DE69929542D1 - Komplexitätsmanagement und analyse genomischer dna - Google Patents

Komplexitätsmanagement und analyse genomischer dna

Info

Publication number
DE69929542D1
DE69929542D1 DE69929542T DE69929542T DE69929542D1 DE 69929542 D1 DE69929542 D1 DE 69929542D1 DE 69929542 T DE69929542 T DE 69929542T DE 69929542 T DE69929542 T DE 69929542T DE 69929542 D1 DE69929542 D1 DE 69929542D1
Authority
DE
Germany
Prior art keywords
analysis
genomic dna
sample
invention further
further provides
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69929542T
Other languages
English (en)
Other versions
DE69929542T2 (de
Inventor
Shoulian Dong
J Lipshutz
J Lockhart
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Affymetrix Inc
Original Assignee
Affymetrix Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Affymetrix Inc filed Critical Affymetrix Inc
Application granted granted Critical
Publication of DE69929542D1 publication Critical patent/DE69929542D1/de
Publication of DE69929542T2 publication Critical patent/DE69929542T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813Hybridisation assays
    • C12Q1/6834Enzymatic or biochemical coupling of nucleic acids to a solid phase
    • C12Q1/6837Enzymatic or biochemical coupling of nucleic acids to a solid phase using probe arrays or probe chips
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844Nucleic acid amplification reactions
    • C12Q1/6853Nucleic acid amplification reactions using modified primers or templates
    • C12Q1/6855Ligating adaptors
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844Nucleic acid amplification reactions
    • C12Q1/6858Allele-specific amplification
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/156Polymorphic or mutational markers
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00Nanotechnology
    • Y10S977/902Specified use of nanostructure
    • Y10S977/904Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
    • Y10S977/924Specified use of nanostructure for medical, immunological, body treatment, or diagnosis using nanostructure as support of dna analysis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
DE69929542T 1998-10-27 1999-10-27 Komplexitätsmanagement und analyse genomischer dna Expired - Lifetime DE69929542T2 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US10586798P 1998-10-27 1998-10-27
US105867P 1998-10-27
US13612599P 1999-05-26 1999-05-26
US136125P 1999-05-26
PCT/US1999/025200 WO2000024939A1 (en) 1998-10-27 1999-10-27 Complexity management and analysis of genomic dna

Publications (2)

Publication Number Publication Date
DE69929542D1 true DE69929542D1 (de) 2006-04-06
DE69929542T2 DE69929542T2 (de) 2006-09-14

Family

ID=26803034

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69929542T Expired - Lifetime DE69929542T2 (de) 1998-10-27 1999-10-27 Komplexitätsmanagement und analyse genomischer dna

Country Status (8)

Country Link
US (3) US6361947B1 (de)
EP (1) EP1124990B1 (de)
JP (1) JP2002528096A (de)
AT (1) ATE316152T1 (de)
AU (1) AU2144000A (de)
CA (1) CA2345441A1 (de)
DE (1) DE69929542T2 (de)
WO (1) WO2000024939A1 (de)

Families Citing this family (179)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6974666B1 (en) * 1994-10-21 2005-12-13 Appymetric, Inc. Methods of enzymatic discrimination enhancement and surface-bound double-stranded DNA
AU753505B2 (en) 1997-10-30 2002-10-17 Cold Spring Harbor Laboratory Probe arrays and methods of using probe arrays for distinguishing DNA
US6703228B1 (en) * 1998-09-25 2004-03-09 Massachusetts Institute Of Technology Methods and products related to genotyping and DNA analysis
WO2000050632A2 (en) * 1999-02-22 2000-08-31 Lynx Therapeutics, Inc. Polymorphic dna fragments and uses thereof
US20060275782A1 (en) 1999-04-20 2006-12-07 Illumina, Inc. Detection of nucleic acid reactions on bead arrays
US20020119448A1 (en) * 1999-06-23 2002-08-29 Joseph A. Sorge Methods of enriching for and identifying polymorphisms
US6958225B2 (en) 1999-10-27 2005-10-25 Affymetrix, Inc. Complexity management of genomic DNA
EP1276900A2 (de) * 2000-01-11 2003-01-22 Maxygen, Inc. Integrierte systeme und verfahren zur generierung und screening der diversität
US20040014056A1 (en) * 2000-05-02 2004-01-22 Jorg Hager Identification of genetic markers
US20020164634A1 (en) * 2000-08-26 2002-11-07 Perlegen Sciences, Inc. Methods for reducing complexity of nucleic acid samples
US20020055112A1 (en) * 2000-08-26 2002-05-09 Nila Patil Methods for reducing complexity of nucleic acid samples
US20020137043A1 (en) * 2000-08-26 2002-09-26 Nila Patil Method for reducing complexity of nucleic acid samples
AR031640A1 (es) * 2000-12-08 2003-09-24 Applied Research Systems Amplificacion isotermica de acidos nucleicos en un soporte solido
WO2002061145A2 (en) * 2001-01-31 2002-08-08 Ambion, Inc. Competitive amplification of fractionated targets from multiple nucleic acid samples
US7138506B2 (en) * 2001-05-09 2006-11-21 Genetic Id, Na, Inc. Universal microarray system
US20030009294A1 (en) * 2001-06-07 2003-01-09 Jill Cheng Integrated system for gene expression analysis
US7297778B2 (en) * 2001-07-25 2007-11-20 Affymetrix, Inc. Complexity management of genomic DNA
US6872529B2 (en) * 2001-07-25 2005-03-29 Affymetrix, Inc. Complexity management of genomic DNA
AU2002357249A1 (en) * 2001-12-13 2003-07-09 Blue Heron Biotechnology, Inc. Methods for removal of double-stranded oligonucleotides containing sequence errors using mismatch recognition proteins
JP2005513457A (ja) * 2001-12-19 2005-05-12 アフィメトリックス インコーポレイテッド アレイプレートおよびアレイプレートを構築するための方法
DE10208333A1 (de) * 2002-02-27 2003-09-04 Axaron Bioscience Ag Analyse von Nukleinsäure-Fragmentmischungen
AU2003220254B2 (en) 2002-03-13 2008-09-18 Syngenta Participations, Ag. Nucleic acid detection method
US20070065816A1 (en) * 2002-05-17 2007-03-22 Affymetrix, Inc. Methods for genotyping
US20040072217A1 (en) * 2002-06-17 2004-04-15 Affymetrix, Inc. Methods of analysis of linkage disequilibrium
US7097976B2 (en) 2002-06-17 2006-08-29 Affymetrix, Inc. Methods of analysis of allelic imbalance
US7108976B2 (en) * 2002-06-17 2006-09-19 Affymetrix, Inc. Complexity management of genomic DNA by locus specific amplification
US9388459B2 (en) 2002-06-17 2016-07-12 Affymetrix, Inc. Methods for genotyping
US7504215B2 (en) 2002-07-12 2009-03-17 Affymetrix, Inc. Nucleic acid labeling methods
US7482170B2 (en) * 2002-09-30 2009-01-27 Roche Nimblegen, Inc. Parallel loading of arrays
JP2006500954A (ja) * 2002-10-01 2006-01-12 ニンブルゲン システムズ インコーポレイテッド 単一のアレイ特徴部に複数のオリゴヌクレオチドを有するマイクロアレイ
US7459273B2 (en) * 2002-10-04 2008-12-02 Affymetrix, Inc. Methods for genotyping selected polymorphism
DE10246824A1 (de) * 2002-10-08 2004-04-22 Axaron Bioscience Ag Hybridisierungsproben reduzierter Komplexität
ATE399882T1 (de) * 2002-11-07 2008-07-15 Yoichi Matsubara Verfahren zum genmutationsnachweis
WO2004067708A2 (en) * 2003-01-17 2004-08-12 Sri International Et Al. Device and method for fragmenting material by hydrodynamic shear
EP1590485A2 (de) * 2003-01-30 2005-11-02 Applera Corporation Genetische polymorphismen, welche mit rheumatoid arthritis assoziiert sind, ihrer verwendungen, und verfahren zu ihren nachweis
US20090124514A1 (en) * 2003-02-26 2009-05-14 Perlegen Sciences, Inc. Selection probe amplification
US20040259125A1 (en) * 2003-02-26 2004-12-23 Omni Genetics, Inc. Methods, systems and apparatus for identifying genetic differences in disease and drug response
US20060183132A1 (en) * 2005-02-14 2006-08-17 Perlegen Sciences, Inc. Selection probe amplification
JP2009521904A (ja) * 2003-03-10 2009-06-11 アプレラ コーポレイション 狭窄に関連する一塩基多型、その検出方法および使用
WO2004081187A2 (en) * 2003-03-10 2004-09-23 Applera Corporation Genetic polymorphisms associated with myocardial infarction, methods of detection and uses thereof
WO2004083403A2 (en) * 2003-03-18 2004-09-30 Applera Corporation Genetic polymorphisms associated with rheumatoid arthritis, methods of detection and uses thereof
EP1613776A1 (de) * 2003-04-02 2006-01-11 Blue Heron Biotechnology, Inc. Fehlerreduktion bei der automatisierten gensynthese
AU2004280531B2 (en) 2003-05-23 2010-03-25 Cold Spring Harbor Laboratory Counting exact word matches in genomes
EP3305919A1 (de) 2003-06-10 2018-04-11 The Trustees of Boston University Nachweismethoden für lungenerkrankungen
US20050181394A1 (en) * 2003-06-20 2005-08-18 Illumina, Inc. Methods and compositions for whole genome amplification and genotyping
US20040259100A1 (en) * 2003-06-20 2004-12-23 Illumina, Inc. Methods and compositions for whole genome amplification and genotyping
WO2005003304A2 (en) * 2003-06-20 2005-01-13 Illumina, Inc. Methods and compositions for whole genome amplification and genotyping
US20050032102A1 (en) * 2003-07-22 2005-02-10 Affymetrix, Inc. Mapping genomic rearrangements
US8114978B2 (en) * 2003-08-05 2012-02-14 Affymetrix, Inc. Methods for genotyping selected polymorphism
US20050100911A1 (en) * 2003-08-06 2005-05-12 Perlegen Sciences, Inc. Methods for enriching populations of nucleic acid samples
EP3246093A1 (de) 2003-10-24 2017-11-22 Aushon Biosystems, Inc. Vorrichtung und verfahren zur ausgabe von flüssigen, halbflüssigen und festen proben
JP4790621B2 (ja) 2003-11-26 2011-10-12 アドバンディーエックス, インコーポレイテッド 特定のStaphylococcus種の分析のためのペプチド核酸プローブ
US20050233354A1 (en) * 2004-01-22 2005-10-20 Affymetrix, Inc. Genotyping degraded or mitochandrial DNA samples
EP1564306B1 (de) 2004-02-17 2013-08-07 Affymetrix, Inc. Verfahren zur Fragmentierung und Markierung von DNS
SE0401270D0 (sv) * 2004-05-18 2004-05-18 Fredrik Dahl Method for amplifying specific nucleic acids in parallel
EP2290074B1 (de) 2004-05-28 2014-12-17 Asuragen, Inc. Verfahren und Zusammensetzungen mit MicroRNA
EP1623996A1 (de) * 2004-08-06 2006-02-08 Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts Verbessertes Verfahren zur Auswahl eines Proteins von einer Bibliothek
US20060073506A1 (en) 2004-09-17 2006-04-06 Affymetrix, Inc. Methods for identifying biological samples
US20060073511A1 (en) 2004-10-05 2006-04-06 Affymetrix, Inc. Methods for amplifying and analyzing nucleic acids
US7682782B2 (en) 2004-10-29 2010-03-23 Affymetrix, Inc. System, method, and product for multiple wavelength detection using single source excitation
JP2006126204A (ja) 2004-10-29 2006-05-18 Affymetrix Inc ポリマーアレイを製造するための自動化方法
EP2287303B1 (de) 2004-11-12 2014-07-02 Asuragen, Inc. Verfahren und Zusammensetzungen, die miRNAs und miRNA-inhibitorischen Molekülen verbunden sind
US20060166224A1 (en) * 2005-01-24 2006-07-27 Norviel Vernon A Associations using genotypes and phenotypes
EP2360279A1 (de) 2005-04-14 2011-08-24 Trustees Of Boston University Diagnose für Lungenerkrankungen mittels Klassenvorhersage
US20060286571A1 (en) 2005-04-28 2006-12-21 Prometheus Laboratories, Inc. Methods of predicting methotrexate efficacy and toxicity
US7452671B2 (en) * 2005-04-29 2008-11-18 Affymetrix, Inc. Methods for genotyping with selective adaptor ligation
US20090142758A1 (en) * 2005-06-23 2009-06-04 Keygene N V Strategies for sequencing complex genomes using high throughput sequencing technologies
ES2387878T3 (es) * 2005-06-23 2012-10-03 Keygene N.V. Estrategias para la identificación de alto rendimiento y la detección de polimorfismos
EP1907577A4 (de) * 2005-06-30 2009-05-13 Syngenta Participations Ag Verfahren zum screening auf genspezifische hybridisierungspolymorphismen (gshp) und deren verwendung bei der genetischen kartierung und markerentwicklung
US20070003938A1 (en) * 2005-06-30 2007-01-04 Perlegen Sciences, Inc. Hybridization of genomic nucleic acid without complexity reduction
GB0514910D0 (en) * 2005-07-20 2005-08-24 Solexa Ltd Method for sequencing a polynucleotide template
GB0514935D0 (en) 2005-07-20 2005-08-24 Solexa Ltd Methods for sequencing a polynucleotide template
ATE453728T1 (de) 2005-09-29 2010-01-15 Keygene Nv Screening mutagenisierter populationen mit hohem durchsatz
US10316364B2 (en) 2005-09-29 2019-06-11 Keygene N.V. Method for identifying the source of an amplicon
GB0522310D0 (en) 2005-11-01 2005-12-07 Solexa Ltd Methods of preparing libraries of template polynucleotides
GB0524069D0 (en) * 2005-11-25 2006-01-04 Solexa Ltd Preparation of templates for solid phase amplification
US7634363B2 (en) * 2005-12-07 2009-12-15 Affymetrix, Inc. Methods for high throughput genotyping
US11306351B2 (en) 2005-12-21 2022-04-19 Affymetrix, Inc. Methods for genotyping
JP5452021B2 (ja) 2005-12-22 2014-03-26 キージーン ナムローゼ フェンノートシャップ ハイスループットaflp系多型検出法
CN101415839B (zh) 2006-02-08 2012-06-27 亿明达剑桥有限公司 对多核苷酸模板进行测序的方法
EP2605018A1 (de) 2006-03-09 2013-06-19 The Trustees of the Boston University Diagnose- und Prognoseverfahren für Lungenerkrankungen mittels Genexpressionsprofilen aus Nasenepithelzellen
US9423397B2 (en) 2006-03-10 2016-08-23 Indx Lifecare, Inc. Waveguide-based detection system with scanning light source
US7951583B2 (en) * 2006-03-10 2011-05-31 Plc Diagnostics, Inc. Optical scanning system
US8288157B2 (en) * 2007-09-12 2012-10-16 Plc Diagnostics, Inc. Waveguide-based optical scanning systems
US9976192B2 (en) 2006-03-10 2018-05-22 Ldip, Llc Waveguide-based detection system with scanning light source
US9528939B2 (en) 2006-03-10 2016-12-27 Indx Lifecare, Inc. Waveguide-based optical scanning systems
US20080009420A1 (en) * 2006-03-17 2008-01-10 Schroth Gary P Isothermal methods for creating clonal single molecule arrays
PT2963127T (pt) 2006-04-04 2017-10-06 Keygene Nv Detecção de alto rendimento de marcadores moleculares com base em fragmentos de restrição
EP2049682A2 (de) * 2006-07-31 2009-04-22 Illumina Cambridge Limited Verfahren zur herstellung von bibliotheken unter vermeidung der bildung von adaptordimeren
EP2520935A3 (de) 2006-08-09 2013-02-13 Homestead Clinical Corporation Organspezifische Proteine und Verfahren zu deren Verwendung
US7754429B2 (en) * 2006-10-06 2010-07-13 Illumina Cambridge Limited Method for pair-wise sequencing a plurity of target polynucleotides
US9845494B2 (en) 2006-10-18 2017-12-19 Affymetrix, Inc. Enzymatic methods for genotyping on arrays
US8026065B2 (en) 2006-11-02 2011-09-27 Yale University Assessment of oocyte competence
US8293684B2 (en) * 2006-11-29 2012-10-23 Exiqon Locked nucleic acid reagents for labelling nucleic acids
WO2008093098A2 (en) * 2007-02-02 2008-08-07 Illumina Cambridge Limited Methods for indexing samples and sequencing multiple nucleotide templates
JP2010527241A (ja) * 2007-05-14 2010-08-12 インサイト ジェネティクス, インコーポレイテッド 単一のヌクレオチドバリエーションについての核酸をスクリーニングする方法
US8200440B2 (en) 2007-05-18 2012-06-12 Affymetrix, Inc. System, method, and computer software product for genotype determination using probe array data
US20080293589A1 (en) * 2007-05-24 2008-11-27 Affymetrix, Inc. Multiplex locus specific amplification
CN102083575B (zh) * 2007-06-25 2014-09-17 阿费梅特里克斯公司 刻印的微码
EP2173909A1 (de) * 2007-07-26 2010-04-14 Roche Diagnostics GmbH Targetvorbereitung zur parallelen sequenzierung komplexer genome
US20090093378A1 (en) * 2007-08-29 2009-04-09 Helen Bignell Method for sequencing a polynucleotide template
US8716190B2 (en) 2007-09-14 2014-05-06 Affymetrix, Inc. Amplification and analysis of selected targets on solid supports
US9388457B2 (en) 2007-09-14 2016-07-12 Affymetrix, Inc. Locus specific amplification using array probes
EP2198050A1 (de) 2007-09-14 2010-06-23 Asuragen, INC. Mikrornas mit unterschiedlicher expression bei zervikalkarzinom und verwendungen davon
WO2009040682A2 (en) * 2007-09-26 2009-04-02 Population Genetics Technologies Ltd. Methods and compositions for reducing the complexity of a nucleic acid sample
JP5683964B2 (ja) 2008-03-11 2015-03-11 ナショナル キャンサー センター Snpアレイを用いた染色体、遺伝子または特定ヌクレオチド配列のコピー数測定方法
US9074244B2 (en) 2008-03-11 2015-07-07 Affymetrix, Inc. Array-based translocation and rearrangement assays
US8258111B2 (en) 2008-05-08 2012-09-04 The Johns Hopkins University Compositions and methods related to miRNA modulation of neovascularization or angiogenesis
GB2461026B (en) * 2008-06-16 2011-03-09 Plc Diagnostics Inc System and method for nucleic acids sequencing by phased synthesis
US8309306B2 (en) * 2008-11-12 2012-11-13 Nodality, Inc. Detection composition
WO2010082815A1 (en) 2009-01-13 2010-07-22 Keygene N.V. Novel genome sequencing strategies
EP3301446B1 (de) 2009-02-11 2020-04-15 Caris MPI, Inc. Molekulare profilierung von tumoren
ES2742251T3 (es) 2009-03-16 2020-02-13 Pangu Biopharma Ltd Composiciones y procedimientos que comprenden variantes de splicing de histidil-tarn sintetasa que tienen actividades biológicas no canónicas
CA2757289A1 (en) 2009-03-31 2010-10-21 Atyr Pharma, Inc. Compositions and methods comprising aspartyl-trna synthetases having non-canonical biological activities
WO2010127001A1 (en) * 2009-04-29 2010-11-04 Plc Diagnostics Inc. Waveguide-based detection system with scanning light source
EP2248914A1 (de) * 2009-05-05 2010-11-10 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Die Verwendung von IIB-Restriktionsendonukleasen in Sequenzierungsanwendungen der zweiten Generation
GB0912909D0 (en) * 2009-07-23 2009-08-26 Olink Genomics Ab Probes for specific analysis of nucleic acids
US8445201B2 (en) * 2009-07-31 2013-05-21 Affymetrix, Inc. Hybridization device, methods, and system using mixing beads
US20110059453A1 (en) * 2009-08-23 2011-03-10 Affymetrix, Inc. Poly(A) Tail Length Measurement by PCR
HUE030765T2 (en) 2009-08-25 2017-05-29 Illumina Inc A method for selecting and amplifying polynucleotides
US10174368B2 (en) 2009-09-10 2019-01-08 Centrillion Technology Holdings Corporation Methods and systems for sequencing long nucleic acids
CN102858995B (zh) 2009-09-10 2016-10-26 森特瑞隆技术控股公司 靶向测序方法
US20160186266A1 (en) 2009-10-27 2016-06-30 Carislife Sciences, Inc. Molecular profiling for personalized medicine
US8501122B2 (en) 2009-12-08 2013-08-06 Affymetrix, Inc. Manufacturing and processing polymer arrays
WO2011071382A1 (en) 2009-12-10 2011-06-16 Keygene N.V. Polymorfphic whole genome profiling
JP5799484B2 (ja) * 2009-12-14 2015-10-28 トヨタ自動車株式会社 Dnaマイクロアレイにおけるプローブ設計方法、当該方法により設計されたプローブを有するdnaマイクロアレイ
US8835358B2 (en) 2009-12-15 2014-09-16 Cellular Research, Inc. Digital counting of individual molecules by stochastic attachment of diverse labels
CA2783548A1 (en) 2009-12-17 2011-06-23 Keygene N.V. Restriction enzyme based whole genome sequencing
GB0922377D0 (en) 2009-12-22 2010-02-03 Arab Gulf University The Mutant LDL receptor
AU2011248625B2 (en) 2010-04-26 2017-01-05 Pangu Biopharma Limited Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of cysteinyl-tRNA synthetase
JP6294074B2 (ja) 2010-04-27 2018-03-14 エータイアー ファーマ, インコーポレイテッド イソロイシルtRNA合成酵素のタンパク質フラグメントに関連した治療用、診断用および抗体組成物の革新的発見
EP2563911B1 (de) 2010-04-28 2021-07-21 aTyr Pharma, Inc. Innovative entdeckung therapeutischer, diagnostischer und antikörperhaltiger zusammensetzungen im zusammenhang mit proteinfragmenten von alanyl-trna-synthetasen
WO2011139907A2 (en) 2010-04-29 2011-11-10 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of valyl trna synthetases
WO2011139854A2 (en) 2010-04-29 2011-11-10 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of asparaginyl trna synthetases
WO2011140135A2 (en) 2010-05-03 2011-11-10 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of methionyl-trna synthetases
WO2011139986A2 (en) 2010-05-03 2011-11-10 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of arginyl-trna synthetases
ES2623805T3 (es) 2010-05-03 2017-07-12 Atyr Pharma, Inc. Descubrimiento innovador de composiciones terapéuticas, de diagnóstico y de anticuerpos relacionadas con fragmentos de proteínas de fenilalanil-alfa-ARNt sintetasas
EP2566499B1 (de) 2010-05-04 2017-01-25 aTyr Pharma, Inc. Innovative entdeckung therapeutischer, diagnostischer und antikörperhaltiger zusammensetzungen im zusammenhang mit proteinfragmenten aus einem p38-multi-trna-synthetase-komplex
US8945541B2 (en) 2010-05-14 2015-02-03 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of phenylalanyl-beta-tRNA synthetases
JP6046607B2 (ja) 2010-05-27 2016-12-21 エータイアー ファーマ, インコーポレイテッド グルタミニルtRNA合成酵素のタンパク質フラグメントに関連した治療用、診断用および抗体組成物の革新的発見
JP5906237B2 (ja) 2010-06-01 2016-04-20 エータイアー ファーマ, インコーポレイテッド リジルtRNA合成酵素のタンパク質フラグメントに関連した治療用、診断用および抗体組成物の革新的発見
CA2804416C (en) 2010-07-12 2020-04-28 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of glycyl-trna synthetases
CN103108650A (zh) 2010-08-25 2013-05-15 Atyr医药公司 与酪氨酰-tRNA合成酶的蛋白片段相关的治疗、诊断和抗体组合物的创新发现
EP2619317B1 (de) * 2010-09-20 2020-09-02 Seegene, Inc. Nachweis von zielnukleinsäuresequenzen mittels exonukleolytischer wirkung anhand von immobilisierten single-labeled-sonden auf einer festphase
AU2012205884A1 (en) 2011-01-14 2013-08-29 Keygene N.V. Paired end random sequence based genotyping
CA2827200A1 (en) 2011-02-24 2012-08-30 Hill's Pet Nutrition, Inc. Compositions and methods for diagnosing and treating kidney disorders in a feline
US20120252682A1 (en) 2011-04-01 2012-10-04 Maples Corporate Services Limited Methods and systems for sequencing nucleic acids
EP2721175B1 (de) 2011-06-15 2015-09-16 Hill's Pet Nutrition, Inc. Zusammensetzungen und verfahren zur diagnose und überwachung von schilddrüsenüberfunktion bei der katze
CA2848304A1 (en) 2011-09-09 2013-03-14 The Board Of Trustees Of The Leland Stanford Junior University Methods for sequencing a polynucleotide
US9644241B2 (en) 2011-09-13 2017-05-09 Interpace Diagnostics, Llc Methods and compositions involving miR-135B for distinguishing pancreatic cancer from benign pancreatic disease
BR112014014907A2 (pt) 2011-12-19 2017-06-13 Hills Pet Nutrition Inc composições e métodos para diagnóstico e tratamento de hipertireoidismo em animais de companhia
EP2802666B1 (de) 2012-01-13 2018-09-19 Data2Bio Genotypisierung durch eine sequenzierung der nächsten generation
US9528107B2 (en) 2012-01-31 2016-12-27 Pacific Biosciences Of California, Inc. Compositions and methods for selection of nucleic acids
AU2013221317B2 (en) 2012-02-16 2017-07-06 Pangu Biopharma Limited Histidyl-tRNA synthetases for treating autoimmune and inflammatory diseases
ES2904816T3 (es) 2012-02-27 2022-04-06 Becton Dickinson Co Composiciones para recuento molecular
US11177020B2 (en) 2012-02-27 2021-11-16 The University Of North Carolina At Chapel Hill Methods and uses for molecular tags
WO2013142389A1 (en) 2012-03-20 2013-09-26 University Of Washington Through Its Center For Commercialization Methods of lowering the error rate of massively parallel dna sequencing using duplex consensus sequencing
WO2014085434A1 (en) 2012-11-27 2014-06-05 Pontificia Universidad Catolica De Chile Compositions and methods for diagnosing thyroid tumors
WO2014098773A1 (en) * 2012-12-21 2014-06-26 Nanyang Technological University Site-specific induction of bimolecular quadruplex-duplex hybrids and methods of using the same
US10107802B2 (en) * 2013-08-21 2018-10-23 Fujirebio Inc. Method for measuring modified nucleobase using solid phase probe, and kit for same
US10018566B2 (en) 2014-02-28 2018-07-10 Ldip, Llc Partially encapsulated waveguide based sensing chips, systems and methods of use
WO2016028887A1 (en) 2014-08-19 2016-02-25 Pacific Biosciences Of California, Inc. Compositions and methods for enrichment of nucleic acids
US10435685B2 (en) 2014-08-19 2019-10-08 Pacific Biosciences Of California, Inc. Compositions and methods for enrichment of nucleic acids
US11181479B2 (en) 2015-02-27 2021-11-23 Ldip, Llc Waveguide-based detection system with scanning light source
US20180305748A1 (en) 2015-10-18 2018-10-25 Affymetrix, Inc. Multiallelic Genotyping of Single Nucleotide Polymorphisms and Indels
ES2911421T3 (es) 2015-12-08 2022-05-19 Twinstrand Biosciences Inc Adaptadores, métodos y composiciones mejorados para secuenciación dúplex
SG11202003885UA (en) 2017-11-08 2020-05-28 Twinstrand Biosciences Inc Reagents and adapters for nucleic acid sequencing and methods for making such reagents and adapters
BR112021000409A2 (pt) 2018-07-12 2021-04-06 Twinstrand Biosciences, Inc. Métodos e reagentes para caracterizar edição genômica, expansão clonal e aplicações associadas
JP2022511633A (ja) 2018-11-28 2022-02-01 キージーン ナムローゼ フェンノートシャップ エンドヌクレアーゼ保護による標的化濃縮
CA3121170A1 (en) 2018-11-30 2020-06-04 Caris Mpi, Inc. Next-generation molecular profiling
CN113474466A (zh) 2019-02-21 2021-10-01 主基因有限公司 多倍体基因分型
JP2022529294A (ja) 2019-04-17 2022-06-20 アイジェノミクス、ソシエダッド、リミターダ 子宮平滑筋腫および平滑筋肉腫の早期診断のための改良方法
WO2021112918A1 (en) 2019-12-02 2021-06-10 Caris Mpi, Inc. Pan-cancer platinum response predictor
EP4073245A1 (de) 2019-12-12 2022-10-19 Keygene N.V. Halbfestkörper-nukleinsäuremanipulation
EP4077661A1 (de) 2019-12-20 2022-10-26 Keygene N.V. Herstellung von ngs-bibliotheken unter verwendung von kovalent verschlossenen nukleinsäuremolekül-enden.
EP4225914A1 (de) 2020-10-06 2023-08-16 Keygene N.V. Gezielte sequenzaddition
US20240002904A1 (en) 2020-11-24 2024-01-04 Keygene N.V. Targeted enrichment using nanopore selective sequencing
EP4251750A1 (de) 2020-11-25 2023-10-04 Koninklijke Nederlandse Akademie van Wetenschappen Ribosomale profilierung in einzelzellen
WO2024121354A1 (en) 2022-12-08 2024-06-13 Keygene N.V. Duplex sequencing with covalently closed dna ends

Family Cites Families (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4675283A (en) * 1984-07-19 1987-06-23 Massachusetts Institute Of Technology Detection and isolation of homologous, repeated and amplified nucleic acid sequences
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
EP0224126A3 (de) 1985-11-25 1989-02-01 The University of Calgary Kovalent gekoppelte komplementäre Oligodeoxynukleotide zur Verwendung als "Primer Linkers" bei Sequenzierung von Nukleinsäuren
US4800159A (en) 1986-02-07 1989-01-24 Cetus Corporation Process for amplifying, detecting, and/or cloning nucleic acid sequences
US5093245A (en) 1988-01-26 1992-03-03 Applied Biosystems Labeling by simultaneous ligation and restriction
US5027877A (en) * 1988-04-14 1991-07-02 Bridgestone Corporation Off-the-road heavy duty pneumatic radial tire
US6107023A (en) 1988-06-17 2000-08-22 Genelabs Technologies, Inc. DNA amplification and subtraction techniques
US5512439A (en) 1988-11-21 1996-04-30 Dynal As Oligonucleotide-linked magnetic particles and uses thereof
US5508178A (en) 1989-01-19 1996-04-16 Rose; Samuel Nucleic acid amplification using single primer
EP0379369B1 (de) 1989-01-19 1996-09-04 BEHRINGWERKE Aktiengesellschaft Nukleinsäure-Amplifikation unter Verwendung eines Einzelprimers
JPH04504356A (ja) 1989-01-31 1992-08-06 ユニバーシティ オブ マイアミ 染色体dnaの顕微解剖と増幅
WO1991005861A1 (en) 1989-10-16 1991-05-02 Genelabs Incorporated Non-specific dna amplification
CA2036946C (en) 1990-04-06 2001-10-16 Kenneth V. Deugau Indexing linkers
WO1992007095A1 (en) 1990-10-15 1992-04-30 Stratagene Arbitrarily primed polymerase chain reaction method for fingerprinting genomes
ZA927323B (en) 1991-09-24 1993-08-30 Keygene Nv Selective restriction fragment amplification: A general method for DNA fingerprinting
WO1993014217A1 (en) * 1992-01-10 1993-07-22 Life Technologies, Inc. Use of predetermined nucleotides having altered base pairing characteristics in the amplification of nucleic acid molecules
EP1382386A3 (de) 1992-02-19 2004-12-01 The Public Health Research Institute Of The City Of New York, Inc. Neue Ordnungen für Oligonukleotide und ihr Nutzen zum Sortieren, Isolieren, Sequenzierung und Manipulieren von Nukleinsäuren
WO1993022457A1 (en) * 1992-04-24 1993-11-11 Massachusetts Institute Of Technology Screening for genetic variation
US5436142A (en) 1992-11-12 1995-07-25 Cold Spring Harbor Laboratory Methods for producing probes capable of distingushing variant genomic sequences
US6277606B1 (en) 1993-11-09 2001-08-21 Cold Spring Harbor Laboratory Representational approach to DNA analysis
US5837832A (en) * 1993-06-25 1998-11-17 Affymetrix, Inc. Arrays of nucleic acid probes on biological chips
US5650274A (en) * 1993-06-25 1997-07-22 Hitachi, Ltd. DNA analyzing method
US5759922A (en) * 1993-08-25 1998-06-02 Micron Technology, Inc. Control of etch profiles during extended overetch
AU8126694A (en) * 1993-10-26 1995-05-22 Affymax Technologies N.V. Arrays of nucleic acid probes on biological chips
US6207373B1 (en) 1998-02-25 2001-03-27 Nanogen, Inc. Methods for determining nature of repeat units in DNA
US6027877A (en) 1993-11-04 2000-02-22 Gene Check, Inc. Use of immobilized mismatch binding protein for detection of mutations and polymorphisms, purification of amplified DNA samples and allele identification
EP0812211A4 (de) 1994-03-18 1998-12-16 Gen Hospital Corp Erkennungsverfahren durch rflp
US5851770A (en) 1994-04-25 1998-12-22 Variagenics, Inc. Detection of mismatches by resolvase cleavage using a magnetic bead support
AU2907695A (en) * 1994-08-08 1996-03-07 Wisconsin Alumni Research Foundation Purification and pharmaceutical compositions containing type g botulinum neurotoxin
US5710000A (en) * 1994-09-16 1998-01-20 Affymetrix, Inc. Capturing sequences adjacent to Type-IIs restriction sites for genomic library mapping
US6013445A (en) 1996-06-06 2000-01-11 Lynx Therapeutics, Inc. Massively parallel signature sequencing by ligation of encoded adaptors
US5565340A (en) 1995-01-27 1996-10-15 Clontech Laboratories, Inc. Method for suppressing DNA fragment amplification during PCR
US5707807A (en) * 1995-03-28 1998-01-13 Research Development Corporation Of Japan Molecular indexing for expressed gene analysis
US5972693A (en) * 1995-10-24 1999-10-26 Curagen Corporation Apparatus for identifying, classifying, or quantifying DNA sequences in a sample without sequencing
EP0779034B1 (de) * 1995-12-12 2003-04-02 Societe Des Produits Nestle S.A. Speiseeis
US5712127A (en) 1996-04-29 1998-01-27 Genescape Inc. Subtractive amplification
DE19620874A1 (de) * 1996-05-23 1997-11-27 Bmw Rolls Royce Gmbh Kraftstoffeinspritzung für eine gestufte Gasturbinen-Brennkammer
US5763239A (en) 1996-06-18 1998-06-09 Diversa Corporation Production and use of normalized DNA libraries
WO1998020165A2 (en) 1996-11-06 1998-05-14 Whitehead Institute For Biomedical Research Biallelic markers
US6060245A (en) 1996-12-13 2000-05-09 Stratagene Methods and adaptors for generating specific nucleic acid populations
US6060240A (en) 1996-12-13 2000-05-09 Arcaris, Inc. Methods for measuring relative amounts of nucleic acids in a complex mixture and retrieval of specific sequences therefrom
AU6024598A (en) 1997-01-10 1998-08-03 Pioneer Hi-Bred International, Inc. Hybridization-based genetic amplification and analysis
US6027945A (en) 1997-01-21 2000-02-22 Promega Corporation Methods of isolating biological target materials using silica magnetic particles
WO1998041657A1 (en) 1997-03-20 1998-09-24 Affymetrix, Inc. Iterative resequencing
JP3693352B2 (ja) 1997-06-13 2005-09-07 アフィメトリックス インコーポレイテッド プローブアレイを使用して、遺伝子多型性を検出し、対立遺伝子発現をモニターする方法
AU753505B2 (en) * 1997-10-30 2002-10-17 Cold Spring Harbor Laboratory Probe arrays and methods of using probe arrays for distinguishing DNA
US6033861A (en) 1997-11-19 2000-03-07 Incyte Genetics, Inc. Methods for obtaining nucleic acid containing a mutation
CA2318371A1 (en) * 1998-01-13 1999-07-22 Biochip Technologies Gmbh Method for the detection of nucleic acid sequences
US6306643B1 (en) 1998-08-24 2001-10-23 Affymetrix, Inc. Methods of using an array of pooled probes in genetic analysis
US6703228B1 (en) 1998-09-25 2004-03-09 Massachusetts Institute Of Technology Methods and products related to genotyping and DNA analysis
EP1001037A3 (de) 1998-09-28 2003-10-01 Whitehead Institute For Biomedical Research Vorselektion und Isolierung eines Einzelnukleotidpolymorphismus
PL207932B1 (pl) * 1999-03-11 2011-02-28 Zeachem Inc Sposób wytwarzania etanolu
US6906643B2 (en) * 2003-04-30 2005-06-14 Hewlett-Packard Development Company, L.P. Systems and methods of viewing, modifying, and interacting with “path-enhanced” multimedia

Also Published As

Publication number Publication date
DE69929542T2 (de) 2006-09-14
AU2144000A (en) 2000-05-15
US6361947B1 (en) 2002-03-26
WO2000024939A1 (en) 2000-05-04
EP1124990A4 (de) 2003-03-12
CA2345441A1 (en) 2000-05-04
EP1124990A1 (de) 2001-08-22
US20020142314A1 (en) 2002-10-03
US20060063158A1 (en) 2006-03-23
EP1124990B1 (de) 2006-01-18
JP2002528096A (ja) 2002-09-03
US7267966B2 (en) 2007-09-11
ATE316152T1 (de) 2006-02-15

Similar Documents

Publication Publication Date Title
DE69929542D1 (de) Komplexitätsmanagement und analyse genomischer dna
Yong et al. Profiling genome-wide DNA methylation
Karemaker et al. Single-cell DNA methylation profiling: technologies and biological applications
Madi et al. The determination of tissue‐specific DNA methylation patterns in forensic biofluids using bisulfite modification and pyrosequencing
Booth et al. Oxidative bisulfite sequencing of 5-methylcytosine and 5-hydroxymethylcytosine
Kantlehner et al. A high-throughput DNA methylation analysis of a single cell
Garrett-Bakelman et al. Enhanced reduced representation bisulfite sequencing for assessment of DNA methylation at base pair resolution
Poptsova et al. Non-random DNA fragmentation in next-generation sequencing
Oyola et al. Efficient depletion of host DNA contamination in malaria clinical sequencing
WO2003010328A3 (en) Complexity management of genomic dna
EP1362929A3 (de) Methoden zur Genotypisierung
US20110237444A1 (en) Methods of mapping genomic methylation patterns
EP1102864A4 (de) Gel mikrotropfen für die genetische analyse
DE60045796D1 (de) Gesamt-chromosom analyse von protein-dns wechselwirkungen
WO2002086163A8 (en) Methods for high throughput genome analysis using restriction site tagged microarrays
DK1034309T3 (da) Fremgangsmåde til fremstilling af komplekse DNA-methylerings-fingeraftryk
WO2003100012A3 (en) Microarrays and method for running hybridization reaction for multiple samples on a single microarray
Schneider Basic issues in forensic DNA typing
Balamurugan et al. Identification of spermatozoa by tissue‐specific differential DNA methylation using bisulfite modification and pyrosequencing
Green et al. Developmental validation of VeriFiler™ Plus PCR Amplification Kit: A 6-dye multiplex assay designed for casework samples
GB2384206A (en) Automated system for two-dimensional electrophoresis
Thomson et al. DNA immunoprecipitation semiconductor sequencing (DIP-SC-seq) as a rapid method to generate genome wide epigenetic signatures
WO2011063210A2 (en) Methods of mapping genomic methylation patterns
BR9914262A (pt) Método para analisar polinucleotìdeos
WO2001026029A3 (en) Method and system for providing genotype clinical information over a computer network

Legal Events

Date Code Title Description
8364 No opposition during term of opposition