NO985222L - Karbolinderivater - Google Patents

Karbolinderivater

Info

Publication number
NO985222L
NO985222L NO985222A NO985222A NO985222L NO 985222 L NO985222 L NO 985222L NO 985222 A NO985222 A NO 985222A NO 985222 A NO985222 A NO 985222A NO 985222 L NO985222 L NO 985222L
Authority
NO
Norway
Prior art keywords
carboline
specific
cgmp
monophosphate
potent
Prior art date
Application number
NO985222A
Other languages
English (en)
Norwegian (no)
Other versions
NO985222D0 (no
Inventor
Agnes Bombrun
Original Assignee
Icos Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9609820.7A external-priority patent/GB9609820D0/en
Priority claimed from GBGB9609777.9A external-priority patent/GB9609777D0/en
Application filed by Icos Corp filed Critical Icos Corp
Publication of NO985222D0 publication Critical patent/NO985222D0/no
Publication of NO985222L publication Critical patent/NO985222L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
NO985222A 1996-05-10 1998-11-09 Karbolinderivater NO985222L (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9609820.7A GB9609820D0 (en) 1996-05-10 1996-05-10 Chemical compounds
GBGB9609777.9A GB9609777D0 (en) 1996-05-10 1996-05-10 Chemical compounds
PCT/EP1997/002277 WO1997043287A1 (en) 1996-05-10 1997-05-05 Carboline derivatives

Publications (2)

Publication Number Publication Date
NO985222D0 NO985222D0 (no) 1998-11-09
NO985222L true NO985222L (no) 1999-01-11

Family

ID=26309303

Family Applications (1)

Application Number Title Priority Date Filing Date
NO985222A NO985222L (no) 1996-05-10 1998-11-09 Karbolinderivater

Country Status (26)

Country Link
US (2) US6117881A (ko)
EP (1) EP0912567B1 (ko)
JP (1) JP3418405B2 (ko)
KR (1) KR20000010918A (ko)
CN (1) CN1067071C (ko)
AP (1) AP9801365A0 (ko)
AT (1) ATE215950T1 (ko)
AU (1) AU711885B2 (ko)
BG (1) BG102879A (ko)
BR (1) BR9709230A (ko)
CA (1) CA2253948C (ko)
CZ (1) CZ358598A3 (ko)
DE (1) DE69711882T2 (ko)
EA (1) EA199800907A1 (ko)
EE (1) EE9800390A (ko)
ES (1) ES2175404T3 (ko)
HU (1) HUP9901478A3 (ko)
IL (1) IL126951A0 (ko)
IS (1) IS4864A (ko)
NO (1) NO985222L (ko)
OA (1) OA10920A (ko)
PL (1) PL329875A1 (ko)
SK (1) SK154498A3 (ko)
TR (1) TR199802282T2 (ko)
WO (1) WO1997043287A1 (ko)
YU (1) YU49898A (ko)

Families Citing this family (61)

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US6331543B1 (en) 1996-11-01 2001-12-18 Nitromed, Inc. Nitrosated and nitrosylated phosphodiesterase inhibitors, compositions and methods of use
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JP2002524564A (ja) * 1998-09-16 2002-08-06 アイコス コーポレイション ｃＧＭＰホスホジエステラーゼ阻害剤としてのカルボリン誘導体
DE19903087A1 (de) * 1999-01-27 2000-08-10 Forssmann Wolf Georg Behandlung von erektilen Dysfunktionen mit C-Typ Natriuretischem Polypeptid (CNP) als Monotherapie oder in Kombination mit Phosphodiesterasehemmern
ES2213004T3 (es) 1999-03-24 2004-08-16 Harbor Branch Oceanographic Institution, Inc. Usos antiinflamatorios de manzaminas.
NO20002097L (no) 1999-04-30 2001-10-26 Lilly Icos Llc Fremstillingsgjenstander
US6451807B1 (en) 1999-04-30 2002-09-17 Lilly Icos, Llc. Methods of treating sexual dysfunction in an individual suffering from a retinal disease, class 1 congestive heart failure, or myocardial infarction using a PDE5 inhibitor
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US6821978B2 (en) 2000-09-19 2004-11-23 Schering Corporation Xanthine phosphodiesterase V inhibitors
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WO2002098875A1 (en) * 2001-06-05 2002-12-12 Lilly Icos Llc Carboline derivatives as pde-5 inhibitors
ATE335742T1 (de) 2001-06-21 2006-09-15 Lilly Icos Llc Carbolinderivate als pdev inhibitoren
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US7667041B2 (en) * 2004-05-26 2010-02-23 Eisai R&D Management Co., Ltd. Cinnamide compound
US7923563B2 (en) 2004-10-26 2011-04-12 Eisai R&D Management Co., Ltd. Amorphous object of cinnamide compound
EP1829874B1 (en) 2004-12-22 2014-02-12 Ono Pharmaceutical Co., Ltd. Tricyclic compound and use thereof
US8506934B2 (en) 2005-04-29 2013-08-13 Robert I. Henkin Methods for detection of biological substances
EP2275095A3 (en) 2005-08-26 2011-08-17 Braincells, Inc. Neurogenesis by muscarinic receptor modulation
EP2258359A3 (en) 2005-08-26 2011-04-06 Braincells, Inc. Neurogenesis by muscarinic receptor modulation with sabcomelin
EP2377530A3 (en) 2005-10-21 2012-06-20 Braincells, Inc. Modulation of neurogenesis by PDE inhibition
EP2314289A1 (en) 2005-10-31 2011-04-27 Braincells, Inc. Gaba receptor mediated modulation of neurogenesis
ZA200804550B (en) 2005-11-09 2009-08-26 Combinatorx Inc Methods, compositions, and kits for the treatment of medical conditions
CA2628047A1 (en) * 2005-11-18 2007-05-24 Eisai R & D Management Co., Ltd. Process for production of cinnamide derivative
EP1953151A4 (en) * 2005-11-18 2010-06-02 Eisai R&D Man Co Ltd SALTS FROM A CYNNAMIDE COMPOUND OR SOLVATE THEREOF
US20070117839A1 (en) * 2005-11-24 2007-05-24 Eisai R&D Management Co., Ltd. Two cyclic cinnamide compound
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TWI370130B (en) 2005-11-24 2012-08-11 Eisai R&D Man Co Ltd Two cyclic cinnamide compound
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WO2008095136A2 (en) 2007-01-31 2008-08-07 Henkin Robert I Methods for detection of biological substances
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JPWO2008140111A1 (ja) * 2007-05-16 2010-08-05 エーザイ・アール・アンド・ディー・マネジメント株式会社 シンナミド誘導体のワンポット製造方法
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US7935815B2 (en) 2007-08-31 2011-05-03 Eisai R&D Management Co., Ltd. Imidazoyl pyridine compounds and salts thereof
JPWO2009096349A1 (ja) * 2008-01-28 2011-05-26 エーザイ・アール・アンド・ディー・マネジメント株式会社 結晶性のシンナミド化合物またはその塩
US8580801B2 (en) 2008-07-23 2013-11-12 Robert I. Henkin Phosphodiesterase inhibitor treatment
US20100216805A1 (en) 2009-02-25 2010-08-26 Braincells, Inc. Modulation of neurogenesis using d-cycloserine combinations
EP2804603A1 (en) 2012-01-10 2014-11-26 President and Fellows of Harvard College Beta-cell replication promoting compounds and methods of their use
WO2014055801A1 (en) 2012-10-05 2014-04-10 Henkin Robert I Phosphodiesterase inhibitors for treating taste and smell disorders
WO2015126944A1 (en) 2014-02-18 2015-08-27 Henkin Robert I Methods and compositions for diagnosing and treating loss and/or distortion of taste or smell
JP2019515643A (ja) * 2015-09-23 2019-06-13 ミネルバ バイオテクノロジーズ コーポレーション 幹細胞分化剤のスクリーニング方法

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Also Published As

Publication number Publication date
IL126951A0 (en) 1999-09-22
DE69711882T2 (de) 2002-10-31
HUP9901478A3 (en) 1999-11-29
CN1067071C (zh) 2001-06-13
IS4864A (is) 1998-10-13
PL329875A1 (en) 1999-04-12
SK154498A3 (en) 2000-01-18
US6117881A (en) 2000-09-12
JP2000513717A (ja) 2000-10-17
EP0912567B1 (en) 2002-04-10
HUP9901478A2 (hu) 1999-08-30
EE9800390A (et) 1999-06-15
TR199802282T2 (xx) 1999-03-22
YU49898A (sh) 2000-03-21
ATE215950T1 (de) 2002-04-15
AU711885B2 (en) 1999-10-21
EA199800907A1 (ru) 1999-04-29
BR9709230A (pt) 1999-08-10
CN1218471A (zh) 1999-06-02
US6306870B1 (en) 2001-10-23
AU2891097A (en) 1997-12-05
NO985222D0 (no) 1998-11-09
AP9801365A0 (en) 1998-12-31
ES2175404T3 (es) 2002-11-16
OA10920A (en) 2003-02-21
DE69711882D1 (en) 2002-05-16
KR20000010918A (ko) 2000-02-25
BG102879A (en) 1999-09-30
EP0912567A1 (en) 1999-05-06
CZ358598A3 (cs) 1999-03-17
CA2253948A1 (en) 1997-11-20
WO1997043287A1 (en) 1997-11-20
CA2253948C (en) 2005-07-26
JP3418405B2 (ja) 2003-06-23

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