NZ206980A - Resolving racemic mixtures of bicyclic imino-alpha-carboxylic esters - Google Patents

Resolving racemic mixtures of bicyclic imino-alpha-carboxylic esters

Info

Publication number
NZ206980A
NZ206980A NZ206980A NZ20698084A NZ206980A NZ 206980 A NZ206980 A NZ 206980A NZ 206980 A NZ206980 A NZ 206980A NZ 20698084 A NZ20698084 A NZ 20698084A NZ 206980 A NZ206980 A NZ 206980A
Authority
NZ
New Zealand
Prior art keywords
formula
carbon atoms
chain
radical
together form
Prior art date
Application number
NZ206980A
Other languages
English (en)
Inventor
R Geiger
V Teetz
D Langner
H Urbach
R Henning
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19833303112 external-priority patent/DE3303112A1/de
Priority claimed from DE19833303139 external-priority patent/DE3303139A1/de
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of NZ206980A publication Critical patent/NZ206980A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/54—Spiro-condensed
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
    • C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Indole Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
NZ206980A 1983-01-31 1984-01-30 Resolving racemic mixtures of bicyclic imino-alpha-carboxylic esters NZ206980A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19833303112 DE3303112A1 (de) 1983-01-31 1983-01-31 Verfahren zur racemattrennung optisch aktiver bicyclischer imino-(alpha)-carbonsaeuren
DE19833303139 DE3303139A1 (de) 1983-01-31 1983-01-31 Verfahren zur herstellung von carboxyalkyldipeptiden

Publications (1)

Publication Number Publication Date
NZ206980A true NZ206980A (en) 1988-05-30

Family

ID=25807929

Family Applications (1)

Application Number Title Priority Date Filing Date
NZ206980A NZ206980A (en) 1983-01-31 1984-01-30 Resolving racemic mixtures of bicyclic imino-alpha-carboxylic esters

Country Status (17)

Country Link
EP (1) EP0115345B1 (enrdf_load_stackoverflow)
JP (1) JPH0788358B2 (enrdf_load_stackoverflow)
KR (1) KR910001438B1 (enrdf_load_stackoverflow)
AU (1) AU566589B2 (enrdf_load_stackoverflow)
CA (2) CA1283249C (enrdf_load_stackoverflow)
DE (1) DE3468415D1 (enrdf_load_stackoverflow)
DK (1) DK174386B1 (enrdf_load_stackoverflow)
ES (2) ES8500228A1 (enrdf_load_stackoverflow)
FI (1) FI88153C (enrdf_load_stackoverflow)
GR (1) GR82650B (enrdf_load_stackoverflow)
HU (1) HU191120B (enrdf_load_stackoverflow)
IE (1) IE56654B1 (enrdf_load_stackoverflow)
IL (1) IL70830A (enrdf_load_stackoverflow)
MA (1) MA20020A1 (enrdf_load_stackoverflow)
NO (1) NO166641C (enrdf_load_stackoverflow)
NZ (1) NZ206980A (enrdf_load_stackoverflow)
PT (1) PT78036B (enrdf_load_stackoverflow)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4500713A (en) * 1982-09-23 1985-02-19 Usv Pharmaceutical Corporation Therapeutic dipeptides
DE3345355A1 (de) * 1983-12-15 1985-06-27 Hoechst Ag, 6230 Frankfurt Verfahren zur racematspaltung bicyclischer imino-(alpha)-carbonsaeureester
EP0190224A1 (en) * 1984-07-30 1986-08-13 Schering Corporation PROCESS FOR THE PREPARATION OF CIS, ENDOOCTAHYDROCYCLOPENTA [b] PYRROLE-2-CARBOXYLATE
HU192914B (en) * 1985-02-11 1987-07-28 Richter Gedeon Vegyeszet Process for producing new 3-/substituted amino/-5-phenyl-2/3h/-furanone derivatives and pharmaceutically acceptable salts
FR2620703B1 (fr) * 1987-09-17 1991-10-04 Adir Procede de synthese industrielle de l'acide perhydroindole carboxylique - 2(2s, 3as, 7as). application a la synthese de carboxyalkyl dipeptides
HU904967D0 (en) * 1988-04-22 1991-01-28 Hoechst Ag Process for producing new azabicyclo(3.3.o)octane-3-carboxylic acid-octylesther derivatives
US6407262B1 (en) 2001-11-21 2002-06-18 Brantford Chemicals Inc. Process for the preparation of Ramipril
WO2006059347A2 (en) * 2004-12-01 2006-06-08 Morepen Laboratories Limited Improved process for preparation of ramipril
US8558023B2 (en) 2010-04-20 2013-10-15 Chiral Quest, Inc. Enantioselective process for cycloalkenyl β-substituted alanines

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2503155A2 (fr) * 1980-10-02 1982-10-08 Science Union & Cie Nouveaux imino diacides substitues, leurs procedes de preparation et leur emploi comme inhibiteur d'enzyme
IE52663B1 (en) * 1980-04-02 1988-01-20 Warner Lambert Co Substituted acyl derivatives of octahydro-1h-indole-2-carboxylic acids
US4374847A (en) * 1980-10-27 1983-02-22 Ciba-Geigy Corporation 1-Carboxyalkanoylindoline-2-carboxylic acids

Also Published As

Publication number Publication date
ES529272A0 (es) 1984-10-01
MA20020A1 (fr) 1984-10-01
PT78036B (de) 1986-05-30
JPH0517439A (ja) 1993-01-26
EP0115345B1 (de) 1988-01-07
IE56654B1 (en) 1991-10-23
PT78036A (de) 1984-02-01
ES8500228A1 (es) 1984-10-01
IL70830A0 (en) 1984-04-30
CA1317067C (en) 1993-04-27
FI840350A0 (fi) 1984-01-27
DE3468415D1 (en) 1988-02-11
CA1283249C (en) 1991-04-16
JPH0788358B2 (ja) 1995-09-27
GR82650B (enrdf_load_stackoverflow) 1985-02-07
EP0115345A1 (de) 1984-08-08
NO166641C (no) 1991-08-21
NO840350L (no) 1984-08-01
FI88153B (fi) 1992-12-31
ES531284A0 (es) 1984-12-01
AU2393384A (en) 1984-08-02
IE840210L (en) 1984-07-31
HUT34159A (en) 1985-02-28
DK174386B1 (da) 2003-01-27
DK41584A (da) 1984-08-01
FI88153C (fi) 1993-04-13
ES8501759A1 (es) 1984-12-01
HU191120B (en) 1987-01-28
FI840350A7 (fi) 1984-08-01
IL70830A (en) 1988-02-29
DK41584D0 (da) 1984-01-30
NO166641B (no) 1991-05-13
AU566589B2 (en) 1987-10-22
KR910001438B1 (ko) 1991-03-07

Similar Documents

Publication Publication Date Title
US4822894A (en) Optically active bicyclic imino-alpha-carboxylic esters
US4591598A (en) Derivatives of 2-azabicyclo[3.1.0]hexane-3-carboxylic acid, and hypotensive use thereof
US4714708A (en) Derivatives of cis, endo-2-azabicyclo[5.3.0]decane-3-carboxylic acid, and their use for treating hypertension
KR920001771B1 (ko) N-알킬화 디펩티드의 제조방법
US4879403A (en) Process for the preparation of cis, endo-2-azabicyclo-[3.3.0]-octane-3-carboxylic acids
US4620012A (en) Spirocyclic aminoacid derivatives, processes for their preparation, agents containing them and their use and new spirocyclic aminoacids as intermediates and processes for their preparation
EP0105102A1 (de) Neue Derivate der 2-Aza-bicyclo(2.2.2)octan-3-carbonsäure, Verfahren zu ihrer Herstellung, diese enthaltende Mittel und deren Verwendung sowie 2-Aza-bicyclo(2.2.2)octan-3-carbonsäure als Zwischenstufe und Verfahren zu deren Herstellung
NZ206980A (en) Resolving racemic mixtures of bicyclic imino-alpha-carboxylic esters
JPH02191251A (ja) （２Ｓ，３↓ａＳ，７↓ａＳ）−２−カルボキシペルヒドロインドールの工業的合成法
JPH047741B2 (enrdf_load_stackoverflow)
US5175306A (en) Process for the resolution of racemates of optically active bicyclic imino-α-carboxylic esters
EP0326974A1 (de) Aminosäureamide mit psychotroper Wirkung, Verfahren zu ihrer Herstellung, sie enthaltende Mittel und deren Verwendung
EP0113880A2 (de) Neue 2-Azabicyclo(2.2.1)heptan-Derivate, Verfahren zu ihrer Herstellung, diese enthaltende Mittel und deren Verwendung sowie 2-Azabicyclo(2.2.1)heptan-Derivate als Zwischenprodukte und Verfahren zu deren Herstellung
US5043346A (en) Amino acid esters, pharmaceuticals containing them, and the use thereof in learning disorders
US4810779A (en) Decapeptides having hypotensive action and process for their preparation
EP0170775B2 (de) Derivate bicyclischer Aminosäuren, Verfahren zu ihrer Herstellung, diese enthaltende Mittel und deren Verwendung sowie neue bicyclische Aminosäuren als Zwischenstufen und Verfahren zu deren Herstellung
KR830002378B1 (ko) 1-(3-메르캅토-2-메틸프로파노일)프롤릴 아미노산 유도체의 제조방법
DE3303139A1 (de) Verfahren zur herstellung von carboxyalkyldipeptiden