NZ586575A - Azaindolizines and methods of use - Google Patents

Info

Publication number

NZ586575A

NZ586575A NZ586575A NZ58657508A NZ586575A NZ 586575 A NZ586575 A NZ 586575A NZ 586575 A NZ586575 A NZ 586575A NZ 58657508 A NZ58657508 A NZ 58657508A NZ 586575 A NZ586575 A NZ 586575A

Authority

NZ

New Zealand

Prior art keywords

compound

cr19r20

alkyl

formula

acid

Prior art date

2007-12-21

Links

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• Global Dossier
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• 238000000034 method Methods 0.000 title claims abstract description 62
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• 230000002401 inhibitory effect Effects 0.000 claims abstract description 16
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• -1 (R)-2,3-dihydroxy-propoxy Chemical group 0.000 claims description 79
• 150000003839 salts Chemical class 0.000 claims description 35
• OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims description 33
• 239000007787 solid Substances 0.000 claims description 28
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• 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims description 23
• 238000004895 liquid chromatography mass spectrometry Methods 0.000 claims description 22
• 239000012267 brine Substances 0.000 claims description 21
• HPALAKNZSZLMCH-UHFFFAOYSA-M sodium;chloride;hydrate Chemical compound O.[Na+].[Cl-] HPALAKNZSZLMCH-UHFFFAOYSA-M 0.000 claims description 21
• 239000002246 antineoplastic agent Substances 0.000 claims description 20
• 229940127089 cytotoxic agent Drugs 0.000 claims description 20
• 229910052943 magnesium sulfate Inorganic materials 0.000 claims description 19
• WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 claims description 18
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 18
• 239000012223 aqueous fraction Substances 0.000 claims description 17
• 125000000217 alkyl group Chemical group 0.000 claims description 15
• 238000003818 flash chromatography Methods 0.000 claims description 15
• 239000008194 pharmaceutical composition Substances 0.000 claims description 13
• 125000004400 (C1-C12) alkyl group Chemical group 0.000 claims description 11
• 229910052731 fluorine Inorganic materials 0.000 claims description 11
• 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 10
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• 238000004519 manufacturing process Methods 0.000 claims description 9
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• WWWTWPXKLJTKPM-UHFFFAOYSA-N 2-aminooxyethanol Chemical compound NOCCO WWWTWPXKLJTKPM-UHFFFAOYSA-N 0.000 claims description 5
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• 125000002393 azetidinyl group Chemical group 0.000 claims description 3
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• 230000004913 activation Effects 0.000 description 10
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• KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 9
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• 125000005842 heteroatom Chemical group 0.000 description 8
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