CN1209805A - 新型稠合的吡咯碳酰胺、新一类的gaba脑受体配位体 - Google Patents

新型稠合的吡咯碳酰胺、新一类的gaba脑受体配位体 Download PDF

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Publication number
CN1209805A
CN1209805A CN97191759A CN97191759A CN1209805A CN 1209805 A CN1209805 A CN 1209805A CN 97191759 A CN97191759 A CN 97191759A CN 97191759 A CN97191759 A CN 97191759A CN 1209805 A CN1209805 A CN 1209805A
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CN
China
Prior art keywords
compound
oxygen
carboxamide
indoles
tetrahydrochysene
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN97191759A
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English (en)
Chinese (zh)
Inventor
帕梅拉·阿尔鲍格
刘刚
肯尼斯·肖
阿兰·哈奇森
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Neurogen Corp
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Neurogen Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neurogen Corp filed Critical Neurogen Corp
Publication of CN1209805A publication Critical patent/CN1209805A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyrrole Compounds (AREA)
  • Indole Compounds (AREA)
CN97191759A 1996-01-19 1997-01-14 新型稠合的吡咯碳酰胺、新一类的gaba脑受体配位体 Pending CN1209805A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/588,711 1996-01-19
US08/588,711 US5804686A (en) 1996-01-19 1996-01-19 fused pyrrolecarboxamides; a new class of GABA brain receptor ligands

Publications (1)

Publication Number Publication Date
CN1209805A true CN1209805A (zh) 1999-03-03

Family

ID=24354983

Family Applications (1)

Application Number Title Priority Date Filing Date
CN97191759A Pending CN1209805A (zh) 1996-01-19 1997-01-14 新型稠合的吡咯碳酰胺、新一类的gaba脑受体配位体

Country Status (26)

Country Link
US (2) US5804686A (enExample)
EP (1) EP1019372B1 (enExample)
JP (1) JP2000503321A (enExample)
KR (1) KR100490108B1 (enExample)
CN (1) CN1209805A (enExample)
AP (1) AP1015A (enExample)
AT (1) ATE322480T1 (enExample)
AU (1) AU1746697A (enExample)
BG (1) BG102634A (enExample)
BR (1) BR9707051A (enExample)
CA (1) CA2243317C (enExample)
CZ (1) CZ215498A3 (enExample)
DE (1) DE69735647T2 (enExample)
ES (1) ES2263170T3 (enExample)
HU (1) HUP9901018A3 (enExample)
IL (1) IL125391A (enExample)
IS (1) IS4798A (enExample)
MX (1) MX9805701A (enExample)
NO (1) NO312670B1 (enExample)
NZ (1) NZ330861A (enExample)
OA (1) OA10811A (enExample)
PL (1) PL327936A1 (enExample)
RU (1) RU2167151C2 (enExample)
SK (1) SK94398A3 (enExample)
UA (1) UA49001C2 (enExample)
WO (1) WO1997026243A1 (enExample)

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US5750702A (en) * 1993-10-27 1998-05-12 Neurogen Corporation Certain pyrrolo pyridine-3-carboxamides; a new class of GABA brain receptor ligands
US6211365B1 (en) 1996-01-19 2001-04-03 Neurogen Corporation Fused pyrrolecarboxamides; a new class of GABA brain receptor ligands
US5804686A (en) * 1996-01-19 1998-09-08 Neurogen Corporation fused pyrrolecarboxamides; a new class of GABA brain receptor ligands
AU2218997A (en) 1996-03-22 1997-10-10 Neurogen Corporation Certain fused pyrrolecarboxamides as gaba brain receptor ligands
US5723462A (en) * 1996-04-26 1998-03-03 Neurogen Corporation Certain fused pyrrolecarboxamides a new class of GABA brain receptor ligands
GT199800179A (es) * 1997-11-13 2000-05-02 Procedimiento de sintesis de pirrol amidas.
EP1030838B1 (en) 1997-11-13 2003-01-22 Pfizer Products Inc. Method of synthesis of pyrrole amides
AU2881199A (en) * 1998-02-26 1999-09-15 Neurogen Corporation Substituted 1,4-dihydro-4-oxonicotinic carboxamides: gaba brain receptor ligands
GB9812038D0 (en) 1998-06-04 1998-07-29 Merck Sharp & Dohme Therapeutic compound
WO2000012492A1 (en) * 1998-09-01 2000-03-09 Nissan Chemical Industries, Ltd. Benzoxazine derivatives
US20050014939A1 (en) * 1999-08-31 2005-01-20 Neurogen Corporation Fused pyrrolecarboxamides: GABA brain receptor ligands
CA2381553A1 (en) * 1999-08-31 2001-03-08 Neurogen Corporation Fused pyrrolecarboxamides: gaba brain receptor ligands
US6723332B2 (en) 2000-05-26 2004-04-20 Neurogen Corporation Oxomidazopyridine-carboxamides
CA2419966A1 (en) * 2000-09-06 2002-03-14 Neurogen Corporation Aryl substituted tetrahydroindazoles and their use as ligands for the gaba-a receptor
CA2419958A1 (en) 2000-09-06 2002-03-14 Neurogen Corporation Substituted fused pyrroleimines and pyrazoleimines
MXPA03004939A (es) * 2000-12-04 2003-09-10 Pfizer Prod Inc Sintesis de pirrolamidas.
US6852730B2 (en) * 2002-02-07 2005-02-08 Neurogen Corporation Substituted fused pyrazolecarboxylic acid arylamides and related compounds
AU2003237881A1 (en) 2002-05-17 2003-12-02 Neurogen Corporation Substituted ring-fused imidazole derivates: gabaa receptor ligands
JP2009506069A (ja) 2005-08-26 2009-02-12 ブレインセルス，インコーポレイティド ムスカリン性受容体調節による神経発生
EP2258359A3 (en) 2005-08-26 2011-04-06 Braincells, Inc. Neurogenesis by muscarinic receptor modulation with sabcomelin
JP2009512711A (ja) 2005-10-21 2009-03-26 ブレインセルス，インコーポレイティド Ｐｄｅ阻害による神経新生の調節
EP2314289A1 (en) 2005-10-31 2011-04-27 Braincells, Inc. Gaba receptor mediated modulation of neurogenesis
US20100216734A1 (en) 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
CA2651862A1 (en) 2006-05-09 2007-11-22 Braincells, Inc. 5 ht receptor mediated neurogenesis
AU2007249399A1 (en) 2006-05-09 2007-11-22 Braincells, Inc. Neurogenesis by modulating angiotensin
WO2008030651A1 (en) 2006-09-08 2008-03-13 Braincells, Inc. Combinations containing a 4-acylaminopyridine derivative
US10954231B2 (en) 2006-10-16 2021-03-23 Bionomics Limited Anxiolytic compounds
US8293737B2 (en) 2006-10-16 2012-10-23 Bionomics Limited Anxiolytic compounds
US20100216805A1 (en) 2009-02-25 2010-08-26 Braincells, Inc. Modulation of neurogenesis using d-cycloserine combinations
PE20131380A1 (es) 2010-08-31 2014-01-05 Meiji Seika Pharma Co Ltd Agente de control de plagas
AU2012222874B2 (en) 2011-03-02 2015-04-16 Bionomics Limited Novel small-molecules as therapeutics
US9133188B2 (en) 2011-05-12 2015-09-15 Bionomics Limited Methods for preparing naphthyridines
CN120081825B (zh) * 2025-05-07 2025-09-16 天津匠新致成科技有限公司 一种化合物及其制备方法和医药用途

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US4075343A (en) * 1976-09-13 1978-02-21 Pfizer Inc. Anti-allergenic 5-alkoxyimidazo[1,2-A]quinoline-2-carboxylic acids and derivatives thereof
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DE3147276A1 (de) * 1981-11-28 1983-06-09 Boehringer Mannheim Gmbh, 6800 Mannheim Verfahren zur herstellung von indolderivaten, deren verwendung als wertvolle zwischenprodukte und neue 4-hydroxyindole
DE3246932A1 (de) * 1982-12-16 1984-06-20 Schering AG, 1000 Berlin und 4709 Bergkamen Substituierte 5h-pyrimido(5,4-b)indole
DE3335323A1 (de) * 1983-09-27 1985-04-04 Schering AG, 1000 Berlin und 4709 Bergkamen Substituierte ss-carboline, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
GB8429739D0 (en) * 1984-11-24 1985-01-03 Fbc Ltd Fungicides
DE3535927A1 (de) * 1985-10-04 1987-04-09 Schering Ag 3-vinyl- und 3-ethinyl-ss-carbolinderivate, ihre herstellung und ihre verwendung als arzneimittel
WO1992006094A1 (en) * 1990-10-09 1992-04-16 Neurogen Corporation Certain cycloalkyl and azacycloalkyl pyrrolopyrimidines; a new class of gaba brain receptor ligands
US5243049A (en) * 1992-01-22 1993-09-07 Neurogen Corporation Certain pyrroloquinolinones: a new class of GABA brain receptor ligands
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US5266698A (en) * 1992-04-30 1993-11-30 Neurogen Corporation Certain aryl and cycloalkyl fused imidazopyrazinediones; a new class of GABA brain receptor ligands
WO1994017095A1 (en) * 1993-01-29 1994-08-04 Ariad Pharmaceuticals, Inc. Analogs of receptor tyrosine activation motifs and therapeutic uses thereof
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US5804686A (en) * 1996-01-19 1998-09-08 Neurogen Corporation fused pyrrolecarboxamides; a new class of GABA brain receptor ligands

Also Published As

Publication number Publication date
US6080873A (en) 2000-06-27
HUP9901018A3 (en) 1999-11-29
IS4798A (is) 1998-07-16
EP1019372B1 (en) 2006-04-05
CZ215498A3 (cs) 1999-09-15
OA10811A (en) 2001-07-05
PL327936A1 (en) 1999-01-04
AU1746697A (en) 1997-08-11
EP1019372A1 (en) 2000-07-19
IL125391A (en) 2004-07-25
WO1997026243A1 (en) 1997-07-24
AP1015A (en) 2001-09-28
NO312670B1 (no) 2002-06-17
CA2243317A1 (en) 1997-07-24
NZ330861A (en) 2000-03-27
HUP9901018A2 (hu) 1999-07-28
RU2167151C2 (ru) 2001-05-20
KR19990077300A (ko) 1999-10-25
ES2263170T3 (es) 2006-12-01
CA2243317C (en) 2007-09-25
DE69735647T2 (de) 2007-05-03
UA49001C2 (uk) 2002-09-16
NO983315D0 (no) 1998-07-17
AP9801297A0 (en) 1998-09-30
ATE322480T1 (de) 2006-04-15
IL125391A0 (en) 1999-03-12
KR100490108B1 (ko) 2005-11-25
MX9805701A (es) 1998-11-30
DE69735647D1 (de) 2006-05-18
BG102634A (en) 1999-08-31
BR9707051A (pt) 1999-07-20
NO983315L (no) 1998-09-03
SK94398A3 (en) 1999-02-11
JP2000503321A (ja) 2000-03-21
US5804686A (en) 1998-09-08

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