RS50841B - Derivati pirolidina kao inhibitori ciklične aspecifične fosfodiesteraze - Google Patents

Derivati pirolidina kao inhibitori ciklične aspecifične fosfodiesteraze

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Publication number
RS50841B
RS50841B YUP-480/02A YUP48002A RS50841B RS 50841 B RS50841 B RS 50841B YU P48002 A YUP48002 A YU P48002A RS 50841 B RS50841 B RS 50841B
Authority
RS
Serbia
Prior art keywords
alkyl
cycloalkyl
aryl
hydrogen
haloalkyl
Prior art date
Application number
YUP-480/02A
Other languages
English (en)
Inventor
Timothy J. Martins
Kerry W. Fowler
Joshua Odingo
Edward A. Kesicki
Amy Oliver
Laurence E. Burgess
John J. Gaudino
Zachary S. Jones
Bradley J. Newhouse
Stephen Schlachter
Original Assignee
Icos Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Icos Corporation filed Critical Icos Corporation
Publication of YU48002A publication Critical patent/YU48002A/sh
Publication of RS50841B publication Critical patent/RS50841B/sr

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Abstract

Jedinjenje formule:gde jeR1 odabran od C1-6 alkil C6-16 biciklični ili policiklični ugljovodonik, aril, cikloalkil, 4-, 5-, ili 6-člani zasićen heterocikl, heteroaril, C1-4alkilenaril, C1-4alkilenOaril, C1-4alkilenheteroaril, C1-4alkilenHet, C2-4alkilenarilOaril, C2-4alkilenski premošteni alkil, C1-4alkilencikloalkil, supstituisan ili nesupstituisan propargil, supstituisan ili nesupstituisan allil, ili halocikloalkil;R2 odabran od metil, ili halo-supstituisan metil, e.g., CHF2;R3 odabran od C(=O)OR7, C(=O)R7, NHC(=O)OR7, C1-3alkilenC(=O)OR8, C1-3alkilenC(=O)R8, C(=NH)NR8R9, C(=O)-C(=O)C(=O)OR8, C1-4alkilenOR8, aril, C1-3alkilenaril, C1-3alkilenheteroaril, SO2heteroaril, Het, ili heteroaril;R4 odabran od vodonik, C1-6 alkil, haloalkil, ili cikloalkil;R5 odabran od C1-6 alkil, alkinil, haloalkil, hidroksialkil, cikloalkil, ili aril;R6 odabran od vodonik, C1-6alkil, i C(=O)R7;R odabran od C1-6 alkil ili cikloalkil, svaki po izboru supstituisan sa jednim ili više: OC(=O)R8, C(=O)OR8, OR8, NR8R9, ili SR8;R8 i R9 , isti ili različiti, odabrani su od vodonika, C1-6 alkil, cikloalkil, aril, heteroaril, C(=O)Oalkil, C(=O)-Oaril, C(=O)alkil, alkilSO2, C(=O)-C1-3alkilenaril, C(=O)OC1-4alkilenaril, C1-4alkilenaril, ili Het, ili R8 i R9 zajedno formiraju 4-člani do 7-člani prsten;R10 odabran od vodonik, alkil, haloalkil, ili cikloalkil;R 11 odabran od alkil, cikloalkil, trifluorometil, aril, aralkil, i NR8R9; injihove soli i solvati.Prijava sadrži još 77 patentnih zahteva.
YUP-480/02A 1999-12-23 2000-11-28 Derivati pirolidina kao inhibitori ciklične aspecifične fosfodiesteraze RS50841B (sr)

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