NO974147L - Heterocykelkarbonylaminosyre hydroksyetylaminosulfonamid retroviral protease - Google Patents

Heterocykelkarbonylaminosyre hydroksyetylaminosulfonamid retroviral protease

Info

Publication number
NO974147L
NO974147L NO974147A NO974147A NO974147L NO 974147 L NO974147 L NO 974147L NO 974147 A NO974147 A NO 974147A NO 974147 A NO974147 A NO 974147A NO 974147 L NO974147 L NO 974147L
Authority
NO
Norway
Prior art keywords
retroviral
protease
retroviral protease
inhibitors
carbonylamino acid
Prior art date
Application number
NO974147A
Other languages
English (en)
Norwegian (no)
Other versions
NO974147D0 (no
Inventor
Daniel P Getman
Gary A Decrescenzo
John N Freskos
Michael L Vazquez
James A Sikorski
Balekudru Devadas
Srivivasan Nagarajan
David L Brown
Joseph J Mcdonald
Original Assignee
Searle & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/474,117 external-priority patent/US5776971A/en
Application filed by Searle & Co filed Critical Searle & Co
Publication of NO974147D0 publication Critical patent/NO974147D0/no
Publication of NO974147L publication Critical patent/NO974147L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • C07K5/06165—Dipeptides with the first amino acid being heterocyclic and Pro-amino acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Virology (AREA)
  • Public Health (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • AIDS & HIV (AREA)
  • Obesity (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Peptides Or Proteins (AREA)
  • Hydrogenated Pyridines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
NO974147A 1995-03-10 1997-09-09 Heterocykelkarbonylaminosyre hydroksyetylaminosulfonamid retroviral protease NO974147L (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US40241995A 1995-03-10 1995-03-10
US08/474,117 US5776971A (en) 1995-03-10 1995-06-07 Heterocyclecarbonyl amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors
PCT/US1996/002683 WO1996028465A1 (en) 1995-03-10 1996-03-07 Heterocyclecarbonyl amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors

Publications (2)

Publication Number Publication Date
NO974147D0 NO974147D0 (no) 1997-09-09
NO974147L true NO974147L (no) 1997-11-04

Family

ID=27017874

Family Applications (1)

Application Number Title Priority Date Filing Date
NO974147A NO974147L (no) 1995-03-10 1997-09-09 Heterocykelkarbonylaminosyre hydroksyetylaminosulfonamid retroviral protease

Country Status (20)

Country Link
US (3) US5972989A (cs)
EP (1) EP0815124B1 (cs)
JP (1) JP4124818B2 (cs)
CN (2) CN1149223C (cs)
AT (1) ATE229033T1 (cs)
AU (1) AU717598B2 (cs)
BR (1) BR9607625A (cs)
CA (1) CA2215022A1 (cs)
CZ (1) CZ297676B6 (cs)
DE (1) DE69625183T2 (cs)
DK (1) DK0815124T3 (cs)
ES (1) ES2190793T3 (cs)
HU (1) HUP9800518A3 (cs)
MX (1) MX9706946A (cs)
NO (1) NO974147L (cs)
NZ (1) NZ306027A (cs)
PL (1) PL184771B1 (cs)
PT (1) PT815124E (cs)
RU (1) RU2174519C2 (cs)
WO (1) WO1996028465A1 (cs)

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US20040122000A1 (en) 1981-01-07 2004-06-24 Vertex Pharmaceuticals Incorporated. Inhibitors of aspartyl protease
US5776971A (en) * 1995-03-10 1998-07-07 G.D. Searle & Co. Heterocyclecarbonyl amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors
DK0815124T3 (da) * 1995-03-10 2003-03-17 Searle & Co Heterocyckliske carbonylaminosyre-hydroxyethylamino-sulfonamidinhibitorer af retrovirale proteaser
US6407134B1 (en) * 1995-03-10 2002-06-18 G. D. Searle & Co. Heterocyclecarbonyl amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors
AU734302B2 (en) * 1997-05-08 2001-06-07 Smithkline Beecham Corporation Protease inhibitors
WO2000002862A1 (en) * 1998-07-08 2000-01-20 G.D. Searle & Co. Retroviral protease inhibitors
KR100650303B1 (ko) 1999-01-28 2006-11-28 아지노모토 가부시키가이샤 α-아미노케톤류의 제조방법
AR031520A1 (es) * 1999-06-11 2003-09-24 Vertex Pharma Un compuesto inhibidor de aspartilo proteasa, una composicion que lo comprende y un metodo para tratar un paciente con dicha composicion
ES2275866T3 (es) 2001-02-14 2007-06-16 Tibotec Pharmaceuticals Ltd. 2-(aminosustituido)-benzotiazol-sulfonamidas de amplio esprecto inhibidoras de la proteasa de vih.
US7244752B2 (en) 2001-04-09 2007-07-17 Tibotec Pharmaceuticals Ltd. Broadspectrum 2-(substituted-amino)-benzoxazole sulfonamide HIV protease inhibitors
EA009590B1 (ru) 2001-05-11 2008-02-28 Тиботек Фармасьютикалз Лтд. 2-аминобензоксазолсульфонамидные ингибиторы вич-протеазы широкого спектра
CN100448444C (zh) 2001-12-21 2009-01-07 泰博特克药品有限公司 含杂环取代苯基的磺酰胺广谱hiv蛋白酶抑制剂
MY142238A (en) * 2002-03-12 2010-11-15 Tibotec Pharm Ltd Broadspectrum substituted benzimidazole sulfonamide hiv protease inhibitors
HRP20050607B1 (hr) * 2002-05-17 2014-07-04 Tibotec Pharmaceuticals Ltd. Supstituirani benzizoksazol sulfonamid hiv proteazni inhibitori širokog spektra
JP4681296B2 (ja) 2002-08-14 2011-05-11 テイボテク・フアーマシユーチカルズ・リミテツド スペクトルの広い置換オキシインドールスルホンアミドｈｉｖプロテアーゼ阻害剤
US20040203166A1 (en) * 2003-04-11 2004-10-14 Sullivan John Timothy Electrolysis apparatus and method utilizing at least one coiled electrode
MXPA06003575A (es) * 2003-09-30 2006-06-05 Tibotec Pharm Ltd Metodos para la preparacion de compuestos de benzoxazol sulfonamida e intermediarios de los mismos.
RS51073B (sr) 2003-12-23 2010-10-31 Tibotec Pharmaceuticals Ltd. Proces za pripremanje (3r,3as,6ar)-heksahidrofuro│2,3-b│ furan-3-il (1s,2r)-3-││(4-aminofenil) sulfonil│(izobutil) amino │-1-benzil-2-hidroksipropilkarbamata
ATE433982T1 (de) 2003-12-23 2009-07-15 Tibotec Pharm Ltd Verfahren zur herstellung von (1s,2r)-3-ää(4- aminophenyl)sulfonylü(isobutyl)aminoü-1-benzyl- - hydroxypropylcarbamidsäure-(3r,3as,6ar)- hexahydrofuroä2,3-büfuran-3-ylester
EP1557166A1 (en) * 2004-01-21 2005-07-27 Newron Pharmaceuticals S.p.A. Alpha-aminoamide derivatives useful in the treatment of lower urinary tract disorders
EP1910317B1 (en) * 2005-07-20 2013-07-03 Eli Lilly And Company 1-amino linked compounds
AU2007285759B2 (en) 2006-08-18 2013-11-21 Sequoia Pharmaceuticals, Inc. Compositions and methods for inhibiting cytochrome P450
CN101965186A (zh) * 2007-11-28 2011-02-02 塞阔伊亚药品公司 抑制细胞色素p450 2d6的化合物和方法
CN109824756B (zh) * 2019-03-19 2022-03-22 山东大学 含有4-(苯磺酰基)哌嗪-2-酮的苯丙氨酸衍生物及其制备方法与应用
CN111205206B (zh) * 2020-02-13 2021-10-22 中国医学科学院医药生物技术研究所 一种包含氨基酸连接链的羰基化合物或其药学上可接受的盐及其制备方法和应用

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US5776971A (en) * 1995-03-10 1998-07-07 G.D. Searle & Co. Heterocyclecarbonyl amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors

Also Published As

Publication number Publication date
WO1996028465A1 (en) 1996-09-19
CZ297676B6 (cs) 2007-03-07
DE69625183T2 (de) 2003-10-09
CA2215022A1 (en) 1996-09-19
CN1530372A (zh) 2004-09-22
PL322179A1 (en) 1998-01-19
DK0815124T3 (da) 2003-03-17
BR9607625A (pt) 1999-06-15
US5972989A (en) 1999-10-26
PT815124E (pt) 2003-04-30
DE69625183D1 (en) 2003-01-16
NZ306027A (en) 1999-03-29
AU5417896A (en) 1996-10-02
CN1183102A (zh) 1998-05-27
NO974147D0 (no) 1997-09-09
PL184771B1 (pl) 2002-12-31
JP4124818B2 (ja) 2008-07-23
EP0815124A1 (en) 1998-01-07
US6214861B1 (en) 2001-04-10
ES2190793T3 (es) 2003-08-16
ATE229033T1 (de) 2002-12-15
MX9706946A (es) 1997-11-29
CN1149223C (zh) 2004-05-12
RU2174519C2 (ru) 2001-10-10
HUP9800518A2 (hu) 1998-06-29
JPH11501920A (ja) 1999-02-16
EP0815124B1 (en) 2002-12-04
US6063795A (en) 2000-05-16
AU717598B2 (en) 2000-03-30
HUP9800518A3 (en) 1998-09-28
CZ282397A3 (cs) 1998-02-18

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