NZ702458A - Benzo [c] isoxazoloazepine bromodomain inhibitors and uses thereof - Google Patents
Benzo [c] isoxazoloazepine bromodomain inhibitors and uses thereofInfo
- Publication number
- NZ702458A NZ702458A NZ702458A NZ70245813A NZ702458A NZ 702458 A NZ702458 A NZ 702458A NZ 702458 A NZ702458 A NZ 702458A NZ 70245813 A NZ70245813 A NZ 70245813A NZ 702458 A NZ702458 A NZ 702458A
- Authority
- NZ
- New Zealand
- Prior art keywords
- benzo
- bromodomain inhibitors
- compounds
- treatment
- present
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A61K31/424—Oxazoles condensed with heterocyclic ring systems, e.g. clavulanic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Oncology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Communicable Diseases (AREA)
- Transplantation (AREA)
- Hematology (AREA)
- Virology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261656205P | 2012-06-06 | 2012-06-06 | |
PCT/US2013/044444 WO2013184876A1 (en) | 2012-06-06 | 2013-06-06 | Benzo [c] isoxazoloazepine bromodomain inhibitors and uses thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
NZ702458A true NZ702458A (en) | 2016-11-25 |
Family
ID=48626693
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NZ702458A NZ702458A (en) | 2012-06-06 | 2013-06-06 | Benzo [c] isoxazoloazepine bromodomain inhibitors and uses thereof |
Country Status (19)
Country | Link |
---|---|
US (2) | US9493483B2 (OSRAM) |
EP (1) | EP2859000B1 (OSRAM) |
JP (1) | JP6154004B2 (OSRAM) |
KR (1) | KR20150023562A (OSRAM) |
CN (1) | CN104428304B (OSRAM) |
AR (1) | AR091285A1 (OSRAM) |
AU (1) | AU2013271569B2 (OSRAM) |
BR (1) | BR112014030165A2 (OSRAM) |
CA (1) | CA2874774C (OSRAM) |
EA (1) | EA026894B1 (OSRAM) |
ES (1) | ES2632774T3 (OSRAM) |
IL (1) | IL235844A (OSRAM) |
IN (1) | IN2014DN10386A (OSRAM) |
MX (1) | MX360598B (OSRAM) |
NZ (1) | NZ702458A (OSRAM) |
SG (1) | SG11201407900WA (OSRAM) |
TW (1) | TWI602820B (OSRAM) |
WO (1) | WO2013184876A1 (OSRAM) |
ZA (1) | ZA201408720B (OSRAM) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2018133139A1 (zh) | 2017-01-21 | 2018-07-26 | 宁波知明生物科技有限公司 | 芍药苷-6'-o-苯磺酸酯在治疗干燥综合征的应用 |
Families Citing this family (26)
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AR084070A1 (es) * | 2010-12-02 | 2013-04-17 | Constellation Pharmaceuticals Inc | Inhibidores del bromodominio y usos de los mismos |
TWI602820B (zh) | 2012-06-06 | 2017-10-21 | 星宿藥物公司 | 溴域抑制劑及其用途 |
EP2864336B1 (en) | 2012-06-06 | 2016-11-23 | Constellation Pharmaceuticals, Inc. | Benzo[b]isoxazoloazepine bromodomain inhibitors and uses thereof |
JP2016511247A (ja) | 2013-02-19 | 2016-04-14 | バイエル ファーマ アクチエンゲゼルシャフト | ビシクロ2,3−ベンゾジアゼピン類及びスピロ環式置換2,3−ベンゾジアゼピン類 |
CA2901805A1 (en) | 2013-02-22 | 2014-08-28 | Bayer Pharma Aktiengesellschaft | 4-substituted pyrrolo- and pyrazolo-diazepines |
WO2014128070A1 (de) | 2013-02-22 | 2014-08-28 | Bayer Pharma Aktiengesellschaft | Pyrrolo- und pyrazolo-triazolodiazepine als bet-proteininhibitoren zur behandlung von hyper-proliferativen erkrankungen |
SG11201506924YA (en) | 2013-03-15 | 2015-09-29 | Incyte Corp | Tricyclic heterocycles as bet protein inhibitors |
EP3019502B1 (en) | 2013-07-08 | 2017-05-17 | Incyte Holdings Corporation | Tricyclic heterocycles as bet protein inhibitors |
US9315501B2 (en) | 2013-11-26 | 2016-04-19 | Incyte Corporation | Bicyclic heterocycles as BET protein inhibitors |
US9399640B2 (en) | 2013-11-26 | 2016-07-26 | Incyte Corporation | Substituted pyrrolo[2,3-c]pyridines and pyrazolo[3,4-c]pyridines as BET protein inhibitors |
WO2015095492A1 (en) | 2013-12-19 | 2015-06-25 | Incyte Corporation | Tricyclic heterocycles as bet protein inhibitors |
WO2015153871A2 (en) * | 2014-04-04 | 2015-10-08 | Constellation Pharmaceuticals, Inc. | EXPRESSION LEVELS OF BCL-xL, BCL2, BCL-w, AND BAD AND CANCER THERAPIES |
EP3674302B1 (en) | 2014-04-23 | 2023-03-01 | Incyte Holdings Corporation | 1h-pyrrolo[2,3-c]pyridin-7(6h)-ones and pyrazolo[3,4-c]pyridin-7(6h)-ones as inhibitors of bet proteins |
WO2015195863A1 (en) * | 2014-06-20 | 2015-12-23 | Constellation Pharmaceuticals, Inc. | Hydrated 2-((4s)-6-(4-chlorophenyl)-1 -methyl-4h-benzo[c]isoxazolo[4,5-e]azepin-4-yl)acetamide |
JP6599979B2 (ja) | 2014-09-15 | 2019-10-30 | インサイト・コーポレイション | Betタンパク質阻害剤として用いるための三環式複素環化合物 |
GB201504694D0 (en) | 2015-03-19 | 2015-05-06 | Glaxosmithkline Ip Dev Ltd | Covalent conjugates |
CA2989313A1 (en) | 2015-06-26 | 2016-12-29 | Tensha Therapeutics, Inc. | Treatment of nut midline carcinoma |
CN108137588B (zh) | 2015-09-09 | 2021-06-18 | 朱比兰特生物系统有限公司 | 三环稠合吡啶-2-酮衍生物及其作为brd4抑制剂的用途 |
WO2017075377A1 (en) | 2015-10-29 | 2017-05-04 | Incyte Corporation | Amorphous solid form of a bet protein inhibitor |
WO2017114843A1 (en) | 2015-12-29 | 2017-07-06 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Xanthine derivative inhibitors of bet proteins |
SI3472157T1 (sl) | 2016-06-20 | 2023-07-31 | Incyte Corporation | Kristalinične trdne oblike zaviralca BET |
EP3707139B1 (en) | 2017-11-06 | 2022-02-16 | Centre National de la Recherche Scientifique | Xanthine derivatives and uses thereof as inhibitors of bromodomains of bet proteins |
KR102026243B1 (ko) * | 2018-01-19 | 2019-09-27 | 연세대학교 산학협력단 | 백혈병 치료용 약학적 조성물 |
US11629152B2 (en) | 2018-03-30 | 2023-04-18 | Kyowa Kirin Co., Ltd. | Compound with anticancer activity |
CN111518045A (zh) * | 2019-02-02 | 2020-08-11 | 博诺康源(北京)药业科技有限公司 | 一种具有苯并七元环结构的化合物、其制备方法及用途 |
US11833155B2 (en) | 2020-06-03 | 2023-12-05 | Incyte Corporation | Combination therapy for treatment of myeloproliferative neoplasms |
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WO2018133139A1 (zh) | 2017-01-21 | 2018-07-26 | 宁波知明生物科技有限公司 | 芍药苷-6'-o-苯磺酸酯在治疗干燥综合征的应用 |
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HK1207372A1 (en) | 2016-01-29 |
BR112014030165A2 (pt) | 2017-06-27 |
EA026894B1 (ru) | 2017-05-31 |
CN104428304A (zh) | 2015-03-18 |
WO2013184876A1 (en) | 2013-12-12 |
CA2874774A1 (en) | 2013-12-12 |
AU2013271569A1 (en) | 2014-12-18 |
JP2015518899A (ja) | 2015-07-06 |
IL235844A0 (en) | 2015-02-01 |
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CA2874774C (en) | 2022-10-04 |
MX360598B (es) | 2018-11-08 |
EP2859000B1 (en) | 2017-04-26 |
WO2013184876A8 (en) | 2014-11-27 |
US9925197B2 (en) | 2018-03-27 |
US9493483B2 (en) | 2016-11-15 |
AU2013271569B2 (en) | 2017-09-14 |
US20150148337A1 (en) | 2015-05-28 |
AR091285A1 (es) | 2015-01-21 |
IL235844A (en) | 2017-04-30 |
TW201402580A (zh) | 2014-01-16 |
ZA201408720B (en) | 2018-05-30 |
SG11201407900WA (en) | 2014-12-30 |
EA201492216A1 (ru) | 2015-03-31 |
KR20150023562A (ko) | 2015-03-05 |
JP6154004B2 (ja) | 2017-06-28 |
CN104428304B (zh) | 2016-09-21 |
IN2014DN10386A (OSRAM) | 2015-08-14 |
ES2632774T3 (es) | 2017-09-15 |
EP2859000A1 (en) | 2015-04-15 |
US20170079984A1 (en) | 2017-03-23 |
TWI602820B (zh) | 2017-10-21 |
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