Chinese University of Hong Kong Size-based genomic analysis
AU2010336017B2 (en) * 2009-12-23 2016-04-28 Genetic Technologies Limited Methods of enriching and detecting fetal nucleic acids
US9323888B2 (en) * 2010-01-19 2016-04-26 Verinata Health, Inc. Detecting and classifying copy number variation
AU2015203579B2 (en) * 2010-01-19 2017-12-21 Verinata Health, Inc. Sequencing methods and compositions for prenatal diagnoses
US9892230B2 (en) 2012-03-08 2018-02-13 The Chinese University Of Hong Kong Size-based analysis of fetal or tumor DNA fraction in plasma
CN106795562B (zh) * 2014-07-18 2022-03-25 香港中文大学 Dna混合物中的组织甲基化模式分析
EP4092680A1 (en) * 2014-09-12 2022-11-23 Illumina Cambridge Limited Detecting repeat expansions with short read sequencing data
WO2016049877A1 (zh) * 2014-09-30 2016-04-07 深圳华大基因股份有限公司 无创产前亲子鉴定中基于str分型技术的检测方法和系统
US10319463B2 (en) * 2015-01-23 2019-06-11 The Chinese University Of Hong Kong Combined size- and count-based analysis of maternal plasma for detection of fetal subchromosomal aberrations
WO2017012544A1 (en) 2015-07-20 2017-01-26 The Chinese University Of Hong Kong Methylation pattern analysis of haplotypes in tissues in dna mixture
HUE064231T2 (hu) * 2015-07-23 2024-02-28 Univ Hong Kong Chinese Sejtmentes DNS fragmentációs mintázatának elemzése
US10095831B2 (en) * 2016-02-03 2018-10-09 Verinata Health, Inc. Using cell-free DNA fragment size to determine copy number variations
IL265769B2 (en) * 2016-10-19 2023-12-01 Univ Hong Kong Chinese Estimation of gestational age using methylation and size profile of maternal plasma DNA
CN109996894A (zh) * 2016-11-18 2019-07-09 香港中文大学 用于单基因疾病的基于通用单倍型的非侵入性产前测试
US10858691B2 (en) * 2017-04-18 2020-12-08 Covaris, Inc. Differential shearing of nucleic acids
US11168356B2 (en) * 2017-11-02 2021-11-09 The Chinese University Of Hong Kong Using nucleic acid size range for noninvasive cancer detection
TW202012636A (zh) * 2018-05-03 2020-04-01 香港中文大學 用於測量游離(cell-free)混合物之特性之經尺寸標記之偏好末端及取向感知分析
US11926821B2 (en) * 2018-10-22 2024-03-12 The Chinese University Of Hong Kong Cell-free DNA quality
CN109402247B (zh) * 2018-11-06 2020-04-07 苏州首度基因科技有限责任公司 一种基于dna变异计数的胎儿染色体检测系统
NZ790326A (en) 2020-02-05 2023-07-28 Univ Hong Kong Chinese Molecular analyses using long cell-free fragments in pregnancy

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IL298811B2 (en) 2023-11-01
US11371084B2 (en) 2022-06-28
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BR122022015680A2 (pt) 2022-12-06
GB2620304A (en) 2024-01-03
GB2605736A (en) 2022-10-12
IL294431B1 (en) 2023-01-01
AU2021216616B2 (en) 2023-04-20
IL294431B2 (en) 2023-05-01
US20210254142A1 (en) 2021-08-19
BR112022015073A2 (pt) 2022-11-16
CN116004786A (zh) 2023-04-25
IL294431A (en) 2022-09-01
AU2021216616A1 (en) 2022-07-21
US11591642B2 (en) 2023-02-28
GB202313363D0 (en) 2023-10-18
US20210265007A1 (en) 2021-08-26
US20220275433A1 (en) 2022-09-01
JP2024045112A (ja) 2024-04-02
GB202305176D0 (en) 2023-05-24
KR20230113840A (ko) 2023-08-01
JP7416501B2 (ja) 2024-01-17
JP2023504939A (ja) 2023-02-07
IL303888A (en) 2023-08-01
GB202209581D0 (en) 2022-08-10
NZ790326A (en) 2023-07-28
GB2605736B (en) 2023-05-24
EP4069864A1 (en) 2022-10-12
JP2023123759A (ja) 2023-09-05
TW202142696A (zh) 2021-11-16
WO2021155831A1 (en) 2021-08-12
CA3164433A1 (en) 2021-08-12
TWI784407B (zh) 2022-11-21
AU2023204613B2 (en) 2023-11-23
IL298811B1 (en) 2023-07-01
CN115066504A (zh) 2022-09-16
KR102662186B1 (ko) 2024-05-07
AU2023204613A1 (en) 2023-08-03
JP7311934B2 (ja) 2023-07-20
GB2614994A (en) 2023-07-26
GB2614994B (en) 2023-10-18
AU2024201092A1 (en) 2024-03-14
MX2022009582A (es) 2022-08-25
TW202307216A (zh) 2023-02-16
KR20220118551A (ko) 2022-08-25

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