NZ204451A - N-(2-methoxyethyl)-noroxymorphone and acid-addition salts thereof - Google Patents
N-(2-methoxyethyl)-noroxymorphone and acid-addition salts thereofInfo
- Publication number
- NZ204451A NZ204451A NZ204451A NZ20445183A NZ204451A NZ 204451 A NZ204451 A NZ 204451A NZ 204451 A NZ204451 A NZ 204451A NZ 20445183 A NZ20445183 A NZ 20445183A NZ 204451 A NZ204451 A NZ 204451A
- Authority
- NZ
- New Zealand
- Prior art keywords
- formula
- noroxymorphone
- methoxyethyl
- compound
- acid
- Prior art date
Links
- 150000003839 salts Chemical class 0.000 title claims description 14
- PBGIBLLOMGURPS-GRGSLBFTSA-N semorphone Chemical compound O([C@H]1C(CC[C@]23O)=O)C4=C5[C@@]12CCN(CCOC)[C@@H]3CC5=CC=C4O PBGIBLLOMGURPS-GRGSLBFTSA-N 0.000 title claims description 14
- 150000001875 compounds Chemical class 0.000 claims description 31
- 239000002253 acid Substances 0.000 claims description 19
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- 238000000034 method Methods 0.000 claims description 15
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- HLMSIZPQBSYUNL-IPOQPSJVSA-N Noroxymorphone Chemical compound O=C([C@@H]1O2)CC[C@@]3(O)[C@H]4CC5=CC=C(O)C2=C5[C@@]13CCN4 HLMSIZPQBSYUNL-IPOQPSJVSA-N 0.000 claims description 4
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Chemical group BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 claims description 4
- 230000036407 pain Effects 0.000 claims description 4
- -1 2-methoxyethyl halide Chemical class 0.000 claims description 3
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- 229910000027 potassium carbonate Inorganic materials 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 description 1
- 229940081974 saccharin Drugs 0.000 description 1
- 235000019204 saccharin Nutrition 0.000 description 1
- 239000000901 saccharin and its Na,K and Ca salt Substances 0.000 description 1
- 229960004889 salicylic acid Drugs 0.000 description 1
- 239000000932 sedative agent Substances 0.000 description 1
- 229940125723 sedative agent Drugs 0.000 description 1
- 230000001624 sedative effect Effects 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 239000004208 shellac Substances 0.000 description 1
- 235000013874 shellac Nutrition 0.000 description 1
- ZLGIYFNHBLSMPS-ATJNOEHPSA-N shellac Chemical compound OCCCCCC(O)C(O)CCCCCCCC(O)=O.C1C23[C@H](C(O)=O)CCC2[C@](C)(CO)[C@@H]1C(C(O)=O)=C[C@@H]3O ZLGIYFNHBLSMPS-ATJNOEHPSA-N 0.000 description 1
- 229940113147 shellac Drugs 0.000 description 1
- 239000000741 silica gel Substances 0.000 description 1
- 229910002027 silica gel Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 229910000029 sodium carbonate Inorganic materials 0.000 description 1
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 238000009492 tablet coating Methods 0.000 description 1
- 239000002700 tablet coating Substances 0.000 description 1
- FQXXSQDCDRQNQE-VMDGZTHMSA-N thebaine Chemical compound C([C@@H](N(CC1)C)C2=CC=C3OC)C4=CC=C(OC)C5=C4[C@@]21[C@H]3O5 FQXXSQDCDRQNQE-VMDGZTHMSA-N 0.000 description 1
- 229930003945 thebaine Natural products 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- 239000004408 titanium dioxide Substances 0.000 description 1
- 235000010215 titanium dioxide Nutrition 0.000 description 1
- MWOOGOJBHIARFG-UHFFFAOYSA-N vanillin Chemical compound COC1=CC(C=O)=CC=C1O MWOOGOJBHIARFG-UHFFFAOYSA-N 0.000 description 1
- FGQOOHJZONJGDT-UHFFFAOYSA-N vanillin Natural products COC1=CC(O)=CC(C=O)=C1 FGQOOHJZONJGDT-UHFFFAOYSA-N 0.000 description 1
- 235000012141 vanillin Nutrition 0.000 description 1
- 210000001177 vas deferen Anatomy 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
- C07D489/08—Oxygen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pain & Pain Management (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19823220831 DE3220831A1 (de) | 1982-06-03 | 1982-06-03 | N-(2-methoxyethyl)-noroxymorphon, dessen saeureadditionssalze, diese enthaltende arzneimittel und verfahren zu deren herstellung |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NZ204451A true NZ204451A (en) | 1986-07-11 |
Family
ID=6165151
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NZ204451A NZ204451A (en) | 1982-06-03 | 1983-06-02 | N-(2-methoxyethyl)-noroxymorphone and acid-addition salts thereof |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US4473573A (en, 2012) |
| EP (1) | EP0096279B1 (en, 2012) |
| JP (1) | JPS591487A (en, 2012) |
| KR (1) | KR900006754B1 (en, 2012) |
| AU (1) | AU558319B2 (en, 2012) |
| CA (1) | CA1196633A (en, 2012) |
| CS (1) | CS236882B2 (en, 2012) |
| CZ (1) | CZ410691A3 (en, 2012) |
| DD (1) | DD209834A5 (en, 2012) |
| DE (2) | DE3220831A1 (en, 2012) |
| DK (1) | DK156068C (en, 2012) |
| ES (1) | ES8403487A1 (en, 2012) |
| FI (1) | FI78101C (en, 2012) |
| GB (1) | GB2121041B (en, 2012) |
| GR (1) | GR78273B (en, 2012) |
| HK (1) | HK1389A (en, 2012) |
| HU (1) | HU185832B (en, 2012) |
| IE (1) | IE55232B1 (en, 2012) |
| IL (1) | IL68872A0 (en, 2012) |
| NO (1) | NO158579C (en, 2012) |
| NZ (1) | NZ204451A (en, 2012) |
| PH (1) | PH19518A (en, 2012) |
| PL (1) | PL139569B1 (en, 2012) |
| PT (1) | PT76805B (en, 2012) |
| SG (1) | SG58788G (en, 2012) |
| SU (1) | SU1195909A3 (en, 2012) |
| ZA (1) | ZA833981B (en, 2012) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4132159A1 (de) * | 1991-09-27 | 1993-04-01 | Boehringer Ingelheim Kg | 14-hydroxy-n-(2-methoxyethyl)-7,8-dihydromorphin und -norisomorphin, verfahren zu deren herstellung und deren verwendung als arzneimittel |
| RU2215741C1 (ru) * | 2002-11-05 | 2003-11-10 | Открытое Акционерное Общество "Международная Научно-Технологическая Корпорация" | Сложные эфиры n-замещенных 14-гидроксиморфинанов и способ их получения |
| RU2215742C1 (ru) * | 2002-11-05 | 2003-11-10 | Открытое Акционерное Общество "Международная Научно-Технологическая Корпорация" | Способ получения сложных эфиров n-замещенных 14-гидроксиморфинанов |
| SMT201900357T1 (it) | 2009-12-04 | 2019-07-11 | Alkermes Pharma Ireland Ltd | Derivati di morfinano per trattamento di abuso di sostanze stupefacenti |
| NZ606730A (en) | 2010-08-23 | 2015-05-29 | Alkermes Pharma Ireland Ltd | Methods for treating antipsychotic-induced weight gain |
| US9211293B2 (en) | 2011-12-15 | 2015-12-15 | Alkermes Pharma Ireland Limited | Opioid agonist antagonist combinations |
| US9656961B2 (en) | 2013-05-24 | 2017-05-23 | Alkermes Pharma Ireland Limited | Methods for treating depressive symptoms |
| WO2014190270A1 (en) | 2013-05-24 | 2014-11-27 | Alkermes Pharma Ireland Limited | Morphan and morphinan analogues, and methods of use |
| WO2022101444A1 (en) | 2020-11-12 | 2022-05-19 | Alkermes Pharma Ireland Limited | Immediate release multilayer tablet |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3332950A (en) * | 1963-03-23 | 1967-07-25 | Endo Lab | 14-hydroxydihydronormorphinone derivatives |
| DE2538075A1 (de) * | 1975-08-27 | 1977-03-17 | Boehringer Sohn Ingelheim | N-tetrahydrofurfuryl-noroxymorphone, deren saeureadditionssalze, diese enthaltende arzneimittel sowie verfahren zu ihrer herstellung |
-
1982
- 1982-06-03 DE DE19823220831 patent/DE3220831A1/de not_active Withdrawn
-
1983
- 1983-05-17 US US06/495,513 patent/US4473573A/en not_active Expired - Fee Related
- 1983-05-20 PH PH28942A patent/PH19518A/en unknown
- 1983-05-21 EP EP83105077A patent/EP0096279B1/de not_active Expired
- 1983-05-21 DE DE8383105077T patent/DE3361165D1/de not_active Expired
- 1983-05-23 SU SU833593066A patent/SU1195909A3/ru active
- 1983-05-31 FI FI831941A patent/FI78101C/fi not_active IP Right Cessation
- 1983-06-01 DD DD83251639A patent/DD209834A5/de not_active IP Right Cessation
- 1983-06-01 PT PT76805A patent/PT76805B/pt not_active IP Right Cessation
- 1983-06-01 PL PL1983242312A patent/PL139569B1/pl unknown
- 1983-06-01 KR KR1019830002440A patent/KR900006754B1/ko not_active Expired
- 1983-06-01 GR GR71534A patent/GR78273B/el unknown
- 1983-06-01 ES ES522897A patent/ES8403487A1/es not_active Expired
- 1983-06-02 IE IE1299/83A patent/IE55232B1/en not_active IP Right Cessation
- 1983-06-02 HU HU831975A patent/HU185832B/hu not_active IP Right Cessation
- 1983-06-02 IL IL68872A patent/IL68872A0/xx not_active IP Right Cessation
- 1983-06-02 NO NO831995A patent/NO158579C/no unknown
- 1983-06-02 CS CS833996A patent/CS236882B2/cs unknown
- 1983-06-02 NZ NZ204451A patent/NZ204451A/en unknown
- 1983-06-02 CA CA000429503A patent/CA1196633A/en not_active Expired
- 1983-06-02 JP JP58098749A patent/JPS591487A/ja active Granted
- 1983-06-02 AU AU15314/83A patent/AU558319B2/en not_active Ceased
- 1983-06-02 ZA ZA833981A patent/ZA833981B/xx unknown
- 1983-06-02 DK DK250783A patent/DK156068C/da not_active IP Right Cessation
- 1983-06-03 GB GB08315292A patent/GB2121041B/en not_active Expired
-
1988
- 1988-09-09 SG SG587/88A patent/SG58788G/en unknown
-
1989
- 1989-01-05 HK HK13/89A patent/HK1389A/xx unknown
-
1991
- 1991-12-27 CZ CS914106A patent/CZ410691A3/cs unknown
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