ATE322480T1 - Kondensierte pyrrolcarboxamide; eine neue klasse von gabe-gehirn-rezeptoren-liganden - Google Patents

Kondensierte pyrrolcarboxamide; eine neue klasse von gabe-gehirn-rezeptoren-liganden

Info

Publication number
ATE322480T1
ATE322480T1 AT97904754T AT97904754T ATE322480T1 AT E322480 T1 ATE322480 T1 AT E322480T1 AT 97904754 T AT97904754 T AT 97904754T AT 97904754 T AT97904754 T AT 97904754T AT E322480 T1 ATE322480 T1 AT E322480T1
Authority
AT
Austria
Prior art keywords
gabe
carboxamides
pyrrol
condensed
new class
Prior art date
Application number
AT97904754T
Other languages
German (de)
English (en)
Inventor
Pamela Albaugh
Gang Liu
Kenneth Shaw
Alan Hutchison
Original Assignee
Neurogen Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neurogen Corp filed Critical Neurogen Corp
Application granted granted Critical
Publication of ATE322480T1 publication Critical patent/ATE322480T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/30Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/52Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyrrole Compounds (AREA)
  • Indole Compounds (AREA)
AT97904754T 1996-01-19 1997-01-14 Kondensierte pyrrolcarboxamide; eine neue klasse von gabe-gehirn-rezeptoren-liganden ATE322480T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/588,711 US5804686A (en) 1996-01-19 1996-01-19 fused pyrrolecarboxamides; a new class of GABA brain receptor ligands

Publications (1)

Publication Number Publication Date
ATE322480T1 true ATE322480T1 (de) 2006-04-15

Family

ID=24354983

Family Applications (1)

Application Number Title Priority Date Filing Date
AT97904754T ATE322480T1 (de) 1996-01-19 1997-01-14 Kondensierte pyrrolcarboxamide; eine neue klasse von gabe-gehirn-rezeptoren-liganden

Country Status (26)

Country Link
US (2) US5804686A (enExample)
EP (1) EP1019372B1 (enExample)
JP (1) JP2000503321A (enExample)
KR (1) KR100490108B1 (enExample)
CN (1) CN1209805A (enExample)
AP (1) AP1015A (enExample)
AT (1) ATE322480T1 (enExample)
AU (1) AU1746697A (enExample)
BG (1) BG102634A (enExample)
BR (1) BR9707051A (enExample)
CA (1) CA2243317C (enExample)
CZ (1) CZ215498A3 (enExample)
DE (1) DE69735647T2 (enExample)
ES (1) ES2263170T3 (enExample)
HU (1) HUP9901018A3 (enExample)
IL (1) IL125391A (enExample)
IS (1) IS4798A (enExample)
MX (1) MX9805701A (enExample)
NO (1) NO312670B1 (enExample)
NZ (1) NZ330861A (enExample)
OA (1) OA10811A (enExample)
PL (1) PL327936A1 (enExample)
RU (1) RU2167151C2 (enExample)
SK (1) SK94398A3 (enExample)
UA (1) UA49001C2 (enExample)
WO (1) WO1997026243A1 (enExample)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5750702A (en) * 1993-10-27 1998-05-12 Neurogen Corporation Certain pyrrolo pyridine-3-carboxamides; a new class of GABA brain receptor ligands
US6211365B1 (en) 1996-01-19 2001-04-03 Neurogen Corporation Fused pyrrolecarboxamides; a new class of GABA brain receptor ligands
US5804686A (en) * 1996-01-19 1998-09-08 Neurogen Corporation fused pyrrolecarboxamides; a new class of GABA brain receptor ligands
AU2218997A (en) 1996-03-22 1997-10-10 Neurogen Corporation Certain fused pyrrolecarboxamides as gaba brain receptor ligands
US5723462A (en) * 1996-04-26 1998-03-03 Neurogen Corporation Certain fused pyrrolecarboxamides a new class of GABA brain receptor ligands
GT199800179A (es) * 1997-11-13 2000-05-02 Procedimiento de sintesis de pirrol amidas.
EP1030838B1 (en) 1997-11-13 2003-01-22 Pfizer Products Inc. Method of synthesis of pyrrole amides
AU2881199A (en) * 1998-02-26 1999-09-15 Neurogen Corporation Substituted 1,4-dihydro-4-oxonicotinic carboxamides: gaba brain receptor ligands
GB9812038D0 (en) 1998-06-04 1998-07-29 Merck Sharp & Dohme Therapeutic compound
WO2000012492A1 (en) * 1998-09-01 2000-03-09 Nissan Chemical Industries, Ltd. Benzoxazine derivatives
US20050014939A1 (en) * 1999-08-31 2005-01-20 Neurogen Corporation Fused pyrrolecarboxamides: GABA brain receptor ligands
CA2381553A1 (en) * 1999-08-31 2001-03-08 Neurogen Corporation Fused pyrrolecarboxamides: gaba brain receptor ligands
US6723332B2 (en) 2000-05-26 2004-04-20 Neurogen Corporation Oxomidazopyridine-carboxamides
CA2419966A1 (en) * 2000-09-06 2002-03-14 Neurogen Corporation Aryl substituted tetrahydroindazoles and their use as ligands for the gaba-a receptor
CA2419958A1 (en) 2000-09-06 2002-03-14 Neurogen Corporation Substituted fused pyrroleimines and pyrazoleimines
MXPA03004939A (es) * 2000-12-04 2003-09-10 Pfizer Prod Inc Sintesis de pirrolamidas.
US6852730B2 (en) * 2002-02-07 2005-02-08 Neurogen Corporation Substituted fused pyrazolecarboxylic acid arylamides and related compounds
AU2003237881A1 (en) 2002-05-17 2003-12-02 Neurogen Corporation Substituted ring-fused imidazole derivates: gabaa receptor ligands
JP2009506069A (ja) 2005-08-26 2009-02-12 ブレインセルス,インコーポレイティド ムスカリン性受容体調節による神経発生
EP2258359A3 (en) 2005-08-26 2011-04-06 Braincells, Inc. Neurogenesis by muscarinic receptor modulation with sabcomelin
JP2009512711A (ja) 2005-10-21 2009-03-26 ブレインセルス,インコーポレイティド Pde阻害による神経新生の調節
EP2314289A1 (en) 2005-10-31 2011-04-27 Braincells, Inc. Gaba receptor mediated modulation of neurogenesis
US20100216734A1 (en) 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
CA2651862A1 (en) 2006-05-09 2007-11-22 Braincells, Inc. 5 ht receptor mediated neurogenesis
AU2007249399A1 (en) 2006-05-09 2007-11-22 Braincells, Inc. Neurogenesis by modulating angiotensin
WO2008030651A1 (en) 2006-09-08 2008-03-13 Braincells, Inc. Combinations containing a 4-acylaminopyridine derivative
US10954231B2 (en) 2006-10-16 2021-03-23 Bionomics Limited Anxiolytic compounds
US8293737B2 (en) 2006-10-16 2012-10-23 Bionomics Limited Anxiolytic compounds
US20100216805A1 (en) 2009-02-25 2010-08-26 Braincells, Inc. Modulation of neurogenesis using d-cycloserine combinations
PE20131380A1 (es) 2010-08-31 2014-01-05 Meiji Seika Pharma Co Ltd Agente de control de plagas
AU2012222874B2 (en) 2011-03-02 2015-04-16 Bionomics Limited Novel small-molecules as therapeutics
US9133188B2 (en) 2011-05-12 2015-09-15 Bionomics Limited Methods for preparing naphthyridines
CN120081825B (zh) * 2025-05-07 2025-09-16 天津匠新致成科技有限公司 一种化合物及其制备方法和医药用途

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3455943A (en) * 1966-10-21 1969-07-15 American Cyanamid Co Certain 5,8-dihydro-beta-carbolines
US4075343A (en) * 1976-09-13 1978-02-21 Pfizer Inc. Anti-allergenic 5-alkoxyimidazo[1,2-A]quinoline-2-carboxylic acids and derivatives thereof
DE3029980A1 (de) * 1980-08-08 1982-03-11 Boehringer Mannheim Gmbh, 6800 Mannheim Indolderivate und verfahren zu ihrer herstellung
JPS57123180A (en) * 1980-12-17 1982-07-31 Schering Ag 3-substituted beta-carboline, manufacture and psychotropic drug containing same
DE3147276A1 (de) * 1981-11-28 1983-06-09 Boehringer Mannheim Gmbh, 6800 Mannheim Verfahren zur herstellung von indolderivaten, deren verwendung als wertvolle zwischenprodukte und neue 4-hydroxyindole
DE3246932A1 (de) * 1982-12-16 1984-06-20 Schering AG, 1000 Berlin und 4709 Bergkamen Substituierte 5h-pyrimido(5,4-b)indole
DE3335323A1 (de) * 1983-09-27 1985-04-04 Schering AG, 1000 Berlin und 4709 Bergkamen Substituierte ss-carboline, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
GB8429739D0 (en) * 1984-11-24 1985-01-03 Fbc Ltd Fungicides
DE3535927A1 (de) * 1985-10-04 1987-04-09 Schering Ag 3-vinyl- und 3-ethinyl-ss-carbolinderivate, ihre herstellung und ihre verwendung als arzneimittel
WO1992006094A1 (en) * 1990-10-09 1992-04-16 Neurogen Corporation Certain cycloalkyl and azacycloalkyl pyrrolopyrimidines; a new class of gaba brain receptor ligands
US5243049A (en) * 1992-01-22 1993-09-07 Neurogen Corporation Certain pyrroloquinolinones: a new class of GABA brain receptor ligands
WO1993017025A1 (en) * 1992-02-19 1993-09-02 The Upjohn Company 3-substituted imidazo(1,5-a)quinoxalines and quinazolines with cns activity
US5266698A (en) * 1992-04-30 1993-11-30 Neurogen Corporation Certain aryl and cycloalkyl fused imidazopyrazinediones; a new class of GABA brain receptor ligands
WO1994017095A1 (en) * 1993-01-29 1994-08-04 Ariad Pharmaceuticals, Inc. Analogs of receptor tyrosine activation motifs and therapeutic uses thereof
FR2705095B1 (fr) * 1993-05-12 1995-06-23 Adir Nouveaux indoles substitués, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent.
US5484944A (en) * 1993-10-27 1996-01-16 Neurogen Corporation Certain fused pyrrolecarboxanilides and their use as GABA brain receptor ligands
US5804686A (en) * 1996-01-19 1998-09-08 Neurogen Corporation fused pyrrolecarboxamides; a new class of GABA brain receptor ligands

Also Published As

Publication number Publication date
US6080873A (en) 2000-06-27
HUP9901018A3 (en) 1999-11-29
IS4798A (is) 1998-07-16
EP1019372B1 (en) 2006-04-05
CZ215498A3 (cs) 1999-09-15
OA10811A (en) 2001-07-05
PL327936A1 (en) 1999-01-04
AU1746697A (en) 1997-08-11
EP1019372A1 (en) 2000-07-19
IL125391A (en) 2004-07-25
WO1997026243A1 (en) 1997-07-24
AP1015A (en) 2001-09-28
NO312670B1 (no) 2002-06-17
CA2243317A1 (en) 1997-07-24
NZ330861A (en) 2000-03-27
HUP9901018A2 (hu) 1999-07-28
RU2167151C2 (ru) 2001-05-20
KR19990077300A (ko) 1999-10-25
ES2263170T3 (es) 2006-12-01
CA2243317C (en) 2007-09-25
DE69735647T2 (de) 2007-05-03
UA49001C2 (uk) 2002-09-16
NO983315D0 (no) 1998-07-17
AP9801297A0 (en) 1998-09-30
IL125391A0 (en) 1999-03-12
KR100490108B1 (ko) 2005-11-25
MX9805701A (es) 1998-11-30
DE69735647D1 (de) 2006-05-18
BG102634A (en) 1999-08-31
BR9707051A (pt) 1999-07-20
CN1209805A (zh) 1999-03-03
NO983315L (no) 1998-09-03
SK94398A3 (en) 1999-02-11
JP2000503321A (ja) 2000-03-21
US5804686A (en) 1998-09-08

Similar Documents

Publication Publication Date Title
ATE322480T1 (de) Kondensierte pyrrolcarboxamide; eine neue klasse von gabe-gehirn-rezeptoren-liganden
ATE239002T1 (de) Einige amido-und amino-substituierte benzylaminderivate: eine neue klasse von neuropeptid y1 spezifischen liganden
NO972091D0 (no) Bestemte substituerte benzylaminderivater; en ny klasse nouropeptid-yl-spesifikke ligander
NO996573D0 (no) Spesielle diarylimidazol-derivater, en ny klasse av NPY- spesifikke ligander
PT84149A (de) Neue thieno-1,4-diazepine
FR2601318B1 (fr) Frein a machoire pour bicyclette
FR2600301B1 (fr) Frein a machoire pour bicyclette
FR2599632B1 (fr) Barre a disque pour exercices de gymnastique
FI931354A7 (fi) Runsaskatalyyttinen menetelmä glukamidipesuaineiden valmistamiseksi
DE69600594D1 (de) Entfernung von hitzestabilem aminsalz von type ii anionentauscherharz
NO20020948D0 (no) Kondenserte pyrrolkarboksamider: GABA hjernereseptorligander
DE68902981D1 (de) Maskenformen zum giessen von metallen.
EP0618256A3 (en) Improved dyeability of synthetic polyamide.
DE69522582D1 (de) NEUE VERWENDUNGEN VON INDOLO-[2,3b]-CHINOXALINEN
DE69831898D1 (de) Anlage zum Überlagern von Zusatzinformation
HUP9900377A2 (hu) Új eljárás 2,3-dihidro-benzofurán-származékok előállítására
FR2747095B1 (fr) Guidon a suspension pour cycle ou motocycle
DE69600839D1 (de) Maschine zum verschliessen von kuvert
ATE231138T1 (de) Bestimmte substituierte benzylaminderivate: eine neue klasse von neuropeptid y1 spezifischen liganden
DE69818765D1 (de) Verfahren zum Bemustern von Kleidungsstücken
FR2649065B1 (fr) Pedalier pour cycle
DK0401116T3 (da) Fremgangsmåde til tørring af karrageener
BR8705579A (pt) Processo para a preparacao de 3-(c1-c12 alquiltio)c3-c10 aldeidos
DE69718173D1 (de) Einige amido- und ammo- substituierte benzylaminderivate: eine neue klasse von neuropeptid y1 spezifische ligande
FR2763346B3 (fr) Poteau escamotable servant a delimiter des zones de passage

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties