YU26799A - Derivati di- ili triaza-spiro/4,5/dekana - Google Patents
Derivati di- ili triaza-spiro/4,5/dekanaInfo
- Publication number
- YU26799A YU26799A YU26799A YU26799A YU26799A YU 26799 A YU26799 A YU 26799A YU 26799 A YU26799 A YU 26799A YU 26799 A YU26799 A YU 26799A YU 26799 A YU26799 A YU 26799A
- Authority
- YU
- Yugoslavia
- Prior art keywords
- lower alkyl
- freely
- substituted
- alcoxy
- phenyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/10—Spiro-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Pain & Pain Management (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Child & Adolescent Psychology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Photoreceptors In Electrophotography (AREA)
- Non-Silver Salt Photosensitive Materials And Non-Silver Salt Photography (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Ovaj pronalazak se odnosi na jedinjenja opste formule u kojoj R1 je C6-C10-cikloalkil, proizvoljno supstituisan nizim alkilom ili -C(O)O- nizim alkilom; dekahidro-naftalen-1-il: dekahidro-naftalen-2-il; indan-1-il ili indan-2-il, proizvoljno supstituisan nizim alkilom; dekahidro-azulen-2-il; biciklo[6.2.0]dek-9-il; acenaften-1-il; 2,3-dihidro-1H-fenalen-1-il; 2,3,3a,4,5,6-heksahidro-1H-fenalen-1-il ili oktahidro-inden-2-il; R2 je vodonik, nizi alkil; =O ili fenil, proizvoljno supstituisan nizim alkilom, halogenom ili alkoksijem; A je cikloheksil ili fenil, proizvoljno supstituisan nizim alkilom, halogenom ili alkoksijem; X je -CH(OH)-; -C(O)-, -CHR3-, -CR3=; -O-, -S-, -CH(OCOOR4)- ili -C(COOR4)=; R3 je vodonik ili nizi alkoksi; R4 je nizi alkil, cikloalkil, fenil ili benzil; i bilo a ili b je proizvoljno dodatna veza, i na njihove farmaceutski prihvatljive kisele adicione soli. Jedinjenja ovog pronalaska su agonisti i/ili antagonisti orfamin FQ (OFQ) receptora i zato korisni u tretiranju bolesti, vezanih za ovaj receptor.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP98110803 | 1998-06-12 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| YU26799A true YU26799A (sh) | 2002-03-18 |
Family
ID=8232113
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| YU26799A YU26799A (sh) | 1998-06-12 | 1999-06-11 | Derivati di- ili triaza-spiro/4,5/dekana |
Country Status (30)
| Country | Link |
|---|---|
| US (1) | US6642247B2 (sh) |
| EP (1) | EP0963985B1 (sh) |
| JP (1) | JP3369123B2 (sh) |
| KR (1) | KR100393311B1 (sh) |
| CN (2) | CN1229377C (sh) |
| AR (1) | AR019860A1 (sh) |
| AT (1) | ATE234302T1 (sh) |
| AU (1) | AU752835B2 (sh) |
| BR (1) | BR9902653A (sh) |
| CA (1) | CA2274201C (sh) |
| CO (1) | CO5040061A1 (sh) |
| CZ (1) | CZ291323B6 (sh) |
| DE (1) | DE69905798T2 (sh) |
| DK (1) | DK0963985T3 (sh) |
| ES (1) | ES2194402T3 (sh) |
| HR (1) | HRP990187A2 (sh) |
| HU (1) | HUP9901910A3 (sh) |
| ID (1) | ID23306A (sh) |
| IL (1) | IL130375A0 (sh) |
| MA (1) | MA26645A1 (sh) |
| NO (1) | NO312591B1 (sh) |
| NZ (1) | NZ336226A (sh) |
| PE (1) | PE20000540A1 (sh) |
| PL (1) | PL333693A1 (sh) |
| PT (1) | PT963985E (sh) |
| SG (1) | SG83135A1 (sh) |
| TR (1) | TR199901380A2 (sh) |
| TW (1) | TW434241B (sh) |
| YU (1) | YU26799A (sh) |
| ZA (2) | ZA993853B (sh) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69923744T2 (de) * | 1998-10-23 | 2006-02-23 | Pfizer Inc. | 1,3,8-Triazaspiro[4,5] decanon Verbindungen als orl1-receptor Agonisten |
| PT1491212E (pt) | 2002-03-29 | 2012-11-16 | Mitsubishi Tanabe Pharma Corp | Medicamento para distúrbios de sono |
| DE102004014296A1 (de) | 2004-03-22 | 2005-10-06 | Grünenthal GmbH | Substituierte 1,4,8-Triazaspiro[4.5]decan-2-on-Verbindingen |
| KR100662191B1 (ko) | 2004-12-23 | 2006-12-27 | 엘지이노텍 주식회사 | 질화물 반도체 발광소자 및 그 제조방법 |
| AU2008219980B2 (en) | 2007-03-01 | 2012-01-12 | Mitsubishi Tanabe Pharma Corporation | Benzimidazole compound and pharmaceutical use thereof |
| TW201016675A (en) | 2008-09-16 | 2010-05-01 | Mitsubishi Tanabe Pharma Corp | Crystalline benzoimidazole compound and salt thereof |
| CN109503582A (zh) * | 2018-12-17 | 2019-03-22 | 上海合全药物研发有限公司 | 顺式螺[哌啶并-4,1＇-吡咯并[3,4-c]吡咯]-1-甲酸叔丁酯的合成方法 |
| CN113966337B (zh) * | 2020-05-12 | 2024-01-02 | 北京广为医药科技有限公司 | 调节nmda受体活性的化合物、其药物组合物及用途 |
| KR20220022988A (ko) | 2020-08-20 | 2022-03-02 | 제트스타 주식회사 | 트랙터용 써레 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS63208844A (ja) * | 1987-02-26 | 1988-08-30 | Konica Corp | 有機着色物質の光褪色防止方法 |
| US5221675A (en) * | 1989-12-15 | 1993-06-22 | Abbott Laboratories | Aza-spirocyclic compounds that enhance cholinergic neurotransmission |
| US5534520A (en) * | 1990-04-10 | 1996-07-09 | Fisher; Abraham | Spiro compounds containing five-membered rings |
| CA2226058C (en) * | 1997-01-30 | 2008-01-29 | F. Hoffmann-La Roche Ag | 8-substituted-1,3,8-triaza-spiro[4.5]decan-4-one derivatives |
-
1999
- 1999-06-07 PT PT99110954T patent/PT963985E/pt unknown
- 1999-06-07 DE DE69905798T patent/DE69905798T2/de not_active Expired - Lifetime
- 1999-06-07 ES ES99110954T patent/ES2194402T3/es not_active Expired - Lifetime
- 1999-06-07 AT AT99110954T patent/ATE234302T1/de not_active IP Right Cessation
- 1999-06-07 EP EP99110954A patent/EP0963985B1/en not_active Expired - Lifetime
- 1999-06-07 DK DK99110954T patent/DK0963985T3/da active
- 1999-06-08 CZ CZ19992039A patent/CZ291323B6/cs not_active IP Right Cessation
- 1999-06-08 ZA ZA9903853A patent/ZA993853B/xx unknown
- 1999-06-08 PE PE1999000486A patent/PE20000540A1/es not_active Application Discontinuation
- 1999-06-09 CA CA2274201A patent/CA2274201C/en not_active Expired - Fee Related
- 1999-06-09 HU HU9901910A patent/HUP9901910A3/hu unknown
- 1999-06-09 JP JP16194399A patent/JP3369123B2/ja not_active Expired - Fee Related
- 1999-06-09 IL IL13037599A patent/IL130375A0/xx unknown
- 1999-06-09 SG SG9902947A patent/SG83135A1/en unknown
- 1999-06-10 AR ARP990102764A patent/AR019860A1/es active IP Right Grant
- 1999-06-10 CO CO99036580A patent/CO5040061A1/es unknown
- 1999-06-10 AU AU34986/99A patent/AU752835B2/en not_active Ceased
- 1999-06-10 MA MA25617A patent/MA26645A1/fr unknown
- 1999-06-10 ZA ZA9903901A patent/ZA993901B/xx unknown
- 1999-06-10 NZ NZ336226A patent/NZ336226A/xx unknown
- 1999-06-11 YU YU26799A patent/YU26799A/sh unknown
- 1999-06-11 PL PL99333693A patent/PL333693A1/xx unknown
- 1999-06-11 BR BR9902653-8A patent/BR9902653A/pt active Search and Examination
- 1999-06-11 US US09/330,724 patent/US6642247B2/en not_active Expired - Fee Related
- 1999-06-11 CN CNB991083741A patent/CN1229377C/zh not_active Expired - Fee Related
- 1999-06-11 CN CN99110904A patent/CN1110497C/zh not_active Expired - Fee Related
- 1999-06-11 NO NO19992876A patent/NO312591B1/no unknown
- 1999-06-11 TW TW088109813A patent/TW434241B/zh not_active IP Right Cessation
- 1999-06-11 TR TR1999/01380A patent/TR199901380A2/xx unknown
- 1999-06-11 HR HR98110803.8A patent/HRP990187A2/hr not_active Application Discontinuation
- 1999-06-12 KR KR10-1999-0021892A patent/KR100393311B1/ko not_active IP Right Cessation
- 1999-06-14 ID IDP990575D patent/ID23306A/id unknown
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