NO972253L - Antitrombotisk middel og anti-von Willebrand faktor monoklonalt antistoff - Google Patents
Antitrombotisk middel og anti-von Willebrand faktor monoklonalt antistoffInfo
- Publication number
- NO972253L NO972253L NO972253A NO972253A NO972253L NO 972253 L NO972253 L NO 972253L NO 972253 A NO972253 A NO 972253A NO 972253 A NO972253 A NO 972253A NO 972253 L NO972253 L NO 972253L
- Authority
- NO
- Norway
- Prior art keywords
- monoclonal antibody
- von willebrand
- willebrand factor
- antithrombotic agent
- action
- Prior art date
Links
- 239000003146 anticoagulant agent Substances 0.000 title abstract 2
- 229960004676 antithrombotic agent Drugs 0.000 title abstract 2
- 229960001134 von willebrand factor Drugs 0.000 title 1
- 208000010110 spontaneous platelet aggregation Diseases 0.000 abstract 3
- 101000782195 Homo sapiens von Willebrand factor Proteins 0.000 abstract 1
- 108010081391 Ristocetin Proteins 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 230000002785 anti-thrombosis Effects 0.000 abstract 1
- 230000000740 bleeding effect Effects 0.000 abstract 1
- BGTFCAQCKWKTRL-YDEUACAXSA-N chembl1095986 Chemical compound C1[C@@H](N)[C@@H](O)[C@H](C)O[C@H]1O[C@@H]([C@H]1C(N[C@H](C2=CC(O)=CC(O[C@@H]3[C@H]([C@@H](O)[C@H](O)[C@@H](CO)O3)O)=C2C=2C(O)=CC=C(C=2)[C@@H](NC(=O)[C@@H]2NC(=O)[C@@H]3C=4C=C(C(=C(O)C=4)C)OC=4C(O)=CC=C(C=4)[C@@H](N)C(=O)N[C@@H](C(=O)N3)[C@H](O)C=3C=CC(O4)=CC=3)C(=O)N1)C(O)=O)=O)C(C=C1)=CC=C1OC1=C(O[C@@H]3[C@H]([C@H](O)[C@@H](O)[C@H](CO[C@@H]5[C@H]([C@@H](O)[C@H](O)[C@@H](C)O5)O)O3)O[C@@H]3[C@H]([C@@H](O)[C@H](O)[C@@H](CO)O3)O[C@@H]3[C@H]([C@H](O)[C@@H](CO)O3)O)C4=CC2=C1 BGTFCAQCKWKTRL-YDEUACAXSA-N 0.000 abstract 1
- 229940034998 human von willebrand factor Drugs 0.000 abstract 1
- 230000009257 reactivity Effects 0.000 abstract 1
- 229950004257 ristocetin Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/36—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against blood coagulation factors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Hematology (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Diabetes (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP29707094 | 1994-11-30 | ||
| PCT/JP1995/002435 WO1996017078A1 (fr) | 1994-11-30 | 1995-11-29 | Agent antithrombotique et anticorps monoclonaux contre le facteur de von willebrand |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO972253D0 NO972253D0 (no) | 1997-05-16 |
| NO972253L true NO972253L (no) | 1997-07-29 |
| NO319738B1 NO319738B1 (no) | 2005-09-12 |
Family
ID=17841828
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO19972253A NO319738B1 (no) | 1994-11-30 | 1997-05-16 | Monoklonalt antistoff mot von Willebrand-faktor, antitrombotisk middel inneholdende dette som aktiv ingrediens, og hybridom som produserer et slikt antistoff |
Country Status (13)
| Country | Link |
|---|---|
| US (3) | US5916805A (no) |
| EP (1) | EP0795608B1 (no) |
| JP (1) | JP3331377B2 (no) |
| KR (1) | KR100406072B1 (no) |
| CN (1) | CN1254275C (no) |
| AT (1) | ATE236993T1 (no) |
| DE (1) | DE69530316T2 (no) |
| DK (1) | DK0795608T3 (no) |
| ES (1) | ES2197210T3 (no) |
| FI (1) | FI119734B (no) |
| NO (1) | NO319738B1 (no) |
| PT (1) | PT795608E (no) |
| WO (1) | WO1996017078A1 (no) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2197210T3 (es) * | 1994-11-30 | 2004-01-01 | Ajinomoto Co., Inc. | Agente antitrombotico y anticuerpos monoclonales contra el factor von willebrand. |
| EP0852951A1 (de) | 1996-11-19 | 1998-07-15 | Roche Diagnostics GmbH | Stabile lyophilisierte pharmazeutische Zubereitungen von mono- oder polyklonalen Antikörpern |
| US6228360B1 (en) * | 1998-08-19 | 2001-05-08 | Ajinomoto Co., Inc. | Antithrombotic agent and humanized anti-von Willebrand factor monoclonal antibody |
| CA2344606A1 (en) * | 1998-10-23 | 2000-05-04 | Huabing Yuan | Conformation-specific anti-von willebrand factor antibodies |
| CN1198198C (zh) * | 2001-02-27 | 2005-04-20 | 索尼公司 | 字符输入方法及字符输入装置 |
| JP2005298336A (ja) * | 2002-01-29 | 2005-10-27 | Ajinomoto Co Inc | 炎症性疾患治療用薬剤 |
| WO2004011030A1 (ja) * | 2002-07-29 | 2004-02-05 | Ajinomoto Co., Inc. | 血小板減少症治療用医薬組成物 |
| US20050136056A1 (en) * | 2002-07-29 | 2005-06-23 | Shunsuke Kageyama | Pharmaceutical composition for the treatment of thrombocytopenia |
| ATE512364T1 (de) * | 2002-08-07 | 2011-06-15 | Ablynx Nv | Modulation der blutplättchen-adhäsion basierend auf dem oberflächen-exponierten beta-switch loop des blutplättchen-glycoproteins ib-alpha |
| US9320792B2 (en) | 2002-11-08 | 2016-04-26 | Ablynx N.V. | Pulmonary administration of immunoglobulin single variable domains and constructs thereof |
| US20060034845A1 (en) * | 2002-11-08 | 2006-02-16 | Karen Silence | Single domain antibodies directed against tumor necrosis factor alpha and uses therefor |
| US20100003253A1 (en) * | 2002-11-08 | 2010-01-07 | Ablynx N.V. | Single domain antibodies directed against epidermal growth factor receptor and uses therefor |
| ES2551682T3 (es) * | 2002-11-08 | 2015-11-23 | Ablynx N.V. | Anticuerpos de dominio simple dirigidos contra factor de necrosis tumoral-alfa y usos para los mismos |
| JP2006520584A (ja) * | 2002-11-08 | 2006-09-14 | アブリンクス エン．ヴェー． | 安定化単一ドメイン抗体 |
| EP1558645B1 (en) * | 2002-11-08 | 2011-07-27 | Ablynx N.V. | Stabilized single domain antibodies in pharmaceutical composition adapted for inhalation |
| NZ576284A (en) * | 2003-01-10 | 2010-07-30 | Ablynx Nv | Therapeutic polypeptides, homologues thereof, fragments thereof and for use in modulating platelet-mediated aggregation |
| JP2006517789A (ja) * | 2003-01-10 | 2006-08-03 | アブリンクス エン．ヴェー． | 治療用ポリペプチド、その相同物、その断片、および血小板媒介凝集の調節での使用 |
| CN1323713C (zh) * | 2003-07-07 | 2007-07-04 | 张新侯 | 可溶性p－选择素及炭疽致死毒素的新用途 |
| JP2008512098A (ja) | 2004-09-07 | 2008-04-24 | アーケミックス コーポレイション | フォン・ビルブラント因子に対するアプタマー、および血栓性疾患の処置剤としてのその使用 |
| US7566701B2 (en) * | 2004-09-07 | 2009-07-28 | Archemix Corp. | Aptamers to von Willebrand Factor and their use as thrombotic disease therapeutics |
| WO2006029258A2 (en) * | 2004-09-07 | 2006-03-16 | Archemix Corp. | Aptamer medicinal chemistry |
| US20080003617A1 (en) * | 2004-12-20 | 2008-01-03 | Xiaomin Fan | Methods for the identification and the isolation of epitope specific antibodies |
| AU2006205900B8 (en) | 2005-01-14 | 2012-04-05 | Ablynx N.V. | Methods and assays for distinguishing between different forms of diseases and disorders characterized by thrombocytopenia and/or by spontaneous interaction between Von Willebrand Factor (vWF) and platelets |
| EP2444424B1 (en) | 2005-05-20 | 2018-08-08 | Ablynx N.V. | Improved nanobodies tm for the treatment of aggregation-mediated disorders |
| EP1958626B1 (en) | 2007-02-13 | 2014-07-23 | Ajinomoto Co., Inc. | Method for inactivating viruses by addition of slightly acidic arginine |
| WO2008150495A2 (en) * | 2007-06-01 | 2008-12-11 | Archemix Corp. | Vwf aptamer formulations and methods for use |
| AR070141A1 (es) * | 2008-01-23 | 2010-03-17 | Glenmark Pharmaceuticals Sa | Anticuerpos humanizados especificos para el factor von willebrand |
| CA2718081A1 (en) * | 2008-03-21 | 2009-09-24 | Ablynx Nv | Von willebrand factor specific binders and methods of use therefor |
| WO2009136568A1 (ja) | 2008-05-08 | 2009-11-12 | 味の素株式会社 | タンパク質のリフォールディング方法 |
| CN102532316B (zh) * | 2010-12-24 | 2014-06-18 | 神州细胞工程有限公司 | 一种抗vWF单克隆抗体及其应用 |
| CN107365388B (zh) | 2011-06-23 | 2021-05-14 | 味之素株式会社 | 多聚体蛋白的制备方法 |
| US20160320416A1 (en) * | 2013-12-18 | 2016-11-03 | Siemens Healthcare Diagnostics Inc. | Detection of endothelial disease |
| US10544231B2 (en) * | 2014-04-16 | 2020-01-28 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Antibodies for the prevention or the treatment of bleeding episodes |
| CA3145453A1 (en) | 2019-07-01 | 2021-01-07 | Tonix Pharma Limited | Anti-cd154 antibodies and uses thereof |
| MX2023008055A (es) | 2021-01-06 | 2023-08-22 | Tonix Pharma Ltd | Métodos para inducir tolerancia inmune con anticuerpos anti-cd154 modificados. |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5202264A (en) * | 1989-10-27 | 1993-04-13 | Health Research, Incorporated | ELISA using multi-species antibodies for detection of von Willebrand factor in multiple species |
| US5342830A (en) * | 1990-11-16 | 1994-08-30 | Cor Therapeutics, Inc. | Antithrombosis agents |
| ES2197210T3 (es) * | 1994-11-30 | 2004-01-01 | Ajinomoto Co., Inc. | Agente antitrombotico y anticuerpos monoclonales contra el factor von willebrand. |
| AU724579B2 (en) | 1996-04-01 | 2000-09-28 | Sankyo Company Limited | Anti-Fas recombinant antibodies and DNA therefor |
-
1995
- 1995-11-29 ES ES95938608T patent/ES2197210T3/es not_active Expired - Lifetime
- 1995-11-29 CN CNB951974742A patent/CN1254275C/zh not_active Expired - Fee Related
- 1995-11-29 AT AT95938608T patent/ATE236993T1/de active
- 1995-11-29 US US08/836,982 patent/US5916805A/en not_active Expired - Lifetime
- 1995-11-29 KR KR1019970703619A patent/KR100406072B1/ko not_active IP Right Cessation
- 1995-11-29 DE DE69530316T patent/DE69530316T2/de not_active Expired - Lifetime
- 1995-11-29 PT PT95938608T patent/PT795608E/pt unknown
- 1995-11-29 EP EP95938608A patent/EP0795608B1/en not_active Expired - Lifetime
- 1995-11-29 JP JP51858396A patent/JP3331377B2/ja not_active Expired - Fee Related
- 1995-11-29 WO PCT/JP1995/002435 patent/WO1996017078A1/ja active IP Right Grant
- 1995-11-29 DK DK95938608T patent/DK0795608T3/da active
-
1997
- 1997-05-16 NO NO19972253A patent/NO319738B1/no not_active IP Right Cessation
- 1997-05-29 FI FI972279A patent/FI119734B/fi not_active IP Right Cessation
-
1999
- 1999-04-26 US US09/299,016 patent/US6280731B1/en not_active Expired - Lifetime
-
2001
- 2001-08-08 US US09/923,952 patent/US6793920B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| WO1996017078A1 (fr) | 1996-06-06 |
| NO319738B1 (no) | 2005-09-12 |
| JP3331377B2 (ja) | 2002-10-07 |
| KR100406072B1 (ko) | 2004-03-30 |
| FI119734B (fi) | 2009-02-27 |
| ATE236993T1 (de) | 2003-04-15 |
| US6280731B1 (en) | 2001-08-28 |
| EP0795608B1 (en) | 2003-04-09 |
| PT795608E (pt) | 2003-08-29 |
| FI972279A (fi) | 1997-07-29 |
| US5916805A (en) | 1999-06-29 |
| ES2197210T3 (es) | 2004-01-01 |
| US20020028204A1 (en) | 2002-03-07 |
| NO972253D0 (no) | 1997-05-16 |
| CN1254275C (zh) | 2006-05-03 |
| DE69530316D1 (de) | 2003-05-15 |
| FI972279A0 (fi) | 1997-05-29 |
| EP0795608A1 (en) | 1997-09-17 |
| US6793920B2 (en) | 2004-09-21 |
| CN1174575A (zh) | 1998-02-25 |
| DK0795608T3 (da) | 2003-07-21 |
| EP0795608A4 (en) | 2001-11-28 |
| DE69530316T2 (de) | 2004-02-12 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM1K | Lapsed by not paying the annual fees |