NZ595168A - Hepatitis c virus inhibitors - Google Patents
Hepatitis c virus inhibitorsInfo
- Publication number
- NZ595168A NZ595168A NZ595168A NZ59516810A NZ595168A NZ 595168 A NZ595168 A NZ 595168A NZ 595168 A NZ595168 A NZ 595168A NZ 59516810 A NZ59516810 A NZ 59516810A NZ 595168 A NZ595168 A NZ 595168A
- Authority
- NZ
- New Zealand
- Prior art keywords
- hepatitis
- diyl
- imidazol
- pyrrolidinyl
- oxo
- Prior art date
Links
- 241000711549 Hepacivirus C Species 0.000 title abstract 3
- 239000003112 inhibitor Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- DKEBEEQSQZZEHR-ATUXXYJQSA-N (2r)-2-(dimethylamino)-1-[(2s)-2-[5-[4-[4-[2-[(2s)-1-[(2r)-2-(dimethylamino)-2-phenylacetyl]pyrrolidin-2-yl]-1h-imidazol-5-yl]phenoxy]phenyl]-1h-imidazol-2-yl]pyrrolidin-1-yl]-2-phenylethanone Chemical compound C1([C@@H](N(C)C)C(=O)N2CCC[C@H]2C=2NC=C(N=2)C2=CC=C(C=C2)OC2=CC=C(C=C2)C2=CN=C(N2)[C@@H]2CCCN2C(=O)[C@H](N(C)C)C=2C=CC=CC=2)=CC=CC=C1 DKEBEEQSQZZEHR-ATUXXYJQSA-N 0.000 abstract 1
- 101800001014 Non-structural protein 5A Proteins 0.000 abstract 1
- WSYZUGFTTGAREQ-MPGLKXPKSA-N [(1S)-2-[(1R,3S,5R)-3-[5-[4-[2-[4-[2-[(1R,3S,5R)-2-[(2S)-2-(carboxyamino)-2-cyclobutylacetyl]-2-azabicyclo[3.1.0]hexan-3-yl]-1H-imidazol-5-yl]phenyl]ethynyl]phenyl]-1H-imidazol-2-yl]-2-azabicyclo[3.1.0]hexan-2-yl]-1-cyclobutyl-2-oxoethyl]carbamic acid Chemical compound C1([C@H](NC(=O)O)C(=O)N2[C@@H](C[C@H]3C[C@H]32)C=2NC(=CN=2)C=2C=CC(=CC=2)C#CC=2C=CC(=CC=2)C=2NC(=NC=2)[C@H]2N([C@@H]3C[C@@H]3C2)C(=O)[C@@H](NC(O)=O)C2CCC2)CCC1 WSYZUGFTTGAREQ-MPGLKXPKSA-N 0.000 abstract 1
- 239000003443 antiviral agent Substances 0.000 abstract 1
- 125000000118 dimethyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Virology (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Communicable Diseases (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US16453109P | 2009-03-30 | 2009-03-30 | |
| US12/729,940 US8796466B2 (en) | 2009-03-30 | 2010-03-23 | Hepatitis C virus inhibitors |
| PCT/US2010/028456 WO2010117635A1 (en) | 2009-03-30 | 2010-03-24 | Hepatitis c virus inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NZ595168A true NZ595168A (en) | 2013-05-31 |
Family
ID=42320079
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NZ595168A NZ595168A (en) | 2009-03-30 | 2010-03-24 | Hepatitis c virus inhibitors |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US8796466B2 (enExample) |
| EP (1) | EP2414350B1 (enExample) |
| JP (1) | JP5612660B2 (enExample) |
| KR (1) | KR20120034603A (enExample) |
| CN (1) | CN102448956B (enExample) |
| AR (1) | AR076002A1 (enExample) |
| AU (1) | AU2010234970A1 (enExample) |
| BR (1) | BRPI1013393A2 (enExample) |
| CA (1) | CA2757269A1 (enExample) |
| CL (1) | CL2011002426A1 (enExample) |
| CO (1) | CO6430431A2 (enExample) |
| EA (1) | EA022384B1 (enExample) |
| IL (1) | IL215055A0 (enExample) |
| MX (1) | MX2011009948A (enExample) |
| NZ (1) | NZ595168A (enExample) |
| PE (1) | PE20120546A1 (enExample) |
| SG (1) | SG174521A1 (enExample) |
| WO (1) | WO2010117635A1 (enExample) |
| ZA (1) | ZA201106795B (enExample) |
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| RU2505540C2 (ru) | 2008-12-23 | 2014-01-27 | Эббви Инк. | Антивирусные соединения |
| US8546405B2 (en) | 2008-12-23 | 2013-10-01 | Abbott Laboratories | Anti-viral compounds |
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| US8394968B2 (en) | 2009-02-17 | 2013-03-12 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| US8242156B2 (en) | 2009-02-17 | 2012-08-14 | Enanta Pharmaceuticals, Inc. | Linked dibenzimidazole derivatives |
| US8188132B2 (en) | 2009-02-17 | 2012-05-29 | Enanta Pharmaceuticals, Inc. | Linked dibenzimidazole derivatives |
| US8101643B2 (en) | 2009-02-27 | 2012-01-24 | Enanta Pharmaceuticals, Inc. | Benzimidazole derivatives |
| US9765087B2 (en) | 2009-02-27 | 2017-09-19 | Enanta Pharmaceuticals, Inc. | Benzimidazole derivatives |
| US8673954B2 (en) | 2009-02-27 | 2014-03-18 | Enanta Pharmaceuticals, Inc. | Benzimidazole derivatives |
| TW201038559A (en) | 2009-04-09 | 2010-11-01 | Bristol Myers Squibb Co | Hepatitis C virus inhibitors |
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2010
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- 2010-03-24 CA CA2757269A patent/CA2757269A1/en not_active Abandoned
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| CN102448956B (zh) | 2015-05-06 |
| BRPI1013393A2 (pt) | 2016-03-29 |
| CO6430431A2 (es) | 2012-04-30 |
| EP2414350B1 (en) | 2014-11-12 |
| US20110077280A1 (en) | 2011-03-31 |
| PE20120546A1 (es) | 2012-05-21 |
| AR076002A1 (es) | 2011-05-11 |
| CA2757269A1 (en) | 2010-10-14 |
| IL215055A0 (en) | 2011-11-30 |
| JP5612660B2 (ja) | 2014-10-22 |
| EP2414350A1 (en) | 2012-02-08 |
| EA201171152A1 (ru) | 2012-10-30 |
| CL2011002426A1 (es) | 2012-03-02 |
| JP2012522053A (ja) | 2012-09-20 |
| SG174521A1 (en) | 2011-10-28 |
| MX2011009948A (es) | 2011-10-06 |
| WO2010117635A1 (en) | 2010-10-14 |
| AU2010234970A1 (en) | 2011-10-06 |
| CN102448956A (zh) | 2012-05-09 |
| ZA201106795B (en) | 2013-02-27 |
| US8796466B2 (en) | 2014-08-05 |
| EA022384B1 (ru) | 2015-12-30 |
| KR20120034603A (ko) | 2012-04-12 |
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