HK1249142A1 - 測定dna甲基化的分析法和癌症的dna甲基化標記 - Google Patents

測定dna甲基化的分析法和癌症的dna甲基化標記

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Publication number
HK1249142A1
HK1249142A1 HK18108557.8A HK18108557A HK1249142A1 HK 1249142 A1 HK1249142 A1 HK 1249142A1 HK 18108557 A HK18108557 A HK 18108557A HK 1249142 A1 HK1249142 A1 HK 1249142A1
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HK
Hong Kong
Prior art keywords
dna methylation
assays
cancer
markers
methylation markers
Prior art date
Application number
HK18108557.8A
Other languages
English (en)
Inventor
Wei Guo
Paolo Piatti
Xiaojing Yang
Xi-Yu Jia
Original Assignee
Zymo Res Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=55650678&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HK1249142(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Zymo Res Corporation filed Critical Zymo Res Corporation
Publication of HK1249142A1 publication Critical patent/HK1249142A1/zh

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/6858—Allele-specific amplification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/6851—Quantitative amplification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2521/00—Reaction characterised by the enzymatic activity
    • C12Q2521/30—Phosphoric diester hydrolysing, i.e. nuclease
    • C12Q2521/331—Methylation site specific nuclease
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2523/00—Reactions characterised by treatment of reaction samples
    • C12Q2523/10—Characterised by chemical treatment
    • C12Q2523/125—Bisulfite(s)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2537/00—Reactions characterised by the reaction format or use of a specific feature
    • C12Q2537/10—Reactions characterised by the reaction format or use of a specific feature the purpose or use of
    • C12Q2537/143—Multiplexing, i.e. use of multiple primers or probes in a single reaction, usually for simultaneously analyse of multiple analysis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2545/00—Reactions characterised by their quantitative nature
    • C12Q2545/10—Reactions characterised by their quantitative nature the purpose being quantitative analysis
    • C12Q2545/101—Reactions characterised by their quantitative nature the purpose being quantitative analysis with an internal standard/control
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2561/00—Nucleic acid detection characterised by assay method
    • C12Q2561/113—Real time assay
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12Q2563/00—Nucleic acid detection characterized by the use of physical, structural and functional properties
    • C12Q2563/107—Nucleic acid detection characterized by the use of physical, structural and functional properties fluorescence
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/154—Methylation markers

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • General Chemical & Material Sciences (AREA)
HK18108557.8A 2015-02-24 2018-07-03 測定dna甲基化的分析法和癌症的dna甲基化標記 HK1249142A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562120373P 2015-02-24 2015-02-24
PCT/US2016/019310 WO2016138105A2 (en) 2015-02-24 2016-02-24 Assays to determine dna methylation and dna methylation markers of cancer

Publications (1)

Publication Number Publication Date
HK1249142A1 true HK1249142A1 (zh) 2018-10-26

Family

ID=55650678

Family Applications (1)

Application Number Title Priority Date Filing Date
HK18108557.8A HK1249142A1 (zh) 2015-02-24 2018-07-03 測定dna甲基化的分析法和癌症的dna甲基化標記

Country Status (5)

Country Link
US (2) US10801060B2 (zh)
EP (2) EP3262191B2 (zh)
CN (2) CN107592885B (zh)
HK (1) HK1249142A1 (zh)
WO (1) WO2016138105A2 (zh)

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CN106480210A (zh) * 2016-11-22 2017-03-08 敬善生物科技（上海）有限公司 一种肿瘤循环dna甲基化检测引物
AU2019253569A1 (en) * 2018-04-12 2020-10-29 Singlera Genomics, Inc. Compositions and methods for cancer or neoplasia assessment
CN111363812B (zh) * 2018-12-25 2023-12-19 广州康立明生物科技股份有限公司 基于dmrta2基因的肺癌诊断剂及试剂盒
WO2020180424A1 (en) 2019-03-04 2020-09-10 Iocurrents, Inc. Data compression and communication using machine learning
CN110387417A (zh) * 2019-06-06 2019-10-29 宽盈医疗科技(上海)有限公司 膀胱癌诊断系统、试剂组合和检测尿液中目的基因甲基化水平的方法
CN114929893A (zh) * 2019-06-24 2022-08-19 齐罗马科德公司 差异定量核酸的方法
CN110283889B (zh) * 2019-07-22 2020-10-13 中南大学 一种双基因监控反应体系、试剂盒及其应用
CN110628910B (zh) * 2019-10-17 2023-06-20 湖南大地同年生物科技有限公司 一种膀胱癌驱动基因点突变甲基化联合辅助诊断方法、试剂盒、系统及应用
CN110872631B (zh) * 2019-12-26 2021-08-10 广州市基准医疗有限责任公司 Dna甲基化生物标志物组合、检测方法和试剂盒
CN110923322B (zh) * 2019-12-26 2020-12-01 广州市基准医疗有限责任公司 膀胱癌相关的dna甲基化生物标志物组合和检测试剂盒
AU2021207992A1 (en) * 2020-01-17 2022-09-01 Nzumbe, Inc. Induction of DNA strand breaks at chromatin targets
CN112662765A (zh) * 2020-03-17 2021-04-16 博尔诚（北京）科技有限公司 一种检测6种中国高发癌症的探针组合物
CN111635938B (zh) * 2020-04-30 2022-07-29 广州康立明生物科技股份有限公司 一种肿瘤检测试剂及试剂盒
CN113528672B (zh) * 2021-09-14 2021-11-30 北京求臻医疗器械有限公司 用于膀胱癌早期筛查的引物和探针组合、试剂盒及应用
CN113667757B (zh) * 2021-10-20 2022-02-22 求臻医学科技（北京）有限公司 用于前列腺癌早期筛查的生物标志物组合、试剂盒及应用
CN114507719A (zh) * 2022-02-23 2022-05-17 厦门飞朔生物技术有限公司 一种针对dna甲基化监测的定量分析方法
WO2023175434A1 (en) * 2022-03-15 2023-09-21 Diagenode S.A. Detection of methylation status of a dna sample

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Also Published As

Publication number Publication date
EP3640341A2 (en) 2020-04-22
EP3640341A3 (en) 2020-08-05
CN107592885B (zh) 2021-04-30
US20210164031A1 (en) 2021-06-03
US20180148776A1 (en) 2018-05-31
US10801060B2 (en) 2020-10-13
EP3262191A2 (en) 2018-01-03
WO2016138105A3 (en) 2016-09-22
WO2016138105A2 (en) 2016-09-01
CN107592885A (zh) 2018-01-16
EP3262191B1 (en) 2019-08-07
EP3640341B1 (en) 2022-07-27
CN113186288A (zh) 2021-07-30
EP3262191B2 (en) 2023-06-14

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