NZ336189A - Diaza-spiro[3,5]nonane derivatives and use in treatment of diseases related to the orphanin receptor - Google Patents

Diaza-spiro[3,5]nonane derivatives and use in treatment of diseases related to the orphanin receptor

Info

Publication number
NZ336189A
NZ336189A NZ336189A NZ33618999A NZ336189A NZ 336189 A NZ336189 A NZ 336189A NZ 336189 A NZ336189 A NZ 336189A NZ 33618999 A NZ33618999 A NZ 33618999A NZ 336189 A NZ336189 A NZ 336189A
Authority
NZ
New Zealand
Prior art keywords
lower alkyl
naphthalen
hydrogen
receptor
treatment
Prior art date
Application number
NZ336189A
Other languages
English (en)
Inventor
Juergen Wichmann
Stephan Roever
Geo Adam
Andrea Cesura
Sabine Kolczewski
Francois Jenck
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of NZ336189A publication Critical patent/NZ336189A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Diabetes (AREA)
  • Vascular Medicine (AREA)
  • Addiction (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Child & Adolescent Psychology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)
NZ336189A 1998-06-12 1999-06-09 Diaza-spiro[3,5]nonane derivatives and use in treatment of diseases related to the orphanin receptor NZ336189A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP98110804 1998-06-12

Publications (1)

Publication Number Publication Date
NZ336189A true NZ336189A (en) 2000-10-27

Family

ID=8232114

Family Applications (1)

Application Number Title Priority Date Filing Date
NZ336189A NZ336189A (en) 1998-06-12 1999-06-09 Diaza-spiro[3,5]nonane derivatives and use in treatment of diseases related to the orphanin receptor

Country Status (28)

Country Link
US (1) US6113527A (https=)
EP (1) EP0970957B1 (https=)
JP (1) JP3286268B2 (https=)
KR (1) KR100344732B1 (https=)
CN (1) CN1107066C (https=)
AR (1) AR019859A1 (https=)
AT (1) ATE204279T1 (https=)
AU (1) AU743983B2 (https=)
BR (1) BR9902651A (https=)
CA (1) CA2274202A1 (https=)
DE (1) DE69900220T2 (https=)
DK (1) DK0970957T3 (https=)
ES (1) ES2162503T3 (https=)
HR (1) HRP990188A2 (https=)
HU (1) HU220894B1 (https=)
ID (1) ID23304A (https=)
IL (1) IL130377A0 (https=)
MA (1) MA26644A1 (https=)
NO (1) NO312590B1 (https=)
NZ (1) NZ336189A (https=)
PE (1) PE20000548A1 (https=)
PL (1) PL333695A1 (https=)
PT (1) PT970957E (https=)
SG (1) SG79259A1 (https=)
SI (1) SI0970957T1 (https=)
TR (1) TR199901381A2 (https=)
YU (1) YU26499A (https=)
ZA (1) ZA993852B (https=)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1406629A1 (en) * 2001-07-02 2004-04-14 Omeros Corporation Method for inducing analgesia comprising administration alternatively of an opioid receptor agonist and an opioid receptor like receptor 1 agonist for and an implantable infusion pump
US20030040479A1 (en) * 2001-07-02 2003-02-27 Omeros Corporation Rotational intrathecal analgesia method and device
JP4056977B2 (ja) * 2002-03-29 2008-03-05 田辺三菱製薬株式会社 睡眠障害治療薬
JP2005289816A (ja) 2002-05-14 2005-10-20 Banyu Pharmaceut Co Ltd ベンズイミダゾール誘導体
WO2004005293A2 (en) * 2002-07-05 2004-01-15 Targacept, Inc. N-aryl diazaspiracyclic compounds and methods of preparation and use thereof
NZ538307A (en) * 2002-09-09 2008-04-30 Janssen Pharmaceutica Nv Hydroxy alkyl substituted 1,3,8-triazaspiro[4.5]decan-4-one derivatives useful for the treatment of ORL-1 receptor mediated disorders
GB0323204D0 (en) 2003-10-03 2003-11-05 Novartis Ag Organic compounds
US20050228023A1 (en) * 2003-12-19 2005-10-13 Sri International Agonist and antagonist ligands of the nociceptin receptor
US20060178390A1 (en) * 2004-08-02 2006-08-10 Alfonzo Jordan 1,3,8-Triazaspiro[4,5]decan-4-one derivatives useful for the treatment of ORL-1 receptor mediated disorders
AU2005277410B2 (en) * 2004-08-20 2010-06-24 Targacept, Inc. The use of N-aryl diazaspiracyclic compounds in the treatment of addiction
US20080247964A1 (en) * 2006-05-08 2008-10-09 Yuelian Xu Substituted azaspiro derivatives
CN103202840B (zh) * 2006-11-28 2015-02-11 詹森药业有限公司 3-(3-氨基-2-(r)-羟基-丙基)-1-(4-氟-苯基)-8-(8-甲基-萘-1-基甲基)-1,3,8-三氮杂-螺[4.5]癸烷-4-酮的盐
JP5490677B2 (ja) * 2007-04-09 2014-05-14 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ 不安及び鬱病の処置のためのｏｒｌ−１受容体リガンドとしての１，３，８−三置換−１，３，８−トリアザ−スピロ［４．５］デカン−４−オン誘導体
KR101704226B1 (ko) 2015-06-30 2017-02-07 현대자동차주식회사 자동차의 쿼터글라스 어셈블리
US20250059187A1 (en) * 2021-12-22 2025-02-20 The Regents Of The University Of California Covalently binding inhibitors of g12s, g12d and/or g12e mutants of k-ras gtpase

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5756743A (en) * 1996-04-10 1998-05-26 Hoechst Marion Roussel Inc. Spiro cyclopent b!indole-piperidines!

Also Published As

Publication number Publication date
DE69900220T2 (de) 2002-05-08
IL130377A0 (en) 2000-06-01
JP3286268B2 (ja) 2002-05-27
EP0970957B1 (en) 2001-08-16
HU220894B1 (en) 2002-06-29
SG79259A1 (en) 2001-03-20
PL333695A1 (en) 1999-12-20
ZA993852B (en) 1999-12-13
CN1242366A (zh) 2000-01-26
DK0970957T3 (da) 2001-12-03
NO992873D0 (no) 1999-06-11
KR100344732B1 (ko) 2002-07-19
BR9902651A (pt) 2000-05-16
AU3498799A (en) 1999-12-23
SI0970957T1 (https=) 2001-12-31
JP2000053679A (ja) 2000-02-22
YU26499A (sh) 2002-09-19
US6113527A (en) 2000-09-05
EP0970957A1 (en) 2000-01-12
AR019859A1 (es) 2002-03-20
DE69900220D1 (de) 2001-09-20
AU743983B2 (en) 2002-02-14
NO992873L (no) 1999-12-13
CA2274202A1 (en) 1999-12-12
TR199901381A3 (tr) 2000-01-21
PT970957E (pt) 2002-02-28
PE20000548A1 (es) 2000-07-15
HU9901911D0 (en) 1999-08-30
ES2162503T3 (es) 2001-12-16
CN1107066C (zh) 2003-04-30
HUP9901911A1 (hu) 2000-05-28
KR20000006060A (ko) 2000-01-25
MA26644A1 (fr) 2004-12-20
NO312590B1 (no) 2002-06-03
TR199901381A2 (xx) 2000-01-21
HRP990188A2 (en) 2000-02-29
ATE204279T1 (de) 2001-09-15
ID23304A (id) 2000-04-05

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