KR100490108B1 - 신규한융합피롤카르복사미드:새로운종류의gaba뇌수용체리간드 - Google Patents

신규한융합피롤카르복사미드:새로운종류의gaba뇌수용체리간드 Download PDF

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Publication number
KR100490108B1
KR100490108B1 KR10-1998-0705446A KR19980705446A KR100490108B1 KR 100490108 B1 KR100490108 B1 KR 100490108B1 KR 19980705446 A KR19980705446 A KR 19980705446A KR 100490108 B1 KR100490108 B1 KR 100490108B1
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South Korea
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alkyl
hydrogen
oxo
carboxamide
indole
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KR10-1998-0705446A
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English (en)
Korean (ko)
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KR19990077300A (ko
Inventor
파멜라 알바우프
강 리우
케니쓰 쇼
앨런 허치슨
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뉴로젠 코포레이션
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyrrole Compounds (AREA)
  • Indole Compounds (AREA)
KR10-1998-0705446A 1996-01-19 1997-01-14 신규한융합피롤카르복사미드:새로운종류의gaba뇌수용체리간드 Expired - Fee Related KR100490108B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/588,711 1996-01-19
US08/588,711 US5804686A (en) 1996-01-19 1996-01-19 fused pyrrolecarboxamides; a new class of GABA brain receptor ligands
US8/588,711 1996-01-19

Publications (2)

Publication Number Publication Date
KR19990077300A KR19990077300A (ko) 1999-10-25
KR100490108B1 true KR100490108B1 (ko) 2005-11-25

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KR10-1998-0705446A Expired - Fee Related KR100490108B1 (ko) 1996-01-19 1997-01-14 신규한융합피롤카르복사미드:새로운종류의gaba뇌수용체리간드

Country Status (26)

Country Link
US (2) US5804686A (enExample)
EP (1) EP1019372B1 (enExample)
JP (1) JP2000503321A (enExample)
KR (1) KR100490108B1 (enExample)
CN (1) CN1209805A (enExample)
AP (1) AP1015A (enExample)
AT (1) ATE322480T1 (enExample)
AU (1) AU1746697A (enExample)
BG (1) BG102634A (enExample)
BR (1) BR9707051A (enExample)
CA (1) CA2243317C (enExample)
CZ (1) CZ215498A3 (enExample)
DE (1) DE69735647T2 (enExample)
ES (1) ES2263170T3 (enExample)
HU (1) HUP9901018A3 (enExample)
IL (1) IL125391A (enExample)
IS (1) IS4798A (enExample)
MX (1) MX9805701A (enExample)
NO (1) NO312670B1 (enExample)
NZ (1) NZ330861A (enExample)
OA (1) OA10811A (enExample)
PL (1) PL327936A1 (enExample)
RU (1) RU2167151C2 (enExample)
SK (1) SK94398A3 (enExample)
UA (1) UA49001C2 (enExample)
WO (1) WO1997026243A1 (enExample)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5750702A (en) * 1993-10-27 1998-05-12 Neurogen Corporation Certain pyrrolo pyridine-3-carboxamides; a new class of GABA brain receptor ligands
US5804686A (en) * 1996-01-19 1998-09-08 Neurogen Corporation fused pyrrolecarboxamides; a new class of GABA brain receptor ligands
US6211365B1 (en) 1996-01-19 2001-04-03 Neurogen Corporation Fused pyrrolecarboxamides; a new class of GABA brain receptor ligands
EP0888300A1 (en) 1996-03-22 1999-01-07 Neurogen Corporation Certain fused pyrrolecarboxamides as gaba brain receptor ligands
US5723462A (en) * 1996-04-26 1998-03-03 Neurogen Corporation Certain fused pyrrolecarboxamides a new class of GABA brain receptor ligands
GT199800179A (es) * 1997-11-13 2000-05-02 Procedimiento de sintesis de pirrol amidas.
EA002243B1 (ru) * 1997-11-13 2002-02-28 Пфайзер Продактс Инк. Способ синтеза пирроламидов
US6156898A (en) * 1998-02-26 2000-12-05 Neurogen Corporation Substituted 1,4-dihydro-4-oxonicotinic carboxamides; GABA brain receptor ligands
GB9812038D0 (en) 1998-06-04 1998-07-29 Merck Sharp & Dohme Therapeutic compound
WO2000012492A1 (en) * 1998-09-01 2000-03-09 Nissan Chemical Industries, Ltd. Benzoxazine derivatives
US20050014939A1 (en) * 1999-08-31 2005-01-20 Neurogen Corporation Fused pyrrolecarboxamides: GABA brain receptor ligands
EE200200111A (et) * 1999-08-31 2003-06-16 Neurogen Corporation Kondenseerunud pürroolkarboksamiidid: aju GABA-retseptori ligandid
US6723332B2 (en) 2000-05-26 2004-04-20 Neurogen Corporation Oxomidazopyridine-carboxamides
MXPA03001951A (es) * 2000-09-06 2003-10-15 Neurogen Corp Pirroliminas y pirazoliminas fusionadas substituidas.
BR0113697A (pt) * 2000-09-06 2003-07-22 Neurogen Corp Composto ou um sal farmaceuticamente aceitável do mesmo, composição farmacêutica, uso de um composto ou sal, embalagem e métodos para, para alterar a atividade transdutora de sinal dos receptores de gabaa, para tratar ansiedade, depressão, um distúrbio do sono, ou demência de alzheimer, para demonstrar a presença dos receptores de gabaa em células ou amostras de tecido e para preparar um composto
MXPA03004939A (es) * 2000-12-04 2003-09-10 Pfizer Prod Inc Sintesis de pirrolamidas.
US6852730B2 (en) * 2002-02-07 2005-02-08 Neurogen Corporation Substituted fused pyrazolecarboxylic acid arylamides and related compounds
CA2486339A1 (en) * 2002-05-17 2003-11-27 Neurogen Corporation Substituted ring-fused imidazole derivates: gabaa receptor ligands
EP2258357A3 (en) 2005-08-26 2011-04-06 Braincells, Inc. Neurogenesis with acetylcholinesterase inhibitor
CA2620333A1 (en) 2005-08-26 2007-03-01 Braincells, Inc. Neurogenesis by muscarinic receptor modulation
JP2009512711A (ja) 2005-10-21 2009-03-26 ブレインセルス，インコーポレイティド Ｐｄｅ阻害による神経新生の調節
US20070112017A1 (en) * 2005-10-31 2007-05-17 Braincells, Inc. Gaba receptor mediated modulation of neurogenesis
US20100216734A1 (en) 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
CA2651862A1 (en) 2006-05-09 2007-11-22 Braincells, Inc. 5 ht receptor mediated neurogenesis
EP2382975A3 (en) 2006-05-09 2012-02-29 Braincells, Inc. Neurogenesis by modulating angiotensin
JP2010502722A (ja) 2006-09-08 2010-01-28 ブレインセルス，インコーポレイティド ４−アシルアミノピリジン誘導体を含む組み合わせ
US10954231B2 (en) 2006-10-16 2021-03-23 Bionomics Limited Anxiolytic compounds
CA2666219C (en) 2006-10-16 2017-02-07 Bionomics Limited Novel anxiolytic compounds
WO2010099217A1 (en) 2009-02-25 2010-09-02 Braincells, Inc. Modulation of neurogenesis using d-cycloserine combinations
EP2789237A1 (en) 2010-08-31 2014-10-15 Meiji Seika Pharma Co., Ltd. Pest control agent
US9023848B2 (en) 2011-03-02 2015-05-05 Bionomics Limited Small-molecules as therapeutics
CN103649086A (zh) 2011-05-12 2014-03-19 生态学有限公司 制备萘啶的方法
CN120081825B (zh) * 2025-05-07 2025-09-16 天津匠新致成科技有限公司 一种化合物及其制备方法和医药用途

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995011885A1 (en) * 1993-10-27 1995-05-04 Neurogen Corporation Certain fused pyrrolecarboxanilides; a new class of gaba brain receptor ligands

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3455943A (en) * 1966-10-21 1969-07-15 American Cyanamid Co Certain 5,8-dihydro-beta-carbolines
US4075343A (en) * 1976-09-13 1978-02-21 Pfizer Inc. Anti-allergenic 5-alkoxyimidazo[1,2-A]quinoline-2-carboxylic acids and derivatives thereof
DE3029980A1 (de) * 1980-08-08 1982-03-11 Boehringer Mannheim Gmbh, 6800 Mannheim Indolderivate und verfahren zu ihrer herstellung
JPS57123180A (en) * 1980-12-17 1982-07-31 Schering Ag 3-substituted beta-carboline, manufacture and psychotropic drug containing same
DE3147276A1 (de) * 1981-11-28 1983-06-09 Boehringer Mannheim Gmbh, 6800 Mannheim Verfahren zur herstellung von indolderivaten, deren verwendung als wertvolle zwischenprodukte und neue 4-hydroxyindole
DE3246932A1 (de) * 1982-12-16 1984-06-20 Schering AG, 1000 Berlin und 4709 Bergkamen Substituierte 5h-pyrimido(5,4-b)indole
DE3335323A1 (de) * 1983-09-27 1985-04-04 Schering AG, 1000 Berlin und 4709 Bergkamen Substituierte ss-carboline, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
GB8429739D0 (en) * 1984-11-24 1985-01-03 Fbc Ltd Fungicides
DE3535927A1 (de) * 1985-10-04 1987-04-09 Schering Ag 3-vinyl- und 3-ethinyl-ss-carbolinderivate, ihre herstellung und ihre verwendung als arzneimittel
JPH06502147A (ja) * 1990-10-09 1994-03-10 ニューロゲン　コーポレイション 或る種のシクロアルキルおよびアザシクロアルキルピロロピリミジン；新規な種類のｇａｂａ脳リセプタリガンド
US5243049A (en) * 1992-01-22 1993-09-07 Neurogen Corporation Certain pyrroloquinolinones: a new class of GABA brain receptor ligands
WO1993017025A1 (en) * 1992-02-19 1993-09-02 The Upjohn Company 3-substituted imidazo(1,5-a)quinoxalines and quinazolines with cns activity
US5266698A (en) * 1992-04-30 1993-11-30 Neurogen Corporation Certain aryl and cycloalkyl fused imidazopyrazinediones; a new class of GABA brain receptor ligands
WO1994017095A1 (en) * 1993-01-29 1994-08-04 Ariad Pharmaceuticals, Inc. Analogs of receptor tyrosine activation motifs and therapeutic uses thereof
FR2705095B1 (fr) * 1993-05-12 1995-06-23 Adir Nouveaux indoles substitués, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent.
US5804686A (en) * 1996-01-19 1998-09-08 Neurogen Corporation fused pyrrolecarboxamides; a new class of GABA brain receptor ligands

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995011885A1 (en) * 1993-10-27 1995-05-04 Neurogen Corporation Certain fused pyrrolecarboxanilides; a new class of gaba brain receptor ligands

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RU2167151C2 (ru) 2001-05-20
WO1997026243A1 (en) 1997-07-24
DE69735647T2 (de) 2007-05-03
JP2000503321A (ja) 2000-03-21
NO983315L (no) 1998-09-03
AP1015A (en) 2001-09-28
UA49001C2 (uk) 2002-09-16
IS4798A (is) 1998-07-16
ATE322480T1 (de) 2006-04-15
AP9801297A0 (en) 1998-09-30
OA10811A (en) 2001-07-05
HUP9901018A3 (en) 1999-11-29
EP1019372B1 (en) 2006-04-05
DE69735647D1 (de) 2006-05-18
US5804686A (en) 1998-09-08
KR19990077300A (ko) 1999-10-25
CA2243317A1 (en) 1997-07-24
MX9805701A (es) 1998-11-30
CN1209805A (zh) 1999-03-03
SK94398A3 (en) 1999-02-11
ES2263170T3 (es) 2006-12-01
NO312670B1 (no) 2002-06-17
IL125391A (en) 2004-07-25
AU1746697A (en) 1997-08-11
EP1019372A1 (en) 2000-07-19
PL327936A1 (en) 1999-01-04
HUP9901018A2 (hu) 1999-07-28
US6080873A (en) 2000-06-27
CA2243317C (en) 2007-09-25
BG102634A (en) 1999-08-31
BR9707051A (pt) 1999-07-20
CZ215498A3 (cs) 1999-09-15
NZ330861A (en) 2000-03-27
NO983315D0 (no) 1998-07-17
IL125391A0 (en) 1999-03-12

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