NO973764L - Nye dipeptidamidiner som trombin-inhibitorer - Google Patents

Nye dipeptidamidiner som trombin-inhibitorer

Info

Publication number
NO973764L
NO973764L NO973764A NO973764A NO973764L NO 973764 L NO973764 L NO 973764L NO 973764 A NO973764 A NO 973764A NO 973764 A NO973764 A NO 973764A NO 973764 L NO973764 L NO 973764L
Authority
NO
Norway
Prior art keywords
dipeptidamidines
novel
thrombin inhibitors
thrombin
inhibitors
Prior art date
Application number
NO973764A
Other languages
English (en)
Norwegian (no)
Other versions
NO973764D0 (no
Inventor
Hans-Joachim Boehm
Hans Wolfgang Hoeffken
Wilfried Hornberger
Stefan Koser
Helmut Mack
Thomas Pfeiffer
Werner Seitz
Thomas Zierke
Original Assignee
Basf Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Basf Ag filed Critical Basf Ag
Publication of NO973764D0 publication Critical patent/NO973764D0/no
Publication of NO973764L publication Critical patent/NO973764L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • C07K5/06165—Dipeptides with the first amino acid being heterocyclic and Pro-amino acid; Derivatives thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Diabetes (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Peptides Or Proteins (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Steroid Compounds (AREA)
NO973764A 1995-02-17 1997-08-15 Nye dipeptidamidiner som trombin-inhibitorer NO973764L (no)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE19505484 1995-02-17
DE19506611 1995-02-24
DE19507455 1995-03-03
PCT/EP1996/000582 WO1996025426A1 (fr) 1995-02-17 1996-02-12 Nouvelles amidines dipeptidiques utilisees comme inhibiteurs de thrombine

Publications (2)

Publication Number Publication Date
NO973764D0 NO973764D0 (no) 1997-08-15
NO973764L true NO973764L (no) 1997-10-15

Family

ID=27214848

Family Applications (1)

Application Number Title Priority Date Filing Date
NO973764A NO973764L (no) 1995-02-17 1997-08-15 Nye dipeptidamidiner som trombin-inhibitorer

Country Status (26)

Country Link
US (3) US6030972A (fr)
EP (1) EP0873356A1 (fr)
JP (1) JPH11500120A (fr)
KR (1) KR100388185B1 (fr)
CN (1) CN1198839C (fr)
AR (1) AR002277A1 (fr)
AU (1) AU708001B2 (fr)
BG (1) BG63697B1 (fr)
BR (1) BR9607582A (fr)
CA (1) CA2211109A1 (fr)
CZ (1) CZ245797A3 (fr)
EA (1) EA199700186A1 (fr)
FI (1) FI973360A (fr)
HR (1) HRP960075B1 (fr)
HU (1) HUP9800263A3 (fr)
IL (1) IL117165A0 (fr)
MX (1) MX9706069A (fr)
MY (1) MY132115A (fr)
NO (1) NO973764L (fr)
NZ (1) NZ302649A (fr)
PL (1) PL321759A1 (fr)
SI (1) SI9620037A (fr)
SK (1) SK104697A3 (fr)
TR (1) TR199700803T1 (fr)
TW (1) TW450968B (fr)
WO (1) WO1996025426A1 (fr)

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US5710130A (en) * 1995-02-27 1998-01-20 Eli Lilly And Company Antithrombotic agents
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Also Published As

Publication number Publication date
MY132115A (en) 2007-09-28
JPH11500120A (ja) 1999-01-06
FI973360A0 (fi) 1997-08-15
US6030972A (en) 2000-02-29
PL321759A1 (en) 1997-12-22
AU4875196A (en) 1996-09-04
HUP9800263A2 (hu) 1998-06-29
CN1198839C (zh) 2005-04-27
CN1175953A (zh) 1998-03-11
BG63697B1 (bg) 2002-09-30
AR002277A1 (es) 1998-03-11
EP0873356A1 (fr) 1998-10-28
MX9706069A (es) 1997-10-31
TR199700803T1 (xx) 1998-02-21
HRP960075B1 (en) 2004-10-31
BR9607582A (pt) 1998-07-07
KR19980702285A (ko) 1998-07-15
WO1996025426A1 (fr) 1996-08-22
CZ245797A3 (cs) 1998-06-17
FI973360A (fi) 1997-08-15
CA2211109A1 (fr) 1996-08-22
SK104697A3 (en) 1998-11-04
TW450968B (en) 2001-08-21
US6900319B2 (en) 2005-05-31
HUP9800263A3 (en) 1998-07-28
US6444817B1 (en) 2002-09-03
NO973764D0 (no) 1997-08-15
NZ302649A (en) 2000-01-28
IL117165A0 (en) 1996-06-18
BG101835A (en) 1998-05-29
AU708001B2 (en) 1999-07-29
EA199700186A1 (ru) 1998-02-26
SI9620037A (sl) 1998-02-28
KR100388185B1 (ko) 2003-11-28
US20020169318A1 (en) 2002-11-14
HRP960075A2 (en) 1997-12-31

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