FI972279A - Antitromboottinen aine ja monoklonaaliset vasta-aineet von Willenbrand-tekijää vastaan - Google Patents

Antitromboottinen aine ja monoklonaaliset vasta-aineet von Willenbrand-tekijää vastaan Download PDF

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Publication number
FI972279A
FI972279A FI972279A FI972279A FI972279A FI 972279 A FI972279 A FI 972279A FI 972279 A FI972279 A FI 972279A FI 972279 A FI972279 A FI 972279A FI 972279 A FI972279 A FI 972279A
Authority
FI
Finland
Prior art keywords
antithrombotic agent
monoclonal antibodies
antibodies against
action
platelet aggregation
Prior art date
Application number
FI972279A
Other languages
English (en)
Swedish (sv)
Other versions
FI119734B (fi
FI972279A0 (fi
Inventor
Mitsuyo Nagano
Hiroshi Yamamoto
Morikazu Kito
Ryota Yoshimoto
Tsuyoshi Kobayashi
Original Assignee
Ajinomoto Kk
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ajinomoto Kk filed Critical Ajinomoto Kk
Publication of FI972279A0 publication Critical patent/FI972279A0/fi
Publication of FI972279A publication Critical patent/FI972279A/fi
Application granted granted Critical
Publication of FI119734B publication Critical patent/FI119734B/fi

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/36—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against blood coagulation factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
FI972279A 1994-11-30 1997-05-29 Veren hyytymistä estävä aine ja von Willebrand-tekijän vastainen monoklonaalinen vasta-aine FI119734B (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP29707094 1994-11-30
JP29707094 1994-11-30
PCT/JP1995/002435 WO1996017078A1 (fr) 1994-11-30 1995-11-29 Agent antithrombotique et anticorps monoclonaux contre le facteur de von willebrand
JP9502435 1995-11-29

Publications (3)

Publication Number Publication Date
FI972279A0 FI972279A0 (fi) 1997-05-29
FI972279A true FI972279A (fi) 1997-07-29
FI119734B FI119734B (fi) 2009-02-27

Family

ID=17841828

Family Applications (1)

Application Number Title Priority Date Filing Date
FI972279A FI119734B (fi) 1994-11-30 1997-05-29 Veren hyytymistä estävä aine ja von Willebrand-tekijän vastainen monoklonaalinen vasta-aine

Country Status (13)

Country Link
US (3) US5916805A (fi)
EP (1) EP0795608B1 (fi)
JP (1) JP3331377B2 (fi)
KR (1) KR100406072B1 (fi)
CN (1) CN1254275C (fi)
AT (1) ATE236993T1 (fi)
DE (1) DE69530316T2 (fi)
DK (1) DK0795608T3 (fi)
ES (1) ES2197210T3 (fi)
FI (1) FI119734B (fi)
NO (1) NO319738B1 (fi)
PT (1) PT795608E (fi)
WO (1) WO1996017078A1 (fi)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1254275C (zh) * 1994-11-30 2006-05-03 味之素株式会社 抗血栓药剂和抗维勒布兰德因子单克隆抗体
EP0852951A1 (de) 1996-11-19 1998-07-15 Roche Diagnostics GmbH Stabile lyophilisierte pharmazeutische Zubereitungen von mono- oder polyklonalen Antikörpern
US6228360B1 (en) * 1998-08-19 2001-05-08 Ajinomoto Co., Inc. Antithrombotic agent and humanized anti-von Willebrand factor monoclonal antibody
AU755549B2 (en) * 1998-10-23 2002-12-12 Brigham And Women's Hospital Conformation-specific anti-von willebrand factor antibodies
CN1198198C (zh) * 2001-02-27 2005-04-20 索尼公司 字符输入方法及字符输入装置
JP2005298336A (ja) * 2002-01-29 2005-10-27 Ajinomoto Co Inc 炎症性疾患治療用薬剤
US20050136056A1 (en) * 2002-07-29 2005-06-23 Shunsuke Kageyama Pharmaceutical composition for the treatment of thrombocytopenia
AU2003252701A1 (en) * 2002-07-29 2004-02-16 Ajinomoto Co., Inc. Medicinal composition for treating thrombopenia
EP1527346B1 (en) * 2002-08-07 2011-06-08 Ablynx N.V. Modulation of platelet adhesion based on the surface exposed beta-switch loop of platelet glycoprotein ib-alpha
EP2316852B1 (en) * 2002-11-08 2014-03-05 Ablynx N.V. Stabilized single domain antibodies
EP1558646A2 (en) * 2002-11-08 2005-08-03 Ablynx N.V. Single domain antibodies directed against interferon- gamma and uses thereof
US20100003253A1 (en) * 2002-11-08 2010-01-07 Ablynx N.V. Single domain antibodies directed against epidermal growth factor receptor and uses therefor
US9320792B2 (en) 2002-11-08 2016-04-26 Ablynx N.V. Pulmonary administration of immunoglobulin single variable domains and constructs thereof
ES2466716T3 (es) * 2002-11-08 2014-06-11 Ablynx N.V. Anticuerpos de un solo dominio estabilizados
US20060034845A1 (en) * 2002-11-08 2006-02-16 Karen Silence Single domain antibodies directed against tumor necrosis factor alpha and uses therefor
NZ576284A (en) * 2003-01-10 2010-07-30 Ablynx Nv Therapeutic polypeptides, homologues thereof, fragments thereof and for use in modulating platelet-mediated aggregation
KR20050092029A (ko) * 2003-01-10 2005-09-16 아블린쓰 엔.브이. 폰 빌레브란트 인자(ｖＷＦ) 또는 콜라겐에 대한낙타과로부터의 재조합 ＶＨＨ 단일 도메인 항체
CN1323713C (zh) * 2003-07-07 2007-07-04 张新侯 可溶性p－选择素及炭疽致死毒素的新用途
CA2579374A1 (en) 2004-09-07 2006-03-30 Archemix Corp. Aptamers to von willebrand factor and their use as thrombotic disease therapeutics
US7566701B2 (en) * 2004-09-07 2009-07-28 Archemix Corp. Aptamers to von Willebrand Factor and their use as thrombotic disease therapeutics
KR20070101226A (ko) * 2004-09-07 2007-10-16 아케믹스 코포레이션 앱타머의 약화학
DK1836500T3 (da) * 2005-01-14 2010-11-01 Ablynx Nv Fremgangsmåde og assays til at skelne mellem forskellige former af sygdomme og lidelser, der er kendetegnet ved thrombocytopeni og/eller ved spantan interaktion mellem von Willbrandfaktor 8vWF) og blodplader
PT2444424T (pt) * 2005-05-20 2018-11-09 Ablynx Nv Nanocorpos tm aperfeiçoados para o tratamento de distúrbios mediados por agregação
EP1918302A3 (en) * 2006-05-18 2009-11-18 AvantGen, Inc. Methods for the identification and the isolation of epitope specific antibodies
EP1958626B1 (en) 2007-02-13 2014-07-23 Ajinomoto Co., Inc. Method for inactivating viruses by addition of slightly acidic arginine
WO2008150495A2 (en) * 2007-06-01 2008-12-11 Archemix Corp. Vwf aptamer formulations and methods for use
AR070141A1 (es) * 2008-01-23 2010-03-17 Glenmark Pharmaceuticals Sa Anticuerpos humanizados especificos para el factor von willebrand
CN101977654A (zh) * 2008-03-21 2011-02-16 埃博灵克斯股份有限公司 冯威勒布兰特因子特异性结合物及其应用方法
EP2281827B1 (en) 2008-05-08 2013-08-21 Ajinomoto Co., Inc. Protein refolding method
CN102532316B (zh) * 2010-12-24 2014-06-18 神州细胞工程有限公司 一种抗vWF单克隆抗体及其应用
JP5858251B2 (ja) 2011-06-23 2016-02-10 味の素株式会社 免疫グロブリン折りたたみ構造を持つタンパク質と、サブユニット構造となりうるタンパク質とを融合させた単量体タンパク質からなる多量体タンパク質の調製方法
EP3084437B1 (en) * 2013-12-18 2018-02-28 Siemens Healthcare Diagnostics Inc. Detection of endothelial disease
US10544231B2 (en) * 2014-04-16 2020-01-28 INSERM (Institut National de la Santé et de la Recherche Médicale) Antibodies for the prevention or the treatment of bleeding episodes
JP2022538674A (ja) 2019-07-01 2022-09-05 トニックス ファーマ リミテッド 抗ｃｄ１５４抗体およびその使用
CA3207098A1 (en) 2021-01-06 2022-07-14 Tonix Pharma Limited Methods of inducing immune tolerance with modified anti-cd154 antibodies

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5202264A (en) * 1989-10-27 1993-04-13 Health Research, Incorporated ELISA using multi-species antibodies for detection of von Willebrand factor in multiple species
US5342830A (en) * 1990-11-16 1994-08-30 Cor Therapeutics, Inc. Antithrombosis agents
CN1254275C (zh) * 1994-11-30 2006-05-03 味之素株式会社 抗血栓药剂和抗维勒布兰德因子单克隆抗体
AU724579B2 (en) 1996-04-01 2000-09-28 Sankyo Company Limited Anti-Fas recombinant antibodies and DNA therefor

Also Published As

Publication number Publication date
CN1254275C (zh) 2006-05-03
DK0795608T3 (da) 2003-07-21
DE69530316T2 (de) 2004-02-12
DE69530316D1 (de) 2003-05-15
EP0795608B1 (en) 2003-04-09
NO319738B1 (no) 2005-09-12
ES2197210T3 (es) 2004-01-01
FI119734B (fi) 2009-02-27
PT795608E (pt) 2003-08-29
ATE236993T1 (de) 2003-04-15
NO972253D0 (no) 1997-05-16
CN1174575A (zh) 1998-02-25
NO972253L (no) 1997-07-29
US6793920B2 (en) 2004-09-21
KR100406072B1 (ko) 2004-03-30
US6280731B1 (en) 2001-08-28
WO1996017078A1 (fr) 1996-06-06
US5916805A (en) 1999-06-29
JP3331377B2 (ja) 2002-10-07
FI972279A0 (fi) 1997-05-29
US20020028204A1 (en) 2002-03-07
EP0795608A1 (en) 1997-09-17
EP0795608A4 (en) 2001-11-28

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