NZ330861A - Fused pyrrolecarboxamides and use as a new class of GABA brain receptor ligands - Google Patents
Fused pyrrolecarboxamides and use as a new class of GABA brain receptor ligandsInfo
- Publication number
- NZ330861A NZ330861A NZ330861A NZ33086197A NZ330861A NZ 330861 A NZ330861 A NZ 330861A NZ 330861 A NZ330861 A NZ 330861A NZ 33086197 A NZ33086197 A NZ 33086197A NZ 330861 A NZ330861 A NZ 330861A
- Authority
- NZ
- New Zealand
- Prior art keywords
- agonists
- substituents
- antagonists
- hydroxyl
- halogen
- Prior art date
Links
- 210000004556 brain Anatomy 0.000 title abstract 3
- RLOQBKJCOAXOLR-UHFFFAOYSA-N 1h-pyrrole-2-carboxamide Chemical class NC(=O)C1=CC=CN1 RLOQBKJCOAXOLR-UHFFFAOYSA-N 0.000 title 1
- BTCSSZJGUNDROE-UHFFFAOYSA-N gamma-aminobutyric acid Chemical class NCCCC(O)=O BTCSSZJGUNDROE-UHFFFAOYSA-N 0.000 title 1
- 239000003446 ligand Substances 0.000 title 1
- 239000000556 agonist Substances 0.000 abstract 4
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 3
- 125000001424 substituent group Chemical group 0.000 abstract 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical group N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- 239000005557 antagonist Substances 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 229910052736 halogen Chemical group 0.000 abstract 2
- 150000002367 halogens Chemical group 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Chemical group 0.000 abstract 2
- 150000002431 hydrogen Chemical group 0.000 abstract 2
- SVUOLADPCWQTTE-UHFFFAOYSA-N 1h-1,2-benzodiazepine Chemical compound N1N=CC=CC2=CC=CC=C12 SVUOLADPCWQTTE-UHFFFAOYSA-N 0.000 abstract 1
- 208000019901 Anxiety disease Diseases 0.000 abstract 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 230000036506 anxiety Effects 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 229940049706 benzodiazepine Drugs 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 238000003745 diagnosis Methods 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 206010015037 epilepsy Diseases 0.000 abstract 1
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 231100000252 nontoxic Toxicity 0.000 abstract 1
- 230000003000 nontoxic effect Effects 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 208000019116 sleep disease Diseases 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 239000011593 sulfur Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pyrrole Compounds (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/588,711 US5804686A (en) | 1996-01-19 | 1996-01-19 | fused pyrrolecarboxamides; a new class of GABA brain receptor ligands |
| PCT/US1997/000519 WO1997026243A1 (en) | 1996-01-19 | 1997-01-14 | Novel fused pyrrolecarboxamides; a new class of gaba brain receptor ligands |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NZ330861A true NZ330861A (en) | 2000-03-27 |
Family
ID=24354983
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NZ330861A NZ330861A (en) | 1996-01-19 | 1997-01-14 | Fused pyrrolecarboxamides and use as a new class of GABA brain receptor ligands |
Country Status (26)
| Country | Link |
|---|---|
| US (2) | US5804686A (enExample) |
| EP (1) | EP1019372B1 (enExample) |
| JP (1) | JP2000503321A (enExample) |
| KR (1) | KR100490108B1 (enExample) |
| CN (1) | CN1209805A (enExample) |
| AP (1) | AP1015A (enExample) |
| AT (1) | ATE322480T1 (enExample) |
| AU (1) | AU1746697A (enExample) |
| BG (1) | BG102634A (enExample) |
| BR (1) | BR9707051A (enExample) |
| CA (1) | CA2243317C (enExample) |
| CZ (1) | CZ215498A3 (enExample) |
| DE (1) | DE69735647T2 (enExample) |
| ES (1) | ES2263170T3 (enExample) |
| HU (1) | HUP9901018A3 (enExample) |
| IL (1) | IL125391A (enExample) |
| IS (1) | IS4798A (enExample) |
| MX (1) | MX9805701A (enExample) |
| NO (1) | NO312670B1 (enExample) |
| NZ (1) | NZ330861A (enExample) |
| OA (1) | OA10811A (enExample) |
| PL (1) | PL327936A1 (enExample) |
| RU (1) | RU2167151C2 (enExample) |
| SK (1) | SK94398A3 (enExample) |
| UA (1) | UA49001C2 (enExample) |
| WO (1) | WO1997026243A1 (enExample) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5750702A (en) * | 1993-10-27 | 1998-05-12 | Neurogen Corporation | Certain pyrrolo pyridine-3-carboxamides; a new class of GABA brain receptor ligands |
| US6211365B1 (en) | 1996-01-19 | 2001-04-03 | Neurogen Corporation | Fused pyrrolecarboxamides; a new class of GABA brain receptor ligands |
| US5804686A (en) * | 1996-01-19 | 1998-09-08 | Neurogen Corporation | fused pyrrolecarboxamides; a new class of GABA brain receptor ligands |
| WO1997034870A1 (en) * | 1996-03-22 | 1997-09-25 | Neurogen Corporation | Certain fused pyrrolecarboxamides as gaba brain receptor ligands |
| US5723462A (en) * | 1996-04-26 | 1998-03-03 | Neurogen Corporation | Certain fused pyrrolecarboxamides a new class of GABA brain receptor ligands |
| GT199800179A (es) * | 1997-11-13 | 2000-05-02 | Procedimiento de sintesis de pirrol amidas. | |
| DK1030838T3 (da) * | 1997-11-13 | 2003-02-24 | Pfizer Prod Inc | Fremgangsmåde til syntese af pyrrolamider |
| WO1999043660A1 (en) * | 1998-02-26 | 1999-09-02 | Neurogen Corporation | Substituted 1,4-dihydro-4-oxonicotinic carboxamides: gaba brain receptor ligands |
| GB9812038D0 (en) | 1998-06-04 | 1998-07-29 | Merck Sharp & Dohme | Therapeutic compound |
| AU5444499A (en) * | 1998-09-01 | 2000-03-21 | Nissan Chemical Industries Ltd. | Benzoxazine derivatives |
| US20050014939A1 (en) * | 1999-08-31 | 2005-01-20 | Neurogen Corporation | Fused pyrrolecarboxamides: GABA brain receptor ligands |
| CA2381553A1 (en) * | 1999-08-31 | 2001-03-08 | Neurogen Corporation | Fused pyrrolecarboxamides: gaba brain receptor ligands |
| AU2001264932A1 (en) | 2000-05-26 | 2001-12-11 | Neurogen Corporation | Oxo-imidazopyrimidine-carboxamides and their use as gaba brain receptor ligands |
| WO2002020492A1 (en) * | 2000-09-06 | 2002-03-14 | Neurogen Corporation | Aryl substituted tetrahydroindazoles and their use as ligands for the gaba-a receptor |
| MXPA03001951A (es) | 2000-09-06 | 2003-10-15 | Neurogen Corp | Pirroliminas y pirazoliminas fusionadas substituidas. |
| EP1339681A1 (en) * | 2000-12-04 | 2003-09-03 | Pfizer Products Inc. | Synthesis of fused pyrrolecarboxamides |
| AU2003212979A1 (en) * | 2002-02-07 | 2003-09-02 | Neurogen Corporation | Substituted fused pyrazolecarboxylic acid arylamides and related compounds |
| JP2006502974A (ja) | 2002-05-17 | 2006-01-26 | ニューロジェン コーポレイション | 置換環縮合イミダゾール誘導体：ｇａｂａａ受容体リガンド |
| JP2009506069A (ja) | 2005-08-26 | 2009-02-12 | ブレインセルス，インコーポレイティド | ムスカリン性受容体調節による神経発生 |
| EP2258358A3 (en) | 2005-08-26 | 2011-09-07 | Braincells, Inc. | Neurogenesis with acetylcholinesterase inhibitor |
| CA2625153A1 (en) | 2005-10-21 | 2007-04-26 | Braincells, Inc. | Modulation of neurogenesis by pde inhibition |
| CA2625210A1 (en) * | 2005-10-31 | 2007-05-10 | Braincells, Inc. | Gaba receptor mediated modulation of neurogenesis |
| US20100216734A1 (en) | 2006-03-08 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis by nootropic agents |
| EP2382975A3 (en) | 2006-05-09 | 2012-02-29 | Braincells, Inc. | Neurogenesis by modulating angiotensin |
| MX2008014320A (es) | 2006-05-09 | 2009-03-25 | Braincells Inc | Neurogenesis mediada por el receptor de 5-hidroxitriptamina. |
| JP2010502722A (ja) | 2006-09-08 | 2010-01-28 | ブレインセルス，インコーポレイティド | ４−アシルアミノピリジン誘導体を含む組み合わせ |
| DK2074123T3 (da) | 2006-10-16 | 2013-01-14 | Bionomics Ltd | Nye anxiolytiske forbindelser |
| US10954231B2 (en) | 2006-10-16 | 2021-03-23 | Bionomics Limited | Anxiolytic compounds |
| WO2010099217A1 (en) | 2009-02-25 | 2010-09-02 | Braincells, Inc. | Modulation of neurogenesis using d-cycloserine combinations |
| CN103254125B (zh) | 2010-08-31 | 2016-04-27 | 明治制果药业株式会社 | 有害生物防除剂 |
| CA2828780A1 (en) | 2011-03-02 | 2012-09-07 | Bionomics Limited | Novel small-molecules as therapeutics |
| CN103649086A (zh) | 2011-05-12 | 2014-03-19 | 生态学有限公司 | 制备萘啶的方法 |
| CN120081825B (zh) * | 2025-05-07 | 2025-09-16 | 天津匠新致成科技有限公司 | 一种化合物及其制备方法和医药用途 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3455943A (en) * | 1966-10-21 | 1969-07-15 | American Cyanamid Co | Certain 5,8-dihydro-beta-carbolines |
| US4075343A (en) * | 1976-09-13 | 1978-02-21 | Pfizer Inc. | Anti-allergenic 5-alkoxyimidazo[1,2-A]quinoline-2-carboxylic acids and derivatives thereof |
| DE3029980A1 (de) * | 1980-08-08 | 1982-03-11 | Boehringer Mannheim Gmbh, 6800 Mannheim | Indolderivate und verfahren zu ihrer herstellung |
| JPS57123180A (en) * | 1980-12-17 | 1982-07-31 | Schering Ag | 3-substituted beta-carboline, manufacture and psychotropic drug containing same |
| DE3147276A1 (de) * | 1981-11-28 | 1983-06-09 | Boehringer Mannheim Gmbh, 6800 Mannheim | Verfahren zur herstellung von indolderivaten, deren verwendung als wertvolle zwischenprodukte und neue 4-hydroxyindole |
| DE3246932A1 (de) * | 1982-12-16 | 1984-06-20 | Schering AG, 1000 Berlin und 4709 Bergkamen | Substituierte 5h-pyrimido(5,4-b)indole |
| DE3335323A1 (de) * | 1983-09-27 | 1985-04-04 | Schering AG, 1000 Berlin und 4709 Bergkamen | Substituierte ss-carboline, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
| GB8429739D0 (en) * | 1984-11-24 | 1985-01-03 | Fbc Ltd | Fungicides |
| DE3535927A1 (de) * | 1985-10-04 | 1987-04-09 | Schering Ag | 3-vinyl- und 3-ethinyl-ss-carbolinderivate, ihre herstellung und ihre verwendung als arzneimittel |
| JPH06502147A (ja) * | 1990-10-09 | 1994-03-10 | ニューロゲン コーポレイション | 或る種のシクロアルキルおよびアザシクロアルキルピロロピリミジン；新規な種類のｇａｂａ脳リセプタリガンド |
| US5243049A (en) * | 1992-01-22 | 1993-09-07 | Neurogen Corporation | Certain pyrroloquinolinones: a new class of GABA brain receptor ligands |
| JPH07503970A (ja) * | 1992-02-19 | 1995-04-27 | ジ・アップジョン・カンパニー | ＣＮＳ活性を有する３−置換イミダゾ（１，５−ａ）−キノキサリン類およびキナゾリン類 |
| US5266698A (en) * | 1992-04-30 | 1993-11-30 | Neurogen Corporation | Certain aryl and cycloalkyl fused imidazopyrazinediones; a new class of GABA brain receptor ligands |
| AU6098194A (en) * | 1993-01-29 | 1994-08-15 | Ariad Pharmaceuticals, Inc. | Analogs of receptor tyrosine activation motifs and therapeutic uses thereof |
| FR2705095B1 (fr) * | 1993-05-12 | 1995-06-23 | Adir | Nouveaux indoles substitués, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent. |
| US5484944A (en) * | 1993-10-27 | 1996-01-16 | Neurogen Corporation | Certain fused pyrrolecarboxanilides and their use as GABA brain receptor ligands |
| US5804686A (en) * | 1996-01-19 | 1998-09-08 | Neurogen Corporation | fused pyrrolecarboxamides; a new class of GABA brain receptor ligands |
-
1996
- 1996-01-19 US US08/588,711 patent/US5804686A/en not_active Expired - Fee Related
-
1997
- 1997-01-14 RU RU98115534/04A patent/RU2167151C2/ru not_active IP Right Cessation
- 1997-01-14 PL PL97327936A patent/PL327936A1/xx unknown
- 1997-01-14 KR KR10-1998-0705446A patent/KR100490108B1/ko not_active Expired - Fee Related
- 1997-01-14 CZ CZ982154A patent/CZ215498A3/cs unknown
- 1997-01-14 IL IL12539197A patent/IL125391A/en not_active IP Right Cessation
- 1997-01-14 SK SK943-98A patent/SK94398A3/sk unknown
- 1997-01-14 BR BR9707051A patent/BR9707051A/pt not_active Application Discontinuation
- 1997-01-14 UA UA98073904A patent/UA49001C2/uk unknown
- 1997-01-14 NZ NZ330861A patent/NZ330861A/xx unknown
- 1997-01-14 WO PCT/US1997/000519 patent/WO1997026243A1/en not_active Ceased
- 1997-01-14 CA CA002243317A patent/CA2243317C/en not_active Expired - Fee Related
- 1997-01-14 ES ES97904754T patent/ES2263170T3/es not_active Expired - Lifetime
- 1997-01-14 EP EP97904754A patent/EP1019372B1/en not_active Expired - Lifetime
- 1997-01-14 AU AU17466/97A patent/AU1746697A/en not_active Abandoned
- 1997-01-14 HU HU9901018A patent/HUP9901018A3/hu unknown
- 1997-01-14 AP APAP/P/1998/001297A patent/AP1015A/en active
- 1997-01-14 CN CN97191759A patent/CN1209805A/zh active Pending
- 1997-01-14 JP JP9526110A patent/JP2000503321A/ja not_active Ceased
- 1997-01-14 DE DE69735647T patent/DE69735647T2/de not_active Expired - Fee Related
- 1997-01-14 AT AT97904754T patent/ATE322480T1/de not_active IP Right Cessation
-
1998
- 1998-07-15 MX MX9805701A patent/MX9805701A/es not_active IP Right Cessation
- 1998-07-15 BG BG102634A patent/BG102634A/xx unknown
- 1998-07-15 OA OA9800115A patent/OA10811A/en unknown
- 1998-07-16 IS IS4798A patent/IS4798A/is unknown
- 1998-07-17 NO NO19983315A patent/NO312670B1/no not_active IP Right Cessation
- 1998-09-04 US US09/148,247 patent/US6080873A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| AU1746697A (en) | 1997-08-11 |
| NO983315L (no) | 1998-09-03 |
| RU2167151C2 (ru) | 2001-05-20 |
| CA2243317A1 (en) | 1997-07-24 |
| US5804686A (en) | 1998-09-08 |
| UA49001C2 (uk) | 2002-09-16 |
| KR100490108B1 (ko) | 2005-11-25 |
| CA2243317C (en) | 2007-09-25 |
| BG102634A (en) | 1999-08-31 |
| BR9707051A (pt) | 1999-07-20 |
| KR19990077300A (ko) | 1999-10-25 |
| NO983315D0 (no) | 1998-07-17 |
| WO1997026243A1 (en) | 1997-07-24 |
| MX9805701A (es) | 1998-11-30 |
| EP1019372B1 (en) | 2006-04-05 |
| EP1019372A1 (en) | 2000-07-19 |
| IL125391A (en) | 2004-07-25 |
| NO312670B1 (no) | 2002-06-17 |
| HUP9901018A2 (hu) | 1999-07-28 |
| IL125391A0 (en) | 1999-03-12 |
| ES2263170T3 (es) | 2006-12-01 |
| CZ215498A3 (cs) | 1999-09-15 |
| AP1015A (en) | 2001-09-28 |
| ATE322480T1 (de) | 2006-04-15 |
| DE69735647D1 (de) | 2006-05-18 |
| AP9801297A0 (en) | 1998-09-30 |
| DE69735647T2 (de) | 2007-05-03 |
| PL327936A1 (en) | 1999-01-04 |
| CN1209805A (zh) | 1999-03-03 |
| JP2000503321A (ja) | 2000-03-21 |
| US6080873A (en) | 2000-06-27 |
| IS4798A (is) | 1998-07-16 |
| SK94398A3 (en) | 1999-02-11 |
| OA10811A (en) | 2001-07-05 |
| HUP9901018A3 (en) | 1999-11-29 |
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