GB2287880A8 - Production of sustained release compositions - Google Patents

Production of sustained release compositions

Info

Publication number
GB2287880A8
GB2287880A8 GB9404928A GB9404928A GB2287880A8 GB 2287880 A8 GB2287880 A8 GB 2287880A8 GB 9404928 A GB9404928 A GB 9404928A GB 9404928 A GB9404928 A GB 9404928A GB 2287880 A8 GB2287880 A8 GB 2287880A8
Authority
GB
United Kingdom
Prior art keywords
production
sustained release
release compositions
compositions
sustained
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
GB9404928A
Other versions
GB9404928D0 (en
GB2287880A (en
Inventor
Ronald Brown Miller
Stewart Thomas Leslie
Kevin John Smith
Sandra Therese Antoi Malkowska
Derek Allan Prater
Trevor John Knott
Joanne Heafield
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Euro Celtique SA
Original Assignee
Euro Celtique SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Euro Celtique SA filed Critical Euro Celtique SA
Priority to GB9404928A priority Critical patent/GB2287880A/en
Priority to NZ260408A priority patent/NZ260408A/en
Priority to IL109460A priority patent/IL109460A/en
Priority to IL11966094A priority patent/IL119660A/en
Publication of GB9404928D0 publication Critical patent/GB9404928D0/en
Priority to SG1996008705A priority patent/SG67347A1/en
Priority to DE69435295T priority patent/DE69435295D1/en
Priority to EP09004973.5A priority patent/EP2103303B1/en
Priority to DK04030658.1T priority patent/DK1527775T3/en
Priority to DE69427472T priority patent/DE69427472T3/en
Priority to DE0699436T priority patent/DE699436T1/en
Priority to ES94303128T priority patent/ES2088312T3/en
Priority to DE0729751T priority patent/DE729751T1/en
Priority to ES04030658T priority patent/ES2346651T3/en
Priority to EP04030658A priority patent/EP1527775B1/en
Priority to ES95114527T priority patent/ES2159591T5/en
Priority to PT04014719T priority patent/PT1468679E/en
Priority to AT04014719T priority patent/ATE303140T1/en
Priority to AT94303128T priority patent/ATE138566T1/en
Priority to AT04030658T priority patent/ATE468850T1/en
Priority to EP94303128A priority patent/EP0624366B1/en
Priority to EP95114527A priority patent/EP0699436B2/en
Priority to DE9422335U priority patent/DE9422335U1/en
Priority to DE09004973T priority patent/DE09004973T8/en
Priority to DK94303128.6T priority patent/DK0624366T3/en
Priority to EP04014719A priority patent/EP1468679B1/en
Priority to AT95114527T priority patent/ATE201989T1/en
Priority to DK04014719T priority patent/DK1468679T3/en
Priority to ES09004973T priority patent/ES2331046T1/en
Priority to DE69434479T priority patent/DE69434479T2/en
Priority to PT04030658T priority patent/PT1527775E/en
Priority to ES04014719T priority patent/ES2247574T3/en
Priority to PT95114527T priority patent/PT699436E/en
Priority to DK95114527.5T priority patent/DK0699436T4/en
Priority to EP96101147A priority patent/EP0729751A1/en
Priority to DE69400215T priority patent/DE69400215T2/en
Priority to CZ19941093A priority patent/CZ288517B6/en
Priority to HU9401478A priority patent/HU228177B1/en
Priority to FI942092A priority patent/FI942092A/en
Priority to CA002123160A priority patent/CA2123160C/en
Priority to NO941719A priority patent/NO306446B1/en
Priority to AU61963/94A priority patent/AU6196394A/en
Priority to JP6096671A priority patent/JP3045924B2/en
Priority to US08/241,129 priority patent/US5591452A/en
Priority to SK1437-98A priority patent/SK283143B6/en
Priority to CN94105356A priority patent/CN1094755C/en
Priority to IDP991104D priority patent/ID25988A/en
Priority to SK541-94A priority patent/SK279971B6/en
Priority to TW085103273A priority patent/TW496736B/en
Priority to IL10994494A priority patent/IL109944A/en
Priority to SG1996009186A priority patent/SG50706A1/en
Priority to DK94304144T priority patent/DK0636370T4/en
Priority to DE69414046T priority patent/DE69414046T3/en
Priority to ES94304144T priority patent/ES2124372T5/en
Priority to EP94304144A priority patent/EP0636370B2/en
Priority to AT94304144T priority patent/ATE172376T1/en
Priority to SK763-94A priority patent/SK280534B6/en
Priority to CZ19941550A priority patent/CZ287918B6/en
Priority to NZ260883A priority patent/NZ260883A/en
Priority to PL94304062A priority patent/PL179282B1/en
Priority to CA002127166A priority patent/CA2127166C/en
Priority to FI943141A priority patent/FI114285B/en
Priority to AU66105/94A priority patent/AU6610594A/en
Priority to NO942470A priority patent/NO306449B1/en
Priority to KR1019940015740A priority patent/KR100365572B1/en
Priority to HU9402007A priority patent/HU220075B/en
Priority to CN 94106701 priority patent/CN1230154C/en
Priority to JP15121994A priority patent/JP3647897B2/en
Priority to BG99077A priority patent/BG62316B1/en
Priority to BG99078A priority patent/BG62473B1/en
Priority to DK94308493T priority patent/DK0654263T3/en
Priority to PT94308493T priority patent/PT654263E/en
Priority to ES94308493T priority patent/ES2168290T3/en
Priority to DE69429710T priority patent/DE69429710T2/en
Priority to EP94308493A priority patent/EP0654263B1/en
Priority to AT94308493T priority patent/ATE212224T1/en
Priority to NZ264953A priority patent/NZ264953A/en
Priority to BG99198A priority patent/BG62429B1/en
Priority to CZ19942866A priority patent/CZ289650B6/en
Priority to IL11170994A priority patent/IL111709A/en
Priority to PL94305939A priority patent/PL178883B1/en
Priority to SK1406-94A priority patent/SK280496B6/en
Priority to NO19944473A priority patent/NO314124B1/en
Priority to HU9403353A priority patent/HU217205B/en
Priority to FI945476A priority patent/FI113335B/en
Priority to KR1019940031398A priority patent/KR100354702B1/en
Priority to CN94118503A priority patent/CN1121213C/en
Priority to AU79015/94A priority patent/AU682223C/en
Priority to JP28993694A priority patent/JP3411114B2/en
Priority to EP95301337A priority patent/EP0672416A1/en
Priority to ZA952103A priority patent/ZA952013B/en
Priority to FI951155A priority patent/FI951155A/en
Priority to CA002144500A priority patent/CA2144500A1/en
Priority to NO950950A priority patent/NO950950L/en
Priority to JP7052498A priority patent/JPH0840905A/en
Priority to AU14755/95A priority patent/AU694475B2/en
Priority to US08/449,772 priority patent/US6326027B1/en
Publication of GB2287880A publication Critical patent/GB2287880A/en
Publication of GB2287880A8 publication Critical patent/GB2287880A8/en
Priority to US08/607,851 priority patent/US5891471A/en
Priority to US08/607,852 priority patent/US5849240A/en
Priority to GR960401422T priority patent/GR3020084T3/en
Priority to US08/677,798 priority patent/US6254887B1/en
Priority to IL11966096A priority patent/IL119660A0/en
Priority to US08/774,229 priority patent/US5843480A/en
Priority to US08/843,571 priority patent/US5879705A/en
Priority to US08/944,106 priority patent/US5965163A/en
Priority to AU39957/97A priority patent/AU3995797A/en
Priority to AU52995/98A priority patent/AU722358B2/en
Priority to JP22971898A priority patent/JP3267561B2/en
Priority to US09/264,399 priority patent/US6143328A/en
Priority to CNB991066421A priority patent/CN1146410C/en
Priority to NO19993484A priority patent/NO313124B1/en
Priority to US09/370,270 priority patent/US6162467A/en
Priority to AT0081699U priority patent/AT3413U3/en
Priority to US09/740,732 priority patent/US20010019725A1/en
Priority to US09/800,204 priority patent/US7074430B2/en
Priority to NO20013566A priority patent/NO331650B1/en
Priority to GR20010401419T priority patent/GR3036565T3/en
Priority to JP2001297270A priority patent/JP3443574B2/en
Priority to JP2002271157A priority patent/JP2003113075A/en
Priority to FI20030560A priority patent/FI121565B/en
Priority to US11/435,015 priority patent/US20060269603A1/en
Priority to US12/152,474 priority patent/US20090117191A1/en
Priority to FI20105856A priority patent/FI122717B/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
    • A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
GB9404928A 1991-12-24 1994-03-14 Production of sustained release compositions Withdrawn GB2287880A (en)

Priority Applications (122)

Application Number Priority Date Filing Date Title
GB9404928A GB2287880A (en) 1994-03-14 1994-03-14 Production of sustained release compositions
NZ260408A NZ260408A (en) 1993-05-10 1994-04-27 Controlled release preparation comprising tramadol
IL109460A IL109460A (en) 1993-05-10 1994-04-27 Controlled release formulation comprising tramadol
IL11966094A IL119660A (en) 1993-05-10 1994-04-27 Controlled release formulation comprising tramadol
SG1996008705A SG67347A1 (en) 1993-05-10 1994-04-29 Controlled release formulation
DE69435295T DE69435295D1 (en) 1993-05-10 1994-04-29 Tramadol-containing drug with controlled release of active ingredient
EP09004973.5A EP2103303B1 (en) 1993-05-10 1994-04-29 Controlled release formulation containing tramadol
DK04030658.1T DK1527775T3 (en) 1993-05-10 1994-04-29 Controlled release tramadol-containing composition
DE69427472T DE69427472T3 (en) 1993-05-10 1994-04-29 Drugs with controlled release of active ingredient
DE0699436T DE699436T1 (en) 1993-05-10 1994-04-29 Controlled drug delivery drugs
ES94303128T ES2088312T3 (en) 1993-05-10 1994-04-29 CONTROLLED RELEASE FORMULATION CONTAINING TRAMADOL.
DE0729751T DE729751T1 (en) 1993-05-10 1994-04-29 Tramadol-containing drug with delayed drug delivery
ES04030658T ES2346651T3 (en) 1993-05-10 1994-04-29 FORMULATION OF CONTROLLED LIBERATION THAT TRAMADOL FORMULATION OF CONTROLLED LIBERATION CONTAINING TRAMADOL.
EP04030658A EP1527775B1 (en) 1993-05-10 1994-04-29 Controlled release formulation containing tramadol
ES95114527T ES2159591T5 (en) 1993-05-10 1994-04-29 Controlled Release Formulation
PT04014719T PT1468679E (en) 1993-05-10 1994-04-29 CONTROLLED FREQUENCY FORMULA CONTAINING TRAMADOL
AT04014719T ATE303140T1 (en) 1993-05-10 1994-04-29 MEDICINAL PRODUCT CONTAINING TRAMADOL WITH CONTROLLED RELEASE OF ACTIVE INGREDIENTS
AT94303128T ATE138566T1 (en) 1993-05-10 1994-04-29 DELAYED RELEASE MEDICINAL PRODUCT CONTAINING TRAMADOL
AT04030658T ATE468850T1 (en) 1993-05-10 1994-04-29 MEDICINAL PRODUCT CONTAINING TRAMADOL WITH CONTROLLED RELEASE OF ACTIVE INGREDIENTS
EP94303128A EP0624366B1 (en) 1993-05-10 1994-04-29 Controlled release formulation containing tramadol
EP95114527A EP0699436B2 (en) 1993-05-10 1994-04-29 Controlled release formulation
DE9422335U DE9422335U1 (en) 1993-05-10 1994-04-29 Controlled release formulation
DE09004973T DE09004973T8 (en) 1993-05-10 1994-04-29 Controlled release formulation
DK94303128.6T DK0624366T3 (en) 1993-05-10 1994-04-29 Composition containing controlled release tramadol
EP04014719A EP1468679B1 (en) 1993-05-10 1994-04-29 Controlled release formulation containing tramadol
AT95114527T ATE201989T1 (en) 1993-05-10 1994-04-29 MEDICINAL PRODUCTS WITH CONTROLLED DELIVERY OF ACTIVE INGREDIENTS
DK04014719T DK1468679T3 (en) 1993-05-10 1994-04-29 Controlled release tramadol-containing formulation
ES09004973T ES2331046T1 (en) 1993-05-10 1994-04-29 CONTROLLED RELEASE FORMULATION.
DE69434479T DE69434479T2 (en) 1993-05-10 1994-04-29 Tramadol-containing drug with controlled release of active ingredient
PT04030658T PT1527775E (en) 1993-05-10 1994-04-29 Controlled release formulation containing tramadol
ES04014719T ES2247574T3 (en) 1993-05-10 1994-04-29 FORMULATION OF CONTROLLED RELEASE THAT INCLUDES TRAMADOL.
PT95114527T PT699436E (en) 1993-05-10 1994-04-29 CONTROLLED LIBERATION FORMULA
DK95114527.5T DK0699436T4 (en) 1993-05-10 1994-04-29 Controlled release preparation
EP96101147A EP0729751A1 (en) 1993-05-10 1994-04-29 Controlled release formulation containing tramadol
DE69400215T DE69400215T2 (en) 1993-05-10 1994-04-29 Tramadol-containing medicine with delayed release of active ingredient
CZ19941093A CZ288517B6 (en) 1993-05-10 1994-05-04 Pharmaceutical preparation in unit dosage form and process of its preparation
HU9401478A HU228177B1 (en) 1993-05-10 1994-05-06 Controlled release formulation containing tramadol
FI942092A FI942092A (en) 1993-05-10 1994-05-06 Restrained released composition
CA002123160A CA2123160C (en) 1993-05-10 1994-05-09 Controlled release formulation
NO941719A NO306446B1 (en) 1993-05-10 1994-05-09 Oral pharmaceutical preparation comprising tramadol with controlled release effect
AU61963/94A AU6196394A (en) 1993-05-10 1994-05-09 Controlled release formulation
JP6096671A JP3045924B2 (en) 1993-05-10 1994-05-10 Controlled release oral drug formulations
US08/241,129 US5591452A (en) 1993-05-10 1994-05-10 Controlled release formulation
SK1437-98A SK283143B6 (en) 1993-05-10 1994-05-10 Pharmaceutical preparation for controlled release
CN94105356A CN1094755C (en) 1993-05-10 1994-05-10 Controlled release formulation
IDP991104D ID25988A (en) 1993-05-10 1994-05-10 DRUG FORMULATION WHICH SOLVED CAN BE ARRANGED (Fraction of P-940726)
SK541-94A SK279971B6 (en) 1993-05-10 1994-05-10 Controlled release pharmaceutical composition and process for its preparation
TW085103273A TW496736B (en) 1993-05-10 1994-05-12 Controlled release formulation
IL10994494A IL109944A (en) 1993-07-01 1994-06-08 Sustained release dosage unit forms containing morphine and a method of preparing these sustained release dosage unit forms
SG1996009186A SG50706A1 (en) 1993-07-01 1994-06-09 Sustained release compositions and a method of preparing pharmaceutical compositions
DK94304144T DK0636370T4 (en) 1993-07-01 1994-06-09 Deposits containing morphine
DE69414046T DE69414046T3 (en) 1993-07-01 1994-06-09 Morphine-containing medicinal compositions with delayed drug delivery
ES94304144T ES2124372T5 (en) 1993-07-01 1994-06-09 SUSTAINED RELEASE COMPOSITIONS CONTAINING MORPHINE.
EP94304144A EP0636370B2 (en) 1993-07-01 1994-06-09 Sustained release compositions containing morphine
AT94304144T ATE172376T1 (en) 1993-07-01 1994-06-09 MORPHINE-CONTAINING MEDICINAL COMPOSITIONS WITH DELAYED RELEASE
SK763-94A SK280534B6 (en) 1993-07-01 1994-06-23 Sustained release preparations of morphine and a method of preparing the same
CZ19941550A CZ287918B6 (en) 1993-07-01 1994-06-23 Orally administered unit dosage form with controlled release and process for preparing thereof
NZ260883A NZ260883A (en) 1993-07-01 1994-06-29 Oral sustained-release medicaments containing morphine
PL94304062A PL179282B1 (en) 1993-07-01 1994-06-30 Retarded release compositions and method of obtaining such compositions
CA002127166A CA2127166C (en) 1993-07-01 1994-06-30 Sustained release morphine compositions and a method of preparation
FI943141A FI114285B (en) 1993-07-01 1994-06-30 Process for preparing sustained release pharmaceutical dosage unit form
AU66105/94A AU6610594A (en) 1991-12-24 1994-06-30 Sustained release compositions and a method of preparing pharmaceutical compositions
NO942470A NO306449B1 (en) 1993-07-01 1994-06-30 Orally administered morphine preparation for sustained release as well as preparation of multiparticulates for use in the preparation
KR1019940015740A KR100365572B1 (en) 1993-07-01 1994-07-01 Sustained-release and pharmaceutical compositions
HU9402007A HU220075B (en) 1993-07-01 1994-07-01 Retarde pharmaceutical compositions containing morphine and process for producing them
CN 94106701 CN1230154C (en) 1993-07-01 1994-07-01 Sustained release compositions and a method of preparing pharmaceutical compositions
JP15121994A JP3647897B2 (en) 1993-07-01 1994-07-01 Sustained release unit dosage form
BG99077A BG62316B1 (en) 1993-10-07 1994-09-29 Pharmaceutical forms with continuous release and method for their preparation
BG99078A BG62473B1 (en) 1993-11-23 1994-09-29 Pharmaceutical preparation with monitored release
DK94308493T DK0654263T3 (en) 1993-11-23 1994-11-17 Process for the preparation of a sustained release preparation
PT94308493T PT654263E (en) 1993-11-23 1994-11-17 METHOD FOR THE PREPARATION OF A PROLONGED LIBERTYACAO COMPOSITION
ES94308493T ES2168290T3 (en) 1993-11-23 1994-11-17 METHOD FOR PREPARING A SUSTAINED RELEASE COMPOSITION.
DE69429710T DE69429710T2 (en) 1993-11-23 1994-11-17 Process for the preparation of a drug composition with delayed drug delivery
EP94308493A EP0654263B1 (en) 1993-11-23 1994-11-17 Method for preparing a sustained release composition
AT94308493T ATE212224T1 (en) 1993-11-23 1994-11-17 METHOD FOR PRODUCING A MEDICINAL COMPOSITION WITH DELAYED RELEASE
NZ264953A NZ264953A (en) 1993-11-23 1994-11-18 Manufacture of drug-containing particles from a mixture of particulate drug and a particulate hydrophobic and/or hydrophilic fusible carrier or diluent in a high speed mixer such that the carrier/diluent melts and breaking up the agglomerates thus formed; sustained release forms
BG99198A BG62429B1 (en) 1993-11-23 1994-11-21 Method for the preparation of pharmaceutical compositions
CZ19942866A CZ289650B6 (en) 1993-11-23 1994-11-21 Process for preparing a medicament controllably releasing active substance thereof
IL11170994A IL111709A (en) 1993-11-23 1994-11-21 Process for the manufacture of sustained release particles and dosage forms comprising particles obtained by the process
PL94305939A PL178883B1 (en) 1993-11-23 1994-11-22 Prolonged release compositions and method of obtaining them
SK1406-94A SK280496B6 (en) 1993-11-23 1994-11-22 Process for preparing particles with permanent release of active substance
NO19944473A NO314124B1 (en) 1993-11-23 1994-11-22 Process for the preparation of particles
HU9403353A HU217205B (en) 1993-11-23 1994-11-22 Sustained release compositions and a method of preparing pharmaceutical compositions
FI945476A FI113335B (en) 1993-11-23 1994-11-22 Process for the preparation of particles useful in pharmaceutical compositions
KR1019940031398A KR100354702B1 (en) 1993-11-23 1994-11-23 Manufacturing method and sustained release composition of pharmaceutical composition
CN94118503A CN1121213C (en) 1993-11-23 1994-11-23 Sustained release compositions and a method of preparing pharmaceutical compositions
AU79015/94A AU682223C (en) 1993-11-23 1994-11-23 Sustained release compositions and a method of preparing pharmaceutical compositions
JP28993694A JP3411114B2 (en) 1993-11-23 1994-11-24 Method for producing long-acting composition and pharmaceutical composition
EP95301337A EP0672416A1 (en) 1994-03-14 1995-03-02 Pharmaceutical composition comprising diamorphine
ZA952103A ZA952013B (en) 1994-03-14 1995-03-10 Pharmaceutical preparation
FI951155A FI951155A (en) 1994-03-14 1995-03-13 Pharmaceutical preparation
CA002144500A CA2144500A1 (en) 1994-03-14 1995-03-13 Pharmaceutical preparation
NO950950A NO950950L (en) 1994-03-14 1995-03-13 Pharmaceutical preparation
JP7052498A JPH0840905A (en) 1994-03-14 1995-03-13 Pharmaceutical preparation
AU14755/95A AU694475B2 (en) 1994-03-14 1995-03-13 Pharmaceutical preparation
US08/449,772 US6326027B1 (en) 1993-05-10 1995-05-24 Controlled release formulation
US08/607,851 US5891471A (en) 1993-11-23 1996-02-27 Pharmaceutical multiparticulates
US08/607,852 US5849240A (en) 1993-11-23 1996-02-27 Method of preparing sustained release pharmaceutical compositions
GR960401422T GR3020084T3 (en) 1993-05-10 1996-05-30 Controlled release formulation containing tramadol.
US08/677,798 US6254887B1 (en) 1993-05-10 1996-07-10 Controlled release tramadol
IL11966096A IL119660A0 (en) 1993-05-10 1996-11-20 Controlled release formulation
US08/774,229 US5843480A (en) 1994-03-14 1996-12-27 Controlled release diamorphine formulation
US08/843,571 US5879705A (en) 1993-07-27 1997-04-18 Sustained release compositions of morphine and a method of preparing pharmaceutical compositions
US08/944,106 US5965163A (en) 1993-11-23 1997-09-30 Substained release compositions and a method of preparing pharmaceutical compositions
AU39957/97A AU3995797A (en) 1993-05-10 1997-10-07 Controlled release formulation
AU52995/98A AU722358B2 (en) 1991-12-24 1998-02-06 Sustained release compositions and a method of preparing pharmaceutical compositions
JP22971898A JP3267561B2 (en) 1993-05-10 1998-08-14 Use of tramadol or a pharmaceutically acceptable salt thereof and analgesic
US09/264,399 US6143328A (en) 1993-07-27 1999-03-08 Sustained release compositions and a method of preparing pharmaceutical compositions
CNB991066421A CN1146410C (en) 1993-05-10 1999-05-17 Controlled release formulation
NO19993484A NO313124B1 (en) 1993-05-10 1999-07-15 Use of tramadol in the manufacture of a medicament for the treatment of pain
US09/370,270 US6162467A (en) 1993-11-23 1999-08-09 Sustained release compositions and a method of preparing pharmaceutical compositions
AT0081699U AT3413U3 (en) 1993-05-10 1999-11-25 MEDICINAL PRODUCT WITH CONTROLLED RELEASE OF TRAMADOL
US09/740,732 US20010019725A1 (en) 1993-11-23 2000-12-19 Sustained release compositions and a method of preparing pharmaceutical compositions
US09/800,204 US7074430B2 (en) 1993-05-10 2001-03-06 Controlled release tramadol tramadol formulation
NO20013566A NO331650B1 (en) 1993-05-10 2001-07-19 Oral preparation of tramadol or a pharmaceutically acceptable salt thereof with controlled release effect
GR20010401419T GR3036565T3 (en) 1993-05-10 2001-09-06 Controlled release formulation
JP2001297270A JP3443574B2 (en) 1993-05-10 2001-09-27 Analgesic containing tramadol or a salt thereof
JP2002271157A JP2003113075A (en) 1993-11-23 2002-09-18 Sustained release composition
FI20030560A FI121565B (en) 1993-05-10 2003-04-14 A process for the preparation of a controlled release formulation of tramadol
US11/435,015 US20060269603A1 (en) 1993-05-10 2006-05-16 Controlled release tramadol formulations
US12/152,474 US20090117191A1 (en) 1993-05-10 2008-05-14 Controlled release tramadol formulations
FI20105856A FI122717B (en) 1993-05-10 2010-08-17 The method produces a controlled release preparation of tramadol hydrochloride

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GB9404928A GB2287880A (en) 1994-03-14 1994-03-14 Production of sustained release compositions

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GB2287880A GB2287880A (en) 1995-10-04
GB2287880A8 true GB2287880A8 (en) 1995-12-04

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6254887B1 (en) 1993-05-10 2001-07-03 Euro-Celtique S.A. Controlled release tramadol

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DE2426812A1 (en) * 1974-06-04 1976-01-02 Klinge Co Chem Pharm Fab PROCESS FOR THE MANUFACTURING OF GRANULES
US5073397A (en) * 1990-07-12 1991-12-17 Procter & Gamble Company Method for preparation of ultrafine citrus fiber and derivative fiber-enriched citrus beverages
US5429825A (en) * 1992-06-26 1995-07-04 Mcneil-Ppc, Inc. Rotomelt granulation

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6254887B1 (en) 1993-05-10 2001-07-03 Euro-Celtique S.A. Controlled release tramadol
US6326027B1 (en) 1993-05-10 2001-12-04 Euro-Celtique S.A. Controlled release formulation

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GB9404928D0 (en) 1994-04-27
ZA952013B (en) 1995-12-11
GB2287880A (en) 1995-10-04

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