NZ576762A - Novel 1,4-benzothiepine 1,1-dioxide derivatives substituted by benzyl radicals, method for their preparation, pharmaceuticals comprising these compounds, and the use thereof - Google Patents

Info

Publication number

NZ576762A

NZ576762A NZ576762A NZ57676207A NZ576762A NZ 576762 A NZ576762 A NZ 576762A NZ 576762 A NZ576762 A NZ 576762A NZ 57676207 A NZ57676207 A NZ 57676207A NZ 576762 A NZ576762 A NZ 576762A

Authority

NZ

New Zealand

Prior art keywords

compound

formula

alkyl

administered

combination

Prior art date

2006-11-14

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• 150000001875 compounds Chemical class 0.000 title claims abstract description 161
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• 238000002360 preparation method Methods 0.000 title description 16
• 238000000034 method Methods 0.000 title description 5
• OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims description 45
• -1 alkaline earth metal salt Chemical class 0.000 claims description 42
• YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 claims description 33
• 239000004480 active ingredient Substances 0.000 claims description 30
• 239000003112 inhibitor Substances 0.000 claims description 28
• 150000003839 salts Chemical class 0.000 claims description 24
• QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 claims description 17
• 239000008194 pharmaceutical composition Substances 0.000 claims description 10
• 238000011282 treatment Methods 0.000 claims description 9
• 230000015572 biosynthetic process Effects 0.000 claims description 7
• 238000003786 synthesis reaction Methods 0.000 claims description 7
• 229910021529 ammonia Inorganic materials 0.000 claims description 6
• 150000003863 ammonium salts Chemical class 0.000 claims description 6
• 208000001072 type 2 diabetes mellitus Diseases 0.000 claims description 5
• 206010022489 Insulin Resistance Diseases 0.000 claims description 4
• XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical group [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 claims description 4
• PCZOHLXUXFIOCF-UHFFFAOYSA-N Monacolin X Natural products C12C(OC(=O)C(C)CC)CC(C)C=C2C=CC(C)C1CCC1CC(O)CC(=O)O1 PCZOHLXUXFIOCF-UHFFFAOYSA-N 0.000 claims description 3
• HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims description 3
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• QLJODMDSTUBWDW-UHFFFAOYSA-N lovastatin hydroxy acid Natural products C1=CC(C)C(CCC(O)CC(O)CC(O)=O)C2C(OC(=O)C(C)CC)CC(C)C=C21 QLJODMDSTUBWDW-UHFFFAOYSA-N 0.000 claims description 3
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• BPRHUIZQVSMCRT-VEUZHWNKSA-N rosuvastatin Chemical compound CC(C)C1=NC(N(C)S(C)(=O)=O)=NC(C=2C=CC(F)=CC=2)=C1\C=C\[C@@H](O)C[C@@H](O)CC(O)=O BPRHUIZQVSMCRT-VEUZHWNKSA-N 0.000 claims description 3
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• 238000004519 manufacturing process Methods 0.000 claims 5
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• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract description 17
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• 239000000243 solution Substances 0.000 description 20
• 239000000556 agonist Substances 0.000 description 15
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• 125000000896 monocarboxylic acid group Chemical group 0.000 description 15
• 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 description 14
• 125000000217 alkyl group Chemical group 0.000 description 13
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