NZ701290A - Pyrrolobenzodiazepines - Google Patents

Pyrrolobenzodiazepines

Info

Publication number
NZ701290A
NZ701290A NZ701290A NZ70129013A NZ701290A NZ 701290 A NZ701290 A NZ 701290A NZ 701290 A NZ701290 A NZ 701290A NZ 70129013 A NZ70129013 A NZ 70129013A NZ 701290 A NZ701290 A NZ 701290A
Authority
NZ
New Zealand
Prior art keywords
pbd
nme
alkyl
amino acid
acid residue
Prior art date
Application number
NZ701290A
Other languages
English (en)
Inventor
Philip Wilson Howard
David Thurston
Khondaker Mirazur Rahman
Original Assignee
Medimmune Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medimmune Ltd filed Critical Medimmune Ltd
Publication of NZ701290A publication Critical patent/NZ701290A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
    • A61K31/5517—1,4-Benzodiazepines, e.g. diazepam or clozapine condensed with five-membered rings having nitrogen as a ring hetero atom, e.g. imidazobenzodiazepines, triazolam
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
NZ701290A 2012-04-30 2013-04-30 Pyrrolobenzodiazepines NZ701290A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261640310P 2012-04-30 2012-04-30
PCT/GB2013/051098 WO2013164593A1 (en) 2012-04-30 2013-04-30 Pyrrolobenzodiazepines

Publications (1)

Publication Number Publication Date
NZ701290A true NZ701290A (en) 2016-08-26

Family

ID=48325770

Family Applications (1)

Application Number Title Priority Date Filing Date
NZ701290A NZ701290A (en) 2012-04-30 2013-04-30 Pyrrolobenzodiazepines

Country Status (14)

Country Link
US (1) US9376440B2 (enExample)
EP (1) EP2855482B1 (enExample)
JP (1) JP6157596B2 (enExample)
KR (1) KR101960129B1 (enExample)
CN (1) CN104684914B (enExample)
AU (1) AU2013255613B2 (enExample)
BR (1) BR112014027143B1 (enExample)
CA (1) CA2871172C (enExample)
ES (1) ES2623042T3 (enExample)
IN (1) IN2014MN02092A (enExample)
MX (1) MX369715B (enExample)
NZ (1) NZ701290A (enExample)
WO (1) WO2013164593A1 (enExample)
ZA (1) ZA201407759B (enExample)

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CA2894959C (en) 2012-12-21 2022-01-11 Spirogen Sarl Unsymmetrical pyrrolobenzodiazepines-dimers for use in the treatment of proliferative and autoimmune diseases
ES2731779T3 (es) 2013-03-13 2019-11-19 Medimmune Ltd Pirrolobenzodiazepinas y conjugados de las mismas
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GB201317981D0 (en) 2013-10-11 2013-11-27 Spirogen Sarl Pyrrolobenzodiazepines and conjugates thereof
GB201317982D0 (en) 2013-10-11 2013-11-27 Spirogen Sarl Pyrrolobenzodiazepines and conjugates thereof
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GB201416112D0 (en) 2014-09-12 2014-10-29 Medimmune Ltd Pyrrolobenzodiazepines and conjugates thereof
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GB201601431D0 (en) 2016-01-26 2016-03-09 Medimmune Ltd Pyrrolobenzodiazepines
GB201602356D0 (en) 2016-02-10 2016-03-23 Medimmune Ltd Pyrrolobenzodiazepine Conjugates
GB201602359D0 (en) 2016-02-10 2016-03-23 Medimmune Ltd Pyrrolobenzodiazepine Conjugates
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GB201702031D0 (en) 2017-02-08 2017-03-22 Medlmmune Ltd Pyrrolobenzodiazepine-antibody conjugates
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JP2020517609A (ja) 2017-04-18 2020-06-18 メディミューン リミテッド ピロロベンゾジアゼピン複合体
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EA039276B1 (ru) 2017-08-18 2021-12-27 Медимьюн Лимитед Пирролобензодиазепиновые конъюгаты
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EP3717021A1 (en) 2017-11-27 2020-10-07 Mersana Therapeutics, Inc. Pyrrolobenzodiazepine antibody conjugates
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JP7177848B2 (ja) 2018-03-28 2022-11-24 田辺三菱製薬株式会社 ｃＭＥＴモノクローナル結合剤の薬物複合体とその使用
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KR20200084802A (ko) 2019-01-03 2020-07-13 주식회사 레고켐 바이오사이언스 안전성이 향상된 피롤로벤조디아제핀 이량체 화합물 및 이의 용도
WO2020141923A2 (ko) 2019-01-03 2020-07-09 주식회사 레고켐 바이오사이언스 안전성이 향상된 피롤로벤조디아제핀 이량체 화합물 및 이의 용도
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Also Published As

Publication number Publication date
WO2013164593A1 (en) 2013-11-07
ZA201407759B (en) 2015-11-25
HK1208444A1 (en) 2016-03-04
MX369715B (es) 2019-11-20
CN104684914A (zh) 2015-06-03
US20150133435A1 (en) 2015-05-14
KR101960129B1 (ko) 2019-03-19
BR112014027143A2 (pt) 2017-06-27
CA2871172A1 (en) 2013-11-07
AU2013255613A1 (en) 2014-11-13
JP2015515972A (ja) 2015-06-04
EP2855482B1 (en) 2017-03-01
BR112014027143B1 (pt) 2020-06-09
EP2855482A1 (en) 2015-04-08
JP6157596B2 (ja) 2017-07-05
CN104684914B (zh) 2017-12-15
CA2871172C (en) 2020-08-25
KR20150016245A (ko) 2015-02-11
MX2014013098A (es) 2015-04-14
IN2014MN02092A (enExample) 2015-09-04
AU2013255613B2 (en) 2017-06-22
US9376440B2 (en) 2016-06-28
ES2623042T3 (es) 2017-07-10

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