YU48002A - Derivati pirolidina kao inhibitori ciklične amp-specifične fosfodiesteraze - Google Patents

Derivati pirolidina kao inhibitori ciklične amp-specifične fosfodiesteraze

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Publication number
YU48002A
YU48002A YU48002A YUP48002A YU48002A YU 48002 A YU48002 A YU 48002A YU 48002 A YU48002 A YU 48002A YU P48002 A YUP48002 A YU P48002A YU 48002 A YU48002 A YU 48002A
Authority
YU
Yugoslavia
Prior art keywords
cyclic amp
phosphodiesterase inhibitors
pyrrolidine derivatives
specific phosphodiesterase
disclosed
Prior art date
Application number
YU48002A
Other languages
English (en)
Inventor
Timothy J. Martins
Kerry W. Fowler
Joshua Odingo
Edward A. Kesicki
Amy Oliver
Laurence E. Burgess
John J. Gaudino
Zachary S. Jones
Bradley J. Newhouse
Stephen Schlachter
Original Assignee
Icos Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Icos Corporation filed Critical Icos Corporation
Publication of YU48002A publication Critical patent/YU48002A/sh
Publication of RS50841B publication Critical patent/RS50841B/sr

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    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
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Abstract

Opisana su nova jedinjenja koja imaju struktumu formulu (II) i koja su snažni i selektivni inhibitori PDE4, kao i postupci za njihovo dobijanje. Takodje je opisana upotreba ovih jedinjenja u lečenju inflamatornih oboljenja i drugih bolesti povezanih sa povišenim nivoima citokina, kao i u lečenju poremećaja centralnog nervnog sistema (CNS).[Novel pyrrolidine compounds having the structural formula (II) that are potent and selective inhibitors of PDE4, as well as methods of making the same, are disclosed. Use of the compounds in the treatment of inflammatory diseases and other diseases involving elevated levels of cytokines, as well as central nervous system (CNS) disorders, also is disclosed.
YUP-480/02A 1999-12-23 2000-11-28 Derivati pirolidina kao inhibitori ciklične aspecifične fosfodiesteraze RS50841B (sr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US09/471,846 US6258833B1 (en) 1999-12-23 1999-12-23 Cyclic AMP-specific phosphodiesterase inhibitors

Publications (2)

Publication Number Publication Date
YU48002A true YU48002A (sh) 2005-11-28
RS50841B RS50841B (sr) 2010-08-31

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EP (1) EP1242400B1 (sh)
JP (1) JP4294903B2 (sh)
KR (1) KR20020063600A (sh)
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