BR0115874A - Sìntese de pirrole-amidas - Google Patents

Sìntese de pirrole-amidas

Info

Publication number
BR0115874A
BR0115874A BR0115874-0A BR0115874A BR0115874A BR 0115874 A BR0115874 A BR 0115874A BR 0115874 A BR0115874 A BR 0115874A BR 0115874 A BR0115874 A BR 0115874A
Authority
BR
Brazil
Prior art keywords
pyrrole
reaction
synthesis
followed
amides synthesis
Prior art date
Application number
BR0115874-0A
Other languages
English (en)
Inventor
John Anthony Ragan
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of BR0115874A publication Critical patent/BR0115874A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/84—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Furan Compounds (AREA)

Abstract

"SìNTESE DE PIRROLE-AMIDAS". Um método para preparação de pirrol-carboxamidas particulares que se ligam seletivamente a receptores GABAa; que compreende a reação de 1,3-cicloalcanodionas com bromoacetato de etila seguido por reação do produto resultante com um haleto de ácido seguido por reação com uma amina aromática e finalmente com uma fonte de amoníaco a uma temperatura elevada.
BR0115874-0A 2000-12-04 2001-11-08 Sìntese de pirrole-amidas BR0115874A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US25066600P 2000-12-04 2000-12-04
PCT/IB2001/002104 WO2002046155A1 (en) 2000-12-04 2001-11-08 Synthesis of fused pyrrolecarboxamides

Publications (1)

Publication Number Publication Date
BR0115874A true BR0115874A (pt) 2003-10-28

Family

ID=22948675

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0115874-0A BR0115874A (pt) 2000-12-04 2001-11-08 Sìntese de pirrole-amidas

Country Status (8)

Country Link
US (2) US20020151718A1 (pt)
EP (1) EP1339681A1 (pt)
JP (1) JP2004515491A (pt)
AU (1) AU2002210855A1 (pt)
BR (1) BR0115874A (pt)
CA (1) CA2430841A1 (pt)
MX (1) MXPA03004939A (pt)
WO (1) WO2002046155A1 (pt)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MXPA04007606A (es) 2002-02-07 2004-11-10 Neurogen Corp Arilamidas de acido pirazolcarboxilico fusionadas substituidas y compuestos relacionados.
CA2937074A1 (en) * 2014-01-24 2015-07-30 Abbvie Inc. Furo-3-carboxamide derivatives and methods of use

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5750702A (en) * 1993-10-27 1998-05-12 Neurogen Corporation Certain pyrrolo pyridine-3-carboxamides; a new class of GABA brain receptor ligands
US5804686A (en) * 1996-01-19 1998-09-08 Neurogen Corporation fused pyrrolecarboxamides; a new class of GABA brain receptor ligands
WO1997034870A1 (en) * 1996-03-22 1997-09-25 Neurogen Corporation Certain fused pyrrolecarboxamides as gaba brain receptor ligands
US5723462A (en) * 1996-04-26 1998-03-03 Neurogen Corporation Certain fused pyrrolecarboxamides a new class of GABA brain receptor ligands
ATE231492T1 (de) * 1997-11-13 2003-02-15 Pfizer Prod Inc Verfahren zur herstellung von pyrrolamiden
WO2000068691A1 (en) * 1999-05-07 2000-11-16 Neurogen Corporation Methods for screening gaba-modulatory compounds for specified pharmacological activities

Also Published As

Publication number Publication date
WO2002046155A1 (en) 2002-06-13
EP1339681A1 (en) 2003-09-03
US20020151718A1 (en) 2002-10-17
MXPA03004939A (es) 2003-09-10
AU2002210855A1 (en) 2002-06-18
JP2004515491A (ja) 2004-05-27
CA2430841A1 (en) 2002-06-13
US20040220253A1 (en) 2004-11-04

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Legal Events

Date Code Title Description
B08F Application fees: application dismissed [chapter 8.6 patent gazette]

Free format text: CONFORME ARTIGO 10O DA RESOLUCAO 124/06, CABE SER ARQUIVADO REFERENTE AO NAO RECOLHIMENTO DA 8A, 9AE 10A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2144 DE 07/02/2012.