MX2014013098A - Pirrolobenzodiacepinas. - Google Patents

Pirrolobenzodiacepinas.

Info

Publication number
MX2014013098A
MX2014013098A MX2014013098A MX2014013098A MX2014013098A MX 2014013098 A MX2014013098 A MX 2014013098A MX 2014013098 A MX2014013098 A MX 2014013098A MX 2014013098 A MX2014013098 A MX 2014013098A MX 2014013098 A MX2014013098 A MX 2014013098A
Authority
MX
Mexico
Prior art keywords
pyrrolobenzodiazepines
pbds
pyrrolobenzodiazepine
pyrrol
methyl
Prior art date
Application number
MX2014013098A
Other languages
English (en)
Other versions
MX369715B (es
Inventor
Philip Wilson Howard
David Thurston
Khondaker Mirazur Rahman
Original Assignee
Spirogen Sarl
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Spirogen Sarl filed Critical Spirogen Sarl
Publication of MX2014013098A publication Critical patent/MX2014013098A/es
Publication of MX369715B publication Critical patent/MX369715B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
    • A61K31/5517—1,4-Benzodiazepines, e.g. diazepam or clozapine condensed with five-membered rings having nitrogen as a ring hetero atom, e.g. imidazobenzodiazepines, triazolam
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia

Abstract

Se encontró que pirrolobenzodiacepinas (PBDS) que tienen un residuo amino basado en (1-metil-1H-pirrol-il)fenilo son compuestos altamente efectivos que tienen citotoxicidad mejorada y propiedades de unión de ADN.
MX2014013098A 2012-04-30 2013-04-30 Pirrolobenzodiacepinas. MX369715B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261640310P 2012-04-30 2012-04-30
PCT/GB2013/051098 WO2013164593A1 (en) 2012-04-30 2013-04-30 Pyrrolobenzodiazepines

Publications (2)

Publication Number Publication Date
MX2014013098A true MX2014013098A (es) 2015-04-14
MX369715B MX369715B (es) 2019-11-20

Family

ID=48325770

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2014013098A MX369715B (es) 2012-04-30 2013-04-30 Pirrolobenzodiacepinas.

Country Status (15)

Country Link
US (1) US9376440B2 (es)
EP (1) EP2855482B1 (es)
JP (1) JP6157596B2 (es)
KR (1) KR101960129B1 (es)
CN (1) CN104684914B (es)
AU (1) AU2013255613B2 (es)
BR (1) BR112014027143B1 (es)
CA (1) CA2871172C (es)
ES (1) ES2623042T3 (es)
HK (1) HK1208444A1 (es)
IN (1) IN2014MN02092A (es)
MX (1) MX369715B (es)
NZ (1) NZ701290A (es)
WO (1) WO2013164593A1 (es)
ZA (1) ZA201407759B (es)

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Also Published As

Publication number Publication date
JP2015515972A (ja) 2015-06-04
BR112014027143B1 (pt) 2020-06-09
IN2014MN02092A (es) 2015-09-04
US9376440B2 (en) 2016-06-28
CN104684914A (zh) 2015-06-03
EP2855482B1 (en) 2017-03-01
US20150133435A1 (en) 2015-05-14
CA2871172C (en) 2020-08-25
JP6157596B2 (ja) 2017-07-05
HK1208444A1 (en) 2016-03-04
KR101960129B1 (ko) 2019-03-19
AU2013255613B2 (en) 2017-06-22
NZ701290A (en) 2016-08-26
KR20150016245A (ko) 2015-02-11
BR112014027143A2 (pt) 2017-06-27
EP2855482A1 (en) 2015-04-08
MX369715B (es) 2019-11-20
CA2871172A1 (en) 2013-11-07
ZA201407759B (en) 2015-11-25
ES2623042T3 (es) 2017-07-10
WO2013164593A1 (en) 2013-11-07
CN104684914B (zh) 2017-12-15
AU2013255613A1 (en) 2014-11-13

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