AR019860A1 - Derivados di o triaza-espiro (4,5) decano, un procedimiento para su preparacion, un medicamento que los comprende y empleo de dichos derivados para la manufactura de un medicamento. - Google Patents
Derivados di o triaza-espiro (4,5) decano, un procedimiento para su preparacion, un medicamento que los comprende y empleo de dichos derivados para la manufactura de un medicamento.Info
- Publication number
- AR019860A1 AR019860A1 ARP990102764A ARP990102764A AR019860A1 AR 019860 A1 AR019860 A1 AR 019860A1 AR P990102764 A ARP990102764 A AR P990102764A AR P990102764 A ARP990102764 A AR P990102764A AR 019860 A1 AR019860 A1 AR 019860A1
- Authority
- AR
- Argentina
- Prior art keywords
- lower alkyl
- medicinal product
- derivatives
- optionally substituted
- triaza
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/10—Spiro-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Pain & Pain Management (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Child & Adolescent Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Photoreceptors In Electrophotography (AREA)
- Non-Silver Salt Photosensitive Materials And Non-Silver Salt Photography (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
Derivados di o triaza-espiro [4,5], caracterizado porque comprenden compuestos de la formula (1) en donde R1 es cicloalquilo de 6 a 10 átomos de carbono,sustituido opcionalemente con alquilo inferior o -C(O)O-alquilo inferior, decahidro-naftalen-1-il o; decahidro-naftalen-2-ilo; indan-1-ilo, opcionalmentesustituido con alquilo inferior; decahidro -azulen-2-ilo; biciclo[6.2.0]dec-9-ilo; acenaftalen-1-ilo; 2,3-dihidro-1H-fenalen-1-ilo; 2,3,3a4,5,6-hexahidro-1H-fenalen-1-ilo u octahidroinden-2-ilo; R2 es hidrogeno, alquilo inferior; =O o fenilo, opcionalmente sustituido con alquilo inferior, halogeno o alcoxilo; A esciclohexilo o fenilo, opcionalmente sustituido con alquilo inferior, halogeno o alcoxilo; X es -CH(OH)-; -C(O)-; CHR3-; -CR3=; -O- ; -S-; -CH(COOR4)- o-C(COOR5)=; Y es -CH2; -CH=; -CH(COOR4)-; -C(COOR4)=; o -C(CN)-; R3 es hidrogeno o alquilo inferior; R4 es alquilo inferior, cicloalquilo, fenilo o bencilo; yo bien a o b es opcionalmente un enlace adicional, mezclasracémicas y s us correspondientes enantiomeros, y sales de adicion de ácido farmacéuticamenteaceptables, de los mismos, un procedimiento para su preparacion, un medicamento que los comprende y empleo de dichos derivados para la manufactura deunmedicamento. Uso: e nfermedades relacionadas con el receptor de orfanina, trastornos psiquiátricos, neurologicos y fisiologicos.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP98110803 | 1998-06-12 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR019860A1 true AR019860A1 (es) | 2002-03-20 |
Family
ID=8232113
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP990102764A AR019860A1 (es) | 1998-06-12 | 1999-06-10 | Derivados di o triaza-espiro (4,5) decano, un procedimiento para su preparacion, un medicamento que los comprende y empleo de dichos derivados para la manufactura de un medicamento. |
Country Status (30)
| Country | Link |
|---|---|
| US (1) | US6642247B2 (es) |
| EP (1) | EP0963985B1 (es) |
| JP (1) | JP3369123B2 (es) |
| KR (1) | KR100393311B1 (es) |
| CN (2) | CN1110497C (es) |
| AR (1) | AR019860A1 (es) |
| AT (1) | ATE234302T1 (es) |
| AU (1) | AU752835B2 (es) |
| BR (1) | BR9902653A (es) |
| CA (1) | CA2274201C (es) |
| CO (1) | CO5040061A1 (es) |
| CZ (1) | CZ291323B6 (es) |
| DE (1) | DE69905798T2 (es) |
| DK (1) | DK0963985T3 (es) |
| ES (1) | ES2194402T3 (es) |
| HR (1) | HRP990187A2 (es) |
| HU (1) | HUP9901910A3 (es) |
| ID (1) | ID23306A (es) |
| IL (1) | IL130375A0 (es) |
| MA (1) | MA26645A1 (es) |
| NO (1) | NO312591B1 (es) |
| NZ (1) | NZ336226A (es) |
| PE (1) | PE20000540A1 (es) |
| PL (1) | PL333693A1 (es) |
| PT (1) | PT963985E (es) |
| SG (1) | SG83135A1 (es) |
| TR (1) | TR199901380A2 (es) |
| TW (1) | TW434241B (es) |
| YU (1) | YU26799A (es) |
| ZA (2) | ZA993853B (es) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2237047T3 (es) * | 1998-10-23 | 2005-07-16 | Pfizer Inc. | Compuestos de 1,3,8-triazaespiro(4,5)decanona como agonistas del receptor orl1. |
| DK1491212T3 (da) | 2002-03-29 | 2012-10-29 | Mitsubishi Tanabe Pharma Corp | Middel til behandling af søvnforstyrrelser |
| DE102004014296A1 (de) | 2004-03-22 | 2005-10-06 | Grünenthal GmbH | Substituierte 1,4,8-Triazaspiro[4.5]decan-2-on-Verbindingen |
| KR100662191B1 (ko) | 2004-12-23 | 2006-12-27 | 엘지이노텍 주식회사 | 질화물 반도체 발광소자 및 그 제조방법 |
| CN101622241B (zh) | 2007-03-01 | 2013-05-22 | 田边三菱制药株式会社 | 苯并咪唑化合物及其医药用途 |
| TW201016675A (en) | 2008-09-16 | 2010-05-01 | Mitsubishi Tanabe Pharma Corp | Crystalline benzoimidazole compound and salt thereof |
| CN109503582A (zh) * | 2018-12-17 | 2019-03-22 | 上海合全药物研发有限公司 | 顺式螺[哌啶并-4,1＇-吡咯并[3,4-c]吡咯]-1-甲酸叔丁酯的合成方法 |
| US20230348493A1 (en) * | 2020-05-12 | 2023-11-02 | Beijing Greatway Pharmaceutical Technology Co., Ltd. | Compound for adjusting activity of nmda receptor, and pharmaceutical composition and use thereof |
| KR20220022988A (ko) | 2020-08-20 | 2022-03-02 | 제트스타 주식회사 | 트랙터용 써레 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS63208844A (ja) * | 1987-02-26 | 1988-08-30 | Konica Corp | 有機着色物質の光褪色防止方法 |
| US5221675A (en) * | 1989-12-15 | 1993-06-22 | Abbott Laboratories | Aza-spirocyclic compounds that enhance cholinergic neurotransmission |
| US5534520A (en) * | 1990-04-10 | 1996-07-09 | Fisher; Abraham | Spiro compounds containing five-membered rings |
| CA2226058C (en) * | 1997-01-30 | 2008-01-29 | F. Hoffmann-La Roche Ag | 8-substituted-1,3,8-triaza-spiro[4.5]decan-4-one derivatives |
-
1999
- 1999-06-07 PT PT99110954T patent/PT963985E/pt unknown
- 1999-06-07 EP EP99110954A patent/EP0963985B1/en not_active Expired - Lifetime
- 1999-06-07 ES ES99110954T patent/ES2194402T3/es not_active Expired - Lifetime
- 1999-06-07 DE DE69905798T patent/DE69905798T2/de not_active Expired - Lifetime
- 1999-06-07 DK DK99110954T patent/DK0963985T3/da active
- 1999-06-07 AT AT99110954T patent/ATE234302T1/de not_active IP Right Cessation
- 1999-06-08 ZA ZA9903853A patent/ZA993853B/xx unknown
- 1999-06-08 CZ CZ19992039A patent/CZ291323B6/cs not_active IP Right Cessation
- 1999-06-08 PE PE1999000486A patent/PE20000540A1/es not_active Application Discontinuation
- 1999-06-09 SG SG9902947A patent/SG83135A1/en unknown
- 1999-06-09 HU HU9901910A patent/HUP9901910A3/hu unknown
- 1999-06-09 JP JP16194399A patent/JP3369123B2/ja not_active Expired - Fee Related
- 1999-06-09 CA CA2274201A patent/CA2274201C/en not_active Expired - Fee Related
- 1999-06-09 IL IL13037599A patent/IL130375A0/xx unknown
- 1999-06-10 AU AU34986/99A patent/AU752835B2/en not_active Ceased
- 1999-06-10 CO CO99036580A patent/CO5040061A1/es unknown
- 1999-06-10 ZA ZA9903901A patent/ZA993901B/xx unknown
- 1999-06-10 AR ARP990102764A patent/AR019860A1/es active IP Right Grant
- 1999-06-10 NZ NZ336226A patent/NZ336226A/xx unknown
- 1999-06-10 MA MA25617A patent/MA26645A1/fr unknown
- 1999-06-11 YU YU26799A patent/YU26799A/sh unknown
- 1999-06-11 BR BR9902653-8A patent/BR9902653A/pt active Search and Examination
- 1999-06-11 CN CN99110904A patent/CN1110497C/zh not_active Expired - Fee Related
- 1999-06-11 US US09/330,724 patent/US6642247B2/en not_active Expired - Fee Related
- 1999-06-11 CN CNB991083741A patent/CN1229377C/zh not_active Expired - Fee Related
- 1999-06-11 TR TR1999/01380A patent/TR199901380A2/xx unknown
- 1999-06-11 PL PL99333693A patent/PL333693A1/xx unknown
- 1999-06-11 HR HR98110803.8A patent/HRP990187A2/hr not_active Application Discontinuation
- 1999-06-11 TW TW088109813A patent/TW434241B/zh not_active IP Right Cessation
- 1999-06-11 NO NO19992876A patent/NO312591B1/no unknown
- 1999-06-12 KR KR10-1999-0021892A patent/KR100393311B1/ko not_active IP Right Cessation
- 1999-06-14 ID IDP990575D patent/ID23306A/id unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration |