MXPA02006212A - Inhibidores de fosfodiesterasa amp-especifica ciclica. - Google Patents

Inhibidores de fosfodiesterasa amp-especifica ciclica.

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Publication number
MXPA02006212A
MXPA02006212A MXPA02006212A MXPA02006212A MXPA02006212A MX PA02006212 A MXPA02006212 A MX PA02006212A MX PA02006212 A MXPA02006212 A MX PA02006212A MX PA02006212 A MXPA02006212 A MX PA02006212A MX PA02006212 A MXPA02006212 A MX PA02006212A
Authority
MX
Mexico
Prior art keywords
ampspecific
cyclic
phosphodiesterase inhibitors
pyrrolidine derivatives
disclosed
Prior art date
Application number
MXPA02006212A
Other languages
English (en)
Inventor
Laurence E Burgess
Original Assignee
Icos Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Icos Corp filed Critical Icos Corp
Publication of MXPA02006212A publication Critical patent/MXPA02006212A/es

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    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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Abstract

Se exponen compuestos novedosos de pirrolidina que son inhibidores potentes y selectivos de la PDE4, asi como tambien los metodos para producir los mismos. Tambien se expone el uso de los compuestos en el tratamiento de enfermedades inflamatorias y otras enfermedades que incluyen niveles elevados de citocinas, asi como tambien trastornos del sistema nervioso central (CNS).
MXPA02006212A 1999-12-23 2000-11-28 Inhibidores de fosfodiesterasa amp-especifica ciclica. MXPA02006212A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/471,846 US6258833B1 (en) 1999-12-23 1999-12-23 Cyclic AMP-specific phosphodiesterase inhibitors
PCT/US2000/032401 WO2001047905A1 (en) 1999-12-23 2000-11-28 Pyrrolidine derivatives as cyclic amp-specific phosphodiesterase inhibitors

Publications (1)

Publication Number Publication Date
MXPA02006212A true MXPA02006212A (es) 2004-02-26

Family

ID=23873210

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA02006212A MXPA02006212A (es) 1999-12-23 2000-11-28 Inhibidores de fosfodiesterasa amp-especifica ciclica.

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US (6) US6258833B1 (es)
EP (1) EP1242400B1 (es)
JP (1) JP4294903B2 (es)
KR (1) KR20020063600A (es)
CN (1) CN1434813A (es)
AT (1) ATE325108T1 (es)
AU (1) AU778543B2 (es)
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HK (1) HK1051359A1 (es)
HR (1) HRP20020541B1 (es)
HU (1) HUP0301113A3 (es)
IL (1) IL150313A0 (es)
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NO (1) NO20023008L (es)
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