PL2084172T3 - Nowe pochodne 1,1-ditlenku 1,4-benzotiepiny podstawione resztami benzylowymi, sposób ich wytwarzania, środki lecznicze zawierające te związki i ich zastosowanie - Google Patents

Nowe pochodne 1,1-ditlenku 1,4-benzotiepiny podstawione resztami benzylowymi, sposób ich wytwarzania, środki lecznicze zawierające te związki i ich zastosowanie

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Publication number
PL2084172T3
PL2084172T3 PL07819434T PL07819434T PL2084172T3 PL 2084172 T3 PL2084172 T3 PL 2084172T3 PL 07819434 T PL07819434 T PL 07819434T PL 07819434 T PL07819434 T PL 07819434T PL 2084172 T3 PL2084172 T3 PL 2084172T3
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Poland
Prior art keywords
benzothiepin
substituted
novel
compounds
benzyl groups
Prior art date
Application number
PL07819434T
Other languages
English (en)
Inventor
Wendelin Frick
Heiner Glombik
Stefan Theis
Hubert Heuer
Hans-Ludwig Schaefer
Werner Kramer
Original Assignee
Sanofi Aventis Deutschland
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Sanofi Aventis Deutschland filed Critical Sanofi Aventis Deutschland
Publication of PL2084172T3 publication Critical patent/PL2084172T3/pl

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    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H5/00Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium
    • C07H5/04Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium to nitrogen
    • C07H5/06Aminosugars
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
    • A61K31/708Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid having oxo groups directly attached to the purine ring system, e.g. guanosine, guanylic acid
    • AHUMAN NECESSITIES
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    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
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    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/04Anorexiants; Antiobesity agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/06Antihyperlipidemics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/48Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07H13/12Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by acids having the group -X-C(=X)-X-, or halides thereof, in which each X means nitrogen, oxygen, sulfur, selenium or tellurium, e.g. carbonic acid, carbamic acid
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    • C07H5/04Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium to nitrogen
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    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
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    • C07H7/00Compounds containing non-saccharide radicals linked to saccharide radicals by a carbon-to-carbon bond
    • C07H7/02Acyclic radicals
    • C07H7/027Keto-aldonic acids

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Cephalosporin Compounds (AREA)
PL07819434T 2006-11-14 2007-10-30 Nowe pochodne 1,1-ditlenku 1,4-benzotiepiny podstawione resztami benzylowymi, sposób ich wytwarzania, środki lecznicze zawierające te związki i ich zastosowanie PL2084172T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE102006053635A DE102006053635B4 (de) 2006-11-14 2006-11-14 Neue mit Benzylresten substituierte 1,4-Benzothiepin-1,1-Dioxidderivate, diese Verbindungen enthaltende Arzneimittel und deren Verwendung
EP07819434A EP2084172B1 (de) 2006-11-14 2007-10-30 Neue mit benzylresten substituierte 1,4-benzothiepin-1,1-dioxidderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung
PCT/EP2007/009393 WO2008058628A1 (de) 2006-11-14 2007-10-30 Neue mit benzylresten substituierte 1,4-benzothiepin-1,1-dioxidderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung

Publications (1)

Publication Number Publication Date
PL2084172T3 true PL2084172T3 (pl) 2011-06-30

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PL07819434T PL2084172T3 (pl) 2006-11-14 2007-10-30 Nowe pochodne 1,1-ditlenku 1,4-benzotiepiny podstawione resztami benzylowymi, sposób ich wytwarzania, środki lecznicze zawierające te związki i ich zastosowanie

Country Status (38)

Country Link
US (1) US7956085B2 (pl)
EP (1) EP2084172B1 (pl)
JP (1) JP5301453B2 (pl)
KR (1) KR101489168B1 (pl)
CN (1) CN101535326B (pl)
AR (2) AR063786A1 (pl)
AT (1) ATE492554T1 (pl)
AU (1) AU2007321496B2 (pl)
BR (1) BRPI0718813B8 (pl)
CA (2) CA2669230C (pl)
CL (1) CL2007003262A1 (pl)
CO (1) CO6190534A2 (pl)
CR (1) CR10733A (pl)
CY (1) CY1111166T1 (pl)
DE (2) DE102006053635B4 (pl)
DK (1) DK2084172T3 (pl)
EC (1) ECSP099327A (pl)
ES (1) ES2358371T3 (pl)
GT (1) GT200900125A (pl)
HK (1) HK1137762A1 (pl)
HR (1) HRP20110197T1 (pl)
IL (1) IL198718A (pl)
MA (1) MA30883B1 (pl)
MX (1) MX2009003958A (pl)
MY (1) MY148429A (pl)
NI (1) NI200900076A (pl)
NO (2) NO342236B1 (pl)
NZ (1) NZ576762A (pl)
PE (1) PE20081493A1 (pl)
PL (1) PL2084172T3 (pl)
PT (1) PT2084172E (pl)
RU (1) RU2456282C2 (pl)
SI (1) SI2084172T1 (pl)
SV (1) SV2009003216A (pl)
TN (1) TN2009000180A1 (pl)
TW (1) TWI414530B (pl)
UY (1) UY30709A1 (pl)
WO (1) WO2008058628A1 (pl)

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CN114072152A (zh) 2019-02-12 2022-02-18 米鲁姆制药公司 患有胆汁盐输出泵缺乏症的患者对asbti的基因型和剂量依赖性应答
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US20100035961A1 (en) 2010-02-11
NI200900076A (es) 2010-01-29
CR10733A (es) 2009-05-25
JP2010509379A (ja) 2010-03-25
BRPI0718813A2 (pt) 2013-12-03
PE20081493A1 (es) 2008-11-24
CN101535326A (zh) 2009-09-16
CA2865332A1 (en) 2008-05-22
PT2084172E (pt) 2011-02-10
KR101489168B1 (ko) 2015-02-03
CA2865332C (en) 2016-03-29
NO342236B1 (no) 2018-04-23
MA30883B1 (fr) 2009-11-02
CY1111166T1 (el) 2015-06-11
ES2358371T3 (es) 2011-05-10
DE102006053635A1 (de) 2008-05-15
SI2084172T1 (sl) 2011-03-31
BRPI0718813B1 (pt) 2020-12-08
NO20180497A1 (no) 2009-07-09
UY30709A1 (es) 2008-07-03
TN2009000180A1 (en) 2010-10-18
HK1137762A1 (en) 2010-08-06
AR063786A1 (es) 2009-02-18
NO20091893L (no) 2009-07-09
BRPI0718813B8 (pt) 2021-05-25
CN101535326B (zh) 2012-10-31
AR109033A2 (es) 2018-10-24
DE102006053635B4 (de) 2011-06-30
RU2456282C2 (ru) 2012-07-20
KR20090082396A (ko) 2009-07-30
CA2669230A1 (en) 2008-05-22
CL2007003262A1 (es) 2008-05-30
TW200837072A (en) 2008-09-16
CA2669230C (en) 2015-01-13
NZ576762A (en) 2010-11-26
DK2084172T3 (da) 2011-04-04
MX2009003958A (es) 2009-04-27
TWI414530B (zh) 2013-11-11
IL198718A0 (en) 2010-02-17
GT200900125A (es) 2011-06-23
ECSP099327A (es) 2009-06-30
RU2009122470A (ru) 2010-12-20
EP2084172A1 (de) 2009-08-05
DE502007006055D1 (de) 2011-02-03
SV2009003216A (es) 2010-05-26
US7956085B2 (en) 2011-06-07
AU2007321496B2 (en) 2012-07-26
MY148429A (en) 2013-04-30
WO2008058628A1 (de) 2008-05-22
ATE492554T1 (de) 2011-01-15
CO6190534A2 (es) 2010-08-19
NO344589B1 (no) 2020-02-03
IL198718A (en) 2012-12-31
HRP20110197T1 (hr) 2011-04-30
JP5301453B2 (ja) 2013-09-25
EP2084172B1 (de) 2010-12-22
AU2007321496A1 (en) 2008-05-22

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