ATE316152T1 - Komplexitätsmanagement und analyse genomischer dna - Google Patents

Komplexitätsmanagement und analyse genomischer dna

Info

Publication number
ATE316152T1
ATE316152T1 AT99965737T AT99965737T ATE316152T1 AT E316152 T1 ATE316152 T1 AT E316152T1 AT 99965737 T AT99965737 T AT 99965737T AT 99965737 T AT99965737 T AT 99965737T AT E316152 T1 ATE316152 T1 AT E316152T1
Authority
AT
Austria
Prior art keywords
analysis
genomic dna
sample
invention further
further provides
Prior art date
Application number
AT99965737T
Other languages
English (en)
Inventor
Shoulian Dong
Robert J Lipshutz
David J Lockhart
Original Assignee
Affymetrix Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Affymetrix Inc filed Critical Affymetrix Inc
Application granted granted Critical
Publication of ATE316152T1 publication Critical patent/ATE316152T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
    • C12Q1/6837—Enzymatic or biochemical coupling of nucleic acids to a solid phase using probe arrays or probe chips
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/6853—Nucleic acid amplification reactions using modified primers or templates
    • C12Q1/6855—Ligating adaptors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/6858—Allele-specific amplification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/902—Specified use of nanostructure
    • Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
    • Y10S977/924—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis using nanostructure as support of dna analysis
AT99965737T 1998-10-27 1999-10-27 Komplexitätsmanagement und analyse genomischer dna ATE316152T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10586798P 1998-10-27 1998-10-27
US13612599P 1999-05-26 1999-05-26

Publications (1)

Publication Number Publication Date
ATE316152T1 true ATE316152T1 (de) 2006-02-15

Family

ID=26803034

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99965737T ATE316152T1 (de) 1998-10-27 1999-10-27 Komplexitätsmanagement und analyse genomischer dna

Country Status (8)

Country Link
US (3) US6361947B1 (de)
EP (1) EP1124990B1 (de)
JP (1) JP2002528096A (de)
AT (1) ATE316152T1 (de)
AU (1) AU2144000A (de)
CA (1) CA2345441A1 (de)
DE (1) DE69929542T2 (de)
WO (1) WO2000024939A1 (de)

Families Citing this family (178)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6974666B1 (en) * 1994-10-21 2005-12-13 Appymetric, Inc. Methods of enzymatic discrimination enhancement and surface-bound double-stranded DNA
ATE537270T1 (de) 1997-10-30 2011-12-15 Cold Spring Harbor Lab Sondenanordnungen und deren verwendungen für verfahren zur dns-unterscheidung
US6703228B1 (en) * 1998-09-25 2004-03-09 Massachusetts Institute Of Technology Methods and products related to genotyping and DNA analysis
JP4669614B2 (ja) * 1999-02-22 2011-04-13 ソレクサ・インコーポレイテッド 多型ｄｎａフラグメントおよびその使用
US20060275782A1 (en) 1999-04-20 2006-12-07 Illumina, Inc. Detection of nucleic acid reactions on bead arrays
US20020119448A1 (en) * 1999-06-23 2002-08-29 Joseph A. Sorge Methods of enriching for and identifying polymorphisms
US6958225B2 (en) 1999-10-27 2005-10-25 Affymetrix, Inc. Complexity management of genomic DNA
US20010039014A1 (en) * 2000-01-11 2001-11-08 Maxygen, Inc. Integrated systems and methods for diversity generation and screening
EP1278894A1 (de) * 2000-05-02 2003-01-29 Centre National De La Recherche Scientifique Identifizierung genetischer marker
US20020055112A1 (en) * 2000-08-26 2002-05-09 Nila Patil Methods for reducing complexity of nucleic acid samples
US20020164634A1 (en) * 2000-08-26 2002-11-07 Perlegen Sciences, Inc. Methods for reducing complexity of nucleic acid samples
US20020137043A1 (en) * 2000-08-26 2002-09-26 Nila Patil Method for reducing complexity of nucleic acid samples
AR031640A1 (es) * 2000-12-08 2003-09-24 Applied Research Systems Amplificacion isotermica de acidos nucleicos en un soporte solido
WO2002061145A2 (en) * 2001-01-31 2002-08-08 Ambion, Inc. Competitive amplification of fractionated targets from multiple nucleic acid samples
WO2002090599A1 (en) * 2001-05-09 2002-11-14 Genetic Id, Inc. Universal microarray system
US20030009294A1 (en) * 2001-06-07 2003-01-09 Jill Cheng Integrated system for gene expression analysis
US7297778B2 (en) * 2001-07-25 2007-11-20 Affymetrix, Inc. Complexity management of genomic DNA
US6872529B2 (en) * 2001-07-25 2005-03-29 Affymetrix, Inc. Complexity management of genomic DNA
WO2003054232A2 (en) * 2001-12-13 2003-07-03 Blue Heron Biotechnology, Inc. Methods for removal of double-stranded oligonucleotides containing sequence errors using mismatch recognition proteins
CN1281324C (zh) * 2001-12-19 2006-10-25 阿菲梅特里克斯公司 阵列板和阵列板的构建方法
DE10208333A1 (de) * 2002-02-27 2003-09-04 Axaron Bioscience Ag Analyse von Nukleinsäure-Fragmentmischungen
JP4274948B2 (ja) 2002-03-13 2009-06-10 シンジェンタ・パティシペーションズ・アクチェンゲゼルシャフト 核酸検出方法
US20070065816A1 (en) * 2002-05-17 2007-03-22 Affymetrix, Inc. Methods for genotyping
US20040072217A1 (en) * 2002-06-17 2004-04-15 Affymetrix, Inc. Methods of analysis of linkage disequilibrium
US7097976B2 (en) 2002-06-17 2006-08-29 Affymetrix, Inc. Methods of analysis of allelic imbalance
US9388459B2 (en) * 2002-06-17 2016-07-12 Affymetrix, Inc. Methods for genotyping
US7108976B2 (en) * 2002-06-17 2006-09-19 Affymetrix, Inc. Complexity management of genomic DNA by locus specific amplification
US7504215B2 (en) 2002-07-12 2009-03-17 Affymetrix, Inc. Nucleic acid labeling methods
US7482170B2 (en) * 2002-09-30 2009-01-27 Roche Nimblegen, Inc. Parallel loading of arrays
DE10393431T5 (de) * 2002-10-01 2005-11-17 Nimblegen Systems, Inc., Madison Mikroarrays mit mehreren Oligonukleotiden in einzelnen Array Features
US7459273B2 (en) * 2002-10-04 2008-12-02 Affymetrix, Inc. Methods for genotyping selected polymorphism
DE10246824A1 (de) * 2002-10-08 2004-04-22 Axaron Bioscience Ag Hybridisierungsproben reduzierter Komplexität
WO2004042057A1 (ja) * 2002-11-07 2004-05-21 Daiichi Pure Chemicals Co., Ltd. 遺伝子変異検出法
WO2004067708A2 (en) * 2003-01-17 2004-08-12 Sri International Et Al. Device and method for fragmenting material by hydrodynamic shear
CA2514950A1 (en) * 2003-01-30 2004-08-12 Applera Corporation Genetic polymorphisms associated with rheumatoid arthritis, methods of detection and uses thereof
US20060183132A1 (en) * 2005-02-14 2006-08-17 Perlegen Sciences, Inc. Selection probe amplification
US20040259125A1 (en) * 2003-02-26 2004-12-23 Omni Genetics, Inc. Methods, systems and apparatus for identifying genetic differences in disease and drug response
US20090124514A1 (en) * 2003-02-26 2009-05-14 Perlegen Sciences, Inc. Selection probe amplification
CA2518957A1 (en) * 2003-03-10 2004-09-23 Applera Corporation Genetic polymorphisms associated with myocardial infarction, methods of detection and uses thereof
JP2009521904A (ja) * 2003-03-10 2009-06-11 アプレラ コーポレイション 狭窄に関連する一塩基多型、その検出方法および使用
CA2519476A1 (en) * 2003-03-18 2004-09-30 Applera Corporation Genetic polymorphisms associated with rheumatoid arthritis, methods of detection and uses thereof
WO2004090170A1 (en) * 2003-04-02 2004-10-21 Blue Heron Biotechnology, Inc. Error reduction in automated gene synthesis
AU2004280531B2 (en) 2003-05-23 2010-03-25 Cold Spring Harbor Laboratory Counting exact word matches in genomes
CA3084542A1 (en) 2003-06-10 2005-01-06 The Trustees Of Boston University Gene expression analysis of airway epithelial cells for diagnosing lung cancer
US20050181394A1 (en) * 2003-06-20 2005-08-18 Illumina, Inc. Methods and compositions for whole genome amplification and genotyping
US20040259100A1 (en) * 2003-06-20 2004-12-23 Illumina, Inc. Methods and compositions for whole genome amplification and genotyping
US7670810B2 (en) 2003-06-20 2010-03-02 Illumina, Inc. Methods and compositions for whole genome amplification and genotyping
US20050032102A1 (en) * 2003-07-22 2005-02-10 Affymetrix, Inc. Mapping genomic rearrangements
US8114978B2 (en) * 2003-08-05 2012-02-14 Affymetrix, Inc. Methods for genotyping selected polymorphism
US20050100911A1 (en) * 2003-08-06 2005-05-12 Perlegen Sciences, Inc. Methods for enriching populations of nucleic acid samples
EP2322278B1 (de) * 2003-10-24 2017-01-04 Aushon Biosystems, Inc. Vorrichtung und Verfahren zur Ausgabe von flüssigen, halbflüssigen und festen Proben
WO2005054516A2 (en) 2003-11-26 2005-06-16 Advandx, Inc. Peptide nucleic acid probes for analysis of certain staphylococcus species
US20050233354A1 (en) * 2004-01-22 2005-10-20 Affymetrix, Inc. Genotyping degraded or mitochandrial DNA samples
EP1564306B1 (de) 2004-02-17 2013-08-07 Affymetrix, Inc. Verfahren zur Fragmentierung und Markierung von DNS
SE0401270D0 (sv) * 2004-05-18 2004-05-18 Fredrik Dahl Method for amplifying specific nucleic acids in parallel
EP2290071B1 (de) 2004-05-28 2014-12-31 Asuragen, Inc. Verfahren und Zusammensetzungen mit MicroRNA
EP1623996A1 (de) * 2004-08-06 2006-02-08 Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts Verbessertes Verfahren zur Auswahl eines Proteins von einer Bibliothek
US20060073506A1 (en) 2004-09-17 2006-04-06 Affymetrix, Inc. Methods for identifying biological samples
EP1645640B1 (de) 2004-10-05 2013-08-21 Affymetrix, Inc. Verfahren zur Detektion von chromosomalen Translokationen
US7682782B2 (en) 2004-10-29 2010-03-23 Affymetrix, Inc. System, method, and product for multiple wavelength detection using single source excitation
EP1652580A1 (de) 2004-10-29 2006-05-03 Affymetrix, Inc. Mikroarray mit hohem Durchsatz, Arrayanordnung und Herstellungsverfahren für Arrays
DK2302055T3 (da) 2004-11-12 2014-10-13 Asuragen Inc Fremgangsmåder og sammensætninger involverende miRNA og miRNA-inhibitormolekyler
US20060166224A1 (en) * 2005-01-24 2006-07-27 Norviel Vernon A Associations using genotypes and phenotypes
EP2360278A1 (de) 2005-04-14 2011-08-24 Trustees Of Boston University Diagnose für Lungenerkrankungen mittels Klassenvorhersage
US20060286571A1 (en) 2005-04-28 2006-12-21 Prometheus Laboratories, Inc. Methods of predicting methotrexate efficacy and toxicity
US7452671B2 (en) * 2005-04-29 2008-11-18 Affymetrix, Inc. Methods for genotyping with selective adaptor ligation
JP5220597B2 (ja) 2005-06-23 2013-06-26 キージーン ナムローゼ フェンノートシャップ １つ又は複数の多型性を同定する方法およびその使用方法
WO2006137734A1 (en) * 2005-06-23 2006-12-28 Keygene N.V. Improved strategies for sequencing complex genomes using high throughput sequencing technologies
US20070003938A1 (en) * 2005-06-30 2007-01-04 Perlegen Sciences, Inc. Hybridization of genomic nucleic acid without complexity reduction
EP1907577A4 (de) * 2005-06-30 2009-05-13 Syngenta Participations Ag Verfahren zum screening auf genspezifische hybridisierungspolymorphismen (gshp) und deren verwendung bei der genetischen kartierung und markerentwicklung
GB0514935D0 (en) 2005-07-20 2005-08-24 Solexa Ltd Methods for sequencing a polynucleotide template
GB0514910D0 (en) * 2005-07-20 2005-08-24 Solexa Ltd Method for sequencing a polynucleotide template
US10316364B2 (en) 2005-09-29 2019-06-11 Keygene N.V. Method for identifying the source of an amplicon
CA2910861C (en) 2005-09-29 2018-08-07 Michael Josephus Theresia Van Eijk High throughput screening of mutagenized populations
GB0522310D0 (en) 2005-11-01 2005-12-07 Solexa Ltd Methods of preparing libraries of template polynucleotides
GB0524069D0 (en) * 2005-11-25 2006-01-04 Solexa Ltd Preparation of templates for solid phase amplification
US7634363B2 (en) 2005-12-07 2009-12-15 Affymetrix, Inc. Methods for high throughput genotyping
US11306351B2 (en) 2005-12-21 2022-04-19 Affymetrix, Inc. Methods for genotyping
EP3404114B1 (de) 2005-12-22 2021-05-05 Keygene N.V. Verfahren zur auf aflp basierenden hochdurchsatz-polymorphismusdetektion
WO2007091077A1 (en) 2006-02-08 2007-08-16 Solexa Limited Method for sequencing a polynucleotide template
EP2605018A1 (de) 2006-03-09 2013-06-19 The Trustees of the Boston University Diagnose- und Prognoseverfahren für Lungenerkrankungen mittels Genexpressionsprofilen aus Nasenepithelzellen
US8288157B2 (en) * 2007-09-12 2012-10-16 Plc Diagnostics, Inc. Waveguide-based optical scanning systems
US9528939B2 (en) 2006-03-10 2016-12-27 Indx Lifecare, Inc. Waveguide-based optical scanning systems
US9976192B2 (en) 2006-03-10 2018-05-22 Ldip, Llc Waveguide-based detection system with scanning light source
US7951583B2 (en) * 2006-03-10 2011-05-31 Plc Diagnostics, Inc. Optical scanning system
US9423397B2 (en) 2006-03-10 2016-08-23 Indx Lifecare, Inc. Waveguide-based detection system with scanning light source
EP2021503A1 (de) * 2006-03-17 2009-02-11 Solexa Ltd. Isothermische methoden zur entstehung von arrays von einzelnen molekülen
DK2002017T3 (en) 2006-04-04 2015-09-07 Keygene Nv High-capacity detection of molecular markers based on restriction fragments
WO2008015396A2 (en) * 2006-07-31 2008-02-07 Solexa Limited Method of library preparation avoiding the formation of adaptor dimers
US8586006B2 (en) 2006-08-09 2013-11-19 Institute For Systems Biology Organ-specific proteins and methods of their use
US7754429B2 (en) 2006-10-06 2010-07-13 Illumina Cambridge Limited Method for pair-wise sequencing a plurity of target polynucleotides
US9845494B2 (en) 2006-10-18 2017-12-19 Affymetrix, Inc. Enzymatic methods for genotyping on arrays
EP2092074A4 (de) 2006-11-02 2010-06-09 Univ Yale Beurteilung der befruchtungsfähigkeit von eizellen
US8293684B2 (en) * 2006-11-29 2012-10-23 Exiqon Locked nucleic acid reagents for labelling nucleic acids
WO2008093098A2 (en) 2007-02-02 2008-08-07 Illumina Cambridge Limited Methods for indexing samples and sequencing multiple nucleotide templates
RU2009146054A (ru) * 2007-05-14 2011-06-20 Инсайт Дженетикс, Инк. (Us) Способы скрининга нуклеиновых кислот для выявления одиночных нуклеотидных вариаций
US8200440B2 (en) 2007-05-18 2012-06-12 Affymetrix, Inc. System, method, and computer software product for genotype determination using probe array data
US20080293589A1 (en) * 2007-05-24 2008-11-27 Affymetrix, Inc. Multiplex locus specific amplification
US8883691B2 (en) * 2007-06-25 2014-11-11 Affymetrix, Inc. Encoded microparticles
EP2173909A1 (de) * 2007-07-26 2010-04-14 Roche Diagnostics GmbH Targetvorbereitung zur parallelen sequenzierung komplexer genome
WO2009032167A1 (en) * 2007-08-29 2009-03-12 Illumina Cambridge Method for sequencing a polynucleotide template
WO2009036332A1 (en) 2007-09-14 2009-03-19 Asuragen, Inc. Micrornas differentially expressed in cervical cancer and uses thereof
US8716190B2 (en) 2007-09-14 2014-05-06 Affymetrix, Inc. Amplification and analysis of selected targets on solid supports
US9388457B2 (en) 2007-09-14 2016-07-12 Affymetrix, Inc. Locus specific amplification using array probes
WO2009040682A2 (en) * 2007-09-26 2009-04-02 Population Genetics Technologies Ltd. Methods and compositions for reducing the complexity of a nucleic acid sample
CA2710807C (en) 2008-03-11 2015-09-08 Kyeong Man Hong Method for measuring chromosome, gene or specific nucleotide sequence copy numbers using snp array
US9074244B2 (en) 2008-03-11 2015-07-07 Affymetrix, Inc. Array-based translocation and rearrangement assays
WO2009137807A2 (en) 2008-05-08 2009-11-12 Asuragen, Inc. Compositions and methods related to mirna modulation of neovascularization or angiogenesis
GB2461026B (en) * 2008-06-16 2011-03-09 Plc Diagnostics Inc System and method for nucleic acids sequencing by phased synthesis
US8309306B2 (en) * 2008-11-12 2012-11-13 Nodality, Inc. Detection composition
JP2012514977A (ja) 2009-01-13 2012-07-05 キージーン・エン・フェー 新規ゲノム配列決定戦略
EP3722810A3 (de) 2009-02-11 2021-01-13 Caris MPI, Inc. Molekulare profilierung von tumoren
CA2755784C (en) 2009-03-16 2020-03-24 Pangu Biopharma Limited Compositions and methods comprising histidyl-trna synthetase splice variants having non-canonical biological activities
EP2414513B1 (de) 2009-03-31 2015-10-28 Atyr Pharma, Inc. Zusammensetzungen und verfahren mit aspartyl-trna-synthetasen mit nichtkanonischen biologischen aktivitäten
EP2425286B1 (de) * 2009-04-29 2020-06-24 Ldip, Llc Auf wellenleitern basierendes detektionssystem mit abtastlichtquelle
EP2248914A1 (de) 2009-05-05 2010-11-10 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Die Verwendung von IIB-Restriktionsendonukleasen in Sequenzierungsanwendungen der zweiten Generation
GB0912909D0 (en) * 2009-07-23 2009-08-26 Olink Genomics Ab Probes for specific analysis of nucleic acids
US8445201B2 (en) * 2009-07-31 2013-05-21 Affymetrix, Inc. Hybridization device, methods, and system using mixing beads
US20110059453A1 (en) * 2009-08-23 2011-03-10 Affymetrix, Inc. Poly(A) Tail Length Measurement by PCR
ES2595055T3 (es) 2009-08-25 2016-12-27 Illumina, Inc. Métodos para seleccionar y amplificar polinucleótidos
US10174368B2 (en) 2009-09-10 2019-01-08 Centrillion Technology Holdings Corporation Methods and systems for sequencing long nucleic acids
CN102858995B (zh) 2009-09-10 2016-10-26 森特瑞隆技术控股公司 靶向测序方法
WO2011056688A2 (en) 2009-10-27 2011-05-12 Caris Life Sciences, Inc. Molecular profiling for personalized medicine
US8501122B2 (en) 2009-12-08 2013-08-06 Affymetrix, Inc. Manufacturing and processing polymer arrays
WO2011071382A1 (en) 2009-12-10 2011-06-16 Keygene N.V. Polymorfphic whole genome profiling
JP5799484B2 (ja) 2009-12-14 2015-10-28 トヨタ自動車株式会社 Ｄｎａマイクロアレイにおけるプローブ設計方法、当該方法により設計されたプローブを有するｄｎａマイクロアレイ
US8835358B2 (en) 2009-12-15 2014-09-16 Cellular Research, Inc. Digital counting of individual molecules by stochastic attachment of diverse labels
CN102656279A (zh) 2009-12-17 2012-09-05 凯津公司 基于全基因组测序的限制性酶
GB0922377D0 (en) 2009-12-22 2010-02-03 Arab Gulf University The Mutant LDL receptor
AU2011248625B2 (en) 2010-04-26 2017-01-05 Pangu Biopharma Limited Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of cysteinyl-tRNA synthetase
JP6294074B2 (ja) 2010-04-27 2018-03-14 エータイアー ファーマ， インコーポレイテッド イソロイシルｔＲＮＡ合成酵素のタンパク質フラグメントに関連した治療用、診断用および抗体組成物の革新的発見
WO2011139853A2 (en) 2010-04-28 2011-11-10 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of alanyl trna synthetases
CA2797374C (en) 2010-04-29 2021-02-16 Pangu Biopharma Limited Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of asparaginyl trna synthetases
CA2797393C (en) 2010-04-29 2020-03-10 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of valyl trna synthetases
US9068177B2 (en) 2010-04-29 2015-06-30 Atyr Pharma, Inc Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of glutaminyl-tRNA synthetases
CN103096925A (zh) 2010-05-03 2013-05-08 Atyr医药公司 与精氨酰-tRNA合成酶的蛋白片段相关的治疗、诊断和抗体组合物的创新发现
CN103096912A (zh) 2010-05-03 2013-05-08 Atyr医药公司 与苯丙氨酰-α-tRNA合成酶的蛋白片段相关的治疗、诊断和抗体组合物的创新发现
CA2797978C (en) 2010-05-03 2019-12-03 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of methionyl-trna synthetases
CN102985103A (zh) 2010-05-04 2013-03-20 Atyr医药公司 与p38多-tRNA合成酶复合物相关的治疗、诊断和抗体组合物的创新发现
JP6396656B2 (ja) 2010-05-14 2018-09-26 エータイアー ファーマ， インコーポレイテッド フェニルアラニルβｔＲＮＡ合成酵素のタンパク質フラグメントに関連した治療用、診断用および抗体組成物の革新的発見
US8962560B2 (en) 2010-06-01 2015-02-24 Atyr Pharma Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of Lysyl-tRNA synthetases
CA2804416C (en) 2010-07-12 2020-04-28 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of glycyl-trna synthetases
AU2011293294B2 (en) 2010-08-25 2016-03-24 Pangu Biopharma Limited Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of Tyrosyl-tRNA synthetases
CN103119175B (zh) * 2010-09-20 2017-11-28 Seegene株式会社 在固相利用单一标记固定化探针及外切核酸活性的靶核酸序列检测
WO2012096579A2 (en) 2011-01-14 2012-07-19 Keygene N.V. Paired end random sequence based genotyping
JP5808825B2 (ja) 2011-02-24 2015-11-10 ヒルズ・ペット・ニュートリシャン・インコーポレーテッド ネコの腎障害を診断および治療する組成物および方法
US20120252682A1 (en) 2011-04-01 2012-10-04 Maples Corporate Services Limited Methods and systems for sequencing nucleic acids
EP2721175B1 (de) 2011-06-15 2015-09-16 Hill's Pet Nutrition, Inc. Zusammensetzungen und verfahren zur diagnose und überwachung von schilddrüsenüberfunktion bei der katze
CA2848304A1 (en) 2011-09-09 2013-03-14 The Board Of Trustees Of The Leland Stanford Junior University Methods for sequencing a polynucleotide
WO2013040251A2 (en) 2011-09-13 2013-03-21 Asurgen, Inc. Methods and compositions involving mir-135b for distinguishing pancreatic cancer from benign pancreatic disease
CN104039823A (zh) 2011-12-19 2014-09-10 希尔氏宠物营养品公司 用于诊断和治疗伴侣动物的甲状腺机能亢进的组合物和方法
EP3434789A1 (de) 2012-01-13 2019-01-30 Data2Bio Genotypisierung durch eine sequenzierung der nächsten generation
US9528107B2 (en) 2012-01-31 2016-12-27 Pacific Biosciences Of California, Inc. Compositions and methods for selection of nucleic acids
RU2659423C2 (ru) 2012-02-16 2018-07-02 ЭйТИР ФАРМА, ИНК. ГИСТИДИЛ-тРНК-СИНТЕТАЗЫ ДЛЯ ЛЕЧЕНИЯ АУТОИММУННЫХ И ВОСПАЛИТЕЛЬНЫХ ЗАБОЛЕВАНИЙ
ES2776673T3 (es) 2012-02-27 2020-07-31 Univ North Carolina Chapel Hill Métodos y usos para etiquetas moleculares
JP6375230B2 (ja) 2012-02-27 2018-08-15 セルラー リサーチ， インコーポレイテッド 分子計数のための組成物およびキット
ES2828661T3 (es) 2012-03-20 2021-05-27 Univ Washington Through Its Center For Commercialization Métodos para reducir la tasa de error de la secuenciación de ADN masiva en paralelo mediante el uso de la secuenciación de secuencia consenso bicatenaria
US10260103B2 (en) 2012-11-27 2019-04-16 Pontificia Universidad Catolica De Chile Compositions and methods for diagnosing thyroid tumors
US10822607B2 (en) * 2012-12-21 2020-11-03 Nanyang Technological University Site-specific induction of bimolecular quadruplex-duplex hybrids and methods of using the same
EP3037532A4 (de) * 2013-08-21 2017-05-03 Fujirebio Inc. Verfahren zur messung modifizierter nukleobasen durch verwendung einer festphasensonde und kit dafür
US10018566B2 (en) 2014-02-28 2018-07-10 Ldip, Llc Partially encapsulated waveguide based sensing chips, systems and methods of use
WO2016028887A1 (en) 2014-08-19 2016-02-25 Pacific Biosciences Of California, Inc. Compositions and methods for enrichment of nucleic acids
US10435685B2 (en) 2014-08-19 2019-10-08 Pacific Biosciences Of California, Inc. Compositions and methods for enrichment of nucleic acids
WO2016138427A1 (en) 2015-02-27 2016-09-01 Indx Lifecare, Inc. Waveguide-based detection system with scanning light source
KR20180071299A (ko) 2015-10-18 2018-06-27 아피메트릭스, 인코포레이티드 단일 뉴클레오타이드 다형 및 인델의 다대립유전자 유전자형분석
CN109072294A (zh) 2015-12-08 2018-12-21 特温斯特兰德生物科学有限公司 用于双重测序的改良衔接子、方法和组合物
AU2018366213A1 (en) 2017-11-08 2020-05-14 Twinstrand Biosciences, Inc. Reagents and adapters for nucleic acid sequencing and methods for making such reagents and adapters
US20210269873A1 (en) 2018-07-12 2021-09-02 Twinstrand Biosciences, Inc. Methods and reagents for characterizing genomic editing, clonal expansion, and associated applications
US20220033879A1 (en) 2018-11-28 2022-02-03 Keygene N.V. Targeted enrichment by endonuclease protection
KR20210111254A (ko) 2018-11-30 2021-09-10 캐리스 엠피아이, 아이엔씨. 차세대 분자 프로파일링
CN113474466A (zh) 2019-02-21 2021-10-01 主基因有限公司 多倍体基因分型
US20220220564A1 (en) 2019-04-17 2022-07-14 Igenomix, S.L. Improved methods for the early diagnosis of uterine leiomyomas and leiomyosarcomas
WO2021112918A1 (en) 2019-12-02 2021-06-10 Caris Mpi, Inc. Pan-cancer platinum response predictor
WO2021116371A1 (en) 2019-12-12 2021-06-17 Keygene N.V. Semi-solid state nucleic acid manipulation
JP2023506631A (ja) 2019-12-20 2023-02-17 キージーン ナムローゼ フェンノートシャップ 共有結合で閉端された核酸分子末端を使用したｎｇｓライブラリー調製
US20230407366A1 (en) 2020-10-06 2023-12-21 Keygene N.V. Targeted sequence addition
EP4251761A1 (de) 2020-11-24 2023-10-04 Keygene N.V. Gezielte anreicherung mittels nanoporenselektiver sequenzierung
EP4251750A1 (de) 2020-11-25 2023-10-04 Koninklijke Nederlandse Akademie van Wetenschappen Ribosomale profilierung in einzelzellen

Family Cites Families (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4675283A (en) * 1984-07-19 1987-06-23 Massachusetts Institute Of Technology Detection and isolation of homologous, repeated and amplified nucleic acid sequences
US4683202A (en) * 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
EP0224126A3 (de) 1985-11-25 1989-02-01 The University of Calgary Kovalent gekoppelte komplementäre Oligodeoxynukleotide zur Verwendung als "Primer Linkers" bei Sequenzierung von Nukleinsäuren
US4800159A (en) 1986-02-07 1989-01-24 Cetus Corporation Process for amplifying, detecting, and/or cloning nucleic acid sequences
US5093245A (en) 1988-01-26 1992-03-03 Applied Biosystems Labeling by simultaneous ligation and restriction
US5027877A (en) * 1988-04-14 1991-07-02 Bridgestone Corporation Off-the-road heavy duty pneumatic radial tire
US6107023A (en) 1988-06-17 2000-08-22 Genelabs Technologies, Inc. DNA amplification and subtraction techniques
US5512439A (en) 1988-11-21 1996-04-30 Dynal As Oligonucleotide-linked magnetic particles and uses thereof
US5508178A (en) 1989-01-19 1996-04-16 Rose; Samuel Nucleic acid amplification using single primer
CA2008096A1 (en) 1989-01-19 1990-07-19 Samuel Rose Nucleic acid amplification using single primer
JPH04504356A (ja) 1989-01-31 1992-08-06 ユニバーシティ オブ マイアミ 染色体ｄｎａの顕微解剖と増幅
CA2067363A1 (en) 1989-10-16 1991-04-17 Michael Lovett Non-specific dna amplification
CA2036946C (en) 1990-04-06 2001-10-16 Kenneth V. Deugau Indexing linkers
WO1992007095A1 (en) 1990-10-15 1992-04-30 Stratagene Arbitrarily primed polymerase chain reaction method for fingerprinting genomes
WO1993006239A1 (en) 1991-09-24 1993-04-01 Keygene N.V. Selective restriction fragment amplification: a general method for dna fingerprinting
WO1993014217A1 (en) * 1992-01-10 1993-07-22 Life Technologies, Inc. Use of predetermined nucleotides having altered base pairing characteristics in the amplification of nucleic acid molecules
AU3728093A (en) * 1992-02-19 1993-09-13 Public Health Research Institute Of The City Of New York, Inc., The Novel oligonucleotide arrays and their use for sorting, isolating, sequencing, and manipulating nucleic acids
WO1993022457A1 (en) * 1992-04-24 1993-11-11 Massachusetts Institute Of Technology Screening for genetic variation
US5436142A (en) 1992-11-12 1995-07-25 Cold Spring Harbor Laboratory Methods for producing probes capable of distingushing variant genomic sequences
US6277606B1 (en) 1993-11-09 2001-08-21 Cold Spring Harbor Laboratory Representational approach to DNA analysis
US5650274A (en) * 1993-06-25 1997-07-22 Hitachi, Ltd. DNA analyzing method
US5837832A (en) * 1993-06-25 1998-11-17 Affymetrix, Inc. Arrays of nucleic acid probes on biological chips
US5759922A (en) * 1993-08-25 1998-06-02 Micron Technology, Inc. Control of etch profiles during extended overetch
JPH09507121A (ja) * 1993-10-26 1997-07-22 アフィマックス テクノロジーズ ナームロゼ ベノートスハップ 生物学的チップ上の核酸プローブアレー
US6207373B1 (en) 1998-02-25 2001-03-27 Nanogen, Inc. Methods for determining nature of repeat units in DNA
US6027877A (en) 1993-11-04 2000-02-22 Gene Check, Inc. Use of immobilized mismatch binding protein for detection of mutations and polymorphisms, purification of amplified DNA samples and allele identification
AU2187295A (en) 1994-03-18 1995-10-09 General Hospital Corporation, The Cleaved amplified rflp detection methods
US5851770A (en) 1994-04-25 1998-12-22 Variagenics, Inc. Detection of mismatches by resolvase cleavage using a magnetic bead support
AU2907695A (en) * 1994-08-08 1996-03-07 Wisconsin Alumni Research Foundation Purification and pharmaceutical compositions containing type g botulinum neurotoxin
US5710000A (en) * 1994-09-16 1998-01-20 Affymetrix, Inc. Capturing sequences adjacent to Type-IIs restriction sites for genomic library mapping
US6013445A (en) 1996-06-06 2000-01-11 Lynx Therapeutics, Inc. Massively parallel signature sequencing by ligation of encoded adaptors
US5565340A (en) 1995-01-27 1996-10-15 Clontech Laboratories, Inc. Method for suppressing DNA fragment amplification during PCR
EP0735144B1 (de) * 1995-03-28 2002-06-05 Japan Science and Technology Corporation Verfahren zur molekularen Indexierung von Genen unter Verwendung von Restriktionsenzymen
US5972693A (en) * 1995-10-24 1999-10-26 Curagen Corporation Apparatus for identifying, classifying, or quantifying DNA sequences in a sample without sequencing
DE69530215T2 (de) * 1995-12-12 2003-11-13 Nestle Sa Speiseeis
US5712127A (en) 1996-04-29 1998-01-27 Genescape Inc. Subtractive amplification
DE19620874A1 (de) * 1996-05-23 1997-11-27 Bmw Rolls Royce Gmbh Kraftstoffeinspritzung für eine gestufte Gasturbinen-Brennkammer
US5763239A (en) 1996-06-18 1998-06-09 Diversa Corporation Production and use of normalized DNA libraries
EP0941366A2 (de) 1996-11-06 1999-09-15 Whitehead Institute For Biomedical Research Biallelische marker
US6060245A (en) 1996-12-13 2000-05-09 Stratagene Methods and adaptors for generating specific nucleic acid populations
US6060240A (en) 1996-12-13 2000-05-09 Arcaris, Inc. Methods for measuring relative amounts of nucleic acids in a complex mixture and retrieval of specific sequences therefrom
US6100030A (en) 1997-01-10 2000-08-08 Pioneer Hi-Bred International, Inc. Use of selective DNA fragment amplification products for hybridization-based genetic fingerprinting, marker assisted selection, and high-throughput screening
US6027945A (en) 1997-01-21 2000-02-22 Promega Corporation Methods of isolating biological target materials using silica magnetic particles
EP0972078B1 (de) 1997-03-20 2005-06-01 Affymetrix, Inc. (a California Corporation) Iterative resequenzierung
DE69833758T2 (de) * 1997-06-13 2006-08-31 Affymetrix, Inc. (n.d.Ges.d.Staates Delaware), Santa Clara Verfahren zur erkennung von genpolymorphismen und allelexpression unter verwendung von sondenchips
ATE537270T1 (de) * 1997-10-30 2011-12-15 Cold Spring Harbor Lab Sondenanordnungen und deren verwendungen für verfahren zur dns-unterscheidung
US6033861A (en) 1997-11-19 2000-03-07 Incyte Genetics, Inc. Methods for obtaining nucleic acid containing a mutation
WO1999036571A2 (en) * 1998-01-13 1999-07-22 Biochip Technologies Gmbh Method for the detection or nucleic acid of nucleic acid sequences
US6306643B1 (en) * 1998-08-24 2001-10-23 Affymetrix, Inc. Methods of using an array of pooled probes in genetic analysis
US6703228B1 (en) * 1998-09-25 2004-03-09 Massachusetts Institute Of Technology Methods and products related to genotyping and DNA analysis
EP1001037A3 (de) 1998-09-28 2003-10-01 Whitehead Institute For Biomedical Research Vorselektion und Isolierung eines Einzelnukleotidpolymorphismus
US6509180B1 (en) * 1999-03-11 2003-01-21 Zeachem Inc. Process for producing ethanol
US6906643B2 (en) * 2003-04-30 2005-06-14 Hewlett-Packard Development Company, L.P. Systems and methods of viewing, modifying, and interacting with “path-enhanced” multimedia

Also Published As

Publication number Publication date
DE69929542D1 (de) 2006-04-06
JP2002528096A (ja) 2002-09-03
EP1124990A1 (de) 2001-08-22
EP1124990A4 (de) 2003-03-12
US20060063158A1 (en) 2006-03-23
DE69929542T2 (de) 2006-09-14
WO2000024939A1 (en) 2000-05-04
CA2345441A1 (en) 2000-05-04
EP1124990B1 (de) 2006-01-18
US7267966B2 (en) 2007-09-11
US20020142314A1 (en) 2002-10-03
AU2144000A (en) 2000-05-15
US6361947B1 (en) 2002-03-26

Similar Documents

Publication Publication Date Title
ATE316152T1 (de) Komplexitätsmanagement und analyse genomischer dna
Yong et al. Profiling genome-wide DNA methylation
Gouil et al. Latest techniques to study DNA methylation
Karemaker et al. Single-cell DNA methylation profiling: technologies and biological applications
Madi et al. The determination of tissue‐specific DNA methylation patterns in forensic biofluids using bisulfite modification and pyrosequencing
Booth et al. Oxidative bisulfite sequencing of 5-methylcytosine and 5-hydroxymethylcytosine
Garrett-Bakelman et al. Enhanced reduced representation bisulfite sequencing for assessment of DNA methylation at base pair resolution
Kantlehner et al. A high-throughput DNA methylation analysis of a single cell
Oyola et al. Efficient depletion of host DNA contamination in malaria clinical sequencing
WO2003010328A3 (en) Complexity management of genomic dna
EP1362929A3 (de) Methoden zur Genotypisierung
US20110237444A1 (en) Methods of mapping genomic methylation patterns
EP1102864A4 (de) Gel mikrotropfen für die genetische analyse
DE60045796D1 (de) Gesamt-chromosom analyse von protein-dns wechselwirkungen
WO2002086163A8 (en) Methods for high throughput genome analysis using restriction site tagged microarrays
DK1034309T3 (da) Fremgangsmåde til fremstilling af komplekse DNA-methylerings-fingeraftryk
WO2003100012A3 (en) Microarrays and method for running hybridization reaction for multiple samples on a single microarray
Lao et al. mRNA-sequencing whole transcriptome analysis of a single cell on the Solid™ system
Balamurugan et al. Identification of spermatozoa by tissue‐specific differential DNA methylation using bisulfite modification and pyrosequencing
Green et al. Developmental validation of VeriFiler™ Plus PCR Amplification Kit: A 6-dye multiplex assay designed for casework samples
GB2384206A (en) Automated system for two-dimensional electrophoresis
Thomson et al. DNA immunoprecipitation semiconductor sequencing (DIP-SC-seq) as a rapid method to generate genome wide epigenetic signatures
WO2011063210A2 (en) Methods of mapping genomic methylation patterns
BR9914262A (pt) Método para analisar polinucleotìdeos
WO2001026029A3 (en) Method and system for providing genotype clinical information over a computer network

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties