AU2008340247B2 - Azaindolizines and methods of use - Google Patents

Azaindolizines and methods of use Download PDF

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Publication number
AU2008340247B2
AU2008340247B2 AU2008340247A AU2008340247A AU2008340247B2 AU 2008340247 B2 AU2008340247 B2 AU 2008340247B2 AU 2008340247 A AU2008340247 A AU 2008340247A AU 2008340247 A AU2008340247 A AU 2008340247A AU 2008340247 B2 AU2008340247 B2 AU 2008340247B2
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AU
Australia
Prior art keywords
alkyl
compound
nnr
nhc
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
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AU2008340247A
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AU2008340247A1 (en
Inventor
Robert Heald
Peter Hewitt
Stephen Price
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Genentech Inc
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Genentech Inc
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Publication of AU2008340247A1 publication Critical patent/AU2008340247A1/en
Application granted granted Critical
Publication of AU2008340247B2 publication Critical patent/AU2008340247B2/en
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AU2008340247A 2007-12-21 2008-12-19 Azaindolizines and methods of use Ceased AU2008340247B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US1594207P 2007-12-21 2007-12-21
US61/015,942 2007-12-21
PCT/US2008/087626 WO2009082687A1 (en) 2007-12-21 2008-12-19 Azaindolizines and methods of use

Publications (2)

Publication Number Publication Date
AU2008340247A1 AU2008340247A1 (en) 2009-07-02
AU2008340247B2 true AU2008340247B2 (en) 2012-11-15

Family

ID=40352017

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2008340247A Ceased AU2008340247B2 (en) 2007-12-21 2008-12-19 Azaindolizines and methods of use

Country Status (12)

Country Link
US (1) US8486963B2 (https=)
EP (1) EP2220092B1 (https=)
JP (1) JP5710269B2 (https=)
KR (1) KR20100099185A (https=)
CN (1) CN101945875B (https=)
AU (1) AU2008340247B2 (https=)
BR (1) BRPI0819505A2 (https=)
CA (1) CA2708176A1 (https=)
ES (1) ES2387707T3 (https=)
IL (1) IL206125A (https=)
NZ (1) NZ586575A (https=)
WO (1) WO2009082687A1 (https=)

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KR20130118612A (ko) * 2012-04-20 2013-10-30 (주)네오믹스 신규한 아미노피리딘 유도체 및 이의 용도
US9532987B2 (en) 2013-09-05 2017-01-03 Genentech, Inc. Use of a combination of a MEK inhibitor and an ERK inhibitor for treatment of hyperproliferative diseases
EP3153469A4 (en) * 2014-06-03 2017-11-29 Gaia Institute Of Environmental Technology, Inc. Amorphous silicon for use in foods, drugs, cosmetics and feed, and production method and production device thereof
KR20180134347A (ko) 2016-04-15 2018-12-18 제넨테크, 인크. 암의 진단 및 치료 방법
PT3624796T (pt) 2017-05-19 2025-06-02 Nflection Therapeutics Inc Compostos de pirrolopiridina-anilina para tratamento de distúrbios dérmicos
JP7237941B2 (ja) 2017-05-19 2023-03-13 エヌフレクション セラピューティクス インコーポレイテッド 皮膚障害の処置用の融合複素環式芳香族アニリン化合物
KR102811888B1 (ko) 2017-09-08 2025-05-27 에프. 호프만-라 로슈 아게 암의 진단 및 치료 방법
EP3752200A1 (en) 2018-02-13 2020-12-23 Vib Vzw Targeting minimal residual disease in cancer with rxr antagonists
EP3793559A1 (en) 2018-05-17 2021-03-24 Bayer Aktiengesellschaft Substituted dihydropyrazolo pyrazine carboxamide derivatives
WO2020106306A1 (en) 2018-11-20 2020-05-28 Nflection Therapeutics, Inc. Cyanoaryl-aniline compounds for treatment of dermal disorders
WO2020106305A1 (en) 2018-11-20 2020-05-28 Nflection Therapeutics, Inc. Thienyl-aniline compounds for treatment of dermal disorders
WO2020106308A1 (en) 2018-11-20 2020-05-28 Nflection Therapeutics, Inc. Naphthyridinone-aniline compounds for treatment of dermal disorders
WO2021094210A1 (en) 2019-11-12 2021-05-20 Bayer Aktiengesellschaft Substituted pyrazine carboxamide derivatives as prostaglandin ep3 receptor antagonists
US20260048075A1 (en) 2022-08-10 2026-02-19 Vib Vzw Inhibition of TCF4/ITF2 in the Treatment of Cancer
WO2026019990A1 (en) 2024-07-18 2026-01-22 Genentech, Inc. Methods of treating cancer with anti-ccr8/anti-cd3 bispecific antibodies

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US20050049276A1 (en) * 2003-07-23 2005-03-03 Warner-Lambert Company, Llc Imidazopyridines and triazolopyridines
US20050153942A1 (en) * 2003-11-19 2005-07-14 Eli Wallace Heterocyclic inhibitors of MEK and methods of use thereof

Also Published As

Publication number Publication date
US20110142826A1 (en) 2011-06-16
IL206125A (en) 2015-08-31
IL206125A0 (en) 2010-11-30
ES2387707T3 (es) 2012-09-28
WO2009082687A1 (en) 2009-07-02
US8486963B2 (en) 2013-07-16
CN101945875B (zh) 2013-04-24
CA2708176A1 (en) 2009-07-02
AU2008340247A1 (en) 2009-07-02
EP2220092B1 (en) 2012-06-06
BRPI0819505A2 (pt) 2017-04-04
KR20100099185A (ko) 2010-09-10
JP5710269B2 (ja) 2015-04-30
CN101945875A (zh) 2011-01-12
JP2011507896A (ja) 2011-03-10
EP2220092A1 (en) 2010-08-25
NZ586575A (en) 2012-03-30
RU2010130315A (ru) 2012-01-27

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Legal Events

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FGA Letters patent sealed or granted (standard patent)
MK14 Patent ceased section 143(a) (annual fees not paid) or expired