HUP9901910A2 - Orfanin FQ(OFQ) receptor agonista és/vagy antagonista di- vagy tri-aza-spiro[4,5]dekán-származékok, előállításuk és alkalmazásuk - Google Patents
Orfanin FQ(OFQ) receptor agonista és/vagy antagonista di- vagy tri-aza-spiro[4,5]dekán-származékok, előállításuk és alkalmazásukInfo
- Publication number
- HUP9901910A2 HUP9901910A2 HU9901910A HUP9901910A HUP9901910A2 HU P9901910 A2 HUP9901910 A2 HU P9901910A2 HU 9901910 A HU9901910 A HU 9901910A HU P9901910 A HUP9901910 A HU P9901910A HU P9901910 A2 HUP9901910 A2 HU P9901910A2
- Authority
- HU
- Hungary
- Prior art keywords
- alkyl
- coor4
- ofq
- receptor
- orphanin
- Prior art date
Links
- 239000000556 agonist Substances 0.000 title 1
- 239000005557 antagonist Substances 0.000 title 1
- PULGYDLMFSFVBL-SMFNREODSA-N nociceptin Chemical compound C([C@@H](C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(O)=O)[C@@H](C)O)NC(=O)CNC(=O)CNC(=O)[C@@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 PULGYDLMFSFVBL-SMFNREODSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 3
- 239000000843 powder Substances 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 125000004094 acenaphthen-1-yl group Chemical group [H]C1=C([H])C2=C3C(=C([H])C([H])=C([H])C3=C1[H])C([H])([H])C2([H])* 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000004129 indan-1-yl group Chemical group [H]C1=C([H])C([H])=C2C(=C1[H])C([H])([H])C([H])([H])C2([H])* 0.000 abstract 1
- 125000004130 indan-2-yl group Chemical group [H]C1=C([H])C([H])=C2C(=C1[H])C([H])([H])C([H])(*)C2([H])[H] 0.000 abstract 1
- 230000000926 neurological effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/10—Spiro-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Pain & Pain Management (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Child & Adolescent Psychology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Photoreceptors In Electrophotography (AREA)
- Non-Silver Salt Photosensitive Materials And Non-Silver Salt Photography (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
A találmány szerinti vegyületek (I) általánős képletében R1 jelentése adőtt esetben alkil- vagy -C(O)O-alkil-csőpőrttalhelyettesített 6-10 szénatőmős ciklőalkilcsőpőrt, dekahidrő-naftalin-1-il-, dekahidrő-naftalin-2-il-csőpőrt, adőtt esetben alkilcsőpőrttalhelyettesített indan-1-il- vagy indan-2-il-csőpőrt, dekahidrő-azűlen-2-il-csőpőrt, biciklő(6.2.0)dec-9-il-csőpőrt, acenaften-1-il-csőpőrt,2,3-dihidrő-1H-fenalen-1-il-csőpőrt vagy őktahidrő-inden-2-il-csőpőrt, R2 jelentése hidrőgénatőm, alkilcsőpőrt, =O, vagy adőtt esetbenhalőgénatőmőt, alkil-, vagy alkőxicsőpőrt helyettesítőt hőrdőzófenilcsőpőrt, A jelentése adőtt esetben halőgénatőmőt, alkil- vagy alkőxicsőpőrt-helyettesítőt hőrdőzó ciklőhexil- vagy fenilcsőpőrt, X jelentése -CH(OH)-, -C(O)-, -CHR3-, -CR3=, -O-, -S-, -CH(COOR4)-vagy -C(COOR4)= csőpőrt, Y jelentése -CH2-, -CH=, -CH(COOR4)-, -C(COOR4)= vagy -C(CN)-csőpőrt, R3 jelentése hidrőgénatőm vagy alkőxicsőpőrt, R4 jelentése alkil-, ciklőalkil-, fenil- vagy benzilcsőpőrt, és a vagyb adőtt esetben jelenlévő tővábbi kötést képvisel. A találmány magábafőglalja a vegyületek gyógyászatilag alkalmas savaddíciós sóit is. Atalálmány szerinti vegyületek az őrfanin FQ (OFQ) receptőrralösszefüggő betegségek, éspedig pszichiátriai, neűrőlógiai ésfiziőlógiai rendellenességek kezelésére alkalmazhatók. ŕ
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP98110803 | 1998-06-12 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| HU9901910D0 HU9901910D0 (en) | 1999-08-30 |
| HUP9901910A2 true HUP9901910A2 (hu) | 2000-04-28 |
| HUP9901910A3 HUP9901910A3 (en) | 2001-11-28 |
Family
ID=8232113
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU9901910A HUP9901910A3 (en) | 1998-06-12 | 1999-06-09 | Di- or triaza-spiro[4,5]decane derivatives as agonist and/or antagonist of the orphanin fq(ofq) receptor, preparation and use thereof |
Country Status (30)
| Country | Link |
|---|---|
| US (1) | US6642247B2 (hu) |
| EP (1) | EP0963985B1 (hu) |
| JP (1) | JP3369123B2 (hu) |
| KR (1) | KR100393311B1 (hu) |
| CN (2) | CN1229377C (hu) |
| AR (1) | AR019860A1 (hu) |
| AT (1) | ATE234302T1 (hu) |
| AU (1) | AU752835B2 (hu) |
| BR (1) | BR9902653A (hu) |
| CA (1) | CA2274201C (hu) |
| CO (1) | CO5040061A1 (hu) |
| CZ (1) | CZ291323B6 (hu) |
| DE (1) | DE69905798T2 (hu) |
| DK (1) | DK0963985T3 (hu) |
| ES (1) | ES2194402T3 (hu) |
| HR (1) | HRP990187A2 (hu) |
| HU (1) | HUP9901910A3 (hu) |
| ID (1) | ID23306A (hu) |
| IL (1) | IL130375A0 (hu) |
| MA (1) | MA26645A1 (hu) |
| NO (1) | NO312591B1 (hu) |
| NZ (1) | NZ336226A (hu) |
| PE (1) | PE20000540A1 (hu) |
| PL (1) | PL333693A1 (hu) |
| PT (1) | PT963985E (hu) |
| SG (1) | SG83135A1 (hu) |
| TR (1) | TR199901380A2 (hu) |
| TW (1) | TW434241B (hu) |
| YU (1) | YU26799A (hu) |
| ZA (2) | ZA993853B (hu) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69923744T2 (de) * | 1998-10-23 | 2006-02-23 | Pfizer Inc. | 1,3,8-Triazaspiro[4,5] decanon Verbindungen als orl1-receptor Agonisten |
| PT1491212E (pt) | 2002-03-29 | 2012-11-16 | Mitsubishi Tanabe Pharma Corp | Medicamento para distúrbios de sono |
| DE102004014296A1 (de) | 2004-03-22 | 2005-10-06 | Grünenthal GmbH | Substituierte 1,4,8-Triazaspiro[4.5]decan-2-on-Verbindingen |
| KR100662191B1 (ko) | 2004-12-23 | 2006-12-27 | 엘지이노텍 주식회사 | 질화물 반도체 발광소자 및 그 제조방법 |
| AU2008219980B2 (en) | 2007-03-01 | 2012-01-12 | Mitsubishi Tanabe Pharma Corporation | Benzimidazole compound and pharmaceutical use thereof |
| TW201016675A (en) | 2008-09-16 | 2010-05-01 | Mitsubishi Tanabe Pharma Corp | Crystalline benzoimidazole compound and salt thereof |
| CN109503582A (zh) * | 2018-12-17 | 2019-03-22 | 上海合全药物研发有限公司 | 顺式螺[哌啶并-4,1＇-吡咯并[3,4-c]吡咯]-1-甲酸叔丁酯的合成方法 |
| CN113966337B (zh) * | 2020-05-12 | 2024-01-02 | 北京广为医药科技有限公司 | 调节nmda受体活性的化合物、其药物组合物及用途 |
| KR20220022988A (ko) | 2020-08-20 | 2022-03-02 | 제트스타 주식회사 | 트랙터용 써레 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS63208844A (ja) * | 1987-02-26 | 1988-08-30 | Konica Corp | 有機着色物質の光褪色防止方法 |
| US5221675A (en) * | 1989-12-15 | 1993-06-22 | Abbott Laboratories | Aza-spirocyclic compounds that enhance cholinergic neurotransmission |
| US5534520A (en) * | 1990-04-10 | 1996-07-09 | Fisher; Abraham | Spiro compounds containing five-membered rings |
| CA2226058C (en) * | 1997-01-30 | 2008-01-29 | F. Hoffmann-La Roche Ag | 8-substituted-1,3,8-triaza-spiro[4.5]decan-4-one derivatives |
-
1999
- 1999-06-07 PT PT99110954T patent/PT963985E/pt unknown
- 1999-06-07 DE DE69905798T patent/DE69905798T2/de not_active Expired - Lifetime
- 1999-06-07 ES ES99110954T patent/ES2194402T3/es not_active Expired - Lifetime
- 1999-06-07 AT AT99110954T patent/ATE234302T1/de not_active IP Right Cessation
- 1999-06-07 EP EP99110954A patent/EP0963985B1/en not_active Expired - Lifetime
- 1999-06-07 DK DK99110954T patent/DK0963985T3/da active
- 1999-06-08 CZ CZ19992039A patent/CZ291323B6/cs not_active IP Right Cessation
- 1999-06-08 ZA ZA9903853A patent/ZA993853B/xx unknown
- 1999-06-08 PE PE1999000486A patent/PE20000540A1/es not_active Application Discontinuation
- 1999-06-09 CA CA2274201A patent/CA2274201C/en not_active Expired - Fee Related
- 1999-06-09 HU HU9901910A patent/HUP9901910A3/hu unknown
- 1999-06-09 JP JP16194399A patent/JP3369123B2/ja not_active Expired - Fee Related
- 1999-06-09 IL IL13037599A patent/IL130375A0/xx unknown
- 1999-06-09 SG SG9902947A patent/SG83135A1/en unknown
- 1999-06-10 AR ARP990102764A patent/AR019860A1/es active IP Right Grant
- 1999-06-10 CO CO99036580A patent/CO5040061A1/es unknown
- 1999-06-10 AU AU34986/99A patent/AU752835B2/en not_active Ceased
- 1999-06-10 MA MA25617A patent/MA26645A1/fr unknown
- 1999-06-10 ZA ZA9903901A patent/ZA993901B/xx unknown
- 1999-06-10 NZ NZ336226A patent/NZ336226A/xx unknown
- 1999-06-11 YU YU26799A patent/YU26799A/sh unknown
- 1999-06-11 PL PL99333693A patent/PL333693A1/xx unknown
- 1999-06-11 BR BR9902653-8A patent/BR9902653A/pt active Search and Examination
- 1999-06-11 US US09/330,724 patent/US6642247B2/en not_active Expired - Fee Related
- 1999-06-11 CN CNB991083741A patent/CN1229377C/zh not_active Expired - Fee Related
- 1999-06-11 CN CN99110904A patent/CN1110497C/zh not_active Expired - Fee Related
- 1999-06-11 NO NO19992876A patent/NO312591B1/no unknown
- 1999-06-11 TW TW088109813A patent/TW434241B/zh not_active IP Right Cessation
- 1999-06-11 TR TR1999/01380A patent/TR199901380A2/xx unknown
- 1999-06-11 HR HR98110803.8A patent/HRP990187A2/hr not_active Application Discontinuation
- 1999-06-12 KR KR10-1999-0021892A patent/KR100393311B1/ko not_active IP Right Cessation
- 1999-06-14 ID IDP990575D patent/ID23306A/id unknown
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