NO993635D0 - Fremgangsmåte for anvendelse av nöytrale lipider for å modifisere in vivro frigjöring fra multivesikulaere liposomer - Google Patents

Fremgangsmåte for anvendelse av nöytrale lipider for å modifisere in vivro frigjöring fra multivesikulaere liposomer

Info

Publication number
NO993635D0
NO993635D0 NO993635A NO993635A NO993635D0 NO 993635 D0 NO993635 D0 NO 993635D0 NO 993635 A NO993635 A NO 993635A NO 993635 A NO993635 A NO 993635A NO 993635 D0 NO993635 D0 NO 993635D0
Authority
NO
Norway
Prior art keywords
modify
neutral lipids
vivo release
multivesicular liposomes
multivesicular
Prior art date
Application number
NO993635A
Other languages
English (en)
Other versions
NO329401B1 (no
NO993635L (no
Inventor
Randall C Willis
Original Assignee
Skye Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Skye Pharma Inc filed Critical Skye Pharma Inc
Publication of NO993635D0 publication Critical patent/NO993635D0/no
Publication of NO993635L publication Critical patent/NO993635L/no
Publication of NO329401B1 publication Critical patent/NO329401B1/no

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • A61K9/127Liposomes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • A61K31/485Morphinan derivatives, e.g. morphine, codeine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/0008Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/0008Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition
    • A61K48/0025Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition wherein the non-active part clearly interacts with the delivered nucleic acid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/87Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/88Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microencapsulation, e.g. using amphiphile liposome vesicle
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • A61K9/127Liposomes
    • A61K9/1271Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
    • A61K9/1272Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers with substantial amounts of non-phosphatidyl, i.e. non-acylglycerophosphate, surfactants as bilayer-forming substances, e.g. cationic lipids
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00Chemistry: analytical and immunological testing
    • Y10S436/829Liposomes, e.g. encapsulation

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Plant Pathology (AREA)
  • Dispersion Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Emergency Medicine (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Pain & Pain Management (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Rheumatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
NO19993635A 1997-01-31 1999-07-27 Fremgangsmate for modifisering av frigjoringshastigheten av en biologisk aktiv forbindelse innkapslet i et multivesikulaert liposom, multivesikulaert liposom samt anvendelse derav. NO329401B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/792,566 US5891467A (en) 1997-01-31 1997-01-31 Method for utilizing neutral lipids to modify in vivo release from multivesicular liposomes
PCT/US1998/001636 WO1998033483A1 (en) 1997-01-31 1998-01-29 Method for utilizing neutral lipids to modify in vivo release from multivesicular liposomes

Publications (3)

Publication Number Publication Date
NO993635D0 true NO993635D0 (no) 1999-07-27
NO993635L NO993635L (no) 1999-09-27
NO329401B1 NO329401B1 (no) 2010-10-11

Family

ID=25157347

Family Applications (2)

Application Number Title Priority Date Filing Date
NO19993635A NO329401B1 (no) 1997-01-31 1999-07-27 Fremgangsmate for modifisering av frigjoringshastigheten av en biologisk aktiv forbindelse innkapslet i et multivesikulaert liposom, multivesikulaert liposom samt anvendelse derav.
NO20100437A NO333827B1 (no) 1997-01-31 2010-03-24 Farmasøytisk preparat og anvendelse derav for forhindring eller forbedring av post-kirurgi eller post-partum smerte.

Family Applications After (1)

Application Number Title Priority Date Filing Date
NO20100437A NO333827B1 (no) 1997-01-31 2010-03-24 Farmasøytisk preparat og anvendelse derav for forhindring eller forbedring av post-kirurgi eller post-partum smerte.

Country Status (12)

Country Link
US (2) US5891467A (no)
EP (2) EP2322143B1 (no)
JP (2) JP3940177B2 (no)
AU (1) AU731038B2 (no)
CA (3) CA2277956C (no)
DK (1) DK0971699T3 (no)
ES (1) ES2529167T3 (no)
IL (1) IL131012A0 (no)
NO (2) NO329401B1 (no)
NZ (1) NZ336843A (no)
PT (1) PT971699E (no)
WO (1) WO1998033483A1 (no)

Families Citing this family (75)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5438075A (en) 1993-03-30 1995-08-01 Skubitz; Keith M. Oral glutamine to reduce stomatitis
ES2373861T3 (es) 1997-09-18 2012-02-09 Pacira Pharmaceuticals, Inc. Composiciones anestésicas liposomiales de liberación sostenida.
EP1030652B1 (en) * 1997-11-14 2012-04-25 Pacira Pharmaceuticals, Inc. Production of multivesicular liposomes
CA2309633C (en) * 1998-10-23 2010-12-14 Idea Innovative Dermale Applikationen Gmbh Method for developing, testing and using associates of macromolecules and complex aggregates for improved payload and controllable de/association rates
EP1140021B1 (en) 1998-12-23 2004-08-04 Idea Ag Improved formulation for topical non-invasive application in vivo
WO2000069470A2 (en) * 1999-05-17 2000-11-23 Aesgen, Inc. Improved cellular uptake of bioactive agents
AU763945B2 (en) * 1999-06-04 2003-08-07 Skyepharma Inc. Oil-core compositions for the sustained release of hydrophobic drugs
CN1116875C (zh) * 2000-10-19 2003-08-06 南京振中生物工程有限公司 紫杉醇脂质组合物及其制备方法
US20030180348A1 (en) * 2002-03-22 2003-09-25 Levinson R. Saul Transcellular drug delivery system
US20040247661A1 (en) * 2002-07-03 2004-12-09 Dov Michaeli Liposomal vaccine
CA2489919A1 (en) * 2002-07-03 2004-01-15 Aphton Corporation Liposomal vaccine
US20050169979A1 (en) * 2002-07-03 2005-08-04 Dov Michaeli Liposomal vaccine
JP4664071B2 (ja) * 2002-08-01 2011-04-06 エーザイ コーポレーション オブ ノース アメリカ グルタミンによるガンの改良治療
US20040213837A1 (en) * 2002-08-05 2004-10-28 Sankaram Mantripragada Oil-core compositions for the sustained release of hydrophobic drugs
ITMI20022323A1 (it) * 2002-10-31 2004-05-01 Maria Rosa Gasco Composizioni farmaceutiche atte al trattamento di malattie oftalmiche.
ES2426915T3 (es) 2003-09-10 2013-10-25 Brentwood Equities Ltd. Diastereoisómeros de 4-ariloxi-3-hidroxipiperidinas
ITMI20041151A1 (it) * 2004-06-09 2004-09-09 Maria Rosa Gasco Nanoparticelle lipidiche come agenti veicolanti per acidi nucleici procedimento per la loro preparazione e loro uso
WO2006113679A2 (en) * 2005-04-15 2006-10-26 Board Of Regents, The University Of Texas System Delivery of sirna by neutral lipid compositions
KR101364374B1 (ko) * 2005-03-14 2014-02-17 더 보드 오브 리전츠 오브 더 유니버시티 오브 텍사스 시스템 생활성 fus1 펩티드 및 나노입자-폴리펩티드 복합체
US20070110674A1 (en) * 2005-07-29 2007-05-17 Yuhong Xu Sono-active liposomes and lipid particles and use thereof as contrast agents and active-agent delivery systems
US20070154546A1 (en) * 2005-12-30 2007-07-05 Zhang Jack Y Sustained release pharmaceutical compositions
CA2661302A1 (en) * 2006-08-16 2008-02-21 Auspex Pharmaceuticals, Inc. Preparation and utility of opioid analgesics
US8067390B2 (en) * 2007-03-02 2011-11-29 The Board Of Regents Of The University Of Texas System Therapeutic targeting of interleukins using siRNA in neutral liposomes
CN102112110A (zh) * 2008-06-06 2011-06-29 米尔纳医疗股份有限公司 用于RNAi试剂体内递送的新型组合物
KR101605932B1 (ko) 2009-12-18 2016-03-24 노파르티스 아게 Hsf1-관련 질환을 치료하기 위한 유기 조성물
IN2012DN06588A (no) 2010-02-10 2015-10-23 Novartis Ag
US20110250264A1 (en) 2010-04-09 2011-10-13 Pacira Pharmaceuticals, Inc. Method for formulating large diameter synthetic membrane vesicles
EA034363B1 (ru) 2010-04-23 2020-01-30 Эрроухед Фармасьютикалс, Инк. Фармацевтическая композиция для ингибирования экспрессии гена beta-enac и ее применение
US9770414B2 (en) * 2010-05-13 2017-09-26 Pacira Pharmaceuticals, Inc. Sustained release formulation of methotrexate as a disease-modifying antirheumatic drug (DMARD) and an anti-cancer agent
JP6194248B2 (ja) 2010-10-28 2017-09-06 パシラ ファーマシューティカルズ インコーポレーテッド 非ステロイド性抗炎症薬の徐放性処方物
CN103153285B (zh) 2010-12-27 2016-10-12 泰尔茂株式会社 脂质体组合物及其制造方法
EP2907504B1 (en) 2011-02-08 2017-06-28 Halozyme, Inc. Composition and lipid formulation of a hyaluronan-degrading enzyme and the use thereof for treatment of benign prostatic hyperplasia
WO2012119095A1 (en) 2011-03-02 2012-09-07 Board Of Regents, The University Of Texas System Fus1/tusc2 therapies
EP3521432A1 (en) 2011-09-02 2019-08-07 Arrowhead Pharmaceuticals, Inc. Organic compositions to treat hsf1-related diseases
GB201119032D0 (en) 2011-11-03 2011-12-14 Isis Innovation Multisomes: encapsulated droplet networks
CA2860676A1 (en) 2012-01-09 2013-07-18 Novartis Ag Organic compositions to treat beta-catenin-related diseases
CN109481455A (zh) 2012-05-02 2019-03-19 箭头研究公司 治疗kras相关疾病的有机组合物
RU2678433C2 (ru) 2012-05-10 2019-01-29 Пейнреформ Лтд. Депо-составы гидрофобного активного ингредиента и способы их получения
CN110464709A (zh) 2012-08-10 2019-11-19 德克萨斯州大学系统董事会 用于治疗中风的神经保护性脂质体组合物和方法
GB201219201D0 (en) 2012-10-25 2012-12-12 Isis Innovation Hydrogel network
GB201219196D0 (en) 2012-10-25 2012-12-12 Isis Innovation Droplet assembly method
JP6416772B2 (ja) 2012-12-07 2018-10-31 オックスフォード ユニヴァーシティ イノヴェーション リミテッド 3dプリンティングによる小滴集合
SG10201706960TA (en) 2013-02-28 2017-10-30 Arrowhead Res Corp Organic compositions to treat epas1-related diseases
BR112015021586B1 (pt) 2013-03-14 2023-01-31 Fresenius Kabi Deutschland Gmbh Formulação de morfina farmacêutica injetável e kit
PT2968729T (pt) 2013-03-14 2018-11-06 Fresenius Kabi Deutschland Gmbh Sistema de acondicionamento para fármacos sensíveis ao oxigénio
US9693958B2 (en) 2013-03-15 2017-07-04 Cureport, Inc. Methods and devices for preparation of lipid nanoparticles
WO2015051135A2 (en) 2013-10-04 2015-04-09 Novartis Ag Organic compositions to treat hepcidin-related diseases
EP3169784B1 (en) 2014-07-16 2020-06-10 Arrowhead Pharmaceuticals, Inc. Rnai compositions to treat apoc3-related diseases
ES2727137T3 (es) 2014-08-28 2019-10-14 Halozyme Inc Terapia combinada con una enzima de degradación de hialuronano y un inhibidor de puntos de control inmunitario
WO2016038550A1 (en) 2014-09-11 2016-03-17 Novartis Ag Inhibition of prmt5 to treat mtap-deficiency-related diseases
WO2016089883A1 (en) 2014-12-01 2016-06-09 Novartis Ag Compositions and methods for diagnosis and treatment of prostate cancer
JP6316182B2 (ja) 2014-12-19 2018-04-25 富士フイルム株式会社 リポソームの製造方法及びリポソーム製造装置
EP3302525A2 (en) 2015-06-05 2018-04-11 Novartis AG Methods and compositions for diagnosing, treating, and monitoring treatment of shank3 deficiency associated disorders
CN106546706B (zh) * 2015-09-21 2020-03-17 上海复旦张江生物医药股份有限公司 pH梯度主动载药法制备的脂质体药物的体外释放测试方法
CN106546705B (zh) * 2015-09-21 2020-03-17 上海复旦张江生物医药股份有限公司 一种脂质体药物体外释放的测试方法
US10736880B2 (en) 2015-12-18 2020-08-11 The Board Of Regents Of The University Of Texas Systems Therapeutics for preterm labor management
JP2019521979A (ja) * 2016-06-13 2019-08-08 アセンディア ファーマシューティカルズ,エルエルシー カルベジロール分散系の非経口徐放送達
WO2018047148A1 (en) 2016-09-12 2018-03-15 Novartis Ag Compounds for the inhibition of mirna
CN110072540B (zh) 2016-10-12 2023-06-02 得克萨斯州大学系统董事会 用于tusc2免疫治疗的方法和组合物
WO2018083606A1 (en) 2016-11-01 2018-05-11 Novartis Ag Methods and compositions for enhancing gene editing
CN109983013A (zh) 2016-11-18 2019-07-05 帕西拉制药有限公司 美洛昔康锌复合物微粒多囊脂质体制剂及其制备方法
KR102069670B1 (ko) * 2017-03-02 2020-01-23 단디바이오사이언스 주식회사 면역활성물질을 포함하는 다중도메인캡슐, 이의 제조방법, 및 이를 포함하는 면역조절 조성물
US11530413B2 (en) 2017-07-21 2022-12-20 Novartis Ag Compositions and methods to treat cancer
TN2020000039A1 (en) 2017-09-11 2021-10-04 Arrowhead Pharmaceuticals Inc Rnai agents and compositions for inhibiting expression of apolipoprotein c-iii (apoc3)
WO2019150309A1 (en) 2018-02-02 2019-08-08 Hammack Scott Modulators of gpr68 and uses thereof for treating and preventing diseases
EP3788138A1 (en) 2018-05-02 2021-03-10 Novartis AG Regulators of human pluripotent stem cells and uses thereof
US20210395721A1 (en) 2018-10-24 2021-12-23 Codiak Biosciences, Inc. Methods to improve potency of electroporation
JP2022519718A (ja) 2019-02-08 2022-03-24 ボード オブ リージェンツ,ザ ユニバーシティ オブ テキサス システム 加齢および加齢性臓器不全に関連する疾患の処置のためのテロメラーゼ含有エキソソーム
CA3175301A1 (en) 2020-04-20 2021-10-28 Hugh D.C. Smyth Biologically active dry powder compositions and method of their manufacture and use
WO2022040435A1 (en) 2020-08-19 2022-02-24 The Board Of Regents Of The University Of Texas System Nanodrugs for targeted drug delivery and use thereof
US11278494B1 (en) 2021-01-22 2022-03-22 Pacira Pharmaceuticals, Inc. Manufacturing of bupivacaine multivesicular liposomes
US11357727B1 (en) 2021-01-22 2022-06-14 Pacira Pharmaceuticals, Inc. Manufacturing of bupivacaine multivesicular liposomes
US11033495B1 (en) 2021-01-22 2021-06-15 Pacira Pharmaceuticals, Inc. Manufacturing of bupivacaine multivesicular liposomes
WO2023225160A1 (en) 2022-05-18 2023-11-23 The Children's Hospital Of Philadelphia Compositions and methods for inducible alternative splicing regulation of gene expression
CN117731835B (zh) * 2023-12-19 2024-08-02 上海花瓣生物科技有限公司 一种含透明质酸钠、琼脂糖微球注射用凝胶的制备方法

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4078052A (en) 1976-06-30 1978-03-07 The United States Of America As Represented By The Secretary Of Health, Education And Welfare Large unilamellar vesicles (LUV) and method of preparing same
CH624011A5 (no) 1977-08-05 1981-07-15 Battelle Memorial Institute
US4235871A (en) 1978-02-24 1980-11-25 Papahadjopoulos Demetrios P Method of encapsulating biologically active materials in lipid vesicles
IT1111367B (it) 1978-11-17 1986-01-13 Serono Ist Farm Processo per la preparazione estemporanea di liposomi e liposomi cosi' ottenuti
US4310506A (en) 1979-02-22 1982-01-12 California Institute Of Technology Means of preparation and applications of liposomes containing high concentrations of entrapped ionic species
US4394372A (en) 1980-12-22 1983-07-19 The Procter & Gamble Company Process for making lipid membrane structures
FR2521565B1 (fr) 1982-02-17 1985-07-05 Dior Sa Parfums Christian Melange pulverulent de constituants lipidiques et de constituants hydrophobes, procede pour le preparer, phases lamellaires lipidiques hydratees et procede de fabrication, compositions pharmaceutiques ou cosmetiques comportant des phases lamellaires lipidiques hydratees
US4522803A (en) 1983-02-04 1985-06-11 The Liposome Company, Inc. Stable plurilamellar vesicles, their preparation and use
US4485054A (en) 1982-10-04 1984-11-27 Lipoderm Pharmaceuticals Limited Method of encapsulating biologically active materials in multilamellar lipid vesicles (MLV)
US5422120A (en) * 1988-05-30 1995-06-06 Depotech Corporation Heterovesicular liposomes
RU2160093C2 (ru) * 1993-11-16 2000-12-10 Скайефарма Инк. Везикулы с регулируемым высвобождением активных ингредиентов
US5993850A (en) * 1994-09-13 1999-11-30 Skyepharma Inc. Preparation of multivesicular liposomes for controlled release of encapsulated biologically active substances
CA2181390C (en) * 1995-07-18 2001-04-24 Pankaj Modi Phospholipid formulations

Also Published As

Publication number Publication date
CA2277956C (en) 2007-01-23
JP3973646B2 (ja) 2007-09-12
CA2277956A1 (en) 1998-08-06
CA2851502C (en) 2016-03-15
IL131012A0 (en) 2001-01-28
EP0971699A4 (en) 2006-05-24
CA2692302A1 (en) 1998-08-06
US5891467A (en) 1999-04-06
CA2692302C (en) 2014-05-13
EP2322143B1 (en) 2017-01-11
CA2851502A1 (en) 1998-08-06
EP0971699A1 (en) 2000-01-19
JP2004262946A (ja) 2004-09-24
PT971699E (pt) 2015-02-04
NO20100437L (no) 1999-09-27
NZ336843A (en) 2001-07-27
AU731038B2 (en) 2001-03-22
DK0971699T3 (en) 2015-02-16
JP3940177B2 (ja) 2007-07-04
EP0971699B1 (en) 2014-11-26
NO329401B1 (no) 2010-10-11
WO1998033483A1 (en) 1998-08-06
US5962016A (en) 1999-10-05
JP2001505224A (ja) 2001-04-17
ES2529167T3 (es) 2015-02-17
NO993635L (no) 1999-09-27
EP2322143A1 (en) 2011-05-18
AU6317898A (en) 1998-08-25
NO333827B1 (no) 2013-09-23

Similar Documents

Publication Publication Date Title
NO993635D0 (no) Fremgangsmåte for anvendelse av nöytrale lipider for å modifisere in vivro frigjöring fra multivesikulaere liposomer
EG21397A (en) Improved in the production of spun-bonded web
NO971149L (no) Fremstilling av multivesikulære liposomer for kontrollert frigivning av aktive midler
HK1038744A1 (zh) 用於治療炎性疾病的化合物
PL331151A1 (en) Analoques of illudin useful as anticarcinogenic agents
NO990974D0 (no) FremgangsmÕte for fremstilling av magnesium
PT1177442E (pt) Determinação de estruturas complexas fosfolípido/lípido com auxílio de acilglicerídeos sintéticos marcados de forma fluorescente
ID24940A (id) Pemakaian ketolida-ketolida untuk pencegahan komplikasi trombotik arteri mengenai aterosklerosis
HK1013215A1 (en) Methods of making sustained release biocidal compositions
NO996432D0 (no) Fremgangsmåte for fremstilling av 4-substituert-1H-indol-3- glykosamider
HUP0004799A3 (en) Use of electrolyte mixtures as sequestering agents
BR9510309A (pt) Composições alvejantes perfumadas
DE10084616T1 (de) Schweißhemmende Aluminiumverbindungen und Verfahren zu ihrer Herstellung
NO20003077L (no) FremgangsmÕte for fremstilling av klorbenzooksazolen
FR2767484B3 (fr) Accessoire pour l'alpinisme rendant auto-bloquant tout descendeur en huit classique
PL316288A1 (en) Peptides suitable to inhibit liberation of pepsin
FI970269A (fi) 1,3-diolipohjaisten esterien seokset, menetelmä 1,3-diolipohjaisten esterien valmistamiseksi sekä esterien käyttö
GB2287880A8 (en) Production of sustained release compositions
TW311392U (en) Improved combination structure of foot stand
TW315724U (en) Structure of treading-exercise machine to simulate the road condition
NO20002476D0 (no) FremgangsmÕte for fremstilling av formylimidazoler
TW345300U (en) Improved structure for stand of Kang-Chia drum
KR970057012U (ko) 오락기용 전면프레임의 결합구조
KR960006851U (ko) 방취겸용 텍숀
TW294896U (en) Improved structure of clothes stand

Legal Events

Date Code Title Description
MK1K Patent expired