AU2013255613B2 - Pyrrolobenzodiazepines - Google Patents

Pyrrolobenzodiazepines Download PDF

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Publication number
AU2013255613B2
AU2013255613B2 AU2013255613A AU2013255613A AU2013255613B2 AU 2013255613 B2 AU2013255613 B2 AU 2013255613B2 AU 2013255613 A AU2013255613 A AU 2013255613A AU 2013255613 A AU2013255613 A AU 2013255613A AU 2013255613 B2 AU2013255613 B2 AU 2013255613B2
Authority
AU
Australia
Prior art keywords
compound according
group
methyl
phenyl
nme
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2013255613A
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English (en)
Other versions
AU2013255613A1 (en
Inventor
Philip Wilson Howard
Khondaker Mirazur RAHMAN
David Thurston
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
MedImmune Ltd
Original Assignee
MedImmune Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by MedImmune Ltd filed Critical MedImmune Ltd
Publication of AU2013255613A1 publication Critical patent/AU2013255613A1/en
Assigned to UCL BUSINESS PLC, MEDIMMUNE LIMITED reassignment UCL BUSINESS PLC Request for Assignment Assignors: SPIROGEN SARL, UCL BUSINESS PLC
Assigned to MEDIMMUNE LIMITED reassignment MEDIMMUNE LIMITED Request for Assignment Assignors: MEDIMMUNE LIMITED, UCL BUSINESS PLC
Application granted granted Critical
Publication of AU2013255613B2 publication Critical patent/AU2013255613B2/en
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
    • A61K31/5517—1,4-Benzodiazepines, e.g. diazepam or clozapine condensed with five-membered rings having nitrogen as a ring hetero atom, e.g. imidazobenzodiazepines, triazolam
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AU2013255613A 2012-04-30 2013-04-30 Pyrrolobenzodiazepines Ceased AU2013255613B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261640310P 2012-04-30 2012-04-30
US61/640,310 2012-04-30
PCT/GB2013/051098 WO2013164593A1 (en) 2012-04-30 2013-04-30 Pyrrolobenzodiazepines

Publications (2)

Publication Number Publication Date
AU2013255613A1 AU2013255613A1 (en) 2014-11-13
AU2013255613B2 true AU2013255613B2 (en) 2017-06-22

Family

ID=48325770

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2013255613A Ceased AU2013255613B2 (en) 2012-04-30 2013-04-30 Pyrrolobenzodiazepines

Country Status (14)

Country Link
US (1) US9376440B2 (enExample)
EP (1) EP2855482B1 (enExample)
JP (1) JP6157596B2 (enExample)
KR (1) KR101960129B1 (enExample)
CN (1) CN104684914B (enExample)
AU (1) AU2013255613B2 (enExample)
BR (1) BR112014027143B1 (enExample)
CA (1) CA2871172C (enExample)
ES (1) ES2623042T3 (enExample)
IN (1) IN2014MN02092A (enExample)
MX (1) MX369715B (enExample)
NZ (1) NZ701290A (enExample)
WO (1) WO2013164593A1 (enExample)
ZA (1) ZA201407759B (enExample)

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WO2014057073A1 (en) 2012-10-12 2014-04-17 Spirogen Sàrl Pyrrolobenzodiazepines and conjugates thereof
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US9567340B2 (en) 2012-12-21 2017-02-14 Medimmune Limited Unsymmetrical pyrrolobenzodiazepines-dimers for use in the treatment of proliferative and autoimmune diseases
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GB201317981D0 (en) 2013-10-11 2013-11-27 Spirogen Sarl Pyrrolobenzodiazepines and conjugates thereof
GB201407816D0 (en) 2014-05-02 2014-06-18 King S College London Pyrrolobenzodiazepine Compounds
GB201416112D0 (en) 2014-09-12 2014-10-29 Medimmune Ltd Pyrrolobenzodiazepines and conjugates thereof
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TW201808936A (zh) 2016-05-18 2018-03-16 美商梅爾莎納醫療公司 吡咯并苯并二氮呯類及其共軛物
US10526294B2 (en) 2016-06-24 2020-01-07 Mersana Therapeutics, Inc. Pyrrolobenzodiazepines and conjugates thereof
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KR20200032243A (ko) 2017-02-08 2020-03-25 에이디씨 테라퓨틱스 에스에이 피롤로벤조디아제핀-항체 컨주게이트
GB201702031D0 (en) 2017-02-08 2017-03-22 Medlmmune Ltd Pyrrolobenzodiazepine-antibody conjugates
EP3604311A4 (en) 2017-03-29 2021-01-13 LegoChem Biosciences, Inc. PYRROLOBENZODIAZEPINE DIMERIC PRECURSOR AND ASSOCIATED LIGAND-BOND CONJUGATE COMPOUND
SI3612537T1 (sl) 2017-04-18 2022-10-28 Medimmune Limited Konjugati pirolobenzodiazepina
EP3612234B1 (en) 2017-04-20 2024-03-13 ADC Therapeutics SA Combination therapy with an anti-axl antibody-drug conjugate
KR102442736B1 (ko) 2017-06-14 2022-09-16 에이디씨 테라퓨틱스 에스에이 항-cd19 adc의 투여를 위한 투약량 체제
CN111065638B (zh) 2017-08-18 2021-04-09 麦迪穆有限责任公司 吡咯并苯并二氮杂䓬缀合物
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KR20200084802A (ko) 2019-01-03 2020-07-13 주식회사 레고켐 바이오사이언스 안전성이 향상된 피롤로벤조디아제핀 이량체 화합물 및 이의 용도
WO2020141923A2 (ko) 2019-01-03 2020-07-09 주식회사 레고켐 바이오사이언스 안전성이 향상된 피롤로벤조디아제핀 이량체 화합물 및 이의 용도
GB201901197D0 (en) 2019-01-29 2019-03-20 Femtogenix Ltd G-A Crosslinking cytotoxic agents
IL286326B2 (en) 2019-03-15 2025-10-01 Medimmune Ltd Azatidobenzodiazepine dimers and conjugates containing them for use in the treatment of cancer
GB2597532A (en) * 2020-07-28 2022-02-02 Femtogenix Ltd Cytotoxic compounds
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GB202405758D0 (en) 2024-04-24 2024-06-05 King S College London Compounds

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Also Published As

Publication number Publication date
EP2855482A1 (en) 2015-04-08
HK1208444A1 (en) 2016-03-04
WO2013164593A1 (en) 2013-11-07
JP6157596B2 (ja) 2017-07-05
NZ701290A (en) 2016-08-26
US20150133435A1 (en) 2015-05-14
CA2871172C (en) 2020-08-25
KR101960129B1 (ko) 2019-03-19
MX369715B (es) 2019-11-20
BR112014027143B1 (pt) 2020-06-09
EP2855482B1 (en) 2017-03-01
ES2623042T3 (es) 2017-07-10
JP2015515972A (ja) 2015-06-04
ZA201407759B (en) 2015-11-25
MX2014013098A (es) 2015-04-14
US9376440B2 (en) 2016-06-28
CN104684914A (zh) 2015-06-03
KR20150016245A (ko) 2015-02-11
CN104684914B (zh) 2017-12-15
AU2013255613A1 (en) 2014-11-13
IN2014MN02092A (enExample) 2015-09-04
CA2871172A1 (en) 2013-11-07
BR112014027143A2 (pt) 2017-06-27

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Owner name: UCL BUSINESS PLC; MEDIMMUNE LIMITED

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PC1 Assignment before grant (sect. 113)

Owner name: MEDIMMUNE LIMITED

Free format text: FORMER APPLICANT(S): MEDIMMUNE LIMITED; UCL BUSINESS PLC

FGA Letters patent sealed or granted (standard patent)
MK14 Patent ceased section 143(a) (annual fees not paid) or expired