KR100344732B1 - 디아자-스피로[3.5]노난 유도체 - Google Patents

디아자-스피로[3.5]노난 유도체 Download PDF

Info

Publication number
KR100344732B1
KR100344732B1 KR1019990021485A KR19990021485A KR100344732B1 KR 100344732 B1 KR100344732 B1 KR 100344732B1 KR 1019990021485 A KR1019990021485 A KR 1019990021485A KR 19990021485 A KR19990021485 A KR 19990021485A KR 100344732 B1 KR100344732 B1 KR 100344732B1
Authority
KR
South Korea
Prior art keywords
phenyl
spiro
diaza
nonan
lower alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
KR1019990021485A
Other languages
English (en)
Korean (ko)
Other versions
KR20000006060A (ko
Inventor
아담지오
세수라안드레아
쟝크프랑소와
콜제비스키사빈
뢰버스테판
위크만쥐르겐
Original Assignee
에프. 호프만-라 로슈 아게
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 에프. 호프만-라 로슈 아게 filed Critical 에프. 호프만-라 로슈 아게
Publication of KR20000006060A publication Critical patent/KR20000006060A/ko
Application granted granted Critical
Publication of KR100344732B1 publication Critical patent/KR100344732B1/ko
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Diabetes (AREA)
  • Vascular Medicine (AREA)
  • Addiction (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Child & Adolescent Psychology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)
KR1019990021485A 1998-06-12 1999-06-10 디아자-스피로[3.5]노난 유도체 Expired - Fee Related KR100344732B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP98110804.6 1998-06-12
EP98110804 1998-06-12

Publications (2)

Publication Number Publication Date
KR20000006060A KR20000006060A (ko) 2000-01-25
KR100344732B1 true KR100344732B1 (ko) 2002-07-19

Family

ID=8232114

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019990021485A Expired - Fee Related KR100344732B1 (ko) 1998-06-12 1999-06-10 디아자-스피로[3.5]노난 유도체

Country Status (28)

Country Link
US (1) US6113527A (https=)
EP (1) EP0970957B1 (https=)
JP (1) JP3286268B2 (https=)
KR (1) KR100344732B1 (https=)
CN (1) CN1107066C (https=)
AR (1) AR019859A1 (https=)
AT (1) ATE204279T1 (https=)
AU (1) AU743983B2 (https=)
BR (1) BR9902651A (https=)
CA (1) CA2274202A1 (https=)
DE (1) DE69900220T2 (https=)
DK (1) DK0970957T3 (https=)
ES (1) ES2162503T3 (https=)
HR (1) HRP990188A2 (https=)
HU (1) HU220894B1 (https=)
ID (1) ID23304A (https=)
IL (1) IL130377A0 (https=)
MA (1) MA26644A1 (https=)
NO (1) NO312590B1 (https=)
NZ (1) NZ336189A (https=)
PE (1) PE20000548A1 (https=)
PL (1) PL333695A1 (https=)
PT (1) PT970957E (https=)
SG (1) SG79259A1 (https=)
SI (1) SI0970957T1 (https=)
TR (1) TR199901381A2 (https=)
YU (1) YU26499A (https=)
ZA (1) ZA993852B (https=)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1406629A1 (en) * 2001-07-02 2004-04-14 Omeros Corporation Method for inducing analgesia comprising administration alternatively of an opioid receptor agonist and an opioid receptor like receptor 1 agonist for and an implantable infusion pump
US20030040479A1 (en) * 2001-07-02 2003-02-27 Omeros Corporation Rotational intrathecal analgesia method and device
JP4056977B2 (ja) * 2002-03-29 2008-03-05 田辺三菱製薬株式会社 睡眠障害治療薬
JP2005289816A (ja) 2002-05-14 2005-10-20 Banyu Pharmaceut Co Ltd ベンズイミダゾール誘導体
WO2004005293A2 (en) * 2002-07-05 2004-01-15 Targacept, Inc. N-aryl diazaspiracyclic compounds and methods of preparation and use thereof
NZ538307A (en) * 2002-09-09 2008-04-30 Janssen Pharmaceutica Nv Hydroxy alkyl substituted 1,3,8-triazaspiro[4.5]decan-4-one derivatives useful for the treatment of ORL-1 receptor mediated disorders
GB0323204D0 (en) 2003-10-03 2003-11-05 Novartis Ag Organic compounds
US20050228023A1 (en) * 2003-12-19 2005-10-13 Sri International Agonist and antagonist ligands of the nociceptin receptor
US20060178390A1 (en) * 2004-08-02 2006-08-10 Alfonzo Jordan 1,3,8-Triazaspiro[4,5]decan-4-one derivatives useful for the treatment of ORL-1 receptor mediated disorders
AU2005277410B2 (en) * 2004-08-20 2010-06-24 Targacept, Inc. The use of N-aryl diazaspiracyclic compounds in the treatment of addiction
US20080247964A1 (en) * 2006-05-08 2008-10-09 Yuelian Xu Substituted azaspiro derivatives
CN103202840B (zh) * 2006-11-28 2015-02-11 詹森药业有限公司 3-(3-氨基-2-(r)-羟基-丙基)-1-(4-氟-苯基)-8-(8-甲基-萘-1-基甲基)-1,3,8-三氮杂-螺[4.5]癸烷-4-酮的盐
JP5490677B2 (ja) * 2007-04-09 2014-05-14 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ 不安及び鬱病の処置のためのｏｒｌ−１受容体リガンドとしての１，３，８−三置換−１，３，８−トリアザ−スピロ［４．５］デカン−４−オン誘導体
KR101704226B1 (ko) 2015-06-30 2017-02-07 현대자동차주식회사 자동차의 쿼터글라스 어셈블리
US20250059187A1 (en) * 2021-12-22 2025-02-20 The Regents Of The University Of California Covalently binding inhibitors of g12s, g12d and/or g12e mutants of k-ras gtpase

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5756743A (en) * 1996-04-10 1998-05-26 Hoechst Marion Roussel Inc. Spiro cyclopent b!indole-piperidines!

Also Published As

Publication number Publication date
DE69900220T2 (de) 2002-05-08
IL130377A0 (en) 2000-06-01
JP3286268B2 (ja) 2002-05-27
EP0970957B1 (en) 2001-08-16
HU220894B1 (en) 2002-06-29
SG79259A1 (en) 2001-03-20
PL333695A1 (en) 1999-12-20
ZA993852B (en) 1999-12-13
CN1242366A (zh) 2000-01-26
DK0970957T3 (da) 2001-12-03
NO992873D0 (no) 1999-06-11
BR9902651A (pt) 2000-05-16
AU3498799A (en) 1999-12-23
SI0970957T1 (https=) 2001-12-31
JP2000053679A (ja) 2000-02-22
YU26499A (sh) 2002-09-19
US6113527A (en) 2000-09-05
EP0970957A1 (en) 2000-01-12
AR019859A1 (es) 2002-03-20
DE69900220D1 (de) 2001-09-20
AU743983B2 (en) 2002-02-14
NO992873L (no) 1999-12-13
CA2274202A1 (en) 1999-12-12
TR199901381A3 (tr) 2000-01-21
PT970957E (pt) 2002-02-28
PE20000548A1 (es) 2000-07-15
HU9901911D0 (en) 1999-08-30
ES2162503T3 (es) 2001-12-16
CN1107066C (zh) 2003-04-30
NZ336189A (en) 2000-10-27
HUP9901911A1 (hu) 2000-05-28
KR20000006060A (ko) 2000-01-25
MA26644A1 (fr) 2004-12-20
NO312590B1 (no) 2002-06-03
TR199901381A2 (xx) 2000-01-21
HRP990188A2 (en) 2000-02-29
ATE204279T1 (de) 2001-09-15
ID23304A (id) 2000-04-05

Similar Documents

Publication Publication Date Title
KR100344732B1 (ko) 디아자-스피로[3.5]노난 유도체
JP3292457B2 (ja) ８−置換−１，３，８−トリアザ−スピロ〔４．５〕デカン−４−オン誘導体
KR100393311B1 (ko) 디아자-스피로[4.5]데칸 유도체 또는 트리아자-스피로[4.5]데칸 유도체
JP3308507B2 (ja) スピロ〔ピペリジン−４，１′−ピロロ〔３，４−ｃ〕ピロール〕
HK1024239A (en) Diaza-spiro[3,5]nonane derivatives
MXPA99005459A (en) Espiro [piperidin-4,1'-pirrolo [3,4-c] pirr
HK1024471A (en) Di-or triaza-spiro[4,5]decane derivatives
CZ208399A3 (cs) Spiro[piperidin-4,l-pyrrol[3,4-c]pyrrol]

Legal Events

Date Code Title Description
A201 Request for examination
PA0109 Patent application

St.27 status event code: A-0-1-A10-A12-nap-PA0109

PA0201 Request for examination

St.27 status event code: A-1-2-D10-D11-exm-PA0201

PG1501 Laying open of application

St.27 status event code: A-1-1-Q10-Q12-nap-PG1501

E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

St.27 status event code: A-1-2-D10-D21-exm-PE0902

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

E701 Decision to grant or registration of patent right
PE0701 Decision of registration

St.27 status event code: A-1-2-D10-D22-exm-PE0701

GRNT Written decision to grant
PR0701 Registration of establishment

St.27 status event code: A-2-4-F10-F11-exm-PR0701

PR1002 Payment of registration fee

St.27 status event code: A-2-2-U10-U11-oth-PR1002

Fee payment year number: 1

PG1601 Publication of registration

St.27 status event code: A-4-4-Q10-Q13-nap-PG1601

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 4

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 5

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 6

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 7

FPAY Annual fee payment

Payment date: 20090630

Year of fee payment: 8

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 8

LAPS Lapse due to unpaid annual fee
PC1903 Unpaid annual fee

St.27 status event code: A-4-4-U10-U13-oth-PC1903

Not in force date: 20100703

Payment event data comment text: Termination Category : DEFAULT_OF_REGISTRATION_FEE

PC1903 Unpaid annual fee

St.27 status event code: N-4-6-H10-H13-oth-PC1903

Ip right cessation event data comment text: Termination Category : DEFAULT_OF_REGISTRATION_FEE

Not in force date: 20100703

R18-X000 Changes to party contact information recorded

St.27 status event code: A-5-5-R10-R18-oth-X000