NZ500687A - A method and a system for determination of particles using array electromagnetic detectors to build an image which is suited for assessment of somatic cells in a liquid sample - Google Patents
A method and a system for determination of particles using array electromagnetic detectors to build an image which is suited for assessment of somatic cells in a liquid sampleInfo
- Publication number
- NZ500687A NZ500687A NZ500687A NZ50068798A NZ500687A NZ 500687 A NZ500687 A NZ 500687A NZ 500687 A NZ500687 A NZ 500687A NZ 50068798 A NZ50068798 A NZ 50068798A NZ 500687 A NZ500687 A NZ 500687A
- Authority
- NZ
- New Zealand
- Prior art keywords
- sample
- particles
- detection elements
- compartment
- assessment
- Prior art date
Links
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Classifications
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- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/14—Optical investigation techniques, e.g. flow cytometry
- G01N15/1456—Optical investigation techniques, e.g. flow cytometry without spatial resolution of the texture or inner structure of the particle, e.g. processing of pulse signals
- G01N15/1459—Optical investigation techniques, e.g. flow cytometry without spatial resolution of the texture or inner structure of the particle, e.g. processing of pulse signals the analysis being performed on a sample stream
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
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Landscapes
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- Investigating Or Analysing Biological Materials (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Sampling And Sample Adjustment (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Dairy Products (AREA)
- Length Measuring Devices By Optical Means (AREA)
Applications Claiming Priority (3)
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| DK50997 | 1997-05-05 | ||
| DK143197 | 1997-12-09 | ||
| PCT/DK1998/000175 WO1998050777A1 (en) | 1997-05-05 | 1998-05-05 | A method and a system for determination of particles in a liquid sample |
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| NZ500687A true NZ500687A (en) | 2001-05-25 |
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| NZ500687A NZ500687A (en) | 1997-05-05 | 1998-05-05 | A method and a system for determination of particles using array electromagnetic detectors to build an image which is suited for assessment of somatic cells in a liquid sample |
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| NZ500686A NZ500686A (en) | 1997-05-05 | 1998-05-05 | A method and a system for determination of the number of somatic cells in milk, utilizing electromagnetic radiation |
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| WO (2) | WO1998050777A1 (enExample) |
Families Citing this family (184)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1935983B1 (en) * | 1997-05-05 | 2011-06-22 | ChemoMetec A/S | Method for determination of biological particles in blood |
| CA2349548C (en) * | 1998-11-05 | 2012-09-25 | Chemometec A/S | A method for the assessment of particles and a system and a device for use in the method |
| NL1010540C2 (nl) * | 1998-11-12 | 2000-05-15 | Maasland Nv | Werkwijze voor het vaststellen van de aanwezigheid van bepaalde stoffen in melk en inrichting voor het toepassen van deze werkwijze. |
| US6562785B1 (en) * | 1999-03-23 | 2003-05-13 | Howard M. Shapiro | Method for overcoming bacterial antibiotic resistance |
| CA2381285C (en) | 1999-08-06 | 2010-04-27 | Ulrik Darling Larsen | Particle characterisation apparatus |
| JP2003511682A (ja) * | 1999-10-08 | 2003-03-25 | カリパー・テクノロジーズ・コープ． | 膜透過電圧測定でのネルンスト電圧感知性染料の使用 |
| US6707548B2 (en) | 2001-02-08 | 2004-03-16 | Array Bioscience Corporation | Systems and methods for filter based spectrographic analysis |
| DE10110066C1 (de) * | 2001-03-02 | 2002-06-20 | Parsum Ges Fuer Partikel Stroe | Meßsonde zur in-line-Bestimmung der Größe von bewegten Partikeln in transparenten Medien |
| EP2184346B1 (en) * | 2001-09-06 | 2017-03-08 | Rapid Micro Biosystems, Inc. | Rapid detection of replicating cells |
| US7528957B2 (en) * | 2001-12-21 | 2009-05-05 | Malvern Instruments Incorporated | Spectrometric process monitoring |
| US7004928B2 (en) | 2002-02-08 | 2006-02-28 | Rosedale Medical, Inc. | Autonomous, ambulatory analyte monitor or drug delivery device |
| SE0201380D0 (sv) † | 2002-05-07 | 2002-05-07 | Delaval Holding Ab | Automatic milk separation |
| WO2003104770A2 (en) | 2002-06-01 | 2003-12-18 | Chempaq A/S | A disposable cartridge for characterizing particles suspended in a liquid |
| US11243494B2 (en) | 2002-07-31 | 2022-02-08 | Abs Global, Inc. | Multiple laminar flow-based particle and cellular separation with laser steering |
| WO2004040605A1 (ja) * | 2002-10-31 | 2004-05-13 | Mitsubishi Chemical Corporation | 電解コンデンサ用電解液及び電解コンデンサ、並びに有機オニウムのテトラフルオロアルミン酸塩の製造方法 |
| EP1558934B1 (en) * | 2002-10-31 | 2013-07-17 | ChemoMetec A/S | A method for assessment of particles |
| US7833802B2 (en) * | 2002-11-21 | 2010-11-16 | Ada Technologies, Inc. | Stroboscopic liberation and methods of use |
| WO2004061436A1 (de) * | 2003-01-03 | 2004-07-22 | Westfaliasurge Gmbh | Vorrichtung und verfahren zum bestimmen des gesundheitsstatus eines tieres |
| SE524587C2 (sv) * | 2003-02-18 | 2004-08-31 | Delaval Holding Ab | Förfarande och anordning för att räkna somatiska celler eller små fettdroppar i mjölk |
| US7052652B2 (en) | 2003-03-24 | 2006-05-30 | Rosedale Medical, Inc. | Analyte concentration detection devices and methods |
| US20050136507A1 (en) * | 2003-12-19 | 2005-06-23 | Sullivan George D. | Portable disposable airborne pathogen collection device and system |
| EP1711793A1 (en) * | 2004-01-26 | 2006-10-18 | Koninklijke Philips Electronics N.V. | Method and device for on-chip magnetic resonance spectroscopy |
| CA2566897A1 (en) * | 2004-05-21 | 2005-12-01 | Mds Inc. Doing Business Through Its Mds Pharma Services Division | Method of quantifying the cell-binding properties of a medical device |
| WO2006025039A2 (en) * | 2004-09-03 | 2006-03-09 | University College Cork - National University Of Ireland, Cork; | An optical detector |
| US7465560B2 (en) * | 2004-11-30 | 2008-12-16 | Purdue Research Foundation | System and method for rapid detection and characterization of bacterial colonies using forward light scattering |
| CA2855108A1 (en) | 2005-02-10 | 2006-08-17 | Koninklijke Philips Electronics N.V. | Dual sample cartridge and method for characterizing particles in liquid |
| WO2006084472A1 (en) | 2005-02-10 | 2006-08-17 | Chempaq A/S | Dual sample cartridge and method for characterizing particle in liquid |
| SE528697C2 (sv) * | 2005-03-11 | 2007-01-30 | Hemocue Ab | Volymetrisk bestämning av antalet vita blodkroppar i ett blodprov |
| US8377711B2 (en) * | 2005-04-04 | 2013-02-19 | Ada Technologies, Inc. | Stroboscopic liberation and methods of use |
| US20060281187A1 (en) | 2005-06-13 | 2006-12-14 | Rosedale Medical, Inc. | Analyte detection devices and methods with hematocrit/volume correction and feedback control |
| US7681436B2 (en) * | 2005-06-22 | 2010-03-23 | Hitek Aqua Systems, Llc | In-situ water analysis method and system |
| US7409853B2 (en) * | 2005-06-30 | 2008-08-12 | Hitek Aqua Systems, Llc | Floatable housing for in situ water monitoring system |
| US20070037135A1 (en) * | 2005-08-08 | 2007-02-15 | Barnes Russell H | System and method for the identification and quantification of a biological sample suspended in a liquid |
| US9057046B2 (en) | 2005-09-26 | 2015-06-16 | Rapid Micro Biosystems, Inc. | Cassette containing growth medium |
| JP5232003B2 (ja) | 2005-09-30 | 2013-07-10 | インテュイティ メディカル インコーポレイテッド | 多部分体液試料採取及び分析カートリッジ |
| US8801631B2 (en) | 2005-09-30 | 2014-08-12 | Intuity Medical, Inc. | Devices and methods for facilitating fluid transport |
| DE102005049473B4 (de) * | 2005-10-13 | 2009-08-27 | BvL Oberflächentechnik GmbH | Oberflächenreinigungsvorrichtung |
| US8798338B2 (en) * | 2006-01-09 | 2014-08-05 | University Of Wyoming | Method and system for counting particles in a laminar flow with an imaging device |
| SE531233C2 (sv) * | 2006-03-28 | 2009-01-27 | Hemocue Ab | Anordning och förfarande för detektion av fluorecensmärkta biologiska komponenter |
| KR20070107947A (ko) * | 2006-05-04 | 2007-11-08 | 대한민국(관리부서:농촌진흥청) | 근적외선 분광 분석 시스템을 이용한 우유 중 요소태질소의분석방법 |
| SE531041C2 (sv) * | 2006-07-17 | 2008-11-25 | Hemocue Ab | Räkning av trombocyter |
| SE530192C2 (sv) | 2006-07-19 | 2008-03-25 | Hemocue Ab | Apparat för avbildning av prov där provhållaren är flyttbar medelst magnetisk växelverkan |
| SE530750C2 (sv) | 2006-07-19 | 2008-09-02 | Hemocue Ab | En mätapparat, en metod och ett datorprogram |
| US7545490B1 (en) | 2006-09-26 | 2009-06-09 | Itt Manufacturing Enterprises, Inc. | Microscope flow cell apparatus for raman analysis of a liquid |
| US8041145B2 (en) * | 2006-11-17 | 2011-10-18 | The Invention Science Fund I, Llc | Distortion compensated imaging |
| DE102006054922B3 (de) * | 2006-11-22 | 2008-01-31 | Durag Gmbh | Vorrichtung zur Begrenzung eines Meßvolumens in einem optischen Meßsystem |
| US8189042B2 (en) * | 2006-12-15 | 2012-05-29 | Pollack Laboratories, Inc. | Vision analysis system for a process vessel |
| WO2008077007A1 (en) * | 2006-12-19 | 2008-06-26 | Cytyc Corporation | Method for analyzing blood content of cytological specimens |
| US8254657B2 (en) * | 2007-01-08 | 2012-08-28 | Pollack Laboratories, Inc. | Image recognition and analysis system and software |
| US8787633B2 (en) * | 2007-01-16 | 2014-07-22 | Purdue Research Foundation | System and method of organism identification |
| WO2008092118A2 (en) * | 2007-01-25 | 2008-07-31 | Ada Technologies, Inc. | Stroboscopic signal amplification and surface enhanced raman spectroscopy |
| USD596271S1 (en) | 2007-07-23 | 2009-07-14 | Hitek Aqua Systems | Floating housing |
| EP2232231A4 (en) * | 2007-12-04 | 2015-12-02 | Particle Measuring Syst | SYSTEMS AND METHODS FOR DETECTION OF NON-ORTHOGONAL PARTICLES |
| US8005280B2 (en) * | 2007-12-12 | 2011-08-23 | Jadak, Llc | Optical imaging clinical sampler |
| SE532499C2 (sv) | 2008-01-18 | 2010-02-09 | Hemocue Ab | Metod och apparat för analys av partiklar i ett vätskeformigt prov |
| US7929121B2 (en) | 2008-03-21 | 2011-04-19 | Abbott Point Of Care, Inc. | Method and apparatus for detecting and counting platelets individually and in aggregate clumps |
| EP2280905B1 (en) | 2008-04-11 | 2016-07-06 | Fluidigm Corporation | Multilevel microfluidic systems and methods |
| US8059909B2 (en) * | 2008-04-29 | 2011-11-15 | Sony Corporation | Adaptive generation of irregular spatial sub-sampling for images |
| US8059908B2 (en) * | 2008-04-29 | 2011-11-15 | Sony Corporation | Adaptive area of influence filter for irregular spatial sub-sampled images |
| US8055087B2 (en) * | 2008-04-29 | 2011-11-08 | Sony Corporation | Sample level variation for spatial sub-sampled images |
| US9394184B1 (en) | 2008-04-30 | 2016-07-19 | Hitek Aqua Systems | System for and method of regulating calcium hardness for a body of water |
| US20090281536A1 (en) * | 2008-05-09 | 2009-11-12 | Hugh Beckman | Medical Device For Diagnosing and Treating Anomalous Tissue and Method for Doing the Same |
| EP2293719B1 (en) | 2008-05-30 | 2015-09-09 | Intuity Medical, Inc. | Body fluid sampling device -- sampling site interface |
| CA2726067C (en) | 2008-06-06 | 2020-10-20 | Intuity Medical, Inc. | Detection meter and mode of operation |
| EP3984454A1 (en) | 2008-06-06 | 2022-04-20 | Intuity Medical, Inc. | Medical diagnostic devices and methods |
| GB0812455D0 (en) * | 2008-07-08 | 2008-08-13 | Ici Ltd | Methods of and apparatus for determining properties relating to multi-phase systems |
| DK2312943T3 (da) | 2008-07-14 | 2020-02-03 | Chemometec As | Fremgangsmåde til vurdering af levedygtige celler og anvendelse af N-(7-dimethylamino-4-methyl-3-coumarinyl)-maleimid (DACM) eller N-(9-acridinyl)maleimid (NAM) til vurdering af apoptose |
| WO2010006616A2 (en) | 2008-07-14 | 2010-01-21 | Chemometec A/S | Method and kit for examination of cells using n-(9-acridinyl)maleimide (nam) or using 7-diethylamino-3-((4'-(iodoacetyl)amino)phenyl)-4-methylcoumarin (cpi) |
| WO2010013757A1 (ja) * | 2008-07-31 | 2010-02-04 | 株式会社クラレ | 体細胞数の測定装置及びセンサ |
| TW201017149A (en) | 2008-08-06 | 2010-05-01 | Invitrox Inc | Use of focused light scattering techniques in biological applications |
| US8947657B2 (en) * | 2008-09-08 | 2015-02-03 | Lawrence Livermore National Security, Llc | Methods for isolation and viability assessment of biological organisms |
| US8830450B2 (en) * | 2009-12-02 | 2014-09-09 | Lawrence Livermore National Security, Llc | Methods and systems for Raman and optical cross-interrogation in flow-through silicon membranes |
| AU2009296528A1 (en) | 2008-09-24 | 2010-04-01 | Straus Holdings Inc. | Imaging analyzer for testing analytes |
| JP2010085194A (ja) * | 2008-09-30 | 2010-04-15 | Sysmex Corp | 試料分析装置 |
| US8154273B2 (en) * | 2008-10-10 | 2012-04-10 | Beckman Coulter, Inc. | Detecting and handling coincidence in particle analysis |
| WO2010045949A2 (en) | 2008-10-21 | 2010-04-29 | Chemometec A/S | A method and apparatus for analysis of a particle |
| DK200801722A (en) | 2008-12-05 | 2010-06-06 | Unisensor As | Optical sectioning of a sample and detection of particles in a sample |
| SE533454C2 (sv) * | 2008-12-18 | 2010-10-05 | Portendo Ab | Detektion av små mängder av ämnen |
| US8058630B2 (en) | 2009-01-16 | 2011-11-15 | Fluidigm Corporation | Microfluidic devices and methods |
| US20120019819A1 (en) * | 2009-01-21 | 2012-01-26 | Rare Light, Inc. | Raman spectroscopy using multiple discrete light sources |
| WO2010085775A2 (en) * | 2009-01-26 | 2010-07-29 | The General Hospital Corporation | System, method and computer-accessible medium for providing wide-field superresolution microscopy |
| WO2010127302A1 (en) * | 2009-05-01 | 2010-11-04 | The Trustees Of Columbia University In The City Of New York | Systems, methods and computer-accessible media for obtaining three-dimensional information from two-dimensional fluorescence emission data |
| US8735056B2 (en) | 2009-05-26 | 2014-05-27 | Invitrox, Inc. | Instrument and method for optical particle sensing |
| GB0910759D0 (en) * | 2009-06-22 | 2009-08-05 | Ucl Business Plc | Microfluidic device |
| US8570370B2 (en) * | 2009-08-31 | 2013-10-29 | Bio-Rad Laboratories, Inc. | Compact automated cell counter |
| WO2011040825A1 (en) * | 2009-09-30 | 2011-04-07 | Quantec Limited | Mastitis measurement |
| WO2011043912A2 (en) * | 2009-10-07 | 2011-04-14 | Marvell World Trade Ltd. | Method and apparatus for power driving |
| EP3106871B1 (en) | 2009-11-30 | 2021-10-27 | Intuity Medical, Inc. | A method of verifying the accuracy of the operation of an analyte monitoring device |
| US8786852B2 (en) * | 2009-12-02 | 2014-07-22 | Lawrence Livermore National Security, Llc | Nanoscale array structures suitable for surface enhanced raman scattering and methods related thereto |
| WO2011066837A1 (en) | 2009-12-04 | 2011-06-09 | Unisensor A/S | System and method for time-related microscopy of biological organisms |
| US8614739B2 (en) * | 2009-12-31 | 2013-12-24 | Pollack Laboratories, Inc. | Apparatus and method for analyzing fluids in vessels and pipelines |
| US9102977B2 (en) | 2010-02-11 | 2015-08-11 | Chemometec A/S | Method for analysis of cellular DNA content |
| CN102792148B (zh) | 2010-03-04 | 2016-06-01 | 皇家飞利浦有限公司 | 柔性样本容器 |
| WO2011162823A1 (en) | 2010-06-25 | 2011-12-29 | Intuity Medical, Inc. | Analyte monitoring methods and systems |
| TWI425202B (zh) * | 2010-07-22 | 2014-02-01 | Univ China Sci & Tech | Infrared lens penetration measurement device |
| US8907312B2 (en) * | 2010-08-20 | 2014-12-09 | Bio-Rad Laboratories, Inc. | Cytometry system with solid numerical-aperture-increasing lens |
| CN103168225B (zh) * | 2010-10-25 | 2015-11-25 | 阿库里赛托梅特斯公司 | 用于收集流式细胞仪中的数据集的系统和用户接口 |
| JP5568444B2 (ja) * | 2010-11-01 | 2014-08-06 | 株式会社日立ハイテクノロジーズ | 欠陥検査方法、微弱光検出方法および微弱光検出器 |
| US10908066B2 (en) | 2010-11-16 | 2021-02-02 | 1087 Systems, Inc. | Use of vibrational spectroscopy for microfluidic liquid measurement |
| US8941062B2 (en) * | 2010-11-16 | 2015-01-27 | 1087 Systems, Inc. | System for identifying and sorting living cells |
| US20120225475A1 (en) | 2010-11-16 | 2012-09-06 | 1087 Systems, Inc. | Cytometry system with quantum cascade laser source, acoustic detector, and micro-fluidic cell handling system configured for inspection of individual cells |
| PL2458367T3 (pl) | 2010-11-25 | 2015-12-31 | Mettler Toledo Gmbh | Urządzenie oraz sposób do rozpoznawania substancji stałych w fazie ciekłej |
| US9522396B2 (en) | 2010-12-29 | 2016-12-20 | S.D. Sight Diagnostics Ltd. | Apparatus and method for automatic detection of pathogens |
| WO2012106294A1 (en) * | 2011-02-04 | 2012-08-09 | Cytonome/St, Llc | Particle sorting apparatus and method |
| US8399262B2 (en) | 2011-03-23 | 2013-03-19 | Darrel A. Mazzari | Biosensor |
| US9612230B2 (en) * | 2011-06-21 | 2017-04-04 | Miura Co., Ltd. | Water quality measuring device |
| US9423335B2 (en) | 2011-07-21 | 2016-08-23 | Invitrox, Inc. | Instrument and method for optical particle sensing |
| EP3106870B1 (en) | 2011-08-03 | 2018-04-11 | Intuity Medical, Inc. | Body fluid sampling arrangement |
| US9182342B2 (en) * | 2011-09-23 | 2015-11-10 | Motion Controls, Llc | Apparatus, system and method for using an LED to identify a presence of a material in a gas and/or a fluid and/or determine properties of the material |
| JP6313211B2 (ja) | 2011-10-25 | 2018-04-18 | デイライト ソリューションズ、インコーポレイテッド | 赤外撮像顕微鏡 |
| PL2776550T3 (pl) | 2011-11-07 | 2018-05-30 | Rapid Micro Biosystems, Inc. | Kaseta do badania sterylności |
| WO2013081534A1 (en) | 2011-12-01 | 2013-06-06 | Delaval Holding Ab | Milking system and method for cleaning in a milking system |
| EP2798350B1 (en) | 2011-12-29 | 2021-07-28 | Sight Diagnostics Ltd. | Methods and systems for detecting a pathogen in a biological sample |
| FR2987117B1 (fr) * | 2012-02-20 | 2014-03-07 | Bio Logic | Spectrometre |
| CN104136906A (zh) * | 2012-02-21 | 2014-11-05 | 株式会社明治 | 乳制品的50％粒径的简便检测方法 |
| US9395304B2 (en) | 2012-03-01 | 2016-07-19 | Lawrence Livermore National Security, Llc | Nanoscale structures on optical fiber for surface enhanced Raman scattering and methods related thereto |
| CN102621116A (zh) * | 2012-03-08 | 2012-08-01 | 华南农业大学 | 一种西洋参质量评价的检测装置及其方法 |
| CA3171698C (en) | 2012-04-16 | 2025-11-18 | Rapid Micro Biosystems, Inc. | CELL CULTURE DEVICE |
| US9389175B2 (en) * | 2012-11-20 | 2016-07-12 | Satish Deshpande | Device and process to approximate somatic cell count of untreated mammalian milk |
| NO335224B1 (no) * | 2013-01-28 | 2014-10-20 | Sinvent As | System og fremgangsmåte for telling av dyreplankton |
| WO2014209471A2 (en) | 2013-04-12 | 2014-12-31 | Daylight Solutions, Inc. | Infrared refractive objective lens assembly |
| EP2999988A4 (en) | 2013-05-23 | 2017-01-11 | S.D. Sight Diagnostics Ltd. | Method and system for imaging a cell sample |
| DK3004838T3 (da) | 2013-05-28 | 2022-06-20 | Chemometec As | Billeddannende cytometer |
| ITVR20130132A1 (it) * | 2013-05-29 | 2014-11-30 | Optoelettronica Italia S R L | Kit per il rilevamento di micro-rna estratto da un campione di fluido corporeo nonché metodo per il rilevamento dello stesso |
| CA2912283A1 (en) | 2013-06-21 | 2014-12-21 | Intuity Medical, Inc. | Analyte monitoring system with audible feedback |
| IL227276A0 (en) | 2013-07-01 | 2014-03-06 | Parasight Ltd | A method and system for preparing a monolayer of cells, particularly suitable for diagnosis |
| US8961904B2 (en) | 2013-07-16 | 2015-02-24 | Premium Genetics (Uk) Ltd. | Microfluidic chip |
| EP3039477B1 (en) | 2013-08-26 | 2021-10-20 | S.D. Sight Diagnostics Ltd. | Digital microscopy systems, methods and computer program products |
| US9536304B2 (en) * | 2013-08-30 | 2017-01-03 | Dairy Quality Inc. | Determining pathogens based on an image of somatic cells in a fluid sample |
| KR101490738B1 (ko) * | 2013-10-15 | 2015-02-11 | (주)한국해양기상기술 | 플랑크톤 검사장치 |
| JP6564781B2 (ja) | 2013-10-29 | 2019-08-21 | アイデックス ラボラトリーズ インコーポレイテッドＩＤＥＸＸ Ｌａｂｏｒａｔｏｒｉｅｓ， Ｉｎｃ． | 液体サンプル中で細菌を検出し、その濃度を決定するための方法および容器 |
| US11796449B2 (en) | 2013-10-30 | 2023-10-24 | Abs Global, Inc. | Microfluidic system and method with focused energy apparatus |
| CN106029863A (zh) | 2013-11-06 | 2016-10-12 | 贝克顿·迪金森公司 | 微流体性装置和制造和使用其的方法 |
| US10018640B2 (en) | 2013-11-13 | 2018-07-10 | Becton, Dickinson And Company | Optical imaging system and methods for using the same |
| DE102014003386B4 (de) * | 2014-03-07 | 2016-06-23 | Celltool Gmbh | Verfahren und Vorrichtung zur Qualitätskontrolle eines Blutprodukts |
| CN107077732B (zh) | 2014-08-27 | 2020-11-24 | 思迪赛特诊断有限公司 | 用于对数字显微镜计算聚焦变化的系统及方法 |
| CN105403538B (zh) * | 2014-08-29 | 2018-11-13 | 清华大学 | 一种测量碳纳米管手性的方法及装置 |
| CN105445226B (zh) * | 2014-08-29 | 2020-04-28 | 清华大学 | 一种观测一维纳米材料的方法及装置 |
| JP2018509615A (ja) | 2015-02-19 | 2018-04-05 | プレミアム ジェネティクス （ユーケー） リミテッド | 走査型赤外線測定システム |
| US11521475B1 (en) | 2015-08-31 | 2022-12-06 | Hitek Aqua Systems | System for and method remotely monitoring chemistry of recreational water facilities |
| EP3859425B1 (en) | 2015-09-17 | 2024-04-17 | S.D. Sight Diagnostics Ltd. | Methods and apparatus for detecting an entity in a bodily sample |
| US10563164B1 (en) | 2015-10-08 | 2020-02-18 | Charm Sciences, Inc. | Plate reader |
| US10948420B2 (en) | 2015-12-09 | 2021-03-16 | Indevr, Inc. | Automated agglutination analyzer with contour comparison |
| WO2017117462A1 (en) | 2015-12-30 | 2017-07-06 | Bio-Rad Laboratories, Inc. | Detection and signal processing system for particle assays |
| EP3397946B1 (en) * | 2015-12-30 | 2021-12-01 | Bio-Rad Laboratories, Inc. | Optical detection system for particles |
| HU231357B1 (hu) * | 2016-01-25 | 2023-03-28 | Számítástechnikai és Automatizálási Kutató Intézet | Eljárás és berendezés minta fluoreszcencia-vizsgálatára |
| CA3018108A1 (en) | 2016-03-18 | 2017-09-21 | ConnectedYard, Inc. | Chemical monitoring devices and methods |
| WO2017168411A1 (en) | 2016-03-30 | 2017-10-05 | S.D. Sight Diagnostics Ltd | Image processing device for identifying blood parasites |
| US10495563B1 (en) | 2016-04-28 | 2019-12-03 | Charm Sciences, Inc. | Plate reader observation methods and operation |
| CN115266540B (zh) | 2016-05-11 | 2025-11-28 | 思迪赛特诊断有限公司 | 对样品实施的光学测量 |
| EP4177593A1 (en) | 2016-05-11 | 2023-05-10 | S.D. Sight Diagnostics Ltd. | Sample carrier for optical measurements |
| JP6954800B2 (ja) * | 2016-11-22 | 2021-10-27 | リオン株式会社 | 生物粒子計数システムおよび生物粒子計数方法 |
| CN108234681B (zh) * | 2016-12-14 | 2021-02-26 | 中国电信股份有限公司 | 地址资源自动回收方法、地址资源管理装置及网络系统 |
| WO2018175549A1 (en) | 2017-03-21 | 2018-09-27 | Hayward Industries, Inc. | Systems and methods for sanitizing pool and spa water |
| JP7058271B2 (ja) * | 2017-07-26 | 2022-04-21 | 浜松ホトニクス株式会社 | 試料観察装置及び試料観察方法 |
| CN107860693A (zh) * | 2017-11-02 | 2018-03-30 | 深圳市卓尔思科技有限公司 | 一种液体检测仪及液体检测方法 |
| JP7214729B2 (ja) | 2017-11-14 | 2023-01-30 | エス．ディー．サイト ダイアグノスティクス リミテッド | 光学測定用試料収容器 |
| CN112740017B (zh) | 2018-04-19 | 2024-12-13 | 曙光诊断学公司 | 靶标检测 |
| WO2019226790A1 (en) | 2018-05-23 | 2019-11-28 | Abs Global, Inc. | Systems and methods for particle focusing in microchannels |
| CN108827936B (zh) * | 2018-06-15 | 2024-03-08 | 何坚 | 一种血液培养报阳检测装置与方法 |
| DE102018215177B4 (de) * | 2018-09-06 | 2025-05-08 | Robert Bosch Gmbh | Autofokus- und Partikelsensorvorrichtung und entsprechendes Verfahren, sowie Kamera- und Partikelsensorsystem |
| NL2021691B1 (en) * | 2018-09-24 | 2020-05-07 | Lely Patent Nv | Milking system with detection system |
| EP3860452A4 (en) | 2018-10-04 | 2022-11-23 | First Light Diagnostics, Inc. | ANALYTICAL TOOL |
| US11721094B2 (en) | 2018-11-07 | 2023-08-08 | Foss Analytical A/S | Milk analyser for classifying milk |
| CN109444009B (zh) * | 2018-12-10 | 2024-02-20 | 红云红河烟草(集团)有限责任公司 | 大气环境中苯并芘的在线直测设备 |
| EP3702776A3 (en) * | 2019-02-26 | 2020-09-16 | Pentair Water Pool and Spa, Inc. | Water quality monitor system and method |
| CN110057730A (zh) * | 2019-03-12 | 2019-07-26 | 天津大学 | 一种人体颗粒物主动吸入浓度测试方法 |
| WO2020215011A1 (en) | 2019-04-18 | 2020-10-22 | Abs Global, Inc. | System and process for continuous addition of cryoprotectant |
| JP7405555B2 (ja) * | 2019-10-08 | 2023-12-26 | 株式会社アドバンテスト | 体細胞計、体細胞測定方法、プログラムおよび記録媒体 |
| US12498325B2 (en) | 2019-10-22 | 2025-12-16 | S.D. Sight Diagnostics Ltd. | Accounting for errors in optical measurements |
| BG67480B1 (bg) | 2019-10-30 | 2022-12-15 | "Милкотроник" Оод | Устройство за диференциално броене на микрочастици в биологични течности |
| DE102019129932B4 (de) * | 2019-11-06 | 2023-12-21 | Technische Universität Braunschweig | Optische Detektionseinrichtung und Verfahren zum Betreiben einer optischen Detektionseinrichtung |
| JP7677972B2 (ja) | 2019-12-12 | 2025-05-15 | エス．ディー．サイト ダイアグノスティックス リミテッド | カラー血液スミア画像の人工的な生成 |
| WO2021116959A1 (en) | 2019-12-12 | 2021-06-17 | S.D. Sight Diagnostics Ltd | Analyzing an analyte disposed within a medium |
| JP7489053B2 (ja) * | 2019-12-16 | 2024-05-23 | 東芝テック株式会社 | 測定装置 |
| US11628439B2 (en) | 2020-01-13 | 2023-04-18 | Abs Global, Inc. | Single-sheath microfluidic chip |
| CN111548902A (zh) * | 2020-04-07 | 2020-08-18 | 广东环凯生物科技有限公司 | 一种微生物检测系统和方法 |
| EP3896432A1 (en) * | 2020-04-15 | 2021-10-20 | HighFly Therapeutics (HK) Limited | A system and a method for fluorescence detection |
| CN115667890B (zh) * | 2020-05-20 | 2024-02-02 | Ysi公司 | 基于空间梯度的荧光计 |
| EP4232601A4 (en) | 2020-10-21 | 2024-10-09 | ABS Global, Inc. | METHODS AND SYSTEMS FOR PROCESSING GENETIC SAMPLES TO DETERMINE IDENTITY OR DETECT CONTAMINATION |
| EP4248190A4 (en) | 2020-11-23 | 2024-12-25 | ABS Global, Inc. | MODULAR FLOW CYTOMETRY SYSTEMS AND METHODS FOR PROCESSING SAMPLES |
| PL245363B1 (pl) * | 2021-01-13 | 2024-07-08 | Ml System Spolka Akcyjna | Urządzenie i sposób do nieinwazyjnego wykrywania i identyfikacji mikroorganizmów w próbkach z materiałów stałych, ciekłych i w próbkach gazowych |
| CN118176415A (zh) * | 2021-09-22 | 2024-06-11 | 阿尔克科学股份有限责任公司 | 用于测定指示炎症的血源性因子的设备、方法、系统 |
| FR3130972B1 (fr) * | 2021-12-20 | 2024-08-16 | Diagdev | Elément pour système de mesure optique |
Family Cites Families (73)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE342501C (enExample) | ||||
| DE459371C (de) | 1926-11-18 | 1928-05-02 | Oerlikon Maschf | Hilfstriebwagen mit elektrischer Kraftanlage fuer elektrische Bahnbetriebe |
| US3679365A (en) * | 1970-01-29 | 1972-07-25 | Technicon Instr | Method for the automatic counting of the somatic cells in milk,and novel reaction reagent for use therewith |
| US3705755A (en) | 1970-08-24 | 1972-12-12 | Stephen Charles Baer | Microscopy apparatus |
| US4075462A (en) * | 1975-01-08 | 1978-02-21 | William Guy Rowe | Particle analyzer apparatus employing light-sensitive electronic detector array |
| US4084905A (en) * | 1976-03-11 | 1978-04-18 | Canadian Patents & Development Limited | Apparatus for detecting and measuring fluorescence emission |
| US4181853A (en) | 1976-12-10 | 1980-01-01 | Varian Associates, Inc. | Liquid chromatography system with packed flow cell for improved fluorescence detection |
| DE2732272C2 (de) | 1977-07-16 | 1979-07-05 | Deutsches Krebsforschungszentrum Stiftung Des Oeffentlichen Rechts, 6900 Heidelberg | Verfahren und Vorrichtung zur Fluoreszenzanalyse von gefärbten Partikeln, insbesondere biologischen Zellen |
| GB2001434A (en) * | 1977-07-19 | 1979-01-31 | Tarkkanen V | Measurement of somatic cells in milk |
| US4295199A (en) * | 1979-10-22 | 1981-10-13 | Bio-Rad Laboratories, Inc. | Automatic fluorometer and data processor for performing fluorescent immunoassays |
| JPS5830049B2 (ja) | 1979-11-20 | 1983-06-27 | 工業技術院長 | 網赤血球自動計測装置 |
| US4460546A (en) | 1980-08-11 | 1984-07-17 | Kapralis Imants P | Trigger to controllably initiate crystallization |
| US4550417A (en) * | 1982-10-15 | 1985-10-29 | Sanki Engineering Co., Ltd. | Apparatus for counting numbers of fine particles |
| JPS59179328A (ja) * | 1983-03-31 | 1984-10-11 | Fujitsu Ltd | モ−ルド方法 |
| DE3329257A1 (de) * | 1983-08-12 | 1985-02-28 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V., 3400 Göttingen | Fluorometer |
| FR2555754A1 (fr) | 1983-11-28 | 1985-05-31 | Inter Inf | Procede et dispositif d'analyse automatique d'echantillons biologiques |
| US4601551A (en) * | 1984-01-23 | 1986-07-22 | The Micromanipulator Microscope Company, Inc. | Manipulation of embryos and ova |
| GB8515132D0 (en) * | 1985-06-14 | 1985-07-17 | British Nuclear Fuels Plc | Measuring photosynthetic activities of plants |
| US4744667A (en) | 1986-02-11 | 1988-05-17 | University Of Massachusetts | Microspectrofluorimeter |
| US4804850A (en) * | 1986-03-14 | 1989-02-14 | Luminis Pty. Limited | Measurement of fluorescence |
| US5147806A (en) * | 1988-04-29 | 1992-09-15 | Igen, Inc. | Method and apparatus for conducting electrochemiluminescence measurements |
| JPS62274241A (ja) | 1986-05-23 | 1987-11-28 | Hitachi Ltd | 細胞分析装置 |
| US4896967A (en) * | 1986-08-15 | 1990-01-30 | Hamilton-Thorn Research | Motility scanner and method |
| US5494800A (en) | 1987-01-29 | 1996-02-27 | Cytosignet, Inc. | Analyte detection in particulate-containing samples |
| US4900685A (en) | 1987-01-29 | 1990-02-13 | Cytosignet, Inc. | Analyte detection in particulate-containing samples |
| GB8726304D0 (en) | 1987-11-10 | 1987-12-16 | Secr Defence | Particle asymmetry analyser |
| DE3817089A1 (de) * | 1988-05-19 | 1989-11-30 | Merck Patent Gmbh | Verfahren und mittel zur bestimmung von bakterien und somatischen zellen in milch |
| JPH026729A (ja) | 1988-06-25 | 1990-01-10 | Shimadzu Corp | 細胞数測定装置 |
| US5104221A (en) | 1989-03-03 | 1992-04-14 | Coulter Electronics Of New England, Inc. | Particle size analysis utilizing polarization intensity differential scattering |
| CA1324894C (en) * | 1989-03-31 | 1993-12-07 | Maritime Scientific Services Ltd. | Method and apparatus for the identification of particles |
| SE465742B (sv) | 1989-04-26 | 1991-10-21 | Migrata Uk Ltd | Kyvett foer upptagning foer minst ett fluidum |
| DE69026780T2 (de) | 1989-09-22 | 1996-11-07 | Fuji Photo Film Co Ltd | Rastermikroskop und Rastermechanismus dafür |
| GB8927744D0 (en) | 1989-12-07 | 1990-02-07 | Diatec A S | Process and apparatus |
| GB8927742D0 (en) * | 1989-12-07 | 1990-02-07 | Diatec A S | Process and apparatus |
| US5093866A (en) | 1990-02-09 | 1992-03-03 | Hamilton Equine Associates Limited | Fluorescence and motility characterization system for cells, bacteria, and particles in fluids |
| DK0479977T3 (da) * | 1990-03-30 | 1998-02-09 | Neuromedical Systems Inc | Fremgangsmåde og apparat til cytologisk prøveklassifikation |
| DK111990D0 (da) | 1990-05-04 | 1990-05-04 | Biometic Aps | Apparat og fremgangsmaade til analyse af en vaeskesuspension |
| DE4017398C2 (de) * | 1990-05-30 | 1993-11-25 | Elemer Dipl Chem Dr Faltusz | Verfahren zur direkten, epifluoroszenzmikroskopischen oder durchflußzytometrischen Simultanbestimmung von mikrobiellen und somatischen Zellen in einer chemisch vorbehandelten Rohmilchprobe |
| JP2939647B2 (ja) * | 1990-07-24 | 1999-08-25 | シスメックス株式会社 | フローイメージングサイトメータにおける自動焦点調整方法 |
| WO1992002632A1 (en) | 1990-07-30 | 1992-02-20 | Sierra Cytometry | Fluorescent dyes for identification and enumeration of viable cells in milk |
| JPH04125609A (ja) | 1990-09-18 | 1992-04-27 | Satoshi Kawada | 光学顕微鏡 |
| JPH04188061A (ja) | 1990-11-22 | 1992-07-06 | Intaadetsuku:Kk | 住血性寄生成虫の観察方法及びその装置 |
| US5196709A (en) | 1991-05-03 | 1993-03-23 | University Of Maryland Systems | Fluorometry method and apparatus using a semiconductor laser diode as a light source |
| JP3102935B2 (ja) * | 1991-11-20 | 2000-10-23 | シスメックス株式会社 | イメージングフローサイトメータ |
| US5291422A (en) | 1992-01-28 | 1994-03-01 | Sgi International | Broadband instrument for nondestructive measurement of material properties |
| EP0556971B1 (en) * | 1992-02-18 | 1999-12-08 | Hitachi, Ltd. | An apparatus for investigating particles in a fluid, and a method of operation thereof |
| CA2100020C (en) | 1992-07-17 | 2001-09-11 | Walter Blumenfeld | Methods and apparatus for detecting bacterial growth by spectrophotometric sampling of a fiber-optic array |
| JP3215175B2 (ja) * | 1992-08-10 | 2001-10-02 | シスメックス株式会社 | 粒子分析装置 |
| JPH06221986A (ja) | 1993-01-26 | 1994-08-12 | Hitachi Ltd | フロー式粒子画像解析方法及びフロー式粒子画像解析装置 |
| US5556764A (en) | 1993-02-17 | 1996-09-17 | Biometric Imaging, Inc. | Method and apparatus for cell counting and cell classification |
| US5306467A (en) | 1993-02-17 | 1994-04-26 | Hamilton-Thorn Research | Apparatus for measurement of cell concentration in a biological sample employing a magnetic slide loading apparatus |
| US5563070A (en) * | 1993-05-28 | 1996-10-08 | Omron Corporation | Method of counting reticulocytes |
| JPH0749300A (ja) * | 1993-08-04 | 1995-02-21 | Otax Kk | 粒子数測定装置 |
| JPH07120375A (ja) * | 1993-10-21 | 1995-05-12 | Hitachi Ltd | フロー式粒子画像解析方法及び装置 |
| US5425451A (en) * | 1994-05-05 | 1995-06-20 | Blase; William F. | Compact disc case |
| IT1269793B (it) | 1994-05-18 | 1997-04-15 | Pluristandard Dott Guido Motol | Procedimento ed apparecchiatura per l'analisi di liquidi eterogenei, particolarmente per il conteggio delle cellule somatiche nel latte vaccino |
| RU2060499C1 (ru) * | 1994-09-30 | 1996-05-20 | Игорь Леонидович Юдин | Устройство для определения количества соматических клеток в молоке |
| EP0713087B1 (en) | 1994-11-17 | 1999-04-14 | Chemunex | Apparatus and process for rapid and ultrasensitive detection and counting of microorganisms by fluorescence |
| DE69417899T2 (de) | 1994-11-17 | 1999-11-04 | Chemunex, Maisons-Alfort | Vorrichtung und Verfahren zum Erkennen und Zählen von selten vorkommenden Säugerzellen |
| JP3122004B2 (ja) | 1995-03-14 | 2001-01-09 | 株式会社ニレコ | 液中分散粒子画像計測装置 |
| US6315955B1 (en) | 1995-04-06 | 2001-11-13 | Delaval International A.B. | Method and apparatus for quantitative particle determination in fluids |
| FR2735255B1 (fr) | 1995-06-12 | 1998-06-19 | Biocom Sa | Procede de numerisation de particules faiblement luminescentes |
| US5798222A (en) | 1995-07-17 | 1998-08-25 | Guava Technologies, Inc. | Apparatus for monitoring substances in organisms |
| JP3446410B2 (ja) * | 1995-07-24 | 2003-09-16 | 株式会社島津製作所 | レーザ回折式粒度分布測定装置 |
| US5713364A (en) | 1995-08-01 | 1998-02-03 | Medispectra, Inc. | Spectral volume microprobe analysis of materials |
| EP0846259A1 (en) | 1995-08-21 | 1998-06-10 | Foss Electric A/S | A method and an apparatus for determining the number of particles or cells in a liquid sample |
| IL123966A (en) | 1995-10-23 | 2000-08-31 | Cytometrics Inc | Method and apparatus for reflected imaging analysis |
| JP3258882B2 (ja) | 1995-11-24 | 2002-02-18 | 株式会社堀場製作所 | 粒度分布測定装置 |
| US6162931A (en) | 1996-04-12 | 2000-12-19 | Molecular Probes, Inc. | Fluorinated xanthene derivatives |
| US6731100B1 (en) * | 1997-05-05 | 2004-05-04 | Chemometec A/S | Method and a system for determination of somatic cells in milk |
| EP1935983B1 (en) * | 1997-05-05 | 2011-06-22 | ChemoMetec A/S | Method for determination of biological particles in blood |
| JP4188061B2 (ja) | 2001-11-30 | 2008-11-26 | セントラル硝子株式会社 | 板ガラスの複合曲げ装置と複合曲げガラス板の成形方法 |
| JP4125609B2 (ja) | 2003-01-23 | 2008-07-30 | 富士フイルム株式会社 | 近接撮影用アダプタ |
-
1998
- 1998-05-05 EP EP08101755A patent/EP1935983B1/en not_active Revoked
- 1998-05-05 NZ NZ500686A patent/NZ500686A/en not_active IP Right Cessation
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- 1998-05-05 AU AU72057/98A patent/AU739824B2/en not_active Expired
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2003
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2005
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2006
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2007
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2008
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2009
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